ATE242234T1 - Bicyclische arylcarboxamide und ihre therapeutische verwendung - Google Patents
Bicyclische arylcarboxamide und ihre therapeutische verwendungInfo
- Publication number
- ATE242234T1 ATE242234T1 AT97912370T AT97912370T ATE242234T1 AT E242234 T1 ATE242234 T1 AT E242234T1 AT 97912370 T AT97912370 T AT 97912370T AT 97912370 T AT97912370 T AT 97912370T AT E242234 T1 ATE242234 T1 AT E242234T1
- Authority
- AT
- Austria
- Prior art keywords
- arylcarboxamides
- bicyclic
- therapeutic use
- phosphodiesterase
- tnf
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9623860.5A GB9623860D0 (en) | 1996-11-15 | 1996-11-15 | Novel compounds |
| GBGB9708062.6A GB9708062D0 (en) | 1997-04-22 | 1997-04-22 | Novel compounds |
| PCT/GB1997/003154 WO1998022460A1 (en) | 1996-11-15 | 1997-11-17 | Bicyclic aryl carboxamides and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE242234T1 true ATE242234T1 (de) | 2003-06-15 |
Family
ID=26310411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97912370T ATE242234T1 (de) | 1996-11-15 | 1997-11-17 | Bicyclische arylcarboxamide und ihre therapeutische verwendung |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6353010B1 (https=) |
| EP (1) | EP0944616B1 (https=) |
| JP (1) | JP2001504479A (https=) |
| KR (1) | KR20000053274A (https=) |
| CN (1) | CN1114604C (https=) |
| AT (1) | ATE242234T1 (https=) |
| AU (1) | AU726590B2 (https=) |
| BR (1) | BR9713507A (https=) |
| CA (1) | CA2268037A1 (https=) |
| CZ (1) | CZ158299A3 (https=) |
| DE (1) | DE69722656T2 (https=) |
| DK (1) | DK0944616T3 (https=) |
| ES (1) | ES2200163T3 (https=) |
| HU (1) | HUP0000189A3 (https=) |
| ID (1) | ID21698A (https=) |
| IL (1) | IL129337A0 (https=) |
| NO (1) | NO992337D0 (https=) |
| NZ (1) | NZ335197A (https=) |
| RU (1) | RU2176642C2 (https=) |
| SK (1) | SK283534B6 (https=) |
| TR (1) | TR199901730T2 (https=) |
| WO (1) | WO1998022460A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000198734A (ja) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | 胃運動性減弱および関連疾患の治療のための運動性増強薬 |
| GB0003254D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| GB0003256D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| KR20040010713A (ko) * | 2001-06-15 | 2004-01-31 | 야마노우치세이야쿠 가부시키가이샤 | 페닐피리딘 카보닐 피페라진 유도체 |
| US20040219142A1 (en) * | 2002-07-19 | 2004-11-04 | Abbott Laboratories S.A. | Treatment of skin and nail disorders using TNFalpha inhibitors |
| AU2004297235A1 (en) | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| US20070225308A1 (en) * | 2004-03-15 | 2007-09-27 | Kyowa Hakko Kogyo Co.,Ltd. | 2-Amino Quinazoline Derivative |
| NZ560969A (en) * | 2005-02-17 | 2010-08-27 | Albany Molecular Res Inc | Benzoxazole carboxamides for treating chemotherapy-induced vomiting and irritable bowel syndrome |
| ES2400287T3 (es) * | 2005-03-14 | 2013-04-08 | High Point Pharmaceuticals, Llc | Derivados de benzazol, composiciones y procedimientos de uso como inhibidores de beta-secretasa |
| CN102961746B (zh) | 2005-05-16 | 2016-06-15 | 艾伯维生物技术有限公司 | TNFα抑制剂治疗腐蚀性多关节炎的用途 |
| RU2008137612A (ru) * | 2006-02-20 | 2010-03-27 | Астеллас Фарма Инк. (Jp) | Амидное производное или его соли |
| US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| EP2007426A4 (en) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS |
| US7553846B2 (en) * | 2006-08-07 | 2009-06-30 | Albany Molecular Research, Inc. | 2-alkylbenzoxazole carboxamides as 5-HT3 modulators |
| JPWO2008026687A1 (ja) * | 2006-09-01 | 2010-01-21 | 杏林製薬株式会社 | ピラゾロピリジンカルボキサミド誘導体及びそれらを含有するホスホジエステラーゼ（ｐｄｅ）阻害剤 |
| KR20090049076A (ko) * | 2006-09-07 | 2009-05-15 | 바이오겐 아이덱 엠에이 인코포레이티드 | 인터루킨-1 수용체-결합 키나제 조절물질로서 인다졸 유도체 |
| EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
| AR067354A1 (es) | 2007-06-29 | 2009-10-07 | Sunesis Pharmaceuticals Inc | Compuestos utiles como inhibidores de la raf quinasa |
| AR075633A1 (es) | 2009-02-27 | 2011-04-20 | Ambit Biosciences Corp | Compuestos moduladores de jak quinasa y sus metodos de uso |
| WO2012030948A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Quinazoline compounds and methods of use thereof |
| US9550737B2 (en) * | 2012-06-11 | 2017-01-24 | Ucb Biopharma Sprl | TNF -α modulating benzimidazoles |
| EA201590482A1 (ru) * | 2012-09-05 | 2015-07-30 | Байер Кропсайенс Аг | Применение замещенных 2-амидобензимидазолов, 2-амидобензоксазолов и 2-амидобензотиазолов или их солей в качестве биологически активных веществ против абиотического стресса растений |
| CN108440333A (zh) * | 2018-03-29 | 2018-08-24 | 江苏道博化工有限公司 | 分散染料中间体的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50140442A (https=) | 1974-04-16 | 1975-11-11 | ||
| EP0116938A1 (en) | 1983-02-14 | 1984-08-29 | Usv Pharmaceutical Corporation | Benzoheterocyclic carbamates |
| DE3835660A1 (de) * | 1988-03-25 | 1989-10-12 | Bayer Ag | 7-substituierte 2-carbonamido-benzthiazol-3-oxide |
| DE4014937A1 (de) | 1990-05-10 | 1991-11-14 | Bayer Ag | 2,3-disubstituierte chinoxaline als leistungsfoerderer fuer tiere |
| GB9219634D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| GB9219632D0 (en) | 1992-09-16 | 1992-10-28 | Ici Plc | Heterocyclic compounds |
| US5559127A (en) | 1992-10-14 | 1996-09-24 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| GB9301660D0 (en) | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9306578D0 (en) | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| KR100381584B1 (ko) * | 1994-07-22 | 2003-08-21 | 알타나 파마 아게 | 디히드로벤조푸란 |
| WO1996004251A1 (en) | 1994-08-03 | 1996-02-15 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic compound |
| EP0785927B1 (en) * | 1994-10-12 | 2003-08-27 | Euroceltique S.A. | Novel benzoxazoles |
| US5665737B1 (en) | 1994-10-12 | 1999-02-16 | Euro Celtique Sa | Substituted benzoxazoles |
-
1997
- 1997-11-17 BR BR9713507-0A patent/BR9713507A/pt unknown
- 1997-11-17 KR KR1019990704253A patent/KR20000053274A/ko not_active Withdrawn
- 1997-11-17 ID IDW990356A patent/ID21698A/id unknown
- 1997-11-17 IL IL12933797A patent/IL129337A0/xx not_active IP Right Cessation
- 1997-11-17 SK SK644-99A patent/SK283534B6/sk unknown
- 1997-11-17 CZ CZ991582A patent/CZ158299A3/cs unknown
- 1997-11-17 TR TR1999/01730T patent/TR199901730T2/xx unknown
- 1997-11-17 NZ NZ335197A patent/NZ335197A/xx unknown
- 1997-11-17 CN CN97199650A patent/CN1114604C/zh not_active Expired - Fee Related
- 1997-11-17 JP JP52334598A patent/JP2001504479A/ja not_active Ceased
- 1997-11-17 AT AT97912370T patent/ATE242234T1/de not_active IP Right Cessation
- 1997-11-17 DK DK97912370T patent/DK0944616T3/da active
- 1997-11-17 RU RU99112569/04A patent/RU2176642C2/ru not_active IP Right Cessation
- 1997-11-17 HU HU0000189A patent/HUP0000189A3/hu unknown
- 1997-11-17 AU AU49602/97A patent/AU726590B2/en not_active Ceased
- 1997-11-17 CA CA002268037A patent/CA2268037A1/en not_active Abandoned
- 1997-11-17 EP EP97912370A patent/EP0944616B1/en not_active Expired - Lifetime
- 1997-11-17 DE DE69722656T patent/DE69722656T2/de not_active Expired - Fee Related
- 1997-11-17 WO PCT/GB1997/003154 patent/WO1998022460A1/en not_active Ceased
- 1997-11-17 ES ES97912370T patent/ES2200163T3/es not_active Expired - Lifetime
-
1999
- 1999-05-14 NO NO992337A patent/NO992337D0/no not_active Application Discontinuation
- 1999-10-21 US US09/422,473 patent/US6353010B1/en not_active Expired - Fee Related
-
2002
- 2002-01-14 US US10/050,005 patent/US20020094987A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL129337A0 (en) | 2000-02-17 |
| EP0944616A1 (en) | 1999-09-29 |
| TR199901730T2 (xx) | 1999-09-21 |
| DE69722656T2 (de) | 2004-05-13 |
| BR9713507A (pt) | 2000-02-29 |
| US6353010B1 (en) | 2002-03-05 |
| SK283534B6 (sk) | 2003-09-11 |
| WO1998022460A1 (en) | 1998-05-28 |
| JP2001504479A (ja) | 2001-04-03 |
| CA2268037A1 (en) | 1998-05-28 |
| KR20000053274A (ko) | 2000-08-25 |
| CN1237168A (zh) | 1999-12-01 |
| DK0944616T3 (da) | 2003-09-29 |
| EP0944616B1 (en) | 2003-06-04 |
| AU4960297A (en) | 1998-06-10 |
| RU2176642C2 (ru) | 2001-12-10 |
| SK64499A3 (en) | 2000-03-13 |
| US20020094987A1 (en) | 2002-07-18 |
| DE69722656D1 (de) | 2003-07-10 |
| ES2200163T3 (es) | 2004-03-01 |
| NO992337L (no) | 1999-05-14 |
| CZ158299A3 (cs) | 1999-09-15 |
| HUP0000189A2 (hu) | 2001-04-28 |
| ID21698A (id) | 1999-07-15 |
| NO992337D0 (no) | 1999-05-14 |
| HUP0000189A3 (en) | 2002-01-28 |
| AU726590B2 (en) | 2000-11-09 |
| NZ335197A (en) | 2000-11-24 |
| CN1114604C (zh) | 2003-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0944616 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |