ATE220424T1 - Herstellung von nukleinsaeurekopien - Google Patents
Herstellung von nukleinsaeurekopienInfo
- Publication number
- ATE220424T1 ATE220424T1 AT95920168T AT95920168T ATE220424T1 AT E220424 T1 ATE220424 T1 AT E220424T1 AT 95920168 T AT95920168 T AT 95920168T AT 95920168 T AT95920168 T AT 95920168T AT E220424 T1 ATE220424 T1 AT E220424T1
- Authority
- AT
- Austria
- Prior art keywords
- strands
- target
- copy target
- oligonucleotides
- copy
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 abstract 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 4
- 230000003321 amplification Effects 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 239000007790 solid phase Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9410804A GB9410804D0 (en) | 1994-05-28 | 1994-05-28 | Producing copies of nucleic acids |
| GBGB9502079.8A GB9502079D0 (en) | 1995-02-02 | 1995-02-02 | Producing copies of nucleic acids |
| PCT/GB1995/001237 WO1995033073A1 (en) | 1994-05-28 | 1995-05-30 | Producing copies of nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE220424T1 true ATE220424T1 (de) | 2002-07-15 |
Family
ID=26304963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95920168T ATE220424T1 (de) | 1994-05-28 | 1995-05-30 | Herstellung von nukleinsaeurekopien |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5922574A (de) |
| EP (1) | EP0763135B1 (de) |
| JP (1) | JPH10500862A (de) |
| CN (1) | CN1152946A (de) |
| AT (1) | ATE220424T1 (de) |
| AU (1) | AU707391B2 (de) |
| CA (1) | CA2191426A1 (de) |
| DE (1) | DE69527355T2 (de) |
| FI (1) | FI964735A7 (de) |
| NZ (1) | NZ287118A (de) |
| WO (1) | WO1995033073A1 (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB9707980D0 (en) | 1997-04-21 | 1997-06-11 | Brax Genomics Ltd | Characterising DNA |
| EP0985142A4 (de) | 1997-05-23 | 2006-09-13 | Lynx Therapeutics Inc | System und gerät zur sequentiellen behandlung von analyten |
| WO1999005321A1 (en) * | 1997-07-22 | 1999-02-04 | Rapigene, Inc. | Amplification and other enzymatic reactions performed on nucleic acid arrays |
| EP0996500A1 (de) | 1997-07-22 | 2000-05-03 | Rapigene, Inc. | Vorrichtung und verfahren zur gruppierung von einer lösung auf einem festen träger |
| US5916776A (en) * | 1997-08-27 | 1999-06-29 | Sarnoff Corporation | Amplification method for a polynucleotide |
| US7060431B2 (en) | 1998-06-24 | 2006-06-13 | Illumina, Inc. | Method of making and decoding of array sensors with microspheres |
| US20040157256A1 (en) * | 1998-09-17 | 2004-08-12 | Taisho Pharmaceutical Co., Ltd. | Immobilized cDNA libraries |
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| EP1165839A2 (de) * | 1999-03-26 | 2002-01-02 | Whitehead Institute For Biomedical Research | Universal arrays |
| DK1471926T3 (da) | 1999-06-01 | 2011-02-28 | Baylor College Medicine | Sammensætninger og fremgangsmåder til terapeutisk anvendelse af en atonal-associeret sekvens |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| AU2002241168B2 (en) * | 2001-04-02 | 2007-10-25 | Point-2-Point Genomics Ltd. | Polynucleotide analysis using combinatorial PCR |
| WO2003064621A2 (en) | 2002-02-01 | 2003-08-07 | Ambion, Inc. | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| EP3415625A1 (de) | 2002-02-01 | 2018-12-19 | Life Technologies Corporation | Doppelsträngige oligonukleotide |
| US7211382B2 (en) * | 2002-04-09 | 2007-05-01 | Orchid Cellmark Inc. | Primer extension using modified nucleotides |
| US6916474B2 (en) | 2002-07-15 | 2005-07-12 | Board Of Regents, The University Of Texas System | Antibodies with increased affinities for anthrax antigens |
| EP2269619A1 (de) | 2002-08-12 | 2011-01-05 | Jennerex Biotherapeutics ULC | Verfahren und Zusammensetzungen in Bezug auf Pockenviren und Krebs |
| EP1654361B2 (de) | 2003-07-25 | 2023-01-18 | Life Technologies Corporation | Verfahren und zusammensetzungen zur herstellung von rna aus einer fixierten probe |
| US20050059024A1 (en) | 2003-07-25 | 2005-03-17 | Ambion, Inc. | Methods and compositions for isolating small RNA molecules |
| ES2345993T3 (es) | 2004-09-14 | 2010-10-07 | The Regents Of The University Of Colorado, A Body Corporate | Metodo para el tratamiento con bucindolol basado en direccionamiento genetico. |
| GB0514910D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Method for sequencing a polynucleotide template |
| GB0514935D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Methods for sequencing a polynucleotide template |
| CN101351213B (zh) * | 2005-09-07 | 2013-10-02 | 詹纳里克斯公司 | 使用表达gm-csf的痘病毒系统性治疗转移性癌和/或全身散布性癌 |
| US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| GB0524069D0 (en) | 2005-11-25 | 2006-01-04 | Solexa Ltd | Preparation of templates for solid phase amplification |
| EP1998800A2 (de) | 2006-01-18 | 2008-12-10 | University Of Chicago | Zusammensetzungen und verfahren in verbindung mit stayphylokokken-bakterienproteinen |
| EP1987159B2 (de) | 2006-02-08 | 2020-08-12 | Illumina Cambridge Limited | Verfahren zur sequenzierung einer polynukleotidmatrize |
| CN102026645B (zh) | 2006-09-15 | 2016-01-27 | 渥太华医院研究机构 | 溶瘤弹状病毒 |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| ATE555128T1 (de) | 2006-11-30 | 2012-05-15 | Res Dev Foundation | Verbesserte immunglobulin-bibliotheken |
| WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| DK2155789T3 (da) | 2007-05-01 | 2013-10-21 | Res Dev Foundation | Immunoglobulin-Fc-biblioteker |
| US20090093378A1 (en) * | 2007-08-29 | 2009-04-09 | Helen Bignell | Method for sequencing a polynucleotide template |
| US12060554B2 (en) | 2008-03-10 | 2024-08-13 | Illumina, Inc. | Method for selecting and amplifying polynucleotides |
| WO2010038042A1 (en) | 2008-10-02 | 2010-04-08 | Illumina Cambridge Ltd. | Nucleic acid sample enrichment for sequencing applications |
| WO2010042481A1 (en) | 2008-10-06 | 2010-04-15 | University Of Chicago | Compositions and methods related to bacterial eap, emp, and/or adsa proteins |
| EP3281947B1 (de) | 2009-04-03 | 2020-02-12 | The University of Chicago | Zusammensetzungen und verfahren in verbindung mit protein-a (spa)-varianten |
| JP5785942B2 (ja) | 2009-06-29 | 2015-09-30 | ルミネックス コーポレーション | ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法 |
| US9409983B2 (en) | 2009-07-23 | 2016-08-09 | The Board Of Trustess Of The University Of Illinois | Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases |
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| WO2011070440A2 (en) | 2009-12-10 | 2011-06-16 | Ottawa Hospital Research Institute | Oncolytic rhabdovirus |
| WO2011079273A2 (en) | 2009-12-23 | 2011-06-30 | Arca Biopharma, Inc. | Methods and compositions for cardiovascular diseases and conditions |
| EP2555794A4 (de) | 2010-04-05 | 2014-01-15 | Univ Chicago | Zusammensetzungen und verfahren im zusammenhang mit protein-a-(spa)-antikörpern als immunreaktionsverstärker |
| ES2655701T3 (es) | 2010-07-02 | 2018-02-21 | The University Of Chicago | Composiciones y métodos relacionados con variantes de la proteína A (SpA) |
| JP5793194B2 (ja) | 2010-09-09 | 2015-10-14 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 感染防御ブドウ球菌抗原が関与する方法および組成物 |
| CN103429258B (zh) | 2011-01-04 | 2016-03-09 | 新罗杰公司 | 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性 |
| AU2012214643B2 (en) | 2011-02-07 | 2016-12-15 | Research Development Foundation | Engineered immunoglobulin Fc polypeptides |
| MX2013009863A (es) | 2011-02-28 | 2013-12-06 | Univ Iowa Res Found | Cambios de la hormona anti-mulleriana en el embarazo y prediccion de sexo y de resultados adversos en el embarazo. |
| AU2012226530B2 (en) | 2011-03-08 | 2016-12-01 | King Abdullah University Of Science And Technology | Molecular biomarker set for early detection of ovarian cancer |
| WO2012136653A1 (en) | 2011-04-08 | 2012-10-11 | Novvac Aps | Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| US9364532B2 (en) | 2011-06-08 | 2016-06-14 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Compositions and methods for glioblastoma treatment |
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| US12510539B2 (en) | 2018-10-18 | 2025-12-30 | Progentec Diagnostics, Inc. | Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity |
| US20210349088A1 (en) | 2018-10-18 | 2021-11-11 | Oklahoma Medical Research Foundation | Biomarkers For A Systemic Lupus Erythematosus (SLE) Disease Activity Immune Index That Characterizes Disease Activity |
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| EP3931206A1 (de) | 2019-02-27 | 2022-01-05 | Evaxion Biotech ApS | Impfstoffe gegen h. influenzae |
| AU2020273471B2 (en) | 2019-05-14 | 2026-05-07 | The University Of Chicago | Methods and compositions comprising Staphylococcus protein A (SpA) variants |
| ES2960366T3 (es) | 2019-08-09 | 2024-03-04 | Univ Freiburg Albert Ludwigs | Método para diagnosticar cáncer de mama |
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| US20230050225A1 (en) | 2020-01-06 | 2023-02-16 | Evaxion Biotech A/S | Vaccines targeting Neisseria gonorrhoeae |
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| JP2025519556A (ja) | 2022-06-10 | 2025-06-26 | リサーチ ディベロップメント ファウンデーション | 操作されたＦｃＲＩＩｂ選択的ＩｇＧ１ Ｆｃバリアントおよびその使用 |
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| CA2011818A1 (en) * | 1989-03-17 | 1990-09-17 | Fred T. Oakes | Methods for purification, amplification and detection of a nucleic acid |
| US5219727A (en) * | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| JPH05506987A (ja) * | 1990-03-07 | 1993-10-14 | エフ．ホフマン ― ラ ロシュ アーゲー | ライム病の診断方法 |
| ATE167523T1 (de) * | 1990-05-11 | 1998-07-15 | Microprobe Corp | Teststreifen zum eintauchen für nukleinsäure- hybridisierungsassays und verfahren zur kovalenten immobilisierung von oligonucleotiden |
| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| CA2055755A1 (en) * | 1990-11-22 | 1992-05-23 | Toshihiko Kishimoto | Method of immobilizing single-stranded dna on carrier at terminal |
| US5437976A (en) * | 1991-08-08 | 1995-08-01 | Arizona Board Of Regents, The University Of Arizona | Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA |
| WO1993004199A2 (en) * | 1991-08-20 | 1993-03-04 | Scientific Generics Limited | Methods of detecting or quantitating nucleic acids and of producing labelled immobilised nucleic acids |
| WO1993009250A1 (en) * | 1991-11-01 | 1993-05-13 | Adelaide Children's Hospital | Solid phase amplification process |
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| CA2128891A1 (en) * | 1992-01-29 | 1993-08-05 | Cylia Keller | Polynucleotide immobilized support |
| AU5298393A (en) * | 1992-10-08 | 1994-05-09 | Regents Of The University Of California, The | Pcr assays to determine the presence and concentration of a target |
| GB9322723D0 (en) * | 1993-11-04 | 1993-12-22 | Tepnel Medical Ltd | Determining nucleic acids |
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-
1995
- 1995-05-30 AU AU25728/95A patent/AU707391B2/en not_active Ceased
- 1995-05-30 CA CA002191426A patent/CA2191426A1/en not_active Abandoned
- 1995-05-30 EP EP95920168A patent/EP0763135B1/de not_active Expired - Lifetime
- 1995-05-30 DE DE69527355T patent/DE69527355T2/de not_active Expired - Lifetime
- 1995-05-30 CN CN95194205A patent/CN1152946A/zh active Pending
- 1995-05-30 AT AT95920168T patent/ATE220424T1/de not_active IP Right Cessation
- 1995-05-30 WO PCT/GB1995/001237 patent/WO1995033073A1/en not_active Ceased
- 1995-05-30 JP JP8500512A patent/JPH10500862A/ja not_active Ceased
- 1995-05-30 NZ NZ287118A patent/NZ287118A/xx unknown
- 1995-11-22 US US08/562,075 patent/US5922574A/en not_active Expired - Lifetime
-
1996
- 1996-11-27 FI FI964735A patent/FI964735A7/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10500862A (ja) | 1998-01-27 |
| FI964735A7 (fi) | 1997-01-27 |
| CN1152946A (zh) | 1997-06-25 |
| EP0763135B1 (de) | 2002-07-10 |
| AU707391B2 (en) | 1999-07-08 |
| EP0763135A1 (de) | 1997-03-19 |
| CA2191426A1 (en) | 1995-12-07 |
| NZ287118A (en) | 1999-01-28 |
| FI964735A0 (fi) | 1996-11-27 |
| US5922574A (en) | 1999-07-13 |
| DE69527355T2 (de) | 2003-03-06 |
| WO1995033073A1 (en) | 1995-12-07 |
| DE69527355D1 (de) | 2002-08-14 |
| AU2572895A (en) | 1995-12-21 |
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