ATE221543T1 - Antivirale pyrimidin-nukleosid-analogen - Google Patents
Antivirale pyrimidin-nukleosid-analogenInfo
- Publication number
- ATE221543T1 ATE221543T1 AT98919313T AT98919313T ATE221543T1 AT E221543 T1 ATE221543 T1 AT E221543T1 AT 98919313 T AT98919313 T AT 98919313T AT 98919313 T AT98919313 T AT 98919313T AT E221543 T1 ATE221543 T1 AT E221543T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- alkyl
- halogens
- cycloalkyl
- aryl
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 229940127073 nucleoside analogue Drugs 0.000 title 1
- 239000002718 pyrimidine nucleoside Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 8
- 150000002367 halogens Chemical class 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 150000001356 alkyl thiols Chemical class 0.000 abstract 1
- -1 arythiol Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9708611.0A GB9708611D0 (en) | 1997-04-28 | 1997-04-28 | Chemical compounds |
| PCT/GB1998/001222 WO1998049177A1 (en) | 1997-04-28 | 1998-04-27 | Anti-viral pyrimidine nucleoside analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE221543T1 true ATE221543T1 (de) | 2002-08-15 |
Family
ID=10811493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98919313T ATE221543T1 (de) | 1997-04-28 | 1998-04-27 | Antivirale pyrimidin-nukleosid-analogen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6573247B1 (https=) |
| EP (1) | EP0980377B1 (https=) |
| JP (1) | JP4514242B2 (https=) |
| AT (1) | ATE221543T1 (https=) |
| AU (1) | AU737902B2 (https=) |
| CA (1) | CA2288147C (https=) |
| DE (1) | DE69806919T2 (https=) |
| DK (1) | DK0980377T3 (https=) |
| ES (1) | ES2181208T3 (https=) |
| GB (1) | GB9708611D0 (https=) |
| NZ (1) | NZ500881A (https=) |
| PT (1) | PT980377E (https=) |
| WO (1) | WO1998049177A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9708611D0 (en) * | 1997-04-28 | 1997-06-18 | Univ Cardiff | Chemical compounds |
| GB9716231D0 (en) | 1997-07-31 | 1997-10-08 | Amersham Int Ltd | Base analogues |
| ATE413881T1 (de) | 1997-08-08 | 2008-11-15 | Celmed Oncology Usa Inc | Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| CA2317505C (en) | 1998-01-23 | 2011-01-04 | Newbiotics, Inc. | Enzyme catalyzed therapeutic agents |
| AU774492B2 (en) | 1999-07-22 | 2004-07-01 | Celmed Oncology (Usa) Inc. | Methods for treating therapy-resistant tumors |
| US6683061B1 (en) | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
| GB0009486D0 (en) * | 2000-04-17 | 2000-06-07 | Univ Cardiff | Chemical compounds |
| GB0011203D0 (en) * | 2000-05-09 | 2000-06-28 | Univ Cardiff | Chemical compounds |
| AU2003225701A1 (en) * | 2002-03-08 | 2003-09-22 | Glen Research Corporation | Fluorescent nitrogenous base and nucleosides incorporating same |
| HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
| GB0609178D0 (en) | 2006-05-09 | 2006-06-21 | Univ Cardiff | Novel compounds |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| EA201270566A1 (ru) * | 2009-10-16 | 2012-11-30 | Риб-Экс Фармасьютикалз, Инк. | Противомикробные соединения и способы их получения и применения |
| NZ599290A (en) | 2009-10-16 | 2014-10-31 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| MX2012004341A (es) | 2009-10-16 | 2012-10-05 | Rib X Pharmaceuticals Inc | Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos. |
| GB201016855D0 (en) * | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| EP2691409B1 (en) | 2011-03-31 | 2018-02-21 | Idenix Pharmaceuticals LLC. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| MY173518A (en) | 2011-04-15 | 2020-01-30 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| GB201111779D0 (en) | 2011-07-08 | 2011-08-24 | Univ Cardiff | Chemical compounds |
| TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
| US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
| CA2873315A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharamaceuticals, Inc. | D-amino acid compounds for liver disease |
| SG11201407336PA (en) | 2012-05-25 | 2015-03-30 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
| WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| KR102001280B1 (ko) | 2012-10-08 | 2019-07-17 | 아이데닉스 파마슈티칼스 엘엘씨 | Hcv 감염에 대한 2'-클로로 뉴클레오시드 유사체 |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| EP2981542B1 (en) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| CA2923214A1 (en) | 2013-09-09 | 2015-03-12 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| EP3038623A4 (en) | 2013-09-09 | 2017-04-19 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| HK1249758A1 (zh) | 2015-03-11 | 2018-11-09 | Melinta Therapeutics, Inc. | 抗微生物化合物及其制备和使用方法 |
| US11098047B2 (en) | 2016-05-06 | 2021-08-24 | BioVersys AG | Antimicrobials and methods of making and using same |
| US12606863B2 (en) | 2021-05-13 | 2026-04-21 | Promega Corporation | Bioluminescent detection of DNA synthesis |
| US20260062437A1 (en) * | 2022-08-26 | 2026-03-05 | Regents Of The University Of Minnesota | Antiviral compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62255499A (ja) * | 1986-04-28 | 1987-11-07 | Teijin Ltd | 螢光性ヌクレオシド又はヌクレオチド |
| US5047519A (en) * | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| GB9109186D0 (en) * | 1991-04-29 | 1991-06-19 | Wellcome Found | Preparation of thionucleosides |
| YU43193A (sh) * | 1992-06-22 | 1997-01-08 | Eli Lilly And Company | 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi |
| JPH06192285A (ja) * | 1992-12-25 | 1994-07-12 | Yamasa Shoyu Co Ltd | １−（β−Ｄ−エリスロ−ペントフラン−２−ウロシル）ピリミジン誘導体の製造法 |
| DE4321978A1 (de) * | 1993-07-01 | 1995-01-12 | Boehringer Mannheim Gmbh | Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| GB9708611D0 (en) * | 1997-04-28 | 1997-06-18 | Univ Cardiff | Chemical compounds |
| GB9716231D0 (en) * | 1997-07-31 | 1997-10-08 | Amersham Int Ltd | Base analogues |
| JP2003527317A (ja) * | 1999-07-22 | 2003-09-16 | ニューバイオティックス インコーポレイテッド | 酵素触媒抗感染性治療剤 |
| CN1390227A (zh) * | 1999-07-22 | 2003-01-08 | 新生物生物公司 | 酶催化的治疗活化 |
| AU774492B2 (en) * | 1999-07-22 | 2004-07-01 | Celmed Oncology (Usa) Inc. | Methods for treating therapy-resistant tumors |
-
1997
- 1997-04-28 GB GBGB9708611.0A patent/GB9708611D0/en active Pending
-
1998
- 1998-04-27 AT AT98919313T patent/ATE221543T1/de active
- 1998-04-27 EP EP98919313A patent/EP0980377B1/en not_active Expired - Lifetime
- 1998-04-27 AU AU72193/98A patent/AU737902B2/en not_active Expired
- 1998-04-27 NZ NZ500881A patent/NZ500881A/en not_active IP Right Cessation
- 1998-04-27 JP JP54673298A patent/JP4514242B2/ja not_active Expired - Lifetime
- 1998-04-27 US US09/403,853 patent/US6573247B1/en not_active Expired - Lifetime
- 1998-04-27 ES ES98919313T patent/ES2181208T3/es not_active Expired - Lifetime
- 1998-04-27 CA CA002288147A patent/CA2288147C/en not_active Expired - Lifetime
- 1998-04-27 DE DE69806919T patent/DE69806919T2/de not_active Expired - Lifetime
- 1998-04-27 PT PT98919313T patent/PT980377E/pt unknown
- 1998-04-27 DK DK98919313T patent/DK0980377T3/da active
- 1998-04-27 WO PCT/GB1998/001222 patent/WO1998049177A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0980377A1 (en) | 2000-02-23 |
| JP4514242B2 (ja) | 2010-07-28 |
| WO1998049177A8 (en) | 2000-01-13 |
| DK0980377T3 (da) | 2002-11-18 |
| ES2181208T3 (es) | 2003-02-16 |
| GB9708611D0 (en) | 1997-06-18 |
| CA2288147C (en) | 2008-03-11 |
| WO1998049177A1 (en) | 1998-11-05 |
| CA2288147A1 (en) | 1998-11-05 |
| EP0980377B1 (en) | 2002-07-31 |
| JP2001522369A (ja) | 2001-11-13 |
| US6573247B1 (en) | 2003-06-03 |
| NZ500881A (en) | 2001-11-30 |
| DE69806919D1 (de) | 2002-09-05 |
| AU737902B2 (en) | 2001-09-06 |
| DE69806919T2 (de) | 2003-02-27 |
| PT980377E (pt) | 2002-12-31 |
| AU7219398A (en) | 1998-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |