ES2099841T3 - 2'-desoxi-2'-fluorocoformicina y estereoisomeros de la misma. - Google Patents
2'-desoxi-2'-fluorocoformicina y estereoisomeros de la misma.Info
- Publication number
- ES2099841T3 ES2099841T3 ES92923538T ES92923538T ES2099841T3 ES 2099841 T3 ES2099841 T3 ES 2099841T3 ES 92923538 T ES92923538 T ES 92923538T ES 92923538 T ES92923538 T ES 92923538T ES 2099841 T3 ES2099841 T3 ES 2099841T3
- Authority
- ES
- Spain
- Prior art keywords
- deoxy
- fluorocoformycin
- epi
- benzoyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F01—MACHINES OR ENGINES IN GENERAL; ENGINE PLANTS IN GENERAL; STEAM ENGINES
- F01K—STEAM ENGINE PLANTS; STEAM ACCUMULATORS; ENGINE PLANTS NOT OTHERWISE PROVIDED FOR; ENGINES USING SPECIAL WORKING FLUIDS OR CYCLES
- F01K23/00—Plants characterised by more than one engine delivering power external to the plant, the engines being driven by different fluids
- F01K23/02—Plants characterised by more than one engine delivering power external to the plant, the engines being driven by different fluids the engine cycles being thermally coupled
- F01K23/06—Plants characterised by more than one engine delivering power external to the plant, the engines being driven by different fluids the engine cycles being thermally coupled combustion heat from one cycle heating the fluid in another cycle
- F01K23/10—Plants characterised by more than one engine delivering power external to the plant, the engines being driven by different fluids the engine cycles being thermally coupled combustion heat from one cycle heating the fluid in another cycle with exhaust fluid of one cycle heating the fluid in another cycle
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Combustion & Propulsion (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
EL 2''-DEOXI-2''-FLUOROCOFORMICINA Y EL 2''-DEOXI-8-EPI-2''FLUOROCOFORMICINA HAN SIDO AHORA SINTETIZADOS MEDIANTE UNA REACCION EN MULTIPLES ETAPAS A TRAVES DEL BROMURO DE 3,5-DI.O-BENZOIL-2-DEOXI2-FLUORO-ALFA 2''-DEOXI-2''-EPI2''-FLUOROCOFORMICINA Y EL 2''-DEOXI-8,2''-DIEPI-2''-FLUOROCOFORMICIN HAN SIDO AHORA SINTETIZADOS A PARTIR DEL BROMURO DE 3,5-DI-O-BENZOIL-2DEOXI-2-FLUORO-ALFA-D-ARABINOFURANOSILO MEDIANTE UNA REACCION EN MULTIPLES ETAPAS. ESTOS CUATRO DERIVADOS DEL 2''-FLUOROCOFORMICINA SON NUEVOS COMPUESTOS Y TIENEN UNA POTENTE ACTIVIDAD INHIBIDORA DE ENZIMAS CONTRA LA DEAMINASA ADENOSINA. EN PARTICULAR, SON UTILES PARA EL TRATAMIENTO DE LEUCEMIA LIMFOCITICA AGUDA EN VIRTUD DE LA ACTIVIDAD ARRIBA MENCIONADA. OTROS NUEVOS COMPUESTOS TAMBIEN OBTENIDOS INCLUYEN VARIOS INTERMEDIOS UTILES PARA LA SINTESIS DE LOS DERIVADOS ARRIBA MENCIONADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP35258891 | 1991-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2099841T3 true ES2099841T3 (es) | 1997-06-01 |
Family
ID=18425076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92923538T Expired - Lifetime ES2099841T3 (es) | 1991-11-14 | 1992-11-13 | 2'-desoxi-2'-fluorocoformicina y estereoisomeros de la misma. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0643069B1 (es) |
JP (1) | JP3030087B2 (es) |
KR (1) | KR0163799B1 (es) |
AT (1) | ATE149510T1 (es) |
AU (1) | AU661520B2 (es) |
CA (1) | CA2122815C (es) |
DE (1) | DE69218005T2 (es) |
DK (1) | DK0643069T3 (es) |
ES (1) | ES2099841T3 (es) |
NO (1) | NO301231B1 (es) |
WO (1) | WO1993010137A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09241294A (ja) * | 1996-03-07 | 1997-09-16 | Microbial Chem Res Found | 2′−デオキシ−2′−ハロコホルマイシン又はその立体異性体の製造法 |
JP6045641B1 (ja) * | 2015-06-04 | 2016-12-14 | 株式会社 資生堂 | 化粧容器 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4625020A (en) * | 1983-11-18 | 1986-11-25 | Bristol-Myers Company | Nucleoside process |
ATE34176T1 (de) * | 1984-03-16 | 1988-05-15 | Warner Lambert Co | 2'-chloropentostatin, eine diese verbindung enthaltende pharmazeutische zusammensetzung und ein mikroorganismus zur herstellung dieser verbindung. |
JPS61199797A (ja) * | 1985-02-28 | 1986-09-04 | Kitasato Inst:The | 新規化合物アデクロリンおよびその製造法 |
JPH0631298B2 (ja) * | 1985-12-18 | 1994-04-27 | 財団法人微生物化学研究会 | 新規アンスラサイクリン誘導体,抗腫瘍剤,及び製造法 |
JPH0798832B2 (ja) * | 1987-05-01 | 1995-10-25 | 財団法人微生物化学研究会 | イミダゾジアゼピン誘導体 |
-
1992
- 1992-11-13 JP JP5509148A patent/JP3030087B2/ja not_active Expired - Lifetime
- 1992-11-13 KR KR1019940701645A patent/KR0163799B1/ko not_active IP Right Cessation
- 1992-11-13 ES ES92923538T patent/ES2099841T3/es not_active Expired - Lifetime
- 1992-11-13 DE DE69218005T patent/DE69218005T2/de not_active Expired - Fee Related
- 1992-11-13 AT AT92923538T patent/ATE149510T1/de not_active IP Right Cessation
- 1992-11-13 AU AU29318/92A patent/AU661520B2/en not_active Ceased
- 1992-11-13 EP EP92923538A patent/EP0643069B1/en not_active Expired - Lifetime
- 1992-11-13 DK DK92923538.0T patent/DK0643069T3/da active
- 1992-11-13 CA CA002122815A patent/CA2122815C/en not_active Expired - Fee Related
- 1992-11-13 WO PCT/JP1992/001489 patent/WO1993010137A1/ja active IP Right Grant
-
1994
- 1994-05-13 NO NO941800A patent/NO301231B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0643069B1 (en) | 1997-03-05 |
AU661520B2 (en) | 1995-07-27 |
JPH06511062A (ja) | 1994-12-08 |
DE69218005T2 (de) | 1997-10-16 |
EP0643069A1 (en) | 1995-03-15 |
JP3030087B2 (ja) | 2000-04-10 |
EP0643069A4 (en) | 1994-11-22 |
CA2122815C (en) | 1998-09-15 |
NO941800L (no) | 1994-07-04 |
DE69218005D1 (de) | 1997-04-10 |
KR0163799B1 (ko) | 1998-11-16 |
WO1993010137A1 (en) | 1993-05-27 |
AU2931892A (en) | 1993-06-15 |
NO301231B1 (no) | 1997-09-29 |
CA2122815A1 (en) | 1993-05-27 |
DK0643069T3 (da) | 1997-09-15 |
NO941800D0 (no) | 1994-05-13 |
ATE149510T1 (de) | 1997-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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