ES8706679A1 - Un procedimiento para preparar derivados de 8-amino-purina - Google Patents

Un procedimiento para preparar derivados de 8-amino-purina

Info

Publication number
ES8706679A1
ES8706679A1 ES554567A ES554567A ES8706679A1 ES 8706679 A1 ES8706679 A1 ES 8706679A1 ES 554567 A ES554567 A ES 554567A ES 554567 A ES554567 A ES 554567A ES 8706679 A1 ES8706679 A1 ES 8706679A1
Authority
ES
Spain
Prior art keywords
group
image
antiviral compounds
atom
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554567A
Other languages
English (en)
Other versions
ES554567A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858511224A external-priority patent/GB8511224D0/en
Priority claimed from GB858511222A external-priority patent/GB8511222D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES554567A0 publication Critical patent/ES554567A0/es
Publication of ES8706679A1 publication Critical patent/ES8706679A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 8-AMINO-PURINA. CONSISTE EN HIDROLIZAR A UN COMPUESTO DE FOMRULA (II) CON AMINA, EN MEDIO ACUOSO Y A TEMPERATURA AMBIENTE, PARA DESBLOQUEAR LOS GRUPOS W, W ELEVADO A 1 E Y DE (II), Y OBTENER UN COMPUESTO DE FORMULA (I), Y SUS SALES Y ESTERES FISIOLOGICAMENTE ACEPTABLES. SIENDO: A=N O =C-NH2; R ELEVADO A 1, H, HA1 O AMINO; R ELEVADO A 2, H O ALQUILO DE C 1 A 4; X, O O S; W, W ELEVADO A 1, Y, GRUPOS BLOQUEANTES ELEGIDOS ENTRE ALCANOILO DE C 1 A 4 (ACETILO) Y GRUPOS ARILMETILO (BENCILO); Y M Y N, 0 O 1. SE UTILIZA PARA COMBATIR LOS HERPES. *FORMULA*
ES554567A 1985-05-02 1986-04-30 Un procedimiento para preparar derivados de 8-amino-purina Expired ES8706679A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858511224A GB8511224D0 (en) 1985-05-02 1985-05-02 Antiviral compounds
GB858511222A GB8511222D0 (en) 1985-05-02 1985-05-02 Antiviral compounds

Publications (2)

Publication Number Publication Date
ES554567A0 ES554567A0 (es) 1987-07-01
ES8706679A1 true ES8706679A1 (es) 1987-07-01

Family

ID=26289208

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554567A Expired ES8706679A1 (es) 1985-05-02 1986-04-30 Un procedimiento para preparar derivados de 8-amino-purina

Country Status (11)

Country Link
US (1) US4714701A (es)
EP (1) EP0201289A3 (es)
AU (1) AU580407B2 (es)
DK (1) DK201086A (es)
ES (1) ES8706679A1 (es)
FI (1) FI861822A (es)
GR (1) GR861163B (es)
HU (1) HU196405B (es)
IL (1) IL78643A0 (es)
NZ (1) NZ216021A (es)
PT (1) PT82486B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
GR862141B (en) * 1985-08-16 1986-12-23 Glaxo Group Ltd Guanine derivatives
IT1199320B (it) * 1986-12-16 1988-12-30 Malesci Sas 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
DE3722802A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag In 6- und 9-stellung substituierte 2-amino-8-aza-purine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
US5013829A (en) * 1989-04-26 1991-05-07 University Of Iowa Research Foundation Stable congener of 2',3'-dideoxyadenosine
CA2021784A1 (en) * 1989-07-24 1991-01-25 Alan D. Borthwick Cyclopentane derivatives
US5120740A (en) * 1989-11-03 1992-06-09 Wisconsin Alumni Research Foundation Prodrugs of 6-mercaptopurine and 6-thioguanine
DE59310344D1 (de) * 1992-09-24 2003-07-24 Hoechst Ag N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
DE69817393T2 (de) 1997-11-28 2004-06-17 Sumitomo Pharmaceuticals Co., Ltd. Neue heterozyklische verbindungen
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
WO2002085905A1 (fr) * 2001-04-17 2002-10-31 Sumitomo Pharmaceuticals Company, Limited Nouveaux derives d'adenine
JP4768263B2 (ja) * 2002-09-27 2011-09-07 大日本住友製薬株式会社 新規アデニン化合物及びその用途
US7138401B2 (en) 2003-09-18 2006-11-21 Conforma Therapeutics Corporation 2-aminopurine analogs having HSP90-inhibiting activity
AU2005226359B2 (en) 2004-03-26 2011-02-03 Astrazeneca Aktiebolag 9-substituted 8-oxoadenine compound
JPWO2005092892A1 (ja) * 2004-03-26 2008-02-14 大日本住友製薬株式会社 ８−オキソアデニン化合物
US7723340B2 (en) * 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
TW200801003A (en) * 2005-09-16 2008-01-01 Astrazeneca Ab Novel compounds
TW200745114A (en) * 2005-09-22 2007-12-16 Astrazeneca Ab Novel compounds
JPWO2007034817A1 (ja) * 2005-09-22 2009-03-26 大日本住友製薬株式会社 新規アデニン化合物
WO2007034881A1 (ja) * 2005-09-22 2007-03-29 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
EP1939200A4 (en) * 2005-09-22 2010-06-16 Dainippon Sumitomo Pharma Co NEW ADENINE CONNECTION
US20080269240A1 (en) * 2005-09-22 2008-10-30 Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan Novel Adenine Compound
WO2008004948A1 (en) * 2006-07-05 2008-01-10 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of tlr7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
WO2008114006A1 (en) * 2007-03-19 2008-09-25 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators
PT2132209E (pt) * 2007-03-19 2014-04-15 Astrazeneca Ab Compostos de 8-oxo-adenina substituídos na posição 9, como moduladores do recetor de tipo ¿toll¿ (tlr7)
EP2138497A4 (en) * 2007-03-20 2012-01-04 Dainippon Sumitomo Pharma Co NEW ADENINE CONNECTION
PE20081887A1 (es) * 2007-03-20 2009-01-16 Dainippon Sumitomo Pharma Co Nuevo compuesto de adenina
PL2155743T3 (pl) * 2007-05-08 2013-01-31 Astrazeneca Ab Imidazochinoliny o właściwościach immunomodulacyjnych
PE20091236A1 (es) 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
PE20091156A1 (es) 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
GB0908772D0 (en) * 2009-05-21 2009-07-01 Astrazeneca Ab New salts 756
SG175796A1 (en) 2009-05-21 2011-12-29 Astrazeneca Ab Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
WO2011068233A1 (en) * 2009-12-03 2011-06-09 Dainippon Sumitomo Pharma Co., Ltd. Imidazoquinolines which act via toll - like receptors (tlr)
WO2012080728A1 (en) 2010-12-16 2012-06-21 Astrazeneca Ab Imidazo [4, 5 -c] quinolin- 1 -yl derivative useful in therapy
ES2627433T3 (es) 2010-12-17 2017-07-28 Sumitomo Dainippon Pharma Co., Ltd. Derivados de purina
MX2014014031A (es) 2012-05-18 2015-02-12 Sumitomo Dainippon Pharma Co Ltd Compuestos de acido carboxilico.
FR3092114B1 (fr) * 2019-01-28 2021-04-30 Univ Grenoble Alpes Nouveaux derives de purine et medicaments les comprenant

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4027025A (en) * 1976-03-01 1977-05-31 Burroughs Wellcome Co. 8-Azapurine derivatives
IE54148B1 (en) * 1981-08-11 1989-07-05 Wellcome Found Antiviral compounds
KR890001487B1 (ko) * 1982-10-14 1989-05-04 더 웰컴 파운데이숀 리미티드 푸린 유도체의 제조방법
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
EP0193454A1 (en) * 1985-02-25 1986-09-03 Merck & Co. Inc. 8-Substituted-9-hydroxyalkyl and hydroxyalkoxymethyl-guanines and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PT82486A (en) 1986-05-01
DK201086A (da) 1986-11-03
DK201086D0 (da) 1986-05-01
US4714701A (en) 1987-12-22
EP0201289A2 (en) 1986-11-12
AU580407B2 (en) 1989-01-12
PT82486B (en) 1988-03-23
IL78643A0 (en) 1986-08-31
EP0201289A3 (en) 1988-06-01
NZ216021A (en) 1990-01-29
AU5700986A (en) 1986-11-06
FI861822A (fi) 1986-11-03
GR861163B (en) 1986-07-28
HU196405B (en) 1988-11-28
ES554567A0 (es) 1987-07-01
FI861822A0 (fi) 1986-04-30
HUT41790A (en) 1987-05-28

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