ATE269852T1 - Entzündungshemmende piperazinyl-benzyl- tetrazolderivate und deren zwischenprodukte - Google Patents

Entzündungshemmende piperazinyl-benzyl- tetrazolderivate und deren zwischenprodukte

Info

Publication number
ATE269852T1
ATE269852T1 AT98924137T AT98924137T ATE269852T1 AT E269852 T1 ATE269852 T1 AT E269852T1 AT 98924137 T AT98924137 T AT 98924137T AT 98924137 T AT98924137 T AT 98924137T AT E269852 T1 ATE269852 T1 AT E269852T1
Authority
AT
Austria
Prior art keywords
piperazinyl
inflammatory
benzyl
intermediate products
tetrazole derivatives
Prior art date
Application number
AT98924137T
Other languages
English (en)
Inventor
Graham Nigel Maw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE269852T1 publication Critical patent/ATE269852T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98924137T 1997-05-19 1998-04-17 Entzündungshemmende piperazinyl-benzyl- tetrazolderivate und deren zwischenprodukte ATE269852T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9709972.5A GB9709972D0 (en) 1997-05-19 1997-05-19 Tetrazoles
PCT/EP1998/002277 WO1998052929A1 (en) 1997-05-19 1998-04-17 Anti-inflammatory piperazinyl-benzyl-tetrazole derivatives and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE269852T1 true ATE269852T1 (de) 2004-07-15

Family

ID=10812431

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98924137T ATE269852T1 (de) 1997-05-19 1998-04-17 Entzündungshemmende piperazinyl-benzyl- tetrazolderivate und deren zwischenprodukte

Country Status (19)

Country Link
US (1) US6514975B1 (de)
EP (1) EP0983251B1 (de)
JP (1) JP2000513024A (de)
AR (1) AR015679A1 (de)
AT (1) ATE269852T1 (de)
AU (1) AU7644998A (de)
BR (1) BR9809648A (de)
CA (1) CA2290501C (de)
DE (1) DE69824724T2 (de)
DK (1) DK0983251T3 (de)
ES (1) ES2221985T3 (de)
GB (1) GB9709972D0 (de)
HR (1) HRP980267A2 (de)
MA (1) MA26499A1 (de)
PA (1) PA8451601A1 (de)
PT (1) PT983251E (de)
TN (1) TNSN98066A1 (de)
WO (1) WO1998052929A1 (de)
ZA (1) ZA984158B (de)

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US5985880A (en) 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
US6054623A (en) * 1998-12-18 2000-04-25 Alliedsignal Inc. Hydroxythiol grignard reaction synthesis
US6503905B1 (en) 1998-12-29 2003-01-07 Pfizer Inc 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
US6455055B1 (en) 1999-02-12 2002-09-24 The Procter & Gamble Company Cosmetic compositions
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
EP1944292B9 (de) 2000-10-31 2016-07-06 Rensselaer Polytechnic Institute 8-substituierte 2,6-Methan-3-Benzazocine und 3-substituerte Morphinane als Liganden des Opioidrezeptors
CA2462953C (en) 2001-10-15 2011-01-04 Janssen Pharmaceutica N.V. Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists
US8575169B2 (en) 2001-10-29 2013-11-05 Versi Group, Llc Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
PL371297A1 (en) * 2001-10-29 2005-06-13 Ardent Pharmaceuticals, Inc. Method of treating depression with delta receptor agonist compounds
JP4665379B2 (ja) * 2002-06-28 2011-04-06 Ｄｉｃ株式会社 ヘリカルツイスティングパワーの増大方法、光学活性化合物、それを含有した液晶組成物及び液晶表示素子
US7132539B2 (en) 2002-10-23 2006-11-07 The Procter & Gamble Company Melanocortin receptor ligands
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
AU2005286733B2 (en) * 2004-09-23 2009-11-05 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US7683168B2 (en) * 2005-04-14 2010-03-23 Mount Cook Bio Sciences, Inc. Compositions of novel opioid compounds and method of use thereof
US7210814B2 (en) * 2005-04-29 2007-05-01 Ultradent Products, Inc. Dental curing light with specially arranged LEDs
CA2653497A1 (en) * 2006-05-26 2007-12-06 Neuromed Pharmaceuticals Ltd. Heterocyclic compounds as calcium channel blockers
PL2041088T3 (pl) 2006-06-28 2014-07-31 Amgen Inc Inhibitory transportera-1 glicyny
WO2010136032A1 (en) 2009-05-29 2010-12-02 Hydrema Produktion A/S A suspension system with inclination stabilization
TR201908514T4 (tr) 2009-12-04 2019-07-22 Alkermes Pharma Ireland Ltd İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇
JP5964809B2 (ja) 2010-03-22 2016-08-03 レンセラール ポリテクニック インスティチュート オピオイド受容体リガンドとしてのカルボキサミド基を含有するモルヒネ誘導体
US8778960B2 (en) 2010-08-23 2014-07-15 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
EP2725908B1 (de) 2011-06-29 2017-05-31 Alkermes, Inc. Peripher wirkende opioidverbindungen
PL3153171T3 (pl) 2011-12-15 2019-02-28 Alkermes Pharma Ireland Limited Samidorfan (alks 33) w połączeniu z buprenorfiną do leczenia zaburzeń depresyjnych
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
AU2014268361B2 (en) 2013-05-24 2018-09-06 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
EP3003311A2 (de) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Verfahren zur behandlung von symptomen für depression
CN106588873B (zh) * 2016-11-21 2019-11-12 云南省药物研究所 一种三芳基二甲基哌嗪乙二磺酸盐的多晶型物及其制备方法和应用
EP4243768A1 (de) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Mehrschichttablette mit sofortiger freisetzung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453285A (en) * 1967-11-29 1969-07-01 Miles Lab Tetrazolyl alkanoic acids
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
EP0585500A1 (de) * 1992-09-04 1994-03-09 Merrell Dow Pharmaceuticals Inc. Diaryl-Piperazinacetamid als antimuscarinische Wirkstoffe
ATE195733T1 (de) * 1993-07-30 2000-09-15 Delta Pharmaceuticals Inc Als heilmittel nutzbare piperazin verbindungen
JPH07247274A (ja) * 1994-03-10 1995-09-26 Wakamoto Pharmaceut Co Ltd ピバル酸 テトラゾリルフェニルエステル誘導体、それらを有効成分として含有するエラスターゼ阻害剤及び肺障害治療剤
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
USH2007H1 (en) * 1996-01-19 2001-12-04 Fmc Corporation Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines

Also Published As

Publication number Publication date
AR015679A1 (es) 2001-05-16
EP0983251A1 (de) 2000-03-08
BR9809648A (pt) 2000-07-11
DE69824724T2 (de) 2005-08-25
MA26499A1 (fr) 2004-12-20
CA2290501C (en) 2003-07-08
US6514975B1 (en) 2003-02-04
PT983251E (pt) 2004-08-31
JP2000513024A (ja) 2000-10-03
HRP980267A2 (en) 1999-02-28
WO1998052929A1 (en) 1998-11-26
PA8451601A1 (es) 2000-05-24
DK0983251T3 (da) 2004-09-27
AU7644998A (en) 1998-12-11
DE69824724D1 (de) 2004-07-29
CA2290501A1 (en) 1998-11-26
TNSN98066A1 (fr) 2005-03-15
ZA984158B (en) 1999-11-19
EP0983251B1 (de) 2004-06-23
ES2221985T3 (es) 2005-01-16
GB9709972D0 (en) 1997-07-09

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