ATE267828T1 - Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystems - Google Patents
Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystemsInfo
- Publication number
- ATE267828T1 ATE267828T1 AT98953243T AT98953243T ATE267828T1 AT E267828 T1 ATE267828 T1 AT E267828T1 AT 98953243 T AT98953243 T AT 98953243T AT 98953243 T AT98953243 T AT 98953243T AT E267828 T1 ATE267828 T1 AT E267828T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- dipyridoimidazole
- treatment
- nervous system
- central nervous
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6124897P | 1997-10-07 | 1997-10-07 | |
| PCT/US1998/020802 WO1999018105A1 (en) | 1997-10-07 | 1998-10-05 | Dipyridoimidazolderivatives useful in treating central nervous system disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267828T1 true ATE267828T1 (de) | 2004-06-15 |
Family
ID=22034585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98953243T ATE267828T1 (de) | 1997-10-07 | 1998-10-05 | Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystems |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5968946A (de) |
| EP (1) | EP1023291B1 (de) |
| JP (1) | JP2001519351A (de) |
| AT (1) | ATE267828T1 (de) |
| AU (1) | AU1066499A (de) |
| CA (1) | CA2305342A1 (de) |
| DE (1) | DE69824195T2 (de) |
| DK (1) | DK1023291T3 (de) |
| ES (1) | ES2221996T3 (de) |
| PT (1) | PT1023291E (de) |
| WO (1) | WO1999018105A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001009132A1 (en) | 1999-08-02 | 2001-02-08 | Ortho-Mcneil Pharmaceutical, Inc. | C-6 RING-SUBSTITUTED PYRIDO[1,2-a]BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS |
| AU2001264932A1 (en) * | 2000-05-26 | 2001-12-11 | Neurogen Corporation | Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands |
| RU2412942C2 (ru) | 2003-10-03 | 2011-02-27 | 3М Инновейтив Пропертиз Компани | Оксизамещенные имидазохинолины, способные модулировать биосинтез цитокинов |
| JP4667384B2 (ja) * | 2003-10-07 | 2011-04-13 | レノビス， インコーポレイテッド | イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法 |
| CA2547020C (en) | 2003-11-25 | 2014-03-25 | 3M Innovative Properties Company | 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier |
| WO2005066172A1 (en) * | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds |
| EP1844201B1 (de) | 2005-02-04 | 2016-08-24 | 3M Innovative Properties Company | Wässrige gelformulierungen mit immunreaktionsmodifikatoren |
| US7576099B2 (en) * | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| WO2006093832A2 (en) * | 2005-02-28 | 2006-09-08 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| WO2008112205A1 (en) * | 2007-03-09 | 2008-09-18 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| CN109982997A (zh) * | 2016-12-06 | 2019-07-05 | 日本化药株式会社 | 3-(吡啶基-2-氨基)丙腈及其类似物的制造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2153842T3 (es) * | 1992-08-19 | 2001-03-16 | Mcneilab Inc | Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central. |
| PT935598E (pt) * | 1996-10-07 | 2004-03-31 | Ortho Mcneil Pharm Inc | Derivados de 3-oxo-pirido (1,2-a)benzimidazole-4-carboxamida alquilo substituidos contendo 5 heteroatomos uteis no tratamento de disturbios do sistema nervoso central |
-
1998
- 1998-10-05 AT AT98953243T patent/ATE267828T1/de not_active IP Right Cessation
- 1998-10-05 PT PT98953243T patent/PT1023291E/pt unknown
- 1998-10-05 DE DE69824195T patent/DE69824195T2/de not_active Expired - Fee Related
- 1998-10-05 AU AU10664/99A patent/AU1066499A/en not_active Abandoned
- 1998-10-05 ES ES98953243T patent/ES2221996T3/es not_active Expired - Lifetime
- 1998-10-05 EP EP98953243A patent/EP1023291B1/de not_active Expired - Lifetime
- 1998-10-05 DK DK98953243T patent/DK1023291T3/da active
- 1998-10-05 US US09/166,327 patent/US5968946A/en not_active Expired - Lifetime
- 1998-10-05 JP JP2000514916A patent/JP2001519351A/ja active Pending
- 1998-10-05 WO PCT/US1998/020802 patent/WO1999018105A1/en not_active Ceased
- 1998-10-05 CA CA002305342A patent/CA2305342A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU1066499A (en) | 1999-04-27 |
| PT1023291E (pt) | 2004-09-30 |
| EP1023291A1 (de) | 2000-08-02 |
| DK1023291T3 (da) | 2004-10-04 |
| DE69824195D1 (de) | 2004-07-01 |
| US5968946A (en) | 1999-10-19 |
| WO1999018105A1 (en) | 1999-04-15 |
| CA2305342A1 (en) | 1999-04-15 |
| DE69824195T2 (de) | 2005-06-23 |
| EP1023291B1 (de) | 2004-05-26 |
| JP2001519351A (ja) | 2001-10-23 |
| ES2221996T3 (es) | 2005-01-16 |
| WO1999018105A8 (en) | 1999-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1023291 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |