ATE243696T1 - C-2 s/o- und s/n-formaldehydacetal-derivate von carbapenem-3-carbonsäuren und deren verwendung als antibiotika und beta-lactamas-inhibitoren - Google Patents
C-2 s/o- und s/n-formaldehydacetal-derivate von carbapenem-3-carbonsäuren und deren verwendung als antibiotika und beta-lactamas-inhibitorenInfo
- Publication number
- ATE243696T1 ATE243696T1 AT99936602T AT99936602T ATE243696T1 AT E243696 T1 ATE243696 T1 AT E243696T1 AT 99936602 T AT99936602 T AT 99936602T AT 99936602 T AT99936602 T AT 99936602T AT E243696 T1 ATE243696 T1 AT E243696T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- derivatives
- formaldehydacetal
- lactamas
- carbapenem
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical compound [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 abstract 1
- OBOXTJCIIVUZEN-UHFFFAOYSA-N [C].[O] Chemical compound [C].[O] OBOXTJCIIVUZEN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98114067A EP0976752A1 (en) | 1998-07-28 | 1998-07-28 | C-2 S/O- and S/N-Formaldehyde acetal derivatives of carbapenem antibiotics |
| PCT/EP1999/005295 WO2000006574A1 (en) | 1998-07-28 | 1999-07-23 | NOVEL C-2 S/O- AND S/N FORMALDEHYDE ACETAL DERIVATIVES OF CARBAPENEM-3-CARBOXYLIC ACIDS AND THEIR USE AS ANTIBIOTICS AND β-LACTAMASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE243696T1 true ATE243696T1 (de) | 2003-07-15 |
Family
ID=8232355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99936602T ATE243696T1 (de) | 1998-07-28 | 1999-07-23 | C-2 s/o- und s/n-formaldehydacetal-derivate von carbapenem-3-carbonsäuren und deren verwendung als antibiotika und beta-lactamas-inhibitoren |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6482818B2 (enExample) |
| EP (2) | EP0976752A1 (enExample) |
| JP (1) | JP4598273B2 (enExample) |
| KR (1) | KR20010086351A (enExample) |
| CN (1) | CN1154649C (enExample) |
| AT (1) | ATE243696T1 (enExample) |
| AU (1) | AU760249B2 (enExample) |
| CA (1) | CA2338776C (enExample) |
| DE (1) | DE69909098T2 (enExample) |
| ES (1) | ES2203164T3 (enExample) |
| HU (1) | HUP0102729A3 (enExample) |
| IL (1) | IL141114A (enExample) |
| MX (1) | MXPA01000905A (enExample) |
| NZ (1) | NZ509578A (enExample) |
| PT (1) | PT1100800E (enExample) |
| WO (1) | WO2000006574A1 (enExample) |
| ZA (1) | ZA200100737B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2576677A1 (en) * | 2004-08-23 | 2006-03-02 | Sicor, Inc. | Synthesis of idarubin aglycone |
| JP5276653B2 (ja) | 2007-05-21 | 2013-08-28 | ハンス・ルドルフ・プフェンドラー | カルバペネム類を含む殺菌性抗ｍｒｓａ活性医薬組成物 |
| CN101412718B (zh) * | 2007-10-19 | 2011-04-27 | 山东轩竹医药科技有限公司 | 含有硫基杂环胺甲酰基的碳青霉烯衍生物 |
| CN103059028B (zh) * | 2013-01-30 | 2014-05-07 | 山东罗欣药业股份有限公司 | 一种替比培南匹伏酯的制备方法 |
| CN114957258A (zh) * | 2021-02-25 | 2022-08-30 | 华东理工大学 | 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58116485A (ja) * | 1981-12-29 | 1983-07-11 | Shionogi & Co Ltd | 新規抗生物質カルバペネム誘導体およびその製造法 |
| GB2116540B (en) * | 1981-11-10 | 1985-07-17 | Shionogi & Co | Pluracidomycin b c and d and analogs thereof their production and a microorganism for use therein |
| JPS58124785A (ja) * | 1982-01-20 | 1983-07-25 | Shionogi & Co Ltd | プルラシドマイシンｂおよびｃのデオキシ体ならびにその製造法 |
| JPS6054387A (ja) * | 1983-08-03 | 1985-03-28 | メルク エンド カムパニ− インコ−ポレ−テツド | チエナマイシンの誘導体製造法 |
| CA1285940C (en) * | 1984-07-02 | 1991-07-09 | Merck & Co., Inc. | Carbapenems having a 2-quaternary heteroarylalkylthio substituent |
| IE851586L (en) * | 1984-07-02 | 1986-01-02 | Interchem Internat S A | I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent |
| JPS63255283A (ja) * | 1987-04-11 | 1988-10-21 | Nippon Redarii Kk | （１ｒ，５ｓ，６ｓ）−２−〔（３−置換イミダゾリニウム−１−イル）アルキル〕チオ−６−〔（ｒ）−１−ヒドロキシエチル〕−１−メチル−カルバペネム−３−カルボキシレ−ト |
| US5116833A (en) * | 1990-10-19 | 1992-05-26 | Bristol-Myers Squibb Company | Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof |
-
1998
- 1998-07-28 EP EP98114067A patent/EP0976752A1/en not_active Withdrawn
-
1999
- 1999-07-23 DE DE69909098T patent/DE69909098T2/de not_active Expired - Lifetime
- 1999-07-23 AU AU51639/99A patent/AU760249B2/en not_active Ceased
- 1999-07-23 PT PT99936602T patent/PT1100800E/pt unknown
- 1999-07-23 CN CNB998091634A patent/CN1154649C/zh not_active Expired - Fee Related
- 1999-07-23 NZ NZ509578A patent/NZ509578A/xx not_active IP Right Cessation
- 1999-07-23 WO PCT/EP1999/005295 patent/WO2000006574A1/en not_active Ceased
- 1999-07-23 HU HU0102729A patent/HUP0102729A3/hu unknown
- 1999-07-23 KR KR1020017001122A patent/KR20010086351A/ko not_active Ceased
- 1999-07-23 IL IL14111499A patent/IL141114A/en not_active IP Right Cessation
- 1999-07-23 CA CA002338776A patent/CA2338776C/en not_active Expired - Fee Related
- 1999-07-23 ES ES99936602T patent/ES2203164T3/es not_active Expired - Lifetime
- 1999-07-23 JP JP2000562374A patent/JP4598273B2/ja not_active Expired - Fee Related
- 1999-07-23 EP EP99936602A patent/EP1100800B1/en not_active Expired - Lifetime
- 1999-07-23 MX MXPA01000905A patent/MXPA01000905A/es not_active IP Right Cessation
- 1999-07-23 AT AT99936602T patent/ATE243696T1/de not_active IP Right Cessation
-
2001
- 2001-01-25 ZA ZA200100737A patent/ZA200100737B/en unknown
- 2001-01-25 US US09/770,536 patent/US6482818B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0102729A2 (hu) | 2002-01-28 |
| KR20010086351A (ko) | 2001-09-10 |
| JP4598273B2 (ja) | 2010-12-15 |
| PT1100800E (pt) | 2003-11-28 |
| AU5163999A (en) | 2000-02-21 |
| ZA200100737B (en) | 2002-07-25 |
| EP0976752A1 (en) | 2000-02-02 |
| IL141114A (en) | 2004-02-08 |
| CN1311790A (zh) | 2001-09-05 |
| EP1100800B1 (en) | 2003-06-25 |
| MXPA01000905A (es) | 2002-06-04 |
| AU760249B2 (en) | 2003-05-08 |
| EP1100800A1 (en) | 2001-05-23 |
| DE69909098D1 (de) | 2003-07-31 |
| CA2338776C (en) | 2008-04-29 |
| US20010031749A1 (en) | 2001-10-18 |
| NZ509578A (en) | 2003-06-30 |
| WO2000006574A1 (en) | 2000-02-10 |
| CN1154649C (zh) | 2004-06-23 |
| ES2203164T3 (es) | 2004-04-01 |
| IL141114A0 (en) | 2002-02-10 |
| HUP0102729A3 (en) | 2002-09-30 |
| CA2338776A1 (en) | 2000-02-10 |
| JP2002521484A (ja) | 2002-07-16 |
| US6482818B2 (en) | 2002-11-19 |
| DE69909098T2 (de) | 2004-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1100800 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |