AR015679A1 - Compuestos de tetrazol, composicion farmaceutica que los contiene, uso de dichos compuestos para la manufactura de medicamentos, intermediarios utiles enmanufactura de dichos compuestos - Google Patents

Compuestos de tetrazol, composicion farmaceutica que los contiene, uso de dichos compuestos para la manufactura de medicamentos, intermediarios utiles enmanufactura de dichos compuestos

Info

Publication number
AR015679A1
AR015679A1 ARP980102281A ARP980102281A AR015679A1 AR 015679 A1 AR015679 A1 AR 015679A1 AR P980102281 A ARP980102281 A AR P980102281A AR P980102281 A ARP980102281 A AR P980102281A AR 015679 A1 AR015679 A1 AR 015679A1
Authority
AR
Argentina
Prior art keywords
alkyl
compounds
manufacture
formula
medicines
Prior art date
Application number
ARP980102281A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR015679A1 publication Critical patent/AR015679A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Tetrazoles y sus sales farmacéuticamente aceptables que son agonistas selectivos para el receptor de opioides delta, particularmente utiles en eltratamiento de enfermedades inflamatorias tales como artritis, psoriasis, asma, enfermedad inflamatoria del intestino, trastornos de la funcion respiratoria,trastornos gastrointestinales tales como enfermedad funcional del intestino y trastornos GI funcionales, de la formula (I) o una sal farmacéuticamenteaceptable del mismo caracterizado porque R1 es H, alcanoílo C2-6, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, (cicloalquil C3-7)-(alquiloC1-4), (alcoxi C1-4)-(alquilo C1-4), carboxi(alquilo C1-4), aril(alquilo C1-4) o heteroaril-(alquilo C1-4); cada uno de R2 y R3 es, inddependientemente, H oalquilo C1-4; R4 se selecciona entre (i) H, (ii) un grupo de la formula R6-(CH2)m-Z-(CH2)n-, donde m es 0, 1, 2, o 3, n es 1, 2 o 3, Z es un enlace directo uO, y R6 es -CO2H o -CO2(alquilo C1-C4), y (iii) un grupo de la formula (II) en la que R7 es H o alquilo C1-4; y R5 es hidroxi, alcoxi C1-4 o -NHSO2(alquiloC1-4); con la condicion de que cuando Z es O, m es 1, 2 o 3 y n es 2 o 3.
ARP980102281A 1997-05-19 1998-05-15 Compuestos de tetrazol, composicion farmaceutica que los contiene, uso de dichos compuestos para la manufactura de medicamentos, intermediarios utiles enmanufactura de dichos compuestos AR015679A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9709972.5A GB9709972D0 (en) 1997-05-19 1997-05-19 Tetrazoles

Publications (1)

Publication Number Publication Date
AR015679A1 true AR015679A1 (es) 2001-05-16

Family

ID=10812431

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980102281A AR015679A1 (es) 1997-05-19 1998-05-15 Compuestos de tetrazol, composicion farmaceutica que los contiene, uso de dichos compuestos para la manufactura de medicamentos, intermediarios utiles enmanufactura de dichos compuestos

Country Status (19)

Country Link
US (1) US6514975B1 (es)
EP (1) EP0983251B1 (es)
JP (1) JP2000513024A (es)
AR (1) AR015679A1 (es)
AT (1) ATE269852T1 (es)
AU (1) AU7644998A (es)
BR (1) BR9809648A (es)
CA (1) CA2290501C (es)
DE (1) DE69824724T2 (es)
DK (1) DK0983251T3 (es)
ES (1) ES2221985T3 (es)
GB (1) GB9709972D0 (es)
HR (1) HRP980267A2 (es)
MA (1) MA26499A1 (es)
PA (1) PA8451601A1 (es)
PT (1) PT983251E (es)
TN (1) TNSN98066A1 (es)
WO (1) WO1998052929A1 (es)
ZA (1) ZA984158B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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US5985880A (en) 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
US6054623A (en) 1998-12-18 2000-04-25 Alliedsignal Inc. Hydroxythiol grignard reaction synthesis
US6503905B1 (en) 1998-12-29 2003-01-07 Pfizer Inc 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
US6455055B1 (en) 1999-02-12 2002-09-24 The Procter & Gamble Company Cosmetic compositions
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
JP4340437B2 (ja) 2000-10-31 2009-10-07 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
AU2002346994B2 (en) 2001-10-15 2007-09-06 Janssen Pharmaceutica N.V. Novel substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists
CN1596113B (zh) * 2001-10-29 2010-05-26 蒙特库克生物科学公司 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用
EP1469850B1 (en) 2002-01-02 2013-01-02 Versi Group, LLC Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
JP4665379B2 (ja) * 2002-06-28 2011-04-06 Ｄｉｃ株式会社 ヘリカルツイスティングパワーの増大方法、光学活性化合物、それを含有した液晶組成物及び液晶表示素子
US7132539B2 (en) 2002-10-23 2006-11-07 The Procter & Gamble Company Melanocortin receptor ligands
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
EP1809104A4 (en) * 2004-09-23 2009-04-29 Alexander Michalow METHODS FOR REGULATING NEUROTRANSMITTER SYSTEMS BY INDUCING COUNTER-ADAPTATIONS
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
AU2006236622B2 (en) * 2005-04-14 2011-09-22 Versi Group Llc Compositions of novel opioid compounds and method of use thereof
US7210814B2 (en) * 2005-04-29 2007-05-01 Ultradent Products, Inc. Dental curing light with specially arranged LEDs
US20100029681A1 (en) * 2006-05-26 2010-02-04 Hassan Pajouhesh Heterocyclic compounds as calcium channel blockers
EA014959B3 (ru) * 2006-06-28 2014-10-30 Амген Инк. Ингибиторы глицинового переносчика-1
US8573616B2 (en) 2009-05-29 2013-11-05 Hydema Produktion A/S Suspension system with inclination stabilization
JP5691042B2 (ja) 2009-12-04 2015-04-01 アルカーメス ファーマ アイルランド リミテッド 薬物過量摂取の治療のためのモルヒナン誘導体
EP2550253B9 (en) 2010-03-22 2016-09-21 Rensselaer Polytechnic Institute Morphinane derivatives containing a carboxamide group as opioid receptor ligands
RS65091B1 (sr) 2010-08-23 2024-02-29 Alkermes Pharma Ireland Ltd Postupci za lečenje povećanja telesne težine indukovanog antipsihoticima
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
EP2725908B1 (en) 2011-06-29 2017-05-31 Alkermes, Inc. Peripherally acting opioid compounds
JP6038170B2 (ja) 2011-12-15 2016-12-07 アルカーメス ファーマ アイルランド リミテッド ブプレノルフィンおよびμ−オピオイド受容体アンタゴニストの組成物
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
AU2014268361B2 (en) 2013-05-24 2018-09-06 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
CN106588873B (zh) * 2016-11-21 2019-11-12 云南省药物研究所 一种三芳基二甲基哌嗪乙二磺酸盐的多晶型物及其制备方法和应用
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

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US3453285A (en) * 1967-11-29 1969-07-01 Miles Lab Tetrazolyl alkanoic acids
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
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JPH07247274A (ja) * 1994-03-10 1995-09-26 Wakamoto Pharmaceut Co Ltd ピバル酸 テトラゾリルフェニルエステル誘導体、それらを有効成分として含有するエラスターゼ阻害剤及び肺障害治療剤
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Also Published As

Publication number Publication date
ATE269852T1 (de) 2004-07-15
DK0983251T3 (da) 2004-09-27
JP2000513024A (ja) 2000-10-03
EP0983251B1 (en) 2004-06-23
DE69824724T2 (de) 2005-08-25
EP0983251A1 (en) 2000-03-08
PT983251E (pt) 2004-08-31
WO1998052929A1 (en) 1998-11-26
ZA984158B (en) 1999-11-19
GB9709972D0 (en) 1997-07-09
AU7644998A (en) 1998-12-11
TNSN98066A1 (fr) 2005-03-15
US6514975B1 (en) 2003-02-04
HRP980267A2 (en) 1999-02-28
PA8451601A1 (es) 2000-05-24
MA26499A1 (fr) 2004-12-20
ES2221985T3 (es) 2005-01-16
CA2290501C (en) 2003-07-08
DE69824724D1 (de) 2004-07-29
BR9809648A (pt) 2000-07-11
CA2290501A1 (en) 1998-11-26

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