ATE230T1 - Diagnostisches mittel zum nachweis proteolytischer enzyme sowie als chromogene hierfuer geeignete indoxyl- bzw. thioindoxylester, verfahren zu deren herstellung sowie deren verwendung zur herstellung diagnostischer mittel. - Google Patents
Diagnostisches mittel zum nachweis proteolytischer enzyme sowie als chromogene hierfuer geeignete indoxyl- bzw. thioindoxylester, verfahren zu deren herstellung sowie deren verwendung zur herstellung diagnostischer mittel.Info
- Publication number
- ATE230T1 ATE230T1 AT79105184T AT79105184T ATE230T1 AT E230 T1 ATE230 T1 AT E230T1 AT 79105184 T AT79105184 T AT 79105184T AT 79105184 T AT79105184 T AT 79105184T AT E230 T1 ATE230 T1 AT E230T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- diagnostic
- thioindoxylesters
- indoxyl
- chromogenic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/50—Indoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2854987A DE2854987A1 (de) | 1978-12-20 | 1978-12-20 | Diagnostische mittel zum nachweis proteolytischer enzyme und dafuer geeignete chromogene |
EP79105184A EP0012957B1 (de) | 1978-12-20 | 1979-12-14 | Diagnostisches Mittel zum Nachweis proteolytischer Enzyme sowie als Chromogene hierfür geeignete Indoxyl- bzw. Thioindoxylester, Verfahren zu deren Herstellung sowie deren Verwendung zur Herstellung diagnostischer Mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE230T1 true ATE230T1 (de) | 1981-10-15 |
Family
ID=6057730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79105184T ATE230T1 (de) | 1978-12-20 | 1979-12-14 | Diagnostisches mittel zum nachweis proteolytischer enzyme sowie als chromogene hierfuer geeignete indoxyl- bzw. thioindoxylester, verfahren zu deren herstellung sowie deren verwendung zur herstellung diagnostischer mittel. |
Country Status (20)
Country | Link |
---|---|
US (1) | US4278763A (fi) |
EP (1) | EP0012957B1 (fi) |
JP (1) | JPS593475B2 (fi) |
AR (1) | AR223505A1 (fi) |
AT (1) | ATE230T1 (fi) |
AU (1) | AU515190B2 (fi) |
BR (1) | BR7908306A (fi) |
CA (1) | CA1130801A (fi) |
CS (1) | CS245763B2 (fi) |
DD (1) | DD147845A5 (fi) |
DE (2) | DE2854987A1 (fi) |
DK (1) | DK155318C (fi) |
ES (1) | ES486932A1 (fi) |
FI (1) | FI77229C (fi) |
HU (1) | HU180431B (fi) |
PL (1) | PL127198B1 (fi) |
PT (1) | PT70608A (fi) |
SU (2) | SU1184444A3 (fi) |
YU (1) | YU311579A (fi) |
ZA (1) | ZA796880B (fi) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3005845A1 (de) * | 1980-02-16 | 1981-09-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aminosaeure- und peptidester von leuko-indoanilinen, verfahren zu deren herstellung sowie diese verbindungen enthaltende mittel zum nachweis proteolytischer enzyme |
DE3017721A1 (de) * | 1980-05-09 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate |
DE3164437D1 (en) * | 1980-08-25 | 1984-08-02 | Kabivitrum Ab | Peptide substrates for determination of protease activity |
US4499185A (en) * | 1982-05-17 | 1985-02-12 | Miles Laboratories, Inc. | Test for esterase activity in a liquid sample |
US4676950A (en) * | 1984-02-03 | 1987-06-30 | Foster Research Corporation | Indicator and test device for detecting occult blood |
US4645842A (en) * | 1984-04-06 | 1987-02-24 | Miles Laboratories, Inc. | Pyrrole compounds for detecting the presence of hydrolytic analytes |
IL73998A (en) * | 1984-04-06 | 1988-08-31 | Miles Lab | Preparation of 3-(n-tosyl-l-alaninyloxy)-pyrrole compounds |
US4716236A (en) * | 1984-04-06 | 1987-12-29 | Miles Laboratories, Inc. | Method for synthesizing esters |
US4657855A (en) * | 1984-04-06 | 1987-04-14 | Miles Laboratories, Inc. | Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample |
DE3412939A1 (de) * | 1984-04-06 | 1985-10-17 | Behringwerke Ag, 3550 Marburg | Substrate fuer hydrolasen, verfahren zu ihrer herstellung und ihre verwendung |
US4637979A (en) * | 1984-04-06 | 1987-01-20 | Miles Laboratories, Inc. | Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent |
DE3413077A1 (de) * | 1984-04-06 | 1985-10-17 | Miles Laboratories, Inc., Elkhart, Ind. | Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
DE3413078A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
DE3446714A1 (de) * | 1984-12-21 | 1986-06-26 | Boehringer Mannheim Gmbh | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
US5179112A (en) * | 1985-04-17 | 1993-01-12 | Ici Americas Inc. | Heterocyclic amide derivatives and pharmaceutical use |
GB8607294D0 (en) * | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
GB8623429D0 (en) * | 1985-10-17 | 1986-11-05 | Ici America Inc | Carboximide derivatives |
US4837235A (en) * | 1985-10-17 | 1989-06-06 | Ici Americas Inc. | Indole and indazole keto sulphones as leukotriene antagonists |
GB8609175D0 (en) * | 1986-04-15 | 1986-05-21 | Ici America Inc | Heterocyclic carboxamides |
EP0470172B1 (en) * | 1989-04-27 | 1995-06-28 | BioControl Systems, Incorporated | Precipitate test for microorganisms |
US5589328A (en) * | 1994-08-04 | 1996-12-31 | Mahant; Vijay K. | Chemiluminescence assays based on indoxyl substrates, thioindoxyl substrates and other substrates |
US5464739A (en) | 1994-08-22 | 1995-11-07 | Bayer Corporation | Composition method for determining the presence of leukocyte cells, esterase or protease in a test sample |
CA2161574A1 (en) | 1994-11-15 | 1996-05-16 | James Noffsinger | Methodology for colorimetrically determining the concentration of white blood cells in a biological fluid |
FR2751663B1 (fr) * | 1996-07-29 | 1998-10-02 | Bio Merieux | Procede de mise en evidence d'une activite enzymatique de microorganismes |
DE19651886A1 (de) * | 1996-12-13 | 1998-06-18 | Merck Patent Gmbh | Mittel und Verfahren zur Bestimmung von hydrolytischen Enzymen |
GB2326712B (en) * | 1997-06-25 | 2001-09-26 | Fujirebio Kk | Colour devoloping method,enzyme immunoassay using the colour developing method,and immunochromatography incorporating the enzyme immunoassay |
DE19735614A1 (de) * | 1997-08-16 | 1999-02-18 | Lothar Dr Seik | Verfahren zum Nachweis der Aktivität von Insulin-like Growth Factor Binding Protein-Proteasen (IGFBP-Proteasen). |
DE19829707C2 (de) * | 1998-07-03 | 2002-07-18 | Macherey Nagel Gmbh & Co Hg | Diagnostisches Mittel zum Nachweis von Leukozyten, Elastasen, Esterasen und Proteasen |
US6528652B1 (en) * | 1999-01-21 | 2003-03-04 | Chronimed | Composition and device for detecting leukocytes in urine |
US6348324B1 (en) | 1999-01-21 | 2002-02-19 | Hypoguard America Limited | Composition and device for detecting leukocytes in urine |
US6709868B2 (en) | 2002-05-20 | 2004-03-23 | Portascience Inc. | Method and apparatus for measuring white blood cell count |
WO2006065899A1 (en) * | 2004-12-13 | 2006-06-22 | Bayer Healthcare Llc | A method of differentiating between blood and control solutions containing a common analyte |
GB2426334A (en) * | 2005-05-20 | 2006-11-22 | Orion Diagnostica Oy | Application of a reagent to a matrix material |
US7504235B2 (en) * | 2005-08-31 | 2009-03-17 | Kimberly-Clark Worldwide, Inc. | Enzyme detection technique |
US7727206B2 (en) * | 2005-12-27 | 2010-06-01 | Gorres Geoffrey H | Device for monitoring a patient for a urinary tract infection |
US9103796B2 (en) * | 2007-12-14 | 2015-08-11 | Kimberly-Clark Worldwide, Inc. | Multi-layered devices for analyte detection |
US11104933B1 (en) * | 2016-03-22 | 2021-08-31 | Cleu Diagnostics, Llc | Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay |
CN116023320A (zh) * | 2022-12-28 | 2023-04-28 | 长春百纯和成医药科技有限公司 | 一种多晶型结构的3-(n-对甲苯磺酰基-l-丙氨酰氧基)吲哚及其制备方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3087794A (en) | 1960-05-23 | 1963-04-30 | Miles Lab | Chemical test for differentiating leucocytes from erythrocytes |
BE615395A (fi) * | 1962-03-21 | |||
GB1128371A (en) | 1965-10-04 | 1968-09-25 | Miles Lab | Diagnostic composition |
DE2118455B1 (de) | 1971-04-16 | 1972-09-21 | Boehringer Mannheim Gmbh | Teststreifen |
US4061625A (en) * | 1975-07-11 | 1977-12-06 | Ab Kabi | Novel chromogenic thrombin substrates |
JPS5263794A (en) * | 1975-11-21 | 1977-05-26 | Shionogi Seiyaku Kk | Test piece for latent blood |
JPS53132539A (en) * | 1977-04-22 | 1978-11-18 | Takeda Chem Ind Ltd | Protected amino acid or peptide having said protected amino acid residue |
JPS53147034A (en) * | 1977-05-30 | 1978-12-21 | Wako Pure Chem Ind Ltd | Gamma-glutamyl-p-aminoanilide derivatives and process for their preparation |
US4216142A (en) * | 1978-12-18 | 1980-08-05 | Abbott Laboratories | Chromogenic substrates for the proteolytic enzymes |
-
1978
- 1978-12-20 DE DE2854987A patent/DE2854987A1/de not_active Withdrawn
-
1979
- 1979-11-30 US US06/099,180 patent/US4278763A/en not_active Expired - Lifetime
- 1979-12-05 CA CA341,299A patent/CA1130801A/en not_active Expired
- 1979-12-13 CS CS798763A patent/CS245763B2/cs unknown
- 1979-12-13 AR AR279277A patent/AR223505A1/es active
- 1979-12-14 DD DD79217706A patent/DD147845A5/de not_active IP Right Cessation
- 1979-12-14 ES ES486932A patent/ES486932A1/es not_active Expired
- 1979-12-14 EP EP79105184A patent/EP0012957B1/de not_active Expired
- 1979-12-14 AU AU53838/79A patent/AU515190B2/en not_active Expired
- 1979-12-14 AT AT79105184T patent/ATE230T1/de not_active IP Right Cessation
- 1979-12-14 DE DE7979105184T patent/DE2960857D1/de not_active Expired
- 1979-12-17 DK DK535679A patent/DK155318C/da not_active IP Right Cessation
- 1979-12-18 PT PT70608A patent/PT70608A/pt unknown
- 1979-12-18 BR BR7908306A patent/BR7908306A/pt unknown
- 1979-12-19 PL PL1979220526A patent/PL127198B1/pl unknown
- 1979-12-19 FI FI793986A patent/FI77229C/fi not_active IP Right Cessation
- 1979-12-19 HU HU79BO1813A patent/HU180431B/hu unknown
- 1979-12-19 SU SU792853140A patent/SU1184444A3/ru active
- 1979-12-19 YU YU03115/79A patent/YU311579A/xx unknown
- 1979-12-19 ZA ZA00796880A patent/ZA796880B/xx unknown
- 1979-12-20 JP JP54164895A patent/JPS593475B2/ja not_active Expired
-
1981
- 1981-10-16 SU SU813346097A patent/SU1156595A3/ru active
Also Published As
Publication number | Publication date |
---|---|
US4278763A (en) | 1981-07-14 |
ZA796880B (en) | 1980-12-31 |
PL127198B1 (en) | 1983-10-31 |
PL220526A1 (fi) | 1980-12-01 |
JPS593475B2 (ja) | 1984-01-24 |
DK155318C (da) | 1989-08-28 |
SU1156595A3 (ru) | 1985-05-15 |
PT70608A (de) | 1980-01-01 |
DK155318B (da) | 1989-03-28 |
DE2960857D1 (en) | 1981-12-03 |
SU1184444A3 (ru) | 1985-10-07 |
DK535679A (da) | 1980-06-21 |
FI77229C (fi) | 1989-02-10 |
JPS5585561A (en) | 1980-06-27 |
ES486932A1 (es) | 1980-05-16 |
FI793986A (fi) | 1980-06-21 |
EP0012957A1 (de) | 1980-07-09 |
DE2854987A1 (de) | 1980-06-26 |
FI77229B (fi) | 1988-10-31 |
AU515190B2 (en) | 1981-03-19 |
YU311579A (en) | 1984-04-30 |
AR223505A1 (es) | 1981-08-31 |
HU180431B (en) | 1983-03-28 |
EP0012957B1 (de) | 1981-09-16 |
CS245763B2 (en) | 1986-10-16 |
AU5383879A (en) | 1980-06-26 |
CA1130801A (en) | 1982-08-31 |
DD147845A5 (de) | 1981-04-22 |
BR7908306A (pt) | 1980-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EELA | Cancelled due to lapse of time |