ATE219103T1 - Cnp-analoge peptide und ihre verwendung - Google Patents
Cnp-analoge peptide und ihre verwendungInfo
- Publication number
- ATE219103T1 ATE219103T1 AT92101621T AT92101621T ATE219103T1 AT E219103 T1 ATE219103 T1 AT E219103T1 AT 92101621 T AT92101621 T AT 92101621T AT 92101621 T AT92101621 T AT 92101621T AT E219103 T1 ATE219103 T1 AT E219103T1
- Authority
- AT
- Austria
- Prior art keywords
- ser
- arg
- gly
- phe
- leu
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 101800000060 C-type natriuretic peptide Proteins 0.000 abstract 1
- 102400001025 CNP-22 Human genes 0.000 abstract 1
- 101800000457 CNP-22 Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1132191 | 1991-01-31 | ||
JP3254066A JP2809533B2 (ja) | 1991-01-31 | 1991-06-28 | Cnp類似体ペプチド |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE219103T1 true ATE219103T1 (de) | 2002-06-15 |
Family
ID=26346733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92101621T ATE219103T1 (de) | 1991-01-31 | 1992-01-31 | Cnp-analoge peptide und ihre verwendung |
Country Status (6)
Country | Link |
---|---|
US (1) | US5434133A (de) |
EP (1) | EP0497368B1 (de) |
JP (1) | JP2809533B2 (de) |
AT (1) | ATE219103T1 (de) |
DE (1) | DE69232636T2 (de) |
ES (1) | ES2178634T3 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6360394A (en) * | 1993-03-03 | 1994-09-26 | Mayo Foundation For Medical Education And Research | Vasonatrin peptide and analogs thereof |
US5665704A (en) * | 1993-11-12 | 1997-09-09 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
US5846932A (en) * | 1993-11-12 | 1998-12-08 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
US6525022B1 (en) | 1993-11-12 | 2003-02-25 | Genentech, Inc. | Receptor specific atrial natriuretic peptides |
KR100691545B1 (ko) * | 1998-09-28 | 2007-03-09 | 산텐 세이야꾸 가부시키가이샤 | 나트륨 이뇨 펩티드를 유효 성분으로하는 누액 분비 촉진또는 각결막 장해 치료용 점안제 |
DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
IL142118A0 (en) * | 2001-03-20 | 2002-03-10 | Prochon Biotech Ltd | Method and composition for treatment of skeletal dysplasias |
BRPI0203172B8 (pt) | 2001-09-28 | 2021-05-25 | Nakao Kazuwa | composição farmacêutica para acondroplasia |
WO2004087059A2 (en) * | 2003-03-26 | 2004-10-14 | The University Of Texas | Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding |
DK1638443T3 (da) * | 2003-06-20 | 2011-02-07 | Mayo Foundation | Isoformer af hjerne-natriuretisk peptid |
EP3620530A1 (de) | 2004-03-31 | 2020-03-11 | Kazuwa Nakao | Zusammensetzung zur erhöhung der körpergrösse |
ES2465141T3 (es) | 2004-03-31 | 2014-06-05 | Kazuwa Nakao | Remedio o medicamento preventivo para la artritis |
HUE039448T2 (hu) | 2004-04-21 | 2018-12-28 | Alexion Pharma Inc | Csontba szállító konjugátumok és alkalmazási módszerük a fehérjék csontba juttatására |
US7795221B2 (en) | 2006-03-30 | 2010-09-14 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
DK2001518T3 (da) | 2006-03-30 | 2013-10-07 | Palatin Technologies Inc | Cykliske natriuretiske peptidfremstillinger |
US8580746B2 (en) | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
MX2009001459A (es) * | 2006-08-08 | 2009-02-19 | Mayo Foundation | Polipeptidos diureticos y natriureticos. |
PT2765139T (pt) * | 2007-07-20 | 2017-07-14 | Mayo Foundation | Polipéptidos natriuréticos |
WO2009046873A1 (en) * | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | Combined use of vasonatrin and gastrin-i as a therapeutic agent |
WO2009036448A2 (en) * | 2007-09-15 | 2009-03-19 | Mayo Foundation For Medical Education And Research | Natriuretic peptide receptor-c agonists |
AR069409A1 (es) * | 2007-11-21 | 2010-01-20 | Biomarin Pharm Inc | Variantes de peptidos natriureticos de tipo c |
WO2009086126A2 (en) * | 2007-12-21 | 2009-07-09 | Mayo Foundation For Medical Education And Research | Natriuretic polypeptides |
HUE032582T2 (en) * | 2009-05-20 | 2017-09-28 | Biomarin Pharm Inc | Variants of C-type natriuretic peptide |
US20120208756A1 (en) | 2009-07-23 | 2012-08-16 | Igisu Co., Ltd | Composition for external preparation for skin |
RU2502519C2 (ru) * | 2009-08-27 | 2013-12-27 | Кёко ЭНДО | Терапевтическое средство для лечения ринита |
WO2012013597A1 (de) * | 2010-07-28 | 2012-02-02 | Justus-Liebig-Universität Giessen | Stoffe und deren verwendung zur beeinflussung natriuretischer peptidrezeptoren |
US9266939B2 (en) | 2010-12-27 | 2016-02-23 | Alexion Pharmaceuticals, Inc. | Compositions comprising natriuretic peptides and methods of use thereof |
BR112013018679B1 (pt) * | 2011-01-21 | 2022-04-12 | Igisu Co. Ltd. | Agente para o tratamento da alopecia e uso de um peptídeo natriurético do tipo c |
WO2012118042A1 (ja) * | 2011-02-28 | 2012-09-07 | 独立行政法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
CN103906761B (zh) | 2011-08-30 | 2016-12-21 | 梅约医学教育与研究基金会 | 利钠多肽 |
WO2013058833A1 (en) | 2011-10-19 | 2013-04-25 | Enobia Canada Limited Partnership | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
US9611305B2 (en) | 2012-01-06 | 2017-04-04 | Mayo Foundation For Medical Education And Research | Treating cardiovascular or renal diseases |
US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
CN104059154B (zh) * | 2014-05-06 | 2017-09-29 | 中国人民解放军第四军医大学 | 一种新的具有抗心力衰竭作用的钠尿肽嵌合体cnaac |
WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
JP6787894B2 (ja) | 2014-12-05 | 2020-11-18 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 組換えアルカリホスファターゼを用いた発作の処置 |
AU2016211447B2 (en) | 2015-01-28 | 2021-09-23 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
US9907834B2 (en) * | 2015-07-30 | 2018-03-06 | Biomarin Pharmaceutical Inc. | Use of C-type natriuretic peptide variants to treat skeletal dysplasia |
KR20180029255A (ko) | 2015-07-31 | 2018-03-20 | 가부시키가이샤 이기스 | Cnp 고리형 펩티드 및 그 고리형 펩티드를 포함하는 의약품, 외용제 및 화장료 |
KR102644116B1 (ko) | 2015-08-17 | 2024-03-05 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼린 포스파타제의 제조 |
JP6868617B2 (ja) | 2015-09-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 低ホスファターゼ血症の組織非特異的アルカリホスファターゼ(tnsalp)酵素補充療法に有効な投薬計画の特定 |
JP2018533571A (ja) | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
AU2016365751B2 (en) | 2015-12-08 | 2023-12-21 | Biomarin Pharmaceutical Inc. | Use of C-type natriuretic peptide variants to treat osteoarthritis |
WO2017155569A1 (en) | 2016-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
WO2017173413A1 (en) | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Treating muscle weakness with alkaline phosphatases |
WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
WO2018035420A1 (en) | 2016-08-18 | 2018-02-22 | Alexion Pharmaceuticals, Inc. | Methods for treating tracheobronchomalacia |
CN110719786A (zh) | 2017-03-31 | 2020-01-21 | 阿雷克森制药公司 | 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法 |
JP2021519590A (ja) | 2018-03-30 | 2021-08-12 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 糖タンパク質の製造 |
WO2024086680A2 (en) | 2022-10-21 | 2024-04-25 | Eli Lilly And Company | Long-acting natriuretic peptides and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4496544A (en) * | 1983-11-10 | 1985-01-29 | Washington University | Atrial Peptides |
JPH0672157B2 (ja) * | 1984-08-29 | 1994-09-14 | 味の素株式会社 | 新規ペプチド |
EP0232078A3 (de) * | 1986-01-31 | 1990-03-14 | Merck & Co. Inc. | Peptide mit ANF-Wirkung |
EP0292256A3 (de) * | 1987-05-19 | 1990-10-03 | Merck & Co. Inc. | Peptide mit ANF-Wirksamkeit |
US4935492A (en) * | 1987-12-24 | 1990-06-19 | California Biotechnology Inc. | Cyclic analogs of atrial natriuretic peptides |
CA1339210C (en) * | 1988-05-31 | 1997-08-05 | John Lewicki | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
DK380288D0 (da) * | 1988-07-07 | 1988-07-07 | Novo Industri As | Hidtil ukendet peptider |
EP0478797B1 (de) * | 1990-04-20 | 1995-04-12 | Hisayuki Matsuo | Neue im schwein vorkommende physiologisch aktive peptide |
JP2801079B2 (ja) * | 1990-11-14 | 1998-09-21 | サントリー株式会社 | Anp関連新規ペプチド |
-
1991
- 1991-06-28 JP JP3254066A patent/JP2809533B2/ja not_active Expired - Lifetime
-
1992
- 1992-01-31 AT AT92101621T patent/ATE219103T1/de not_active IP Right Cessation
- 1992-01-31 DE DE69232636T patent/DE69232636T2/de not_active Expired - Lifetime
- 1992-01-31 US US07/828,450 patent/US5434133A/en not_active Expired - Lifetime
- 1992-01-31 EP EP92101621A patent/EP0497368B1/de not_active Expired - Lifetime
- 1992-01-31 ES ES92101621T patent/ES2178634T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0497368A1 (de) | 1992-08-05 |
US5434133A (en) | 1995-07-18 |
DE69232636T2 (de) | 2002-12-05 |
JPH069688A (ja) | 1994-01-18 |
ES2178634T3 (es) | 2003-01-01 |
JP2809533B2 (ja) | 1998-10-08 |
EP0497368B1 (de) | 2002-06-12 |
DE69232636D1 (de) | 2002-07-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |