AR015679A1 - Compuestos de tetrazol, composicion farmaceutica que los contiene, uso de dichos compuestos para la manufactura de medicamentos, intermediarios utiles enmanufactura de dichos compuestos - Google Patents
Compuestos de tetrazol, composicion farmaceutica que los contiene, uso de dichos compuestos para la manufactura de medicamentos, intermediarios utiles enmanufactura de dichos compuestosInfo
- Publication number
- AR015679A1 AR015679A1 ARP980102281A ARP980102281A AR015679A1 AR 015679 A1 AR015679 A1 AR 015679A1 AR P980102281 A ARP980102281 A AR P980102281A AR P980102281 A ARP980102281 A AR P980102281A AR 015679 A1 AR015679 A1 AR 015679A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- compounds
- manufacture
- formula
- medicines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Tetrazoles y sus sales farmacéuticamente aceptables que son agonistas selectivos para el receptor de opioides delta, particularmente utiles en eltratamiento de enfermedades inflamatorias tales como artritis, psoriasis, asma, enfermedad inflamatoria del intestino, trastornos de la funcion respiratoria,trastornos gastrointestinales tales como enfermedad funcional del intestino y trastornos GI funcionales, de la formula (I) o una sal farmacéuticamenteaceptable del mismo caracterizado porque R1 es H, alcanoílo C2-6, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, (cicloalquil C3-7)-(alquiloC1-4), (alcoxi C1-4)-(alquilo C1-4), carboxi(alquilo C1-4), aril(alquilo C1-4) o heteroaril-(alquilo C1-4); cada uno de R2 y R3 es, inddependientemente, H oalquilo C1-4; R4 se selecciona entre (i) H, (ii) un grupo de la formula R6-(CH2)m-Z-(CH2)n-, donde m es 0, 1, 2, o 3, n es 1, 2 o 3, Z es un enlace directo uO, y R6 es -CO2H o -CO2(alquilo C1-C4), y (iii) un grupo de la formula (II) en la que R7 es H o alquilo C1-4; y R5 es hidroxi, alcoxi C1-4 o -NHSO2(alquiloC1-4); con la condicion de que cuando Z es O, m es 1, 2 o 3 y n es 2 o 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9709972.5A GB9709972D0 (en) | 1997-05-19 | 1997-05-19 | Tetrazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
AR015679A1 true AR015679A1 (es) | 2001-05-16 |
Family
ID=10812431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980102281A AR015679A1 (es) | 1997-05-19 | 1998-05-15 | Compuestos de tetrazol, composicion farmaceutica que los contiene, uso de dichos compuestos para la manufactura de medicamentos, intermediarios utiles enmanufactura de dichos compuestos |
Country Status (19)
Country | Link |
---|---|
US (1) | US6514975B1 (es) |
EP (1) | EP0983251B1 (es) |
JP (1) | JP2000513024A (es) |
AR (1) | AR015679A1 (es) |
AT (1) | ATE269852T1 (es) |
AU (1) | AU7644998A (es) |
BR (1) | BR9809648A (es) |
CA (1) | CA2290501C (es) |
DE (1) | DE69824724T2 (es) |
DK (1) | DK0983251T3 (es) |
ES (1) | ES2221985T3 (es) |
GB (1) | GB9709972D0 (es) |
HR (1) | HRP980267A2 (es) |
MA (1) | MA26499A1 (es) |
PA (1) | PA8451601A1 (es) |
PT (1) | PT983251E (es) |
TN (1) | TNSN98066A1 (es) |
WO (1) | WO1998052929A1 (es) |
ZA (1) | ZA984158B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
US6054623A (en) * | 1998-12-18 | 2000-04-25 | Alliedsignal Inc. | Hydroxythiol grignard reaction synthesis |
US6503905B1 (en) | 1998-12-29 | 2003-01-07 | Pfizer Inc | 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives |
US6455055B1 (en) | 1999-02-12 | 2002-09-24 | The Procter & Gamble Company | Cosmetic compositions |
PE20010623A1 (es) * | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
EP1944292B9 (en) | 2000-10-31 | 2016-07-06 | Rensselaer Polytechnic Institute | 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
CA2462953C (en) | 2001-10-15 | 2011-01-04 | Janssen Pharmaceutica N.V. | Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
US8575169B2 (en) | 2001-10-29 | 2013-11-05 | Versi Group, Llc | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
PL371297A1 (en) * | 2001-10-29 | 2005-06-13 | Ardent Pharmaceuticals, Inc. | Method of treating depression with delta receptor agonist compounds |
JP4665379B2 (ja) * | 2002-06-28 | 2011-04-06 | Dic株式会社 | ヘリカルツイスティングパワーの増大方法、光学活性化合物、それを含有した液晶組成物及び液晶表示素子 |
US7132539B2 (en) | 2002-10-23 | 2006-11-07 | The Procter & Gamble Company | Melanocortin receptor ligands |
US20050026879A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20090297611A1 (en) * | 2003-07-31 | 2009-12-03 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
AU2005286733B2 (en) * | 2004-09-23 | 2009-11-05 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
US7683168B2 (en) * | 2005-04-14 | 2010-03-23 | Mount Cook Bio Sciences, Inc. | Compositions of novel opioid compounds and method of use thereof |
US7210814B2 (en) * | 2005-04-29 | 2007-05-01 | Ultradent Products, Inc. | Dental curing light with specially arranged LEDs |
CA2653497A1 (en) * | 2006-05-26 | 2007-12-06 | Neuromed Pharmaceuticals Ltd. | Heterocyclic compounds as calcium channel blockers |
PL2041088T3 (pl) | 2006-06-28 | 2014-07-31 | Amgen Inc | Inhibitory transportera-1 glicyny |
WO2010136032A1 (en) | 2009-05-29 | 2010-12-02 | Hydrema Produktion A/S | A suspension system with inclination stabilization |
TR201908514T4 (tr) | 2009-12-04 | 2019-07-22 | Alkermes Pharma Ireland Ltd | İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇ |
JP5964809B2 (ja) | 2010-03-22 | 2016-08-03 | レンセラール ポリテクニック インスティチュート | オピオイド受容体リガンドとしてのカルボキサミド基を含有するモルヒネ誘導体 |
US8778960B2 (en) | 2010-08-23 | 2014-07-15 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
WO2012138888A1 (en) | 2011-04-05 | 2012-10-11 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
EP2725908B1 (en) | 2011-06-29 | 2017-05-31 | Alkermes, Inc. | Peripherally acting opioid compounds |
PL3153171T3 (pl) | 2011-12-15 | 2019-02-28 | Alkermes Pharma Ireland Limited | Samidorfan (alks 33) w połączeniu z buprenorfiną do leczenia zaburzeń depresyjnych |
US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
AU2014268361B2 (en) | 2013-05-24 | 2018-09-06 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
EP3003311A2 (en) | 2013-05-24 | 2016-04-13 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
CN106588873B (zh) * | 2016-11-21 | 2019-11-12 | 云南省药物研究所 | 一种三芳基二甲基哌嗪乙二磺酸盐的多晶型物及其制备方法和应用 |
EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3453285A (en) * | 1967-11-29 | 1969-07-01 | Miles Lab | Tetrazolyl alkanoic acids |
GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
EP0585500A1 (en) * | 1992-09-04 | 1994-03-09 | Merrell Dow Pharmaceuticals Inc. | Diaryl piperazineacetamides as antimuscarinic agents |
ATE195733T1 (de) * | 1993-07-30 | 2000-09-15 | Delta Pharmaceuticals Inc | Als heilmittel nutzbare piperazin verbindungen |
JPH07247274A (ja) * | 1994-03-10 | 1995-09-26 | Wakamoto Pharmaceut Co Ltd | ピバル酸 テトラゾリルフェニルエステル誘導体、それらを有効成分として含有するエラスターゼ阻害剤及び肺障害治療剤 |
SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
USH2007H1 (en) * | 1996-01-19 | 2001-12-04 | Fmc Corporation | Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines |
-
1997
- 1997-05-19 GB GBGB9709972.5A patent/GB9709972D0/en active Pending
-
1998
- 1998-04-17 DK DK98924137T patent/DK0983251T3/da active
- 1998-04-17 AT AT98924137T patent/ATE269852T1/de not_active IP Right Cessation
- 1998-04-17 BR BR9809648-6A patent/BR9809648A/pt not_active IP Right Cessation
- 1998-04-17 AU AU76449/98A patent/AU7644998A/en not_active Abandoned
- 1998-04-17 DE DE69824724T patent/DE69824724T2/de not_active Expired - Fee Related
- 1998-04-17 JP JP10549851A patent/JP2000513024A/ja not_active Ceased
- 1998-04-17 CA CA002290501A patent/CA2290501C/en not_active Expired - Fee Related
- 1998-04-17 ES ES98924137T patent/ES2221985T3/es not_active Expired - Lifetime
- 1998-04-17 PT PT98924137T patent/PT983251E/pt unknown
- 1998-04-17 WO PCT/EP1998/002277 patent/WO1998052929A1/en active IP Right Grant
- 1998-04-17 EP EP98924137A patent/EP0983251B1/en not_active Expired - Lifetime
- 1998-04-17 US US09/367,322 patent/US6514975B1/en not_active Expired - Fee Related
- 1998-05-15 AR ARP980102281A patent/AR015679A1/es unknown
- 1998-05-15 PA PA19988451601A patent/PA8451601A1/es unknown
- 1998-05-18 ZA ZA9804158A patent/ZA984158B/xx unknown
- 1998-05-18 MA MA25079A patent/MA26499A1/fr unknown
- 1998-05-18 TN TNTNSN98066A patent/TNSN98066A1/fr unknown
- 1998-05-19 HR HR9709972.5A patent/HRP980267A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0983251A1 (en) | 2000-03-08 |
BR9809648A (pt) | 2000-07-11 |
DE69824724T2 (de) | 2005-08-25 |
MA26499A1 (fr) | 2004-12-20 |
CA2290501C (en) | 2003-07-08 |
US6514975B1 (en) | 2003-02-04 |
PT983251E (pt) | 2004-08-31 |
JP2000513024A (ja) | 2000-10-03 |
HRP980267A2 (en) | 1999-02-28 |
WO1998052929A1 (en) | 1998-11-26 |
PA8451601A1 (es) | 2000-05-24 |
DK0983251T3 (da) | 2004-09-27 |
AU7644998A (en) | 1998-12-11 |
DE69824724D1 (de) | 2004-07-29 |
CA2290501A1 (en) | 1998-11-26 |
TNSN98066A1 (fr) | 2005-03-15 |
ZA984158B (en) | 1999-11-19 |
EP0983251B1 (en) | 2004-06-23 |
ES2221985T3 (es) | 2005-01-16 |
ATE269852T1 (de) | 2004-07-15 |
GB9709972D0 (en) | 1997-07-09 |
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