ATE267828T1 - Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystems - Google Patents
Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystemsInfo
- Publication number
- ATE267828T1 ATE267828T1 AT98953243T AT98953243T ATE267828T1 AT E267828 T1 ATE267828 T1 AT E267828T1 AT 98953243 T AT98953243 T AT 98953243T AT 98953243 T AT98953243 T AT 98953243T AT E267828 T1 ATE267828 T1 AT E267828T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- dipyridoimidazole
- treatment
- nervous system
- central nervous
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6124897P | 1997-10-07 | 1997-10-07 | |
| PCT/US1998/020802 WO1999018105A1 (en) | 1997-10-07 | 1998-10-05 | Dipyridoimidazolderivatives useful in treating central nervous system disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267828T1 true ATE267828T1 (de) | 2004-06-15 |
Family
ID=22034585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98953243T ATE267828T1 (de) | 1997-10-07 | 1998-10-05 | Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystems |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5968946A (de) |
| EP (1) | EP1023291B1 (de) |
| JP (1) | JP2001519351A (de) |
| AT (1) | ATE267828T1 (de) |
| AU (1) | AU1066499A (de) |
| CA (1) | CA2305342A1 (de) |
| DE (1) | DE69824195T2 (de) |
| DK (1) | DK1023291T3 (de) |
| ES (1) | ES2221996T3 (de) |
| PT (1) | PT1023291E (de) |
| WO (1) | WO1999018105A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003506373A (ja) * | 1999-08-02 | 2003-02-18 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 中枢神経系疾患の治療で有用なＣ−６環置換ピリド［１，２−ａ］ベンズイミダゾール誘導体 |
| AU2001264932A1 (en) | 2000-05-26 | 2001-12-11 | Neurogen Corporation | Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands |
| AR046046A1 (es) | 2003-10-03 | 2005-11-23 | 3M Innovative Properties Co | Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas. |
| MXPA06003951A (es) * | 2003-10-07 | 2006-06-27 | Renovis Inc | Derivados de amida como ligandos del canal de ion y composiciones farmaceuticas y sus metodos de uso. |
| CA2547020C (en) | 2003-11-25 | 2014-03-25 | 3M Innovative Properties Company | 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier |
| JP2007530450A (ja) | 2003-12-29 | 2007-11-01 | スリーエム イノベイティブ プロパティズ カンパニー | ピペラジン、［１，４］ジアゼパン、［１，４］ジアゾカン、および［１，５］ジアゾカン縮合イミダゾ環化合物 |
| AU2006210392A1 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune response modifiers |
| EP1853269A4 (de) * | 2005-02-28 | 2011-09-07 | Renovis Inc | Amidderivate als ionenkanalliganden und pharmazeutische zusammensetzungen sowie verfahren damit |
| US7576099B2 (en) * | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| JP2010520875A (ja) * | 2007-03-09 | 2010-06-17 | レノビス， インコーポレイテッド | Ｐ２ｘ７調節因子としてのビシクロヘテロアリール化合物およびその使用 |
| WO2018105492A1 (ja) | 2016-12-06 | 2018-06-14 | 日本化薬株式会社 | ３－（ピリジル－２－アミノ）プロピオニトリル及びその類縁体の製造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0656002B1 (de) * | 1992-08-19 | 2000-11-08 | Mcneilab, Inc. | 3-oxo-pyrido [1,2-a] benzimidazol-4-carboxyl und 4-oxo-azepino [1,2-a] benzimidazol-5-carboxyl derivate geeignet für die behandlung von zentralnervensystemerkrankungen |
| PT935598E (pt) * | 1996-10-07 | 2004-03-31 | Ortho Mcneil Pharm Inc | Derivados de 3-oxo-pirido (1,2-a)benzimidazole-4-carboxamida alquilo substituidos contendo 5 heteroatomos uteis no tratamento de disturbios do sistema nervoso central |
-
1998
- 1998-10-05 PT PT98953243T patent/PT1023291E/pt unknown
- 1998-10-05 DE DE69824195T patent/DE69824195T2/de not_active Expired - Fee Related
- 1998-10-05 ES ES98953243T patent/ES2221996T3/es not_active Expired - Lifetime
- 1998-10-05 JP JP2000514916A patent/JP2001519351A/ja active Pending
- 1998-10-05 AU AU10664/99A patent/AU1066499A/en not_active Abandoned
- 1998-10-05 EP EP98953243A patent/EP1023291B1/de not_active Expired - Lifetime
- 1998-10-05 CA CA002305342A patent/CA2305342A1/en not_active Abandoned
- 1998-10-05 AT AT98953243T patent/ATE267828T1/de not_active IP Right Cessation
- 1998-10-05 US US09/166,327 patent/US5968946A/en not_active Expired - Lifetime
- 1998-10-05 WO PCT/US1998/020802 patent/WO1999018105A1/en not_active Ceased
- 1998-10-05 DK DK98953243T patent/DK1023291T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DK1023291T3 (da) | 2004-10-04 |
| JP2001519351A (ja) | 2001-10-23 |
| WO1999018105A8 (en) | 1999-06-10 |
| EP1023291B1 (de) | 2004-05-26 |
| CA2305342A1 (en) | 1999-04-15 |
| AU1066499A (en) | 1999-04-27 |
| PT1023291E (pt) | 2004-09-30 |
| DE69824195T2 (de) | 2005-06-23 |
| US5968946A (en) | 1999-10-19 |
| EP1023291A1 (de) | 2000-08-02 |
| DE69824195D1 (de) | 2004-07-01 |
| ES2221996T3 (es) | 2005-01-16 |
| WO1999018105A1 (en) | 1999-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1023291 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |