ES2168586T3 - Un procedimiento para la preparacion de 2'-desoxi-2'-halocoformicinas o estereoisomeros de las mismas. - Google Patents
Un procedimiento para la preparacion de 2'-desoxi-2'-halocoformicinas o estereoisomeros de las mismas.Info
- Publication number
- ES2168586T3 ES2168586T3 ES97400511T ES97400511T ES2168586T3 ES 2168586 T3 ES2168586 T3 ES 2168586T3 ES 97400511 T ES97400511 T ES 97400511T ES 97400511 T ES97400511 T ES 97400511T ES 2168586 T3 ES2168586 T3 ES 2168586T3
- Authority
- ES
- Spain
- Prior art keywords
- deoxy
- halocoformycin
- chem
- formula
- stereoisomeros
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN OBJETO DE LA PRESENTE INVENCION, ES PROPORCIONAR UN NUEVO PROCEDIMIENTO DE SINTESIS DE UNA 2''-DESOXI-2''-HALOCOFORMICINA, QUE PRESENTA UNA ACTIVIDAD INHIBIDORA FRENTE A LA ADENOSINA DESAMINASA, CON UN ELEVADO RENDIMIENTO EN LA PRACTICA. POR TANTO, SE PROPORCIONA UN PROCEDIMIENTO QUE COMPRENDE REACCIONES MULTIETAPAS, UTILIZANDO COMO INTERMEDIARIO UN TERT-BUTIL 1-(3,5DI-O-ACIL-2-DESOXI-2-HALO-{BE}-D-RIBOFURANOSIL O ARABINOFURANOSIL)-5-AMINOIMIDAZOL-4-CARBOXILATO, DE FORMULA (II) (II) PRODUCIENDOSE UNA 2''-DESOXI-2''-HALOCOFORMICINA O UNA 2''-DESOXI2''-EPI-2''-HALOCONFORMICINA, DE FORMULA (I-A) (I-A) Y, ASIMISMO, UNA 2''-DESOXI-8-EPI-2''-HALOCONFORMICINA O UNA 2''DESOXI-8,2''-DIEPI-2''-HALOCONFORMICINA, DE FORMULA (I-B) (I-B) SE PUEDE PREDECIR QUE LA 2''-DESOXI-2''-HALOCONFORMICINA Y LOS EPIMEROS DE LA MISMA, SERAN UTILES COMO MEDICAMENTOS PARA LEUCEMIAS LINFOCITICAS Y PARA VARIAS ENFERMEDADES ATRIBUIBLES A LAS ACCIONES DE LA ADENOSINA DESAMINASA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8078084A JPH09241294A (ja) | 1996-03-07 | 1996-03-07 | 2′−デオキシ−2′−ハロコホルマイシン又はその立体異性体の製造法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2168586T3 true ES2168586T3 (es) | 2002-06-16 |
Family
ID=13651989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97400511T Expired - Lifetime ES2168586T3 (es) | 1996-03-07 | 1997-03-06 | Un procedimiento para la preparacion de 2'-desoxi-2'-halocoformicinas o estereoisomeros de las mismas. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5831072A (es) |
EP (1) | EP0794194B1 (es) |
JP (1) | JPH09241294A (es) |
AT (1) | ATE210676T1 (es) |
DE (1) | DE69708950T2 (es) |
ES (1) | ES2168586T3 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005027838A2 (en) * | 2003-09-15 | 2005-03-31 | Supergen, Inc. | Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives |
FR2881798B1 (fr) | 2005-02-10 | 2010-08-20 | Valeo Equip Electr Moteur | Dispositif de demarrage d'un moteur thermique |
US20100261666A1 (en) * | 2009-04-14 | 2010-10-14 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for the treatment of myocardial dysfunction associated with sirs or sepsis |
CN113980860B (zh) * | 2021-11-23 | 2023-09-08 | 天津商业大学 | 一种高产喷司他丁和2’-氨基-2’-脱氧腺苷的野野村菌及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923785A (en) * | 1974-04-22 | 1975-12-02 | Parke Davis & Co | (R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol |
US4117229A (en) * | 1977-10-11 | 1978-09-26 | Warner-Lambert Company | 2-amino-1-(5-amino-1h-imidazol-4-yl)ethanone and method of preparation |
EP0156524B1 (en) * | 1984-03-16 | 1988-05-11 | Warner-Lambert Company | 2'-chloropentostatin, a pharmaceutical composition comprising the compound and a novel microorganism for producing the compound |
US4713372A (en) * | 1984-03-16 | 1987-12-15 | Warner-Lambert Company | 2-chloropentostatin compound having adenosine diaminase inhibitory activity |
JPS61199797A (ja) * | 1985-02-28 | 1986-09-04 | Kitasato Inst:The | 新規化合物アデクロリンおよびその製造法 |
JPH0798832B2 (ja) * | 1987-05-01 | 1995-10-25 | 財団法人微生物化学研究会 | イミダゾジアゼピン誘導体 |
NO169858C (no) * | 1989-03-02 | 1992-08-12 | Roger Sten Snarli | Innretning ved rulle- eller foldesjalusi |
ES2099841T3 (es) * | 1991-11-14 | 1997-06-01 | Zaidan Hojin Biseibutsu | 2'-desoxi-2'-fluorocoformicina y estereoisomeros de la misma. |
-
1996
- 1996-03-07 JP JP8078084A patent/JPH09241294A/ja active Pending
-
1997
- 1997-03-04 US US08/808,033 patent/US5831072A/en not_active Expired - Fee Related
- 1997-03-06 AT AT97400511T patent/ATE210676T1/de not_active IP Right Cessation
- 1997-03-06 EP EP97400511A patent/EP0794194B1/en not_active Expired - Lifetime
- 1997-03-06 ES ES97400511T patent/ES2168586T3/es not_active Expired - Lifetime
- 1997-03-06 DE DE69708950T patent/DE69708950T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5831072A (en) | 1998-11-03 |
DE69708950D1 (de) | 2002-01-24 |
EP0794194B1 (en) | 2001-12-12 |
EP0794194A1 (en) | 1997-09-10 |
DE69708950T2 (de) | 2002-08-08 |
ATE210676T1 (de) | 2001-12-15 |
JPH09241294A (ja) | 1997-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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