ATE252891T1 - Kationische lipid-nukleinsäure komplexe - Google Patents

Kationische lipid-nukleinsäure komplexe

Info

Publication number
ATE252891T1
ATE252891T1 AT97934685T AT97934685T ATE252891T1 AT E252891 T1 ATE252891 T1 AT E252891T1 AT 97934685 T AT97934685 T AT 97934685T AT 97934685 T AT97934685 T AT 97934685T AT E252891 T1 ATE252891 T1 AT E252891T1
Authority
AT
Austria
Prior art keywords
acid complexes
cationic lipid
lipid
suspension
nuclic acid
Prior art date
Application number
AT97934685T
Other languages
English (en)
Inventor
Rainer Bischoff
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Application granted granted Critical
Publication of ATE252891T1 publication Critical patent/ATE252891T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97934685T 1996-08-26 1997-08-25 Kationische lipid-nukleinsäure komplexe ATE252891T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96401819 1996-08-26
PCT/IB1997/001030 WO1998008489A1 (en) 1996-08-26 1997-08-25 Cationic lipid-nucleic acid complexes

Publications (1)

Publication Number Publication Date
ATE252891T1 true ATE252891T1 (de) 2003-11-15

Family

ID=8225285

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97934685T ATE252891T1 (de) 1996-08-26 1997-08-25 Kationische lipid-nukleinsäure komplexe

Country Status (11)

Country Link
US (1) US6271208B1 (de)
EP (1) EP0941066B1 (de)
JP (1) JP2000516948A (de)
AT (1) ATE252891T1 (de)
AU (1) AU729077B2 (de)
CA (1) CA2264140A1 (de)
DE (1) DE69725877T2 (de)
DK (1) DK0941066T3 (de)
ES (1) ES2208936T3 (de)
PT (1) PT941066E (de)
WO (1) WO1998008489A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509032B1 (en) 1991-08-28 2003-01-21 Mcmaster University Cationic amphiphiles
US5795587A (en) * 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6008202A (en) 1995-01-23 1999-12-28 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5981501A (en) * 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
US6120794A (en) 1995-09-26 2000-09-19 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells
WO1997039019A1 (en) * 1996-04-12 1997-10-23 University Of Pittsburgh Novel cationic cholesteryl derivatives containing cyclic polar groups
US6093816A (en) * 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US6410328B1 (en) * 1998-02-03 2002-06-25 Protiva Biotherapeutics Inc. Sensitizing cells to compounds using lipid-mediated gene and compound delivery
EP1013772A1 (de) * 1998-12-21 2000-06-28 Transgene S.A. Verfahren zur Herstellung einer stabilen Posiplexe-Suspension
DE19944262A1 (de) * 1999-09-15 2001-03-29 Cardiogene Gentherapeutische S Pharmazeutische Zusammensetzung in Form eines Nukleinsäure-Lipid-Komplexes, ihre Herstellung und Verwendung in der Gentherapie
US7189705B2 (en) * 2000-04-20 2007-03-13 The University Of British Columbia Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
WO2002043769A2 (en) * 2000-11-29 2002-06-06 Gencell S.A. Neutral and anionic colloidal particles for gene delivery
WO2002088318A2 (en) * 2001-04-30 2002-11-07 Targeted Genetics Corporation Lipid-comprising drug delivery complexes and methods for their production
EP1359228B1 (de) * 2002-04-23 2013-11-27 Accenture Global Services Limited Nukleinsäure authentifikation mittels detektion des streulichtes
US20040180438A1 (en) * 2002-04-26 2004-09-16 Pachuk Catherine J. Methods and compositions for silencing genes without inducing toxicity
EP2298358A1 (de) * 2002-05-06 2011-03-23 Alnylam Pharmaceuticals Inc. Methoden zum Nukleinsäuren-Transfer
WO2004011624A2 (en) * 2002-07-31 2004-02-05 Nucleonics, Inc. Double stranded rna structures and constructs, and methods for generating and using the same
US20040187445A1 (en) * 2003-03-28 2004-09-30 Hildebrand John Joseph Gripping arm assembly for loading a filled inner container into an outer container
KR100931784B1 (ko) 2003-10-23 2009-12-14 오츠카 세이야쿠 가부시키가이샤 방출조절성 멸균 아리피프라졸 주사제, 그 제조방법
DK1792927T3 (da) 2004-09-22 2013-06-10 Nippon Kayaku Kk Ny blokcopolymer, micelletilberedning og anticancermiddel indeholdende samme som aktiv ingrediens
KR20080106254A (ko) 2006-03-28 2008-12-04 니폰 가야꾸 가부시끼가이샤 탁산류의 고분자 결합체
CN101448875A (zh) 2006-05-18 2009-06-03 日本化药株式会社 鬼臼毒素类的高分子量结合体
WO2008056596A1 (fr) 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
JP5548365B2 (ja) 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
US8357531B2 (en) 2007-07-03 2013-01-22 Transgene S.A. Immortalized avian cell lines
LT2170279T (lt) 2007-07-31 2018-03-12 Otsuka Pharmaceutical Co., Ltd. Aripiprazolo suspensijos ir liofilizuotos kompozicijos gamybos būdai
JP5349318B2 (ja) 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
JP5687899B2 (ja) * 2008-03-18 2015-03-25 日本化薬株式会社 生理活性物質の高分子結合体
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
CN102065901B (zh) * 2008-06-19 2013-03-06 日本新药株式会社 药物载体
EP2431403B1 (de) 2009-05-15 2016-09-28 Nipponkayaku Kabushikikaisha Polymerkonjugat aus einer bioaktiven substanz mit einer hydroxidgruppe
ME03091B (de) 2009-12-01 2019-01-20 Translate Bio Inc Ausgabe von mrna zur vermehrung von proteinen und enzymen bei humangenetischen erkrankungen
TW201304805A (zh) 2010-11-17 2013-02-01 Nippon Kayaku Kk 新穎之胞核苷系代謝拮抗劑之高分子衍生物
US8853377B2 (en) 2010-11-30 2014-10-07 Shire Human Genetic Therapies, Inc. mRNA for use in treatment of human genetic diseases
PT2717893T (pt) 2011-06-08 2019-08-20 Translate Bio Inc Composições de nanopartículas lipídicas e métodos para transferência de arnm
WO2013035641A1 (ja) 2011-09-11 2013-03-14 日本化薬株式会社 ブロック共重合体の製造方法
US20150267192A1 (en) 2012-06-08 2015-09-24 Shire Human Genetic Therapies, Inc. Nuclease resistant polynucleotides and uses thereof
CA2904151C (en) 2013-03-14 2023-09-12 Shire Human Genetic Therapies, Inc. Cftr mrna compositions and related methods and uses
KR20150128687A (ko) 2013-03-14 2015-11-18 샤이어 휴먼 지네틱 테라피즈 인크. 메신저 rna의 정제 방법
WO2015011633A1 (en) * 2013-07-23 2015-01-29 Protiva Biotherapeutics, Inc. Compositions and methods for delivering messenger rna
EA201992208A1 (ru) 2013-10-22 2020-07-31 Транслейт Био, Инк. ЛЕЧЕНИЕ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
BR112016009014B1 (pt) 2013-10-22 2024-02-06 Translate Bio, Inc USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE
KR102739894B1 (ko) 2014-04-25 2024-12-05 샤이어 휴먼 지네틱 테라피즈 인크. 메신저 rna 의 정제 방법
MX2019010155A (es) 2017-02-27 2020-12-10 Translate Bio Inc Arnm de cftr optimizado por codón novedoso.
WO2018213476A1 (en) 2017-05-16 2018-11-22 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr
KR102056144B1 (ko) 2018-03-08 2019-12-16 주식회사 파마리서치프로덕트 Dna 단편 혼합물이 고농도로 함유된 유동성을 갖는 액제 조성물 및 이의 제조방법
WO2020041793A1 (en) 2018-08-24 2020-02-27 Translate Bio, Inc. Methods for purification of messenger rna
MX2021005969A (es) 2018-11-21 2021-09-14 Translate Bio Inc Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr nebulizado.
WO2022204219A1 (en) 2021-03-22 2022-09-29 Recode Therapeutics, Inc. Compositions and methods for targeted delivery to cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225212A (en) * 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5527528A (en) 1989-10-20 1996-06-18 Sequus Pharmaceuticals, Inc. Solid-tumor treatment method
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
EP0826063A1 (de) 1995-04-25 1998-03-04 Vical Incorporated Einzelfläschehene formulierungen von dna (lipid-komplexen)
JPH11508231A (ja) * 1995-05-26 1999-07-21 ソマティックス セラピー コーポレイション 安定な脂質／核酸複合体を含む送達ビヒクル
US5705385A (en) * 1995-06-07 1998-01-06 Inex Pharmaceuticals Corporation Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
ATE285477T1 (de) * 1995-06-07 2005-01-15 Inex Pharmaceutical Corp Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
US5830878A (en) * 1995-06-07 1998-11-03 Megabios Corporation Cationic lipid: DNA complexes for gene targeting
US5932241A (en) * 1995-06-07 1999-08-03 Valentis, Incorporated Cationic lipid DNA complexes for gene targeting

Also Published As

Publication number Publication date
DE69725877T2 (de) 2004-07-22
ES2208936T3 (es) 2004-06-16
JP2000516948A (ja) 2000-12-19
CA2264140A1 (en) 1998-03-05
DE69725877D1 (de) 2003-12-04
EP0941066B1 (de) 2003-10-29
WO1998008489A1 (en) 1998-03-05
PT941066E (pt) 2004-03-31
AU3781597A (en) 1998-03-19
EP0941066A1 (de) 1999-09-15
US6271208B1 (en) 2001-08-07
AU729077B2 (en) 2001-01-25
DK0941066T3 (da) 2004-02-23

Similar Documents

Publication Publication Date Title
ATE252891T1 (de) Kationische lipid-nukleinsäure komplexe
GR3030206T3 (en) Cationic lipids.
ATE152748T1 (de) Verfahren zur herstellung von siloxanoxyalkylencopolymeren
MY115980A (en) Topical ketoconazole emulsions.
BG102758A (en) Method for improving of contrast means
FR2415099A1 (fr) Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes
RU94042393A (ru) Галихондрины, родственные соединения и способ лечения опухоли у млекопитающих
EA200000239A1 (ru) Стимуляторы секреции гормона роста
DE60027765D1 (de) Verfahren zur herstellung von mechanischer pulpe
BG101892A (en) Sugar-modified cytostatics
DE3681133D1 (de) Verfahren zur herstellung einer polysaccharid-in-oel-dispersion und so hergestellte dispersion.
ATE207892T1 (de) Verfahren zur herstellung von dithiobis- alkanesulfonaten und phosphonaten
ES446173A1 (es) Procedimiento con su dispositivo de realizacion para la so- lubilizacion de una suspension de cascina en polvo en medio acuoso.
FR2372817A1 (fr) Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
ATE14219T1 (de) Verfahren zur herstellung von 3-oxonitrilen.
HU912271D0 (en) Process for the production of bis/4-(2,6-dialkyl)phenol/-silane derivatives with antiatherosclerotic effect
WO1997008934A3 (en) Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
ES8102058A1 (es) Procedimiento para la obtencion de suspensiones acuosas de zeolita estables
ATE494371T1 (de) Nukleinsäureleitern
RU94040182A (ru) Эмульсионное взрывчатое вещество
AU576407B2 (en) 2-carbamoyl nicotinic acids and 3-quinolinecarboxylic acids
BG28422A3 (bg) Акарицидно средство и метод за борба с акари
DK0479906T3 (da) Forbedret cellulose-kromatografibærer
ATE30014T1 (de) Derivate der 2,2-diaethoxypropionsaeure.
DE69927247D1 (de) Verfahren zur herstellung von fleischprodukten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0941066

Country of ref document: EP

REN Ceased due to non-payment of the annual fee