ATE260338T1 - Hefestämme und modifizierte albumine - Google Patents
Hefestämme und modifizierte albumineInfo
- Publication number
- ATE260338T1 ATE260338T1 AT95909880T AT95909880T ATE260338T1 AT E260338 T1 ATE260338 T1 AT E260338T1 AT 95909880 T AT95909880 T AT 95909880T AT 95909880 T AT95909880 T AT 95909880T AT E260338 T1 ATE260338 T1 AT E260338T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- albumin
- yeast strains
- yeast
- yap3p
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9404270A GB9404270D0 (en) | 1994-03-05 | 1994-03-05 | Yeast strains and modified albumins |
| PCT/GB1995/000434 WO1995023857A1 (en) | 1994-03-05 | 1995-03-01 | Yeast strains and modified albumins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE260338T1 true ATE260338T1 (de) | 2004-03-15 |
Family
ID=10751353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95909880T ATE260338T1 (de) | 1994-03-05 | 1995-03-01 | Hefestämme und modifizierte albumine |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5965386A (de) |
| EP (1) | EP0749478B1 (de) |
| JP (1) | JP3795073B2 (de) |
| KR (1) | KR100372514B1 (de) |
| AT (1) | ATE260338T1 (de) |
| AU (1) | AU683728B2 (de) |
| CA (1) | CA2183241C (de) |
| DE (1) | DE69532603T2 (de) |
| DK (1) | DK0749478T3 (de) |
| ES (1) | ES2216007T3 (de) |
| GB (2) | GB9404270D0 (de) |
| PT (1) | PT749478E (de) |
| WO (1) | WO1995023857A1 (de) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| DE69717629T2 (de) * | 1996-07-05 | 2003-09-11 | Novo Nordisk A/S, Bagsvaerd | Verfahren zur produktion von polypeptiden |
| WO1998001473A1 (en) * | 1996-07-05 | 1998-01-15 | Novo Nordisk A/S | Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides |
| US6110703A (en) * | 1996-07-05 | 2000-08-29 | Novo Nordisk A/S | Method for the production of polypeptides |
| US6274305B1 (en) | 1996-12-19 | 2001-08-14 | Tufts University | Inhibiting proliferation of cancer cells |
| US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
| AU2241699A (en) * | 1998-01-27 | 1999-08-09 | Board Of Regents Of The University And Community College System Of Nevada, The | Expression of proteolytically-sensitive peptides |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| ES2529300T3 (es) | 2000-04-12 | 2015-02-18 | Novozymes Biopharma Dk A/S | Proteínas de fusión de albúmina |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1317278B1 (de) * | 2000-09-11 | 2009-11-11 | Dana-Farber Cancer Institute, Inc. | Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren |
| WO2002058450A2 (en) * | 2000-12-22 | 2002-08-01 | Dana-Faber Cancer Institute, Inc. | Regulation of cell growth by muc1 |
| US20050054051A1 (en) * | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7507413B2 (en) * | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP2003047471A (ja) * | 2001-08-01 | 2003-02-18 | Kirin Brewery Co Ltd | 異種タンパク質の分泌生産に優れた改変酵母およびその酵母を用いた異種タンパク質の製造法 |
| US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| WO2003059934A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
| US7879365B2 (en) * | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
| WO2003066085A1 (en) | 2002-02-07 | 2003-08-14 | Delta Biotechnology Limited | Albumin-fused anti-angiogenesis peptides |
| JP4464269B2 (ja) | 2002-04-26 | 2010-05-19 | 協和発酵キリン株式会社 | 哺乳類型糖鎖生産メチロトロフ酵母 |
| ATE480624T1 (de) * | 2002-06-29 | 2010-09-15 | Korea Res Inst Of Bioscience | Yapsin-mangelmutantenstamm von hansenula polymorpha sowie verfahren zur herstellung rekombinanter proteine damit |
| CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20080090770A1 (en) * | 2003-04-11 | 2008-04-17 | Belmares Michael P | Modulation of Muc1 Mediated Signal Transduction |
| US8129506B2 (en) * | 2003-10-24 | 2012-03-06 | Genzyme Corporation | Modulation of the interaction of MUC1 with MUC1 ligands |
| GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
| GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| BRPI0418304A (pt) * | 2004-01-07 | 2007-05-02 | Trimeris Inc | peptìdeo sintético, uso do mesmo, composição farmacêutica, seqüência de nucleotìdeos, e, métodos para inibição da transmissão de hiv para uma célula, para inibição da fusão de hiv, e para tratamento de um indivìduo infectado com hiv |
| EP1718367A1 (de) * | 2004-02-23 | 2006-11-08 | Genzyme Corporation | Muc1-antagonisten-verstärkung von durch todes-rezeptor-ligand ausgelöster apoptose |
| WO2006034455A2 (en) | 2004-09-23 | 2006-03-30 | Vasgene Therapeutics, Inc. | Polipeptide compounds for inhibiting angiogenesis and tumor growth |
| EP2330200B1 (de) | 2004-12-23 | 2017-04-05 | Albumedix A/S | Genexpressionstechnik |
| EP1933873A4 (de) | 2005-10-13 | 2009-12-02 | Human Genome Sciences Inc | Verfahren und zusammensetzung zur verwendung bei der behandlung von patienten mit autoantikörper-positiven leiden |
| CN101415723B (zh) * | 2006-02-02 | 2014-06-25 | 特里梅里斯公司 | 具有改良生物学特性的hiv融合抑制肽 |
| CA2658654A1 (en) | 2006-07-24 | 2008-01-31 | Biorexis Pharmaceutical Corporation | Exendin fusion proteins |
| WO2008019368A2 (en) * | 2006-08-07 | 2008-02-14 | Teva Biopharmaceuticals Usa, Inc. | Albumin-insulin fusion proteins |
| EP2615108B1 (de) | 2006-09-08 | 2016-10-26 | Ambrx, Inc. | Modifiziertes humanes Plasmapolypeptid oder Fc-Gerüste und deren Verwendungen |
| WO2008097844A2 (en) * | 2007-02-02 | 2008-08-14 | Dana -Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins |
| US7972870B2 (en) | 2007-02-02 | 2011-07-05 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3 |
| WO2008124013A1 (en) * | 2007-04-03 | 2008-10-16 | Trimeris, Inc. | Novel formulations for delivery of antiviral peptide therapeutics |
| EP2594583A1 (de) | 2007-08-08 | 2013-05-22 | Novozymes Biopharma DK A/S | Transferrinvarianten und Konjugate |
| JP2010540528A (ja) * | 2007-09-25 | 2010-12-24 | トリメリス,インコーポレーテッド | 治療的抗ウイルス性ペプチドの新規合成方法 |
| JP2012516878A (ja) | 2009-02-06 | 2012-07-26 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | 精製プロセス |
| KR101722961B1 (ko) | 2009-02-11 | 2017-04-04 | 알부메딕스 에이/에스 | 알부민 변이체 및 접합체 |
| ES2700230T3 (es) * | 2009-10-30 | 2019-02-14 | Albumedix Ltd | Variantes de albúmina |
| EP2504355B1 (de) | 2009-11-25 | 2015-07-22 | Novo Nordisk A/S | Verfahren zur herstellung von polypeptiden |
| ES2678144T3 (es) * | 2010-02-16 | 2018-08-09 | Medimmune, Llc | Composiciones relacionadas con SAH y métodos de uso |
| WO2011118807A1 (ja) * | 2010-03-26 | 2011-09-29 | アサヒビール株式会社 | 酵母の培養方法 |
| US10233228B2 (en) | 2010-04-09 | 2019-03-19 | Albumedix Ltd | Albumin derivatives and variants |
| US9045564B2 (en) | 2011-02-15 | 2015-06-02 | Medimmune, Llc | HSA-related compositions and methods of use |
| CN103379915A (zh) * | 2011-02-15 | 2013-10-30 | 米迪缪尼有限公司 | Hsa相关组合物及使用方法 |
| CA2828811C (en) | 2011-03-03 | 2021-09-21 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
| JP6430828B2 (ja) | 2011-05-05 | 2018-11-28 | アルブミディクス リミティド | アルブミン変異体 |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| DK2825556T3 (en) | 2012-03-16 | 2018-04-16 | Albumedix As | albumin Variants |
| CA2878640C (en) | 2012-07-13 | 2023-10-24 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
| RU2670063C2 (ru) | 2012-11-08 | 2018-10-17 | Альбумедикс А/С | Варианты альбумина |
| CA2903739A1 (en) * | 2013-03-06 | 2014-09-12 | Glaxosmithkline Llc | Host cells and methods of use |
| WO2014165093A2 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto |
| WO2015001460A2 (en) * | 2013-07-01 | 2015-01-08 | Biocon Limited | Signal sequence for protein expression in pichia pastoris |
| EP3337816B1 (de) | 2015-08-20 | 2024-02-14 | Albumedix Ltd | Albumin-varianten und -konjugate |
| AU2019369403B2 (en) | 2018-10-29 | 2025-04-17 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| CN116744984A (zh) | 2020-12-28 | 2023-09-12 | 达沃有限公司 | 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料 |
| CN114957448B (zh) * | 2022-06-08 | 2023-08-25 | 中国农业科学院生物技术研究所 | 一种高效表达α-乳白蛋白的酵母菌株和α-乳白蛋白及其应用 |
| CN118580980B (zh) * | 2024-08-07 | 2024-10-15 | 通化安睿特生物制药股份有限公司 | 一种用于制备重组人白蛋白的重组工程菌及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01240191A (ja) * | 1988-02-16 | 1989-09-25 | Green Cross Corp:The | 酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現 |
| DK0548012T3 (da) * | 1991-12-16 | 1998-04-14 | Ciba Geigy Ag | Endoplasmatisk reticulum-placeret rekombinant dibasisk endoprotease samt dens anvendelse |
| US5440018A (en) * | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
-
1994
- 1994-03-05 GB GB9404270A patent/GB9404270D0/en active Pending
-
1995
- 1995-03-01 DE DE69532603T patent/DE69532603T2/de not_active Expired - Lifetime
- 1995-03-01 JP JP52276295A patent/JP3795073B2/ja not_active Expired - Lifetime
- 1995-03-01 CA CA002183241A patent/CA2183241C/en not_active Expired - Lifetime
- 1995-03-01 AT AT95909880T patent/ATE260338T1/de active
- 1995-03-01 GB GB9616724A patent/GB2301365B/en not_active Revoked
- 1995-03-01 PT PT95909880T patent/PT749478E/pt unknown
- 1995-03-01 ES ES95909880T patent/ES2216007T3/es not_active Expired - Lifetime
- 1995-03-01 EP EP95909880A patent/EP0749478B1/de not_active Expired - Lifetime
- 1995-03-01 US US08/702,572 patent/US5965386A/en not_active Expired - Lifetime
- 1995-03-01 WO PCT/GB1995/000434 patent/WO1995023857A1/en not_active Ceased
- 1995-03-01 KR KR1019960704819A patent/KR100372514B1/ko not_active Expired - Lifetime
- 1995-03-01 DK DK95909880T patent/DK0749478T3/da active
- 1995-03-01 AU AU18183/95A patent/AU683728B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE69532603T2 (de) | 2005-01-05 |
| GB2301365B (en) | 1997-07-30 |
| CA2183241C (en) | 2002-05-21 |
| PT749478E (pt) | 2004-07-30 |
| AU683728B2 (en) | 1997-11-20 |
| JP3795073B2 (ja) | 2006-07-12 |
| GB9616724D0 (en) | 1996-09-25 |
| EP0749478A1 (de) | 1996-12-27 |
| CA2183241A1 (en) | 1995-09-08 |
| GB2301365A (en) | 1996-12-04 |
| WO1995023857A1 (en) | 1995-09-08 |
| US5965386A (en) | 1999-10-12 |
| AU1818395A (en) | 1995-09-18 |
| DE69532603D1 (de) | 2004-04-01 |
| KR100372514B1 (ko) | 2004-04-30 |
| DK0749478T3 (da) | 2004-06-28 |
| JPH09509581A (ja) | 1997-09-30 |
| ES2216007T3 (es) | 2004-10-16 |
| GB9404270D0 (en) | 1994-04-20 |
| EP0749478B1 (de) | 2004-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0749478 Country of ref document: EP |
|
| EEFA | Change of the company name | ||
| EEIH | Change in the person of patent owner |