ATE243256T1 - Fermentative herstellung von biotin - Google Patents
Fermentative herstellung von biotinInfo
- Publication number
- ATE243256T1 ATE243256T1 AT97106762T AT97106762T ATE243256T1 AT E243256 T1 ATE243256 T1 AT E243256T1 AT 97106762 T AT97106762 T AT 97106762T AT 97106762 T AT97106762 T AT 97106762T AT E243256 T1 ATE243256 T1 AT E243256T1
- Authority
- AT
- Austria
- Prior art keywords
- biotin
- desthiobiotin
- production
- nifu
- nifs
- Prior art date
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title abstract 10
- 229960002685 biotin Drugs 0.000 title abstract 5
- 235000020958 biotin Nutrition 0.000 title abstract 5
- 239000011616 biotin Substances 0.000 title abstract 5
- 238000012262 fermentative production Methods 0.000 title 1
- AUTOLBMXDDTRRT-JGVFFNPUSA-N (4R,5S)-dethiobiotin Chemical compound C[C@@H]1NC(=O)N[C@@H]1CCCCCC(O)=O AUTOLBMXDDTRRT-JGVFFNPUSA-N 0.000 abstract 4
- 101100165384 Arabidopsis thaliana BIO2 gene Proteins 0.000 abstract 2
- 101100184272 Arabidopsis thaliana NIFS1 gene Proteins 0.000 abstract 2
- 102100035406 Cysteine desulfurase, mitochondrial Human genes 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
- C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96107064 | 1996-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE243256T1 true ATE243256T1 (de) | 2003-07-15 |
Family
ID=8222753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97106762T ATE243256T1 (de) | 1996-05-06 | 1997-04-24 | Fermentative herstellung von biotin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6361978B1 (de) |
| EP (1) | EP0806479B1 (de) |
| JP (1) | JP4084440B2 (de) |
| CN (1) | CN1161476C (de) |
| AT (1) | ATE243256T1 (de) |
| BR (1) | BR9703055A (de) |
| DE (1) | DE69722852T2 (de) |
| DK (1) | DK0806479T3 (de) |
| ES (1) | ES2201219T3 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0853127T3 (da) | 1996-09-27 | 2005-03-07 | Dsm Ip Assets Bv | Biotin-biosyntese-gener II |
| DE19731274A1 (de) | 1997-07-22 | 1999-01-28 | Basf Ag | Verfahren zur Herstellung von Biotin |
| DE19806872A1 (de) * | 1998-02-19 | 1999-08-26 | Basf Ag | Verfahren zur Herstellung von Biotin |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61149091A (ja) | 1984-12-24 | 1986-07-07 | Nippon Soda Co Ltd | ビオチン合成酵素をコ−ドする二重鎖ｄｎａ、それを含む微生物及びビオチンの製造法 |
| NZ217336A (en) * | 1985-08-26 | 1988-06-30 | Amgen | Production of biotin from microorganisms |
| JPS62155081A (ja) | 1985-12-27 | 1987-07-10 | Shiseido Co Ltd | 新規微生物およびそれを用いる醗酵法によるビオチンの製造法 |
| JP2722504B2 (ja) | 1988-07-14 | 1998-03-04 | 田辺製薬株式会社 | 新規微生物及びそれを用いるｄ−ビオチンの製法 |
| FR2642768B1 (fr) | 1989-01-19 | 1991-05-17 | Transgene Sa | Procede perfectionne pour l'expression de la biotine dans bacillus sphaericus |
| JPH03240489A (ja) | 1990-02-19 | 1991-10-25 | Mitsubishi Petrochem Co Ltd | 新規なプラスミド、それを保有するコリネ型細菌及びビオチンの製造法 |
| JPH06339371A (ja) * | 1991-04-15 | 1994-12-13 | Nippon Zeon Co Ltd | クレビシエラ属に属する形質転換微生物及びそれを用いたビオチンの製造方法 |
| PL179166B1 (pl) * | 1992-10-02 | 2000-07-31 | Lonza Ag | Sposób wytwarzania biotyny PL PL PL |
| JP3240489B2 (ja) | 1993-01-21 | 2001-12-17 | 株式会社日立製作所 | Ｉｇｂｔの過電流保護装置及びｉｇｂｔの保護装置 |
| JPH07236493A (ja) | 1994-03-03 | 1995-09-12 | Shiseido Co Ltd | デスチオビオチンからビオチンへの変換方法 |
| JP3180174B2 (ja) | 1994-06-23 | 2001-06-25 | 新日本製鐵株式会社 | 窒素酸化物含有排ガスの生物学的脱硝方法 |
| DK0747483T3 (da) | 1995-06-09 | 2004-06-28 | Dsm Ip Assets Bv | Fermentativ carotenoid-produktion |
-
1997
- 1997-04-24 DE DE69722852T patent/DE69722852T2/de not_active Expired - Fee Related
- 1997-04-24 US US08/840,059 patent/US6361978B1/en not_active Expired - Fee Related
- 1997-04-24 AT AT97106762T patent/ATE243256T1/de not_active IP Right Cessation
- 1997-04-24 ES ES97106762T patent/ES2201219T3/es not_active Expired - Lifetime
- 1997-04-24 DK DK97106762T patent/DK0806479T3/da active
- 1997-04-24 EP EP97106762A patent/EP0806479B1/de not_active Expired - Lifetime
- 1997-05-02 JP JP11457197A patent/JP4084440B2/ja not_active Expired - Fee Related
- 1997-05-05 CN CNB971097798A patent/CN1161476C/zh not_active Expired - Fee Related
- 1997-05-05 BR BR9703055A patent/BR9703055A/pt active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| ES2201219T3 (es) | 2004-03-16 |
| JPH1033189A (ja) | 1998-02-10 |
| JP4084440B2 (ja) | 2008-04-30 |
| US6361978B1 (en) | 2002-03-26 |
| CN1161476C (zh) | 2004-08-11 |
| EP0806479B1 (de) | 2003-06-18 |
| CN1170762A (zh) | 1998-01-21 |
| BR9703055A (pt) | 1998-09-29 |
| DK0806479T3 (da) | 2003-10-06 |
| DE69722852T2 (de) | 2004-05-06 |
| DE69722852D1 (de) | 2003-07-24 |
| EP0806479A1 (de) | 1997-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0806479 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |