ATE210676T1 - Verfahren zur herstellung von 2'-deoxy-2'- halocoformycin oder stereoisomere davon - Google Patents
Verfahren zur herstellung von 2'-deoxy-2'- halocoformycin oder stereoisomere davonInfo
- Publication number
- ATE210676T1 ATE210676T1 AT97400511T AT97400511T ATE210676T1 AT E210676 T1 ATE210676 T1 AT E210676T1 AT 97400511 T AT97400511 T AT 97400511T AT 97400511 T AT97400511 T AT 97400511T AT E210676 T1 ATE210676 T1 AT E210676T1
- Authority
- AT
- Austria
- Prior art keywords
- deoxy
- halocoformycin
- chem
- formula
- epi
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 abstract 2
- 102000055025 Adenosine deaminases Human genes 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000003747 lymphoid leukemia Diseases 0.000 abstract 1
- 238000003541 multi-stage reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8078084A JPH09241294A (ja) | 1996-03-07 | 1996-03-07 | ２′−デオキシ−２′−ハロコホルマイシン又はその立体異性体の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210676T1 true ATE210676T1 (de) | 2001-12-15 |
Family
ID=13651989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97400511T ATE210676T1 (de) | 1996-03-07 | 1997-03-06 | Verfahren zur herstellung von 2'-deoxy-2'- halocoformycin oder stereoisomere davon |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5831072A (de) |
| EP (1) | EP0794194B1 (de) |
| JP (1) | JPH09241294A (de) |
| AT (1) | ATE210676T1 (de) |
| DE (1) | DE69708950T2 (de) |
| ES (1) | ES2168586T3 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE027338T2 (en) * | 2003-09-15 | 2016-09-28 | Hospira Uk Ltd | Synthesis and preparation of pentostatin and its precursors, analogues and derivatives |
| FR2881798B1 (fr) | 2005-02-10 | 2010-08-20 | Valeo Equip Electr Moteur | Dispositif de demarrage d'un moteur thermique |
| US20100261666A1 (en) * | 2009-04-14 | 2010-10-14 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for the treatment of myocardial dysfunction associated with sirs or sepsis |
| CN113980860B (zh) * | 2021-11-23 | 2023-09-08 | 天津商业大学 | 一种高产喷司他丁和2’-氨基-2’-脱氧腺苷的野野村菌及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3923785A (en) * | 1974-04-22 | 1975-12-02 | Parke Davis & Co | (R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol |
| US4117229A (en) * | 1977-10-11 | 1978-09-26 | Warner-Lambert Company | 2-amino-1-(5-amino-1h-imidazol-4-yl)ethanone and method of preparation |
| EP0156524B1 (de) * | 1984-03-16 | 1988-05-11 | Warner-Lambert Company | 2'-Chloropentostatin, eine diese Verbindung enthaltende pharmazeutische Zusammensetzung und ein Mikroorganismus zur Herstellung dieser Verbindung |
| US4713372A (en) * | 1984-03-16 | 1987-12-15 | Warner-Lambert Company | 2-chloropentostatin compound having adenosine diaminase inhibitory activity |
| JPS61199797A (ja) * | 1985-02-28 | 1986-09-04 | Kitasato Inst:The | 新規化合物アデクロリンおよびその製造法 |
| JPH0798832B2 (ja) * | 1987-05-01 | 1995-10-25 | 財団法人微生物化学研究会 | イミダゾジアゼピン誘導体 |
| NO169858C (no) * | 1989-03-02 | 1992-08-12 | Roger Sten Snarli | Innretning ved rulle- eller foldesjalusi |
| CA2122815C (en) * | 1991-11-14 | 1998-09-15 | Tomio Takeuchi | 2'-deoxy-2'-fluorocoformycin and stereoisomers thereof |
-
1996
- 1996-03-07 JP JP8078084A patent/JPH09241294A/ja active Pending
-
1997
- 1997-03-04 US US08/808,033 patent/US5831072A/en not_active Expired - Fee Related
- 1997-03-06 DE DE69708950T patent/DE69708950T2/de not_active Expired - Fee Related
- 1997-03-06 ES ES97400511T patent/ES2168586T3/es not_active Expired - Lifetime
- 1997-03-06 EP EP97400511A patent/EP0794194B1/de not_active Expired - Lifetime
- 1997-03-06 AT AT97400511T patent/ATE210676T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09241294A (ja) | 1997-09-16 |
| EP0794194B1 (de) | 2001-12-12 |
| US5831072A (en) | 1998-11-03 |
| DE69708950T2 (de) | 2002-08-08 |
| EP0794194A1 (de) | 1997-09-10 |
| DE69708950D1 (de) | 2002-01-24 |
| ES2168586T3 (es) | 2002-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |