ES2168586T3 - Un procedimiento para la preparacion de 2'-desoxi-2'-halocoformicinas o estereoisomeros de las mismas. - Google Patents

Un procedimiento para la preparacion de 2'-desoxi-2'-halocoformicinas o estereoisomeros de las mismas.

Info

Publication number
ES2168586T3
ES2168586T3 ES97400511T ES97400511T ES2168586T3 ES 2168586 T3 ES2168586 T3 ES 2168586T3 ES 97400511 T ES97400511 T ES 97400511T ES 97400511 T ES97400511 T ES 97400511T ES 2168586 T3 ES2168586 T3 ES 2168586T3
Authority
ES
Spain
Prior art keywords
deoxy
halocoformycin
chem
formula
stereoisomeros
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97400511T
Other languages
English (en)
Inventor
Tomio Takeuchi
Sumio Umezawa
Tsutomu Tsuchiya
Yoshiaki Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of ES2168586T3 publication Critical patent/ES2168586T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN OBJETO DE LA PRESENTE INVENCION, ES PROPORCIONAR UN NUEVO PROCEDIMIENTO DE SINTESIS DE UNA 2''-DESOXI-2''-HALOCOFORMICINA, QUE PRESENTA UNA ACTIVIDAD INHIBIDORA FRENTE A LA ADENOSINA DESAMINASA, CON UN ELEVADO RENDIMIENTO EN LA PRACTICA. POR TANTO, SE PROPORCIONA UN PROCEDIMIENTO QUE COMPRENDE REACCIONES MULTIETAPAS, UTILIZANDO COMO INTERMEDIARIO UN TERT-BUTIL 1-(3,5DI-O-ACIL-2-DESOXI-2-HALO-{BE}-D-RIBOFURANOSIL O ARABINOFURANOSIL)-5-AMINOIMIDAZOL-4-CARBOXILATO, DE FORMULA (II) (II) PRODUCIENDOSE UNA 2''-DESOXI-2''-HALOCOFORMICINA O UNA 2''-DESOXI2''-EPI-2''-HALOCONFORMICINA, DE FORMULA (I-A) (I-A) Y, ASIMISMO, UNA 2''-DESOXI-8-EPI-2''-HALOCONFORMICINA O UNA 2''DESOXI-8,2''-DIEPI-2''-HALOCONFORMICINA, DE FORMULA (I-B) (I-B) SE PUEDE PREDECIR QUE LA 2''-DESOXI-2''-HALOCONFORMICINA Y LOS EPIMEROS DE LA MISMA, SERAN UTILES COMO MEDICAMENTOS PARA LEUCEMIAS LINFOCITICAS Y PARA VARIAS ENFERMEDADES ATRIBUIBLES A LAS ACCIONES DE LA ADENOSINA DESAMINASA.
ES97400511T 1996-03-07 1997-03-06 Un procedimiento para la preparacion de 2'-desoxi-2'-halocoformicinas o estereoisomeros de las mismas. Expired - Lifetime ES2168586T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8078084A JPH09241294A (ja) 1996-03-07 1996-03-07 ２′−デオキシ−２′−ハロコホルマイシン又はその立体異性体の製造法

Publications (1)

Publication Number Publication Date
ES2168586T3 true ES2168586T3 (es) 2002-06-16

Family

ID=13651989

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97400511T Expired - Lifetime ES2168586T3 (es) 1996-03-07 1997-03-06 Un procedimiento para la preparacion de 2'-desoxi-2'-halocoformicinas o estereoisomeros de las mismas.

Country Status (6)

Country Link
US (1) US5831072A (es)
EP (1) EP0794194B1 (es)
JP (1) JPH09241294A (es)
AT (1) ATE210676T1 (es)
DE (1) DE69708950T2 (es)
ES (1) ES2168586T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027838A2 (en) * 2003-09-15 2005-03-31 Supergen, Inc. Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives
FR2881798B1 (fr) 2005-02-10 2010-08-20 Valeo Equip Electr Moteur Dispositif de demarrage d'un moteur thermique
US20100261666A1 (en) * 2009-04-14 2010-10-14 The Board Of Trustees Of The University Of Illinois Compositions and methods for the treatment of myocardial dysfunction associated with sirs or sepsis
CN113980860B (zh) * 2021-11-23 2023-09-08 天津商业大学 一种高产喷司他丁和2’-氨基-2’-脱氧腺苷的野野村菌及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923785A (en) * 1974-04-22 1975-12-02 Parke Davis & Co (R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol
US4117229A (en) * 1977-10-11 1978-09-26 Warner-Lambert Company 2-amino-1-(5-amino-1h-imidazol-4-yl)ethanone and method of preparation
EP0156524B1 (en) * 1984-03-16 1988-05-11 Warner-Lambert Company 2'-chloropentostatin, a pharmaceutical composition comprising the compound and a novel microorganism for producing the compound
US4713372A (en) * 1984-03-16 1987-12-15 Warner-Lambert Company 2-chloropentostatin compound having adenosine diaminase inhibitory activity
JPS61199797A (ja) * 1985-02-28 1986-09-04 Kitasato Inst:The 新規化合物アデクロリンおよびその製造法
JPH0798832B2 (ja) * 1987-05-01 1995-10-25 財団法人微生物化学研究会 イミダゾジアゼピン誘導体
NO169858C (no) * 1989-03-02 1992-08-12 Roger Sten Snarli Innretning ved rulle- eller foldesjalusi
ES2099841T3 (es) * 1991-11-14 1997-06-01 Zaidan Hojin Biseibutsu 2'-desoxi-2'-fluorocoformicina y estereoisomeros de la misma.

Also Published As

Publication number Publication date
US5831072A (en) 1998-11-03
DE69708950D1 (de) 2002-01-24
EP0794194B1 (en) 2001-12-12
EP0794194A1 (en) 1997-09-10
DE69708950T2 (de) 2002-08-08
ATE210676T1 (de) 2001-12-15
JPH09241294A (ja) 1997-09-16

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