ATE230T1 - DIAGNOSTIC MEANS FOR DETECTING PROTEOLYTIC ENZYMES AND AS CHROMOGENIC INDOXYL- OR THIOINDOXYLESTERS, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF DIAGNOSTIC AGENTS. - Google Patents

DIAGNOSTIC MEANS FOR DETECTING PROTEOLYTIC ENZYMES AND AS CHROMOGENIC INDOXYL- OR THIOINDOXYLESTERS, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF DIAGNOSTIC AGENTS.

Info

Publication number
ATE230T1
ATE230T1 AT79105184T AT79105184T ATE230T1 AT E230 T1 ATE230 T1 AT E230T1 AT 79105184 T AT79105184 T AT 79105184T AT 79105184 T AT79105184 T AT 79105184T AT E230 T1 ATE230 T1 AT E230T1
Authority
AT
Austria
Prior art keywords
preparation
diagnostic
thioindoxylesters
indoxyl
chromogenic
Prior art date
Application number
AT79105184T
Other languages
German (de)
Inventor
Dieter Dr.Rer.Nat. Berger
Franz Dr.Rer.Nat. Braun
Werner Dr.Rer.Nat. Guethlein
Manfred Dr.Rer.Nat. Kuhr
Wolfgang Dr.Rer.Nat. Werner
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6057730&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE230(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of ATE230T1 publication Critical patent/ATE230T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/50—Indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT79105184T 1978-12-20 1979-12-14 DIAGNOSTIC MEANS FOR DETECTING PROTEOLYTIC ENZYMES AND AS CHROMOGENIC INDOXYL- OR THIOINDOXYLESTERS, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF DIAGNOSTIC AGENTS. ATE230T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2854987A DE2854987A1 (en) 1978-12-20 1978-12-20 DIAGNOSTIC AGENTS FOR DETECTING PROTEOLYTIC ENZYMS AND CHROMOGENS SUITABLE FOR THIS
EP79105184A EP0012957B1 (en) 1978-12-20 1979-12-14 Diagnostic means for the detection of proteolytic enzymes and indoxyl or thioindoxyl ester chromogens useful therefor, process for their preparation and their use in the preparation of diagnostic means

Publications (1)

Publication Number Publication Date
ATE230T1 true ATE230T1 (en) 1981-10-15

Family

ID=6057730

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79105184T ATE230T1 (en) 1978-12-20 1979-12-14 DIAGNOSTIC MEANS FOR DETECTING PROTEOLYTIC ENZYMES AND AS CHROMOGENIC INDOXYL- OR THIOINDOXYLESTERS, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF DIAGNOSTIC AGENTS.

Country Status (20)

Country Link
US (1) US4278763A (en)
EP (1) EP0012957B1 (en)
JP (1) JPS593475B2 (en)
AR (1) AR223505A1 (en)
AT (1) ATE230T1 (en)
AU (1) AU515190B2 (en)
BR (1) BR7908306A (en)
CA (1) CA1130801A (en)
CS (1) CS245763B2 (en)
DD (1) DD147845A5 (en)
DE (2) DE2854987A1 (en)
DK (1) DK155318C (en)
ES (1) ES486932A1 (en)
FI (1) FI77229C (en)
HU (1) HU180431B (en)
PL (1) PL127198B1 (en)
PT (1) PT70608A (en)
SU (2) SU1184444A3 (en)
YU (1) YU311579A (en)
ZA (1) ZA796880B (en)

Families Citing this family (39)

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Publication number Priority date Publication date Assignee Title
DE3005845A1 (en) * 1980-02-16 1981-09-03 Boehringer Mannheim Gmbh, 6800 Mannheim AMINO ACID AND PEPTIDESTERS OF LEUKO-INDOANILINES, METHOD FOR THE PRODUCTION THEREOF AND MEANS CONTAINING THESE COMPOUNDS FOR DETECTING PROTEOLYTIC ENZYMS
DE3017721A1 (en) * 1980-05-09 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim AGENT FOR DETECTING ESTEROLYTIC AND / OR PROTEOLYTIC ENZYME AND SUBSTRATES SUITABLE FOR THIS
WO1982000641A1 (en) * 1980-08-25 1982-03-04 Ab Kabivitrum Peptide substrates for determination of protease activity
US4499185A (en) * 1982-05-17 1985-02-12 Miles Laboratories, Inc. Test for esterase activity in a liquid sample
US4676950A (en) * 1984-02-03 1987-06-30 Foster Research Corporation Indicator and test device for detecting occult blood
DE3412939A1 (en) * 1984-04-06 1985-10-17 Behringwerke Ag, 3550 Marburg SUBSTRATES FOR HYDROLASES, METHOD FOR THEIR PRODUCTION AND THEIR USE
US4716236A (en) * 1984-04-06 1987-12-29 Miles Laboratories, Inc. Method for synthesizing esters
US4645842A (en) * 1984-04-06 1987-02-24 Miles Laboratories, Inc. Pyrrole compounds for detecting the presence of hydrolytic analytes
US4657855A (en) * 1984-04-06 1987-04-14 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample
DE3413077A1 (en) * 1984-04-06 1985-10-17 Miles Laboratories, Inc., Elkhart, Ind. CHROMOGENEIC AMINO ACID AND PEPTIDESTERS, METHOD FOR THE PRODUCTION THEREOF, USE OF THESE COMPOUNDS IN ANALYZING METHODS AND MEANS FOR DETECTING ESTEROLYTIC AND / OR PROTEOLYTIC ENZYMES
DE3413078A1 (en) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. CHROMOGENEIC AMINO ACID AND PEPTIDESTERS, METHOD FOR THE PRODUCTION THEREOF, USE OF THESE COMPOUNDS IN ANALYZING METHODS AND MEANS FOR DETECTING ESTEROLYTIC AND / OR PROTEOLYTIC ENZYMES
IL73998A (en) * 1984-04-06 1988-08-31 Miles Lab Preparation of 3-(n-tosyl-l-alaninyloxy)-pyrrole compounds
US4637979A (en) * 1984-04-06 1987-01-20 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent
DE3446714A1 (en) * 1984-12-21 1986-06-26 Boehringer Mannheim Gmbh METHOD FOR DETECTING THE PRESENCE OF AN ALLERGY AND FOR SPECIFIC DETECTING THE ALLERGY RESPONSIBLE FOR THE ALLERGY
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
US5179112A (en) * 1985-04-17 1993-01-12 Ici Americas Inc. Heterocyclic amide derivatives and pharmaceutical use
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
EP0227241B1 (en) * 1985-10-17 1996-09-11 Zeneca Inc. Medicinal indole and indazole keto sulphone derivatives
GB8609175D0 (en) * 1986-04-15 1986-05-21 Ici America Inc Heterocyclic carboxamides
EP0470172B1 (en) * 1989-04-27 1995-06-28 BioControl Systems, Incorporated Precipitate test for microorganisms
US5589328A (en) * 1994-08-04 1996-12-31 Mahant; Vijay K. Chemiluminescence assays based on indoxyl substrates, thioindoxyl substrates and other substrates
US5464739A (en) 1994-08-22 1995-11-07 Bayer Corporation Composition method for determining the presence of leukocyte cells, esterase or protease in a test sample
CA2161574A1 (en) 1994-11-15 1996-05-16 James Noffsinger Methodology for colorimetrically determining the concentration of white blood cells in a biological fluid
FR2751663B1 (en) * 1996-07-29 1998-10-02 Bio Merieux METHOD FOR EVIDENCE OF AN ENZYMATIC ACTIVITY OF MICROORGANISMS
DE19651886A1 (en) * 1996-12-13 1998-06-18 Merck Patent Gmbh Means and methods for the determination of hydrolytic enzymes
GB2326712B (en) * 1997-06-25 2001-09-26 Fujirebio Kk Colour devoloping method,enzyme immunoassay using the colour developing method,and immunochromatography incorporating the enzyme immunoassay
DE19735614A1 (en) * 1997-08-16 1999-02-18 Lothar Dr Seik Detection of protease activity for insulin-like growth factor binding proteins
DE19829707C2 (en) * 1998-07-03 2002-07-18 Macherey Nagel Gmbh & Co Hg Diagnostic agent for the detection of leukocytes, elastases, esterases and proteases
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) * 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
US6709868B2 (en) * 2002-05-20 2004-03-23 Portascience Inc. Method and apparatus for measuring white blood cell count
JP5009808B2 (en) * 2004-12-13 2012-08-22 バイエル・ヘルスケア・エルエルシー A method for distinguishing blood from a control solution containing a common analyte
GB2426334A (en) * 2005-05-20 2006-11-22 Orion Diagnostica Oy Application of a reagent to a matrix material
US7504235B2 (en) * 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US7727206B2 (en) * 2005-12-27 2010-06-01 Gorres Geoffrey H Device for monitoring a patient for a urinary tract infection
US9103796B2 (en) * 2007-12-14 2015-08-11 Kimberly-Clark Worldwide, Inc. Multi-layered devices for analyte detection
US11104933B1 (en) * 2016-03-22 2021-08-31 Cleu Diagnostics, Llc Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay
CN115667894A (en) 2020-04-30 2023-01-31 口腔科学国际公司 Kits and methods for monitoring oral inflammation associated with periodontal disease
CN116023320A (en) * 2022-12-28 2023-04-28 长春百纯和成医药科技有限公司 3- (N-p-toluenesulfonyl-L-alanyloxy) indole with polymorphic structure, and preparation method and application thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3087794A (en) 1960-05-23 1963-04-30 Miles Lab Chemical test for differentiating leucocytes from erythrocytes
BE615395A (en) * 1962-03-21
GB1128371A (en) 1965-10-04 1968-09-25 Miles Lab Diagnostic composition
DE2118455B1 (en) 1971-04-16 1972-09-21 Boehringer Mannheim Gmbh Test strips
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
JPS5263794A (en) * 1975-11-21 1977-05-26 Shionogi Seiyaku Kk Test piece for latent blood
JPS53132539A (en) * 1977-04-22 1978-11-18 Takeda Chem Ind Ltd Protected amino acid or peptide having said protected amino acid residue
JPS53147034A (en) * 1977-05-30 1978-12-21 Wako Pure Chem Ind Ltd Gamma-glutamyl-p-aminoanilide derivatives and process for their preparation
US4216142A (en) * 1978-12-18 1980-08-05 Abbott Laboratories Chromogenic substrates for the proteolytic enzymes

Also Published As

Publication number Publication date
DK155318C (en) 1989-08-28
DD147845A5 (en) 1981-04-22
YU311579A (en) 1984-04-30
CS245763B2 (en) 1986-10-16
ES486932A1 (en) 1980-05-16
DE2854987A1 (en) 1980-06-26
FI77229C (en) 1989-02-10
EP0012957A1 (en) 1980-07-09
US4278763A (en) 1981-07-14
HU180431B (en) 1983-03-28
JPS593475B2 (en) 1984-01-24
PL220526A1 (en) 1980-12-01
AU5383879A (en) 1980-06-26
EP0012957B1 (en) 1981-09-16
CA1130801A (en) 1982-08-31
DK155318B (en) 1989-03-28
DE2960857D1 (en) 1981-12-03
AR223505A1 (en) 1981-08-31
AU515190B2 (en) 1981-03-19
FI77229B (en) 1988-10-31
PL127198B1 (en) 1983-10-31
FI793986A7 (en) 1980-06-21
DK535679A (en) 1980-06-21
PT70608A (en) 1980-01-01
SU1156595A3 (en) 1985-05-15
BR7908306A (en) 1980-09-09
JPS5585561A (en) 1980-06-27
ZA796880B (en) 1980-12-31
SU1184444A3 (en) 1985-10-07

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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time