ATE231733T1 - Gasbetätigtes element zum austragen von genmaterial - Google Patents

Gasbetätigtes element zum austragen von genmaterial

Info

Publication number
ATE231733T1
ATE231733T1 AT95909280T AT95909280T ATE231733T1 AT E231733 T1 ATE231733 T1 AT E231733T1 AT 95909280 T AT95909280 T AT 95909280T AT 95909280 T AT95909280 T AT 95909280T AT E231733 T1 ATE231733 T1 AT E231733T1
Authority
AT
Austria
Prior art keywords
particles
genetic material
discharging
gas
actuated element
Prior art date
Application number
AT95909280T
Other languages
English (en)
Inventor
Dennis E Mccabe
Original Assignee
Powderject Vaccines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Powderject Vaccines Inc filed Critical Powderject Vaccines Inc
Application granted granted Critical
Publication of ATE231733T1 publication Critical patent/ATE231733T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/30Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3015Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A61M2005/005Magazines with multiple ampoules directly inserted into an injection or infusion device, e.g. revolver-like magazines containing ampoules with or without needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053Media being expelled from injector by pressurised fluid or vacuum

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Surface Treatments For Metallic Materials (AREA)
  • Air Bags (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95909280T 1994-01-21 1995-01-20 Gasbetätigtes element zum austragen von genmaterial ATE231733T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18481294A 1994-01-21 1994-01-21
PCT/US1995/000780 WO1995019799A1 (en) 1994-01-21 1995-01-20 Gas driven gene delivery instrument

Publications (1)

Publication Number Publication Date
ATE231733T1 true ATE231733T1 (de) 2003-02-15

Family

ID=22678443

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95909280T ATE231733T1 (de) 1994-01-21 1995-01-20 Gasbetätigtes element zum austragen von genmaterial
AT02023522T ATE300609T1 (de) 1994-01-21 1995-01-20 Gasbetätigtes element zum austragen von genmaterial

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02023522T ATE300609T1 (de) 1994-01-21 1995-01-20 Gasbetätigtes element zum austragen von genmaterial

Country Status (15)

Country Link
US (2) US5584807A (de)
EP (3) EP1293559B1 (de)
JP (1) JP3221683B2 (de)
CN (1) CN1112943C (de)
AT (2) ATE231733T1 (de)
AU (1) AU674815B2 (de)
BR (1) BR9505691A (de)
CA (2) CA2501743C (de)
DE (2) DE69529495T2 (de)
DK (2) DK0690732T3 (de)
ES (2) ES2192573T3 (de)
NZ (1) NZ279995A (de)
PT (1) PT690732E (de)
RU (1) RU2134295C1 (de)
WO (1) WO1995019799A1 (de)

Families Citing this family (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW404844B (en) 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
JP3221683B2 (ja) * 1994-01-21 2001-10-22 パウダージェクト ヴァクシンズ, インコーポレイテッド ガス駆動型遺伝子搬入装置
US5899880A (en) * 1994-04-08 1999-05-04 Powderject Research Limited Needleless syringe using supersonic gas flow for particle delivery
GB9416663D0 (en) 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
WO1996012513A1 (en) * 1994-10-24 1996-05-02 Oxford Biosciences Limited Particle delivery
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
GB9502879D0 (en) * 1995-02-14 1995-04-05 Oxford Biosciences Ltd Particle delivery
US7223739B1 (en) 1995-06-07 2007-05-29 Powderject Vaccines, Inc. Adjuvanted genetic vaccines
US6013050A (en) * 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
US5922685A (en) * 1996-06-05 1999-07-13 Powderject Vaccines, Inc. IL-12 gene therapy of tumors
EP1378525A3 (de) * 1996-06-07 2004-01-14 Neorx Corporation Humanisierte Antikörper die and das gleiche Antigen wie Antikörper NR-LU-13 binden und deren Verwendung in "Pretargeting" Verfahren
CA2257141C (en) * 1996-06-14 2006-11-28 Powderject Vaccines, Inc. Sample delivery module for particle acceleration apparatus
US6893664B1 (en) * 1996-06-17 2005-05-17 Powderject Research Limited Particle delivery techniques
CN1109748C (zh) * 1996-09-25 2003-05-28 鲍德杰克特疫苗公司 气动微粒输送装置
DE19648625A1 (de) * 1996-11-13 1998-05-14 Soft Gene Gmbh Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer
US5733600A (en) 1996-11-13 1998-03-31 Powderject Vaccines, Inc. Method and apparatus for preparing sample cartridges for a particle acceleration device
DE19648656B4 (de) * 1996-11-14 2005-08-11 Hiper Ceramics Gmbh Vorrichtung zum Beschleunigen von Partikeln auf Zellen zum ballistischen Transfer
US6200959B1 (en) * 1996-12-04 2001-03-13 Powerject Vaccines Inc. Genetic induction of anti-viral immune response and genetic vaccine for filovirus
US6433154B1 (en) 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US5947928A (en) * 1997-06-19 1999-09-07 Mile Creek Capital, Llc Drug delivery system
US6570062B1 (en) 1997-07-21 2003-05-27 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6548642B1 (en) * 1997-07-21 2003-04-15 Ohio University Synthetic genes for plant gums
US6639050B1 (en) * 1997-07-21 2003-10-28 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US7378506B2 (en) * 1997-07-21 2008-05-27 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6355415B1 (en) 1997-09-29 2002-03-12 Ohio University Compositions and methods for the use of ribozymes to determine gene function
US5994624A (en) * 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
WO1999026653A1 (en) * 1997-11-20 1999-06-03 United States Army Medical Research And Material Command Dna vaccines against tick-borne flaviviruses
US6475994B2 (en) * 1998-01-07 2002-11-05 Donald A. Tomalia Method and articles for transfection of genetic material
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6686513B1 (en) 1998-03-19 2004-02-03 The United States Of America As Represented By The Secretary Of Agriculture Sugarcane ubi9 gene promoter sequence and methods of use thereof
US6706948B1 (en) 1998-03-19 2004-03-16 The United States Of America As Represented By The Secretary Of Agriculture Sugarcane UBI9 gene promoter and methods of use thereof
KR20010052345A (ko) 1998-05-12 2001-06-25 수잔 씨 복 인간 항트롬빈 3 및 그에 관련된 방법
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
ES2259846T3 (es) * 1998-10-19 2006-10-16 Powderject Vaccines, Inc. Promotores minimo y uso de los mismos.
US6881723B1 (en) 1998-11-05 2005-04-19 Powderject Vaccines, Inc. Nucleic acid constructs
US6232113B1 (en) 1998-12-08 2001-05-15 Tien-Li Lee Particle bombardment device
WO2000047227A2 (en) 1999-02-09 2000-08-17 Powderject Vaccines, Inc. Mycobacterium tuberculosis, immunization
WO2000063385A2 (en) * 1999-04-21 2000-10-26 Powderject Vaccines, Inc. Nucleic acid immunization
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6398808B1 (en) 1999-06-15 2002-06-04 Scimed Life Systems, Inc. Localized delivery of genetic information from biostable materials
US7074210B2 (en) * 1999-10-11 2006-07-11 Felton International, Inc. Universal protector cap with auto-disable features for needle-free injectors
EP1220697B1 (de) 1999-10-11 2004-12-29 Felton International, Inc. Universelle antiinfektionsschutzvorrichtung für nadellose injektoren
US7135282B1 (en) 1999-10-14 2006-11-14 The Dow Chemical Company Viral particles with exogenous internal epitopes
PT1913957E (pt) * 1999-11-03 2010-05-05 Powderject Vaccines Inc Vacinas genéticas adjuvantes
DK1913957T3 (da) * 1999-11-03 2010-05-10 Powderject Vaccines Inc Genetiske adjuvant-vacciner
US7196066B1 (en) * 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
US20040234539A1 (en) * 1999-11-03 2004-11-25 Powderject Research Limited Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
JP2004522403A (ja) * 1999-11-03 2004-07-29 パウダージェクト ヴァクシンズ,インコーポレイテッド 抗原発現を駆動する哺乳動物cd80/cd86遺伝子プロモーターを有する核酸ワクチン組成物
US20040109874A1 (en) * 1999-11-10 2004-06-10 Powderject Vaccines, Inc. Induction of mucosal immunity by vaccination via the skin route
US7029457B2 (en) * 1999-11-23 2006-04-18 Felton International, Inc. Jet injector with hand piece
US7887506B1 (en) 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US6770054B1 (en) 1999-11-23 2004-08-03 Felton International, Inc. Injector assembly with driving means and locking means
CN1079430C (zh) * 1999-12-11 2002-02-20 周芳 一种高压气体基因枪
FR2802820B1 (fr) * 1999-12-27 2002-10-18 Poudres & Explosifs Ste Nale Seringue sans aiguille fonctionnant par effet tube a choc, avec maintien prealable du principe actif sur le cote
DE60143425D1 (de) 2000-02-23 2010-12-23 Smithkline Beecham Biolog Neue verbindungen
GB0006263D0 (en) * 2000-03-15 2000-05-03 Powderject Res Ltd Apparatus and method for adjusting the characteristics of a needleless syringe
GB0008494D0 (en) 2000-04-07 2000-05-24 Secr Defence Microprojectile delivery system
US6716190B1 (en) * 2000-04-19 2004-04-06 Scimed Life Systems, Inc. Device and methods for the delivery and injection of therapeutic and diagnostic agents to a target site within a body
WO2001087491A1 (en) 2000-05-16 2001-11-22 Regents Of The University Of Minnesota High mass throughput particle generation using multiple nozzle spraying
EP1961819A3 (de) 2000-06-28 2008-11-12 Corixa Corporation Zusammensetzungen und Verfahren zur Heilung und Diagnose von Lungenkrebs
US6878861B2 (en) * 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
GB0025710D0 (en) * 2000-10-20 2000-12-06 Medical Res Council Biolistic device
CA2324045A1 (fr) * 2000-10-20 2002-04-20 Universite De Sherbrooke Seringue sans aiguille pour l'injection sous-cutanee de poudres medicamenteuses
US7060442B2 (en) * 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
AU2002241726A1 (en) * 2000-11-02 2002-06-11 Powderject Vaccines, Inc. Compositions and therapeutical use of polynucleotides encoding tcrs
US6902933B2 (en) * 2000-11-03 2005-06-07 Regents Of The University Of Michigan Surface transfection and expression procedure
US6897067B2 (en) * 2000-11-03 2005-05-24 Regents Of The University Of Michigan Surface transfection and expression procedure
CA2427916C (en) * 2000-11-03 2012-01-17 The Regents Of The University Of Michigan Surface transfection and expression procedure
US7226764B1 (en) 2000-11-08 2007-06-05 The Board Of Trustees Operating Michigan State University Compositions and methods for the synthesis and subsequent modification of uridine-5′-diphosphosulfoquinovose (UDP-SQ)
US6638246B1 (en) * 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
US7255865B2 (en) * 2000-12-05 2007-08-14 Allergan, Inc. Methods of administering botulinum toxin
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
GB0100756D0 (en) * 2001-01-11 2001-02-21 Powderject Res Ltd Needleless syringe
CA2340998C (en) 2001-03-21 2012-01-03 Saskatchewan Wheat Pool Selective modification of plant fatty acids
US7169597B2 (en) * 2001-04-13 2007-01-30 Michigan State University Compositions and methods for the production of betaine lipids
US7241935B2 (en) * 2001-04-13 2007-07-10 The Board Of Trustees Operating Michigan State University Compositions and methods for the production of betaine lipids
EP1515982A4 (de) 2001-05-09 2005-10-26 Corixa Corp Zusammensetzungen und verfahren zur therapie und diagnose von prostatakrebs
US7247338B2 (en) 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
JP2005525081A (ja) 2001-06-05 2005-08-25 カレン ケイ. オオイシ 植物からの生物活性ミュラー管抑制物質を含むTGF−βタンパク質の遺伝子発現および産生法
US8061006B2 (en) * 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
WO2003020936A1 (en) * 2001-08-31 2003-03-13 The Dow Chemical Company Nucleic acid compositions conferring altered metabolic characteristics
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
CN100392085C (zh) * 2001-09-20 2008-06-04 葛兰素集团有限公司 疫苗
US8920375B2 (en) * 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
EP1469903A2 (de) * 2001-09-28 2004-10-27 BioValve Technologies, Inc. Mikronadel mit membran
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US20040048822A1 (en) * 2001-11-01 2004-03-11 Juan Harrison Nucleic acid immunization
JP2003164289A (ja) * 2001-11-30 2003-06-10 Seikagaku Kogyo Co Ltd 骨組織導入用遺伝子
CA2860702C (en) 2001-12-17 2019-02-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
CA2473717A1 (en) * 2002-01-25 2003-07-31 Glaxo Group Limited Dna dosage forms
US7255986B2 (en) * 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
US20030163111A1 (en) * 2002-02-26 2003-08-28 Daellenbach Keith K. End effector for needle-free injection system
NZ534881A (en) 2002-03-19 2006-09-29 Plant Res Internat B Mammalian GnTIII expression in plants
CA2799805C (en) 2002-03-19 2016-05-17 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
CA2380671A1 (fr) * 2002-04-05 2003-10-05 Stephane Dufresne Seringue sans aiguille pour l'injection sous-cutanee de gouttelettes medicamenteuses
US7078037B2 (en) * 2002-04-19 2006-07-18 The Arizona Board Of Regents On Behalf Of The University Of Arizona Peptides and DNA encoding the peptides useful for immunizations against Coccidioides spp. infections
USD488862S1 (en) 2002-06-04 2004-04-20 Felton International, Inc. Handpiece for jet injector
AU2003247582A1 (en) * 2002-06-20 2004-01-06 Board Of Trustees Operating Michigan State University Plastid division and related genes and proteins, and methods of use
EP1517605A2 (de) 2002-06-28 2005-03-30 University of Guelph Gene aus luzerne (medicago sativa), die während der ernte induzierbar werden und methoden für deren verwendung
US7329798B2 (en) * 2002-06-28 2008-02-12 University Of Guelph Harvest-inducible regulatory elements and methods of using same
EP1545593A1 (de) * 2002-09-27 2005-06-29 PowderJect Research Limited Mit nukleinsäure überzogene partikel
US20050272030A1 (en) * 2002-09-27 2005-12-08 Powder Ject Research Limited Nucleic acid constructs for gene expression
US6920521B2 (en) * 2002-10-10 2005-07-19 International Business Machines Corporation Method and system of managing virtualized physical memory in a data processing system
US6863731B2 (en) * 2002-10-18 2005-03-08 Controls Corporation Of America System for deposition of inert barrier coating to increase corrosion resistance
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
ES2556970T3 (es) 2003-01-06 2016-01-21 Corixa Corporation Ciertos compuestos de fosfato de aminoalquil glucosaminida y sus usos
FR2850564B1 (fr) * 2003-02-05 2006-06-02 Arcadophta Dispositif et procede de preparation extemporanee d'une quantite individuelle de fluide sterile
US7262027B2 (en) * 2003-03-14 2007-08-28 Medical College Of Ohio Polypeptide and DNA immunization against Coccidioides spp. infections
EP1462801A3 (de) * 2003-03-24 2005-01-05 Tepnel Lifecodes Methoden zur messung der negativkontrolle in mehrfachanalyt-assays
US20060252120A1 (en) * 2003-05-09 2006-11-09 Kieliszewski Marcia J Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US7655833B2 (en) * 2003-05-29 2010-02-02 Brookhaven Science Associates, Llc ADS genes for reducing saturated fatty acid levels in seed oils
GB0321615D0 (en) 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
WO2005035771A2 (en) * 2003-10-10 2005-04-21 Powderject Vaccines, Inc. Nucleic acid constructs
USD519633S1 (en) 2003-11-12 2006-04-25 Powderject Research Limited Syringe
US8147426B2 (en) * 2003-12-31 2012-04-03 Nipro Diagnostics, Inc. Integrated diagnostic test system
NZ548513A (en) * 2004-01-14 2010-05-28 Univ Ohio Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
US7432057B2 (en) * 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
AU2004201456B2 (en) * 2004-04-08 2005-11-17 Ronald Allan Greenberg Apparatus and method for transdermal delivery of fluids including oxygen
CA2573918A1 (en) * 2004-04-19 2005-11-24 Ohio University Cross-linkable glycoproteins and methods of making the same
US7217428B2 (en) * 2004-05-28 2007-05-15 Technology Innovations Llc Drug delivery apparatus utilizing cantilever
AU2005268917B2 (en) 2004-08-02 2010-05-20 Basf Plant Science Gmbh Method for isolation of transcription termination sequences
JP2008513406A (ja) 2004-09-22 2008-05-01 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
US7892836B2 (en) * 2005-02-11 2011-02-22 The Regents Of The University Of California Pneumatic capillary gun for ballistic delivery of microscopic particles into tissue
EP2166099B1 (de) 2005-03-08 2012-12-19 BASF Plant Science GmbH Expressionsverstärkende Intronsequenzen
WO2006125065A2 (en) * 2005-05-18 2006-11-23 The Board Of Trustees Operating Michigan State University Resistance to soybean aphid in early maturing soybean germplasm
WO2007008708A2 (en) * 2005-07-08 2007-01-18 Ohio University Methods of predicting hyp-glycosylation sites for proteins expressed and secreted in plant cells, and related methods and products
US20070055199A1 (en) * 2005-08-10 2007-03-08 Gilbert Scott J Drug delivery device for buccal and aural applications and other areas of the body difficult to access
US8562620B2 (en) * 2008-04-21 2013-10-22 Dfine, Inc. Bone treatment systems
EP1979488A4 (de) 2006-01-09 2009-05-27 Univ California Immunstimulierende kombinationen aus tnfrsf, tlr, nlr, rhr, purinergischem rezeptor, und zytokin-rezeptor-antaonisten für impfstoffe und die tumorimmuntherapie
US20080313769A9 (en) 2006-01-12 2008-12-18 Athenix Corporation EPSP synthase domains conferring glyphosate resistance
US20070164133A1 (en) * 2006-01-18 2007-07-19 Hao-Jan Lin Low pressure gas accelerated gene gun
EP1988941A2 (de) 2006-01-31 2008-11-12 Nanocopoeia, Inc. Oberflächenbeschichtung mit nanoteilchen
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
CA2637883C (en) 2006-01-31 2015-07-07 Regents Of The University Of Minnesota Electrospray coating of objects
US20070190635A1 (en) * 2006-02-10 2007-08-16 Hai-Lung Huang Percussion mechanism for a gene gun
EP1996009A4 (de) 2006-03-02 2009-09-30 Athenix Corp Verfahren und zusammensetzungen für erhöhte enzymaktivität bei transgenen pflanzen
DK2656832T3 (en) 2006-05-11 2019-04-08 Regenics As Compositions for use in wound healing
US7977535B2 (en) 2006-07-12 2011-07-12 Board Of Trustees Of Michigan State University DNA encoding ring zinc-finger protein and the use of the DNA in vectors and bacteria and in plants
US8680235B2 (en) * 2006-09-22 2014-03-25 Stowers Institute For Medical Research Branchiostoma derived fluorescent proteins
US20090061492A1 (en) * 2006-11-15 2009-03-05 The Board Of Trustees For Michigan State University System Method for producing biodiesel
US9040816B2 (en) 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
EP2121720A4 (de) 2007-02-12 2010-05-12 Us Army Dna-impfstoffe auf basis von puumala-virus m-segmenten mit voller länge
GB0708758D0 (en) * 2007-05-04 2007-06-13 Powderject Res Ltd Particle cassettes and process thereof
DE102007026752A1 (de) * 2007-06-09 2008-12-11 Ivonne Silvester Vorrichtung zur Aufbewahrung und Applikation von Wirkstoffen
EP2215231A4 (de) 2007-10-15 2010-12-01 Univ Queensland Expressionssystem zur modulation einer immunantwort
CN101998965B (zh) 2007-11-01 2014-03-12 安斯泰来制药有限公司 免疫抑制性多肽与核酸
US9839772B2 (en) 2008-05-06 2017-12-12 Cook Medical Technologies Llc Apparatus and methods for delivering therapeutic agents
US9133475B2 (en) 2008-11-26 2015-09-15 Board Of Trustees Of Michigan State University Aphid resistant soybean plants
US8362318B2 (en) 2008-12-18 2013-01-29 Board Of Trustees Of Michigan State University Enzyme directed oil biosynthesis in microalgae
CA2747390C (en) 2008-12-23 2016-10-04 Wilson-Cook Medical Inc. Apparatus and methods for containing and delivering therapeutic agents
CN101768213B (zh) 2008-12-30 2012-05-30 中国科学院遗传与发育生物学研究所 一种与植物分蘖数目相关的蛋白及其编码基因与应用
CN101817879A (zh) 2009-02-26 2010-09-01 中国科学院遗传与发育生物学研究所 金属硫蛋白及其编码基因与应用
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US8118777B2 (en) * 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
TWI400103B (zh) * 2009-12-03 2013-07-01 Leader Machine Co Ltd Drug delivery device
US20110159577A1 (en) * 2009-12-30 2011-06-30 E. I. Du Pont De Nemours And Company Divider for use with biolistic bombardment device
WO2011082253A2 (en) 2009-12-30 2011-07-07 Board Of Trustees Of Michigan State University A method to produce acetyldiacylglycerols (ac-tags) by expression ofan acetyltransferase gene isolated from euonymus alatus (burning bush)
US9795658B2 (en) 2010-04-20 2017-10-24 Admedus Vaccines Pty Ltd Expression system for modulating an immune response
AU2011249478B2 (en) 2010-05-06 2014-12-04 Regenics As Use of cellular extracts for skin rejuvenation
US9227021B2 (en) 2010-06-29 2016-01-05 Genesis Biosystems, Inc. Microneedle roller (MNR) infusion system
EP2621282B1 (de) 2010-09-28 2020-04-15 The Regents of The University of California Gaba-agonisten zur behandlung von erkrankungen im zusammenhang mit dem stoffwechselsyndrom und gaba-kombinationen zur behandlung oder prophylaxe von diabetes vom typ i
US20120135526A1 (en) * 2010-11-23 2012-05-31 Kenneth Greenberg Low-pressure biolistic barrels
GB201021881D0 (en) * 2010-12-23 2011-02-02 Profibrix Bv Powder delivery device
US9315826B2 (en) 2011-01-31 2016-04-19 The United States of America as rep. by the Sec'y of the Army, for U.S. Army Medical Research Institute of Infectious Diseases Nucleic acids containing a synthetic codon-optimized Sin Nombre virus full-length M gene
US10849975B2 (en) 2011-02-03 2020-12-01 Thomas Jefferson University Multivalent vaccines for rabies virus and filoviruses
US8388569B2 (en) * 2011-04-19 2013-03-05 Xerox Corporation Delivery devices and methods with collimated gas stream and particle source
US8486002B2 (en) * 2011-04-19 2013-07-16 Palo Alto Research Center Incorporated Drug delivery devices and methods with collimated gas stream and release-activatable tape
US8430839B2 (en) * 2011-04-19 2013-04-30 Palo Alto Research Center Incorporated Drug delivery devices and methods with collimated gas stream and drug reservoir
DE102011100450B8 (de) * 2011-04-27 2013-10-17 Jörg Gerlach Apparat zum Sprühen von Zellen, Herstellung des Apparates, Methode zum Sprühen mit dem Apparat und eine Zellsuspension gesprüht mit dem Apparat
ES2549780T3 (es) * 2011-04-27 2015-11-02 Biom'up Dispensador de polvo hemostático biomédico
AU2012273153A1 (en) 2011-06-21 2013-05-02 Oncofactor Corporation Compositions and methods for the therapy and diagnosis of cancer
CN102250757B (zh) * 2011-07-20 2013-01-09 宁波新芝生物科技股份有限公司 一种基因枪
SG11201408101TA (en) 2012-06-05 2015-01-29 Univ Australian Vaccination with interleukin-4 antagonists
EP3459522B1 (de) 2012-12-10 2021-02-17 Regenics AS Verwendung von zellextrakten zur wundbehandlung
CA2836403A1 (en) 2013-01-04 2014-07-04 Board Of Trustees Of Michigan State University New sources of aphid resistance in soybean plants
US9783817B2 (en) 2013-03-04 2017-10-10 Arkansas State University Methods of expressing and detecting activity of expansin in plant cells
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US10392629B2 (en) 2014-01-17 2019-08-27 Board Of Trustees Of Michigan State University Increased caloric and nutritional content of plant biomass
US9714429B2 (en) 2014-01-28 2017-07-25 Arkansas State University Regulatory sequence of cupin family gene
WO2015193653A1 (en) 2014-06-16 2015-12-23 Consejo Nacional De Investigaciones Cientificas Y Tecnicas Oxidative resistance chimeric genes and proteins, and transgenic plants including the same
US10039885B2 (en) 2015-02-09 2018-08-07 Palo Alto Research Center Incorporated System and method for enhancing particle delivery to biological tissue
US10449297B2 (en) * 2015-02-09 2019-10-22 Palo Alto Research Center Incorporated Alignment of elongated particles in a particle delivery device
WO2016154010A1 (en) 2015-03-20 2016-09-29 Makidon Paul Immunogenic compositions for use in vaccination against bordetella
JP2017000667A (ja) * 2015-06-16 2017-01-05 国立大学法人三重大学 無針注射器及びそれを用いた注射対象領域へのdna導入方法
KR102895580B1 (ko) 2015-12-09 2025-12-03 진강 메디신 (오스트레일리아) 피티와이 엘티디 치료를 위한 면역조절용 조성물
US11041170B2 (en) 2016-04-04 2021-06-22 Thomas Jefferson University Multivalent vaccines for rabies virus and coronaviruses
CN105820942B (zh) * 2016-05-24 2017-12-19 中国农业科学院棉花研究所 一种基因枪用活塞样品架
AU2017283496B2 (en) 2016-06-14 2020-07-16 Renovacare Sciences Corp. Modular device for cell spraying
WO2018018082A1 (en) 2016-07-26 2018-02-01 The Australian National University Immunostimulatory compositions and uses therefor
FR3085959B1 (fr) * 2018-09-18 2020-11-20 Centre Nat Rech Scient Dispositif de distribution de microbulles pour une sonoporation cellulaire
US20210379118A1 (en) 2018-10-19 2021-12-09 Regenics As Use of egg cellular extract for wound healing
US20220396811A1 (en) * 2019-11-26 2022-12-15 Georgia Tech Research Corporation Systems and Devices for Delivering Cargo Material and Methods of Delivering Cargo Materials
WO2021195089A1 (en) 2020-03-23 2021-09-30 Sorrento Therapeutics, Inc. Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof
BR112022023464A2 (pt) 2020-06-05 2022-12-20 Cook Medical Technologies Llc Endoscópios médicos para entregar agentes terapêuticos
EP4274648A4 (de) * 2021-01-10 2024-08-21 Orlance, Inc. Medizinische abgabevorrichtung
CA3225582A1 (en) * 2021-06-24 2022-12-29 Avectas Limited Spray nozzle
US12543936B2 (en) 2021-07-14 2026-02-10 Cook Medical Technologies Llc Systems and methods for preventing clogging of a delivery system
US12496429B2 (en) 2022-10-18 2025-12-16 Cook Medical Technologies Llc Systems and methods for delivering pressurized fluid to a target site alone or in conjunction with therapeutic agents

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2632444A (en) * 1951-06-14 1953-03-24 Kas John Leo Pellet injector
US2850013A (en) * 1956-03-20 1958-09-02 Cordis Nat Animal pellet injector gun
US3518990A (en) * 1968-05-02 1970-07-07 Oscar H Banker Gun type inoculator
US3744493A (en) * 1972-01-10 1973-07-10 Syntex Corp Implanter having an improved cartridge ejector
GB8311345D0 (en) * 1983-04-26 1983-06-02 Dobson Park Ind Oral administration of capsules to animals
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
IL84459A (en) * 1986-12-05 1993-07-08 Agracetus Apparatus and method for the injection of carrier particles carrying genetic material into living cells
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5120657A (en) * 1986-12-05 1992-06-09 Agracetus, Inc. Apparatus for genetic transformation
US4941880A (en) * 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
AU628029B2 (en) * 1987-11-16 1992-09-10 Sy-Quest International Limited Improved apparatus for hypodermic injection of liquids
US5179022A (en) * 1988-02-29 1993-01-12 E. I. Du Pont De Nemours & Co. Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner
DK479189D0 (da) * 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
CN1052695A (zh) * 1989-12-22 1991-07-03 中国科学院生物物理研究所 一种转移基因的方法及其转移基因的粒子枪
US5066587A (en) * 1990-01-26 1991-11-19 The Upjohn Company Gas driven microprojectile accelerator and method of use
US5204253A (en) * 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5149655A (en) * 1990-06-21 1992-09-22 Agracetus, Inc. Apparatus for genetic transformation
WO1992004439A1 (en) * 1990-08-30 1992-03-19 Brian John Bellhouse Ballistic apparatus
US5147295A (en) * 1991-01-23 1992-09-15 Ideal Instruments, Inc. Retractable implanter
TW404844B (en) * 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
JP3221683B2 (ja) * 1994-01-21 2001-10-22 パウダージェクト ヴァクシンズ, インコーポレイテッド ガス駆動型遺伝子搬入装置

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RU2134295C1 (ru) 1999-08-10
EP0690732B1 (de) 2003-01-29
NZ279995A (en) 1998-04-27
CA2501743C (en) 2008-11-18
DE69534348T2 (de) 2006-05-24
US5865796A (en) 1999-02-02
DE69534348D1 (de) 2005-09-01
BR9505691A (pt) 1996-01-16
EP1550713A2 (de) 2005-07-06
EP1550713A3 (de) 2007-09-12
JP3221683B2 (ja) 2001-10-22
EP1293559A1 (de) 2003-03-19
AU1729595A (en) 1995-08-08
CA2158733A1 (en) 1995-07-27
JPH08509131A (ja) 1996-10-01
CA2501743A1 (en) 1995-07-27
DK1293559T3 (da) 2005-11-28
PT690732E (pt) 2003-06-30
ES2192573T3 (es) 2003-10-16
EP0690732A1 (de) 1996-01-10
ATE300609T1 (de) 2005-08-15
WO1995019799A1 (en) 1995-07-27
EP1293559B1 (de) 2005-07-27
ES2247248T3 (es) 2006-03-01
AU674815B2 (en) 1997-01-09
CN1112943C (zh) 2003-07-02
EP0690732A4 (de) 1996-06-12
HK1013804A1 (en) 1999-09-10
US5584807A (en) 1996-12-17
CN1124460A (zh) 1996-06-12
DK0690732T3 (da) 2003-05-19
CA2158733C (en) 2007-01-16
DE69529495D1 (de) 2003-03-06

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