ATE199724T1 - Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose - Google Patents

Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose

Info

Publication number
ATE199724T1
ATE199724T1 AT96300419T AT96300419T ATE199724T1 AT E199724 T1 ATE199724 T1 AT E199724T1 AT 96300419 T AT96300419 T AT 96300419T AT 96300419 T AT96300419 T AT 96300419T AT E199724 T1 ATE199724 T1 AT E199724T1
Authority
AT
Austria
Prior art keywords
ribo
difluoro
deoxy
pentofuranosyl
cytosine
Prior art date
Application number
AT96300419T
Other languages
English (en)
Inventor
David D Wirth
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE199724T1 publication Critical patent/ATE199724T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT96300419T 1995-02-03 1996-01-22 Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose ATE199724T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/383,165 US5559222A (en) 1995-02-03 1995-02-03 Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose

Publications (1)

Publication Number Publication Date
ATE199724T1 true ATE199724T1 (de) 2001-03-15

Family

ID=23511995

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96300419T ATE199724T1 (de) 1995-02-03 1996-01-22 Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose

Country Status (10)

Country Link
US (2) US5559222A (de)
EP (1) EP0727433B1 (de)
JP (1) JPH08245685A (de)
AT (1) ATE199724T1 (de)
CA (1) CA2168080C (de)
DE (1) DE69612024T2 (de)
DK (1) DK0727433T3 (de)
ES (1) ES2154788T3 (de)
GR (1) GR3035931T3 (de)
PT (1) PT727433E (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
EP1280753A1 (de) * 2000-04-21 2003-02-05 Rhodia/Chirex, Inc. Verfahren zur herstellung von r-1-(aryloxy)propan-2-ol
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
ATE458743T1 (de) * 2005-03-04 2010-03-15 Fresenius Kabi Oncology Ltd Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'- difluor-d-ribufuranosylnukleosiden
AU2006255706B2 (en) * 2005-06-03 2011-06-23 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
KR20080099263A (ko) * 2006-02-07 2008-11-12 케마지스 리미티드 젬시타빈 및 관련된 중간체의 제조 방법
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
CN101024667B (zh) * 2007-03-30 2011-01-26 湖北益泰药业有限公司 盐酸吉西他宾的合成方法
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
EP0184365B1 (de) * 1984-12-04 1993-08-04 Eli Lilly And Company Tumorbehandlung bei Säugetieren
ES2176279T3 (es) * 1987-08-28 2002-12-01 Lilly Co Eli Procedimiento estereoselectivo para preparar 2`-2`-difluorolactonen protegidos.
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4954623A (en) * 1989-03-20 1990-09-04 Eli Lilly And Company Recovery of difluoro sugar
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів

Also Published As

Publication number Publication date
DE69612024T2 (de) 2001-09-06
CA2168080C (en) 2007-05-29
PT727433E (pt) 2001-06-29
ES2154788T3 (es) 2001-04-16
CA2168080A1 (en) 1996-08-04
EP0727433A1 (de) 1996-08-21
EP0727433B1 (de) 2001-03-14
DE69612024D1 (de) 2001-04-19
GR3035931T3 (en) 2001-08-31
DK0727433T3 (da) 2001-04-17
US5608043A (en) 1997-03-04
JPH08245685A (ja) 1996-09-24
US5559222A (en) 1996-09-24

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