ATE209645T1 - Neue verbindung, verfahren zu ihrer herstellung und antitumormittel - Google Patents

Neue verbindung, verfahren zu ihrer herstellung und antitumormittel

Info

Publication number
ATE209645T1
ATE209645T1 AT95920265T AT95920265T ATE209645T1 AT E209645 T1 ATE209645 T1 AT E209645T1 AT 95920265 T AT95920265 T AT 95920265T AT 95920265 T AT95920265 T AT 95920265T AT E209645 T1 ATE209645 T1 AT E209645T1
Authority
AT
Austria
Prior art keywords
hydrogen atom
group
lower alkyl
production
alkyl group
Prior art date
Application number
AT95920265T
Other languages
German (de)
English (en)
Inventor
Kyoji Tomita
Katsumi Chiba
Shigeki Kashimoto
Koh-Ichiro Shibamori
Yasunori Tsuzuki
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Application granted granted Critical
Publication of ATE209645T1 publication Critical patent/ATE209645T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95920265T 1994-06-14 1995-06-06 Neue verbindung, verfahren zu ihrer herstellung und antitumormittel ATE209645T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP19792194 1994-07-28
JP30691494 1994-11-15
JP33995694 1994-12-28
JP8170595 1995-03-13
PCT/JP1995/001110 WO1995034559A1 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Publications (1)

Publication Number Publication Date
ATE209645T1 true ATE209645T1 (de) 2001-12-15

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920265T ATE209645T1 (de) 1994-06-14 1995-06-06 Neue verbindung, verfahren zu ihrer herstellung und antitumormittel

Country Status (26)

Country Link
US (1) US5817669A (cg-RX-API-DMAC10.html)
EP (1) EP0787726B1 (cg-RX-API-DMAC10.html)
JP (1) JP3391796B2 (cg-RX-API-DMAC10.html)
KR (1) KR100350921B1 (cg-RX-API-DMAC10.html)
CN (1) CN1053668C (cg-RX-API-DMAC10.html)
AT (1) ATE209645T1 (cg-RX-API-DMAC10.html)
AU (1) AU679859B2 (cg-RX-API-DMAC10.html)
BR (1) BR9508037A (cg-RX-API-DMAC10.html)
CA (1) CA2192824C (cg-RX-API-DMAC10.html)
CZ (1) CZ292631B6 (cg-RX-API-DMAC10.html)
DE (1) DE69524251T2 (cg-RX-API-DMAC10.html)
DK (1) DK0787726T3 (cg-RX-API-DMAC10.html)
ES (1) ES2163512T3 (cg-RX-API-DMAC10.html)
FI (1) FI112485B (cg-RX-API-DMAC10.html)
HU (1) HU220072B (cg-RX-API-DMAC10.html)
MX (1) MX9606331A (cg-RX-API-DMAC10.html)
NO (1) NO307255B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ287139A (cg-RX-API-DMAC10.html)
PL (1) PL181867B1 (cg-RX-API-DMAC10.html)
PT (1) PT787726E (cg-RX-API-DMAC10.html)
RO (1) RO117793B1 (cg-RX-API-DMAC10.html)
RU (1) RU2151770C1 (cg-RX-API-DMAC10.html)
SI (1) SI0787726T1 (cg-RX-API-DMAC10.html)
SK (1) SK281341B6 (cg-RX-API-DMAC10.html)
TW (1) TW319769B (cg-RX-API-DMAC10.html)
WO (1) WO1995034559A1 (cg-RX-API-DMAC10.html)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003027112A1 (en) 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 1, 8-naphthyridine derivatives as antidiabetics
US6802423B2 (en) * 2002-02-20 2004-10-12 Trans Global Foods, Inc. Disposable food delivery apparatus
US7163948B2 (en) * 2003-04-07 2007-01-16 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
PL1666477T3 (pl) * 2003-09-10 2013-11-29 Kyorin Seiyaku Kk Pochodna kwasu 7-(4-podstawionego-3-cyklopropyloaminometylo-1- pirolidynylo)chinolonokarboksylowego
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
CN103083316B (zh) * 2004-03-15 2015-09-30 逊尼希思制药公司 Sns-595及其使用方法
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
BRPI0518164A (pt) * 2004-10-14 2008-11-04 Hoffmann La Roche quinazolinilmetilenotiazolinonas como inibidores de cdk1
RU2405781C2 (ru) * 2004-10-14 2010-12-10 Ф.Хоффманн-Ля Рош Аг 1, 5-нафтиридиназолидиноны, обладающие cdk1 антипролиферативной активностью
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
CA2619663A1 (en) * 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. Human ribosomal dna(rdna) and ribosomal rna (rrna) nucleic acids and uses thereof
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
KR20080041298A (ko) * 2005-09-02 2008-05-09 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한(＋)-1,4-디히드로-7-[(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
KR20140057409A (ko) * 2005-09-02 2014-05-12 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한 (＋)-1,4-디히드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
WO2007033232A1 (en) * 2005-09-14 2007-03-22 Janssen Pharmaceutica, N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase
JP2009539994A (ja) 2006-06-12 2009-11-19 サネシス ファーマシューティカルズ， インコーポレイテッド 癌の治療のための化合物及び組成物
US20100048609A1 (en) * 2006-08-01 2010-02-25 Jacobs Jeffrey W Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
DK2049109T3 (en) * 2006-08-02 2016-01-11 Sunesis Pharmaceuticals Inc Combined use of (+) - 1,4-dihydro-7 - [(3S, 4S) -3-methoxy-4- (methylamino) -1-pyrrolidinyl] -4-oxo-1- (2-thiazolyl) -1,8-naphthyridine-3-carboxylic acid and cytarabine (Ara-C) for the treatment of leukemia
JP6029808B2 (ja) * 2007-10-22 2016-11-24 サネシス ファーマシューティカルズ， インコーポレイテッド 併用療法における（＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の使用方法
US20110008371A1 (en) * 2007-12-10 2011-01-13 Sunesis Pharmaceuticals, Inc Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
CA2748066C (en) 2008-12-31 2017-06-27 Anantha Sudhakar Method of preparing (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
EP3287126A1 (en) 2009-02-27 2018-02-28 Sunesis Pharmaceuticals, Inc. Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity
UA110465C2 (en) 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
TW201120037A (en) * 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer
SMT201700035T1 (it) * 2011-05-13 2017-03-08 Array Biopharma Inc Composti di pirrolidinil urea, pirrolidinil tiourea e pirrolidinil guanidina come inibitori di chinasi trka
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
WO2018174266A1 (ja) 2017-03-24 2018-09-27 湧永製薬株式会社 新規ピリドンカルボン酸誘導体又はその塩

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988463A (en) * 1974-05-06 1976-10-26 Merck & Co., Inc. Method of preventing metastasis of H. Ep. No. 3
US4384001A (en) * 1978-12-21 1983-05-17 Gosalvez Mario Treatment of tumors with thiazolidine-4-carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
EP0154780B1 (en) * 1984-01-26 1990-04-11 Abbott Laboratories Quinoline antibacterial compounds
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
JPS61251667A (ja) * 1985-04-30 1986-11-08 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
IE60420B1 (en) * 1985-06-13 1994-07-13 Schering Corp Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
WO1986007357A2 (en) * 1985-06-14 1986-12-18 Upjohn Co Cyclopentapyrazole and tetrahydroindazole compounds
JPS6233176A (ja) * 1985-08-05 1987-02-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
JP2704428B2 (ja) * 1988-06-15 1998-01-26 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

Also Published As

Publication number Publication date
ES2163512T3 (es) 2002-02-01
BR9508037A (pt) 1997-09-16
RU2151770C1 (ru) 2000-06-27
CZ364396A3 (en) 1997-06-11
EP0787726B1 (en) 2001-11-28
HU220072B (hu) 2001-10-28
NZ287139A (en) 1997-07-27
FI112485B (fi) 2003-12-15
PL317726A1 (en) 1997-04-28
TW319769B (cg-RX-API-DMAC10.html) 1997-11-11
AU2576795A (en) 1996-01-05
PL181867B1 (pl) 2001-09-28
DE69524251D1 (de) 2002-01-10
SK281341B6 (sk) 2001-02-12
US5817669A (en) 1998-10-06
SK157496A3 (en) 1997-08-06
PT787726E (pt) 2002-04-29
HUT75777A (en) 1997-05-28
FI965020A7 (fi) 1996-12-16
SI0787726T1 (en) 2002-04-30
KR100350921B1 (ko) 2002-11-18
HK1000495A1 (en) 2002-07-19
JP3391796B2 (ja) 2003-03-31
WO1995034559A1 (en) 1995-12-21
DE69524251T2 (de) 2002-07-11
HU9603455D0 (en) 1997-02-28
NO965305L (no) 1997-02-04
EP0787726A1 (en) 1997-08-06
NO965305D0 (no) 1996-12-11
CN1158614A (zh) 1997-09-03
CN1053668C (zh) 2000-06-21
CZ292631B6 (cs) 2003-11-12
FI965020A0 (fi) 1996-12-13
NO307255B1 (no) 2000-03-06
MX9606331A (es) 1997-03-29
CA2192824C (en) 2006-11-07
AU679859B2 (en) 1997-07-10
RO117793B1 (ro) 2002-07-30
EP0787726A4 (cg-RX-API-DMAC10.html) 1997-08-06
CA2192824A1 (en) 1995-12-21
DK0787726T3 (da) 2002-02-11

Similar Documents

Publication Publication Date Title
ATE209645T1 (de) Neue verbindung, verfahren zu ihrer herstellung und antitumormittel
ATE254612T1 (de) Zuckerderivate, geliermittel, geliermittelzubereitungen, verfahren zu ihrer herstellung und gelzubereitungen
ATE123494T1 (de) Chinolon-derivate und deren salze, verfahren zu deren herstellung und diese enthaltende antibakterielle wirkstoffe.
ATE19773T1 (de) Nitroaliphatische verbindungen, verfahren zu deren herstellung und deren verwendung.
GR3033519T3 (en) Substituted pyridinesulfonamide compounds, herbicidal compositions containing them, and process for their production.
DE69311500D1 (de) 2,3-Diphenyl-5-pyrrolyl-furan Derivate, Verfahren und Zwischenprodukte für ihre Herstellung und ihre Verwendung als entzündungshemmende, antiallergische und blutplättchenaggregationshemmende Mittel
ATE148128T1 (de) Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
DE3174132D1 (en) New ethenylimidazole derivatives, processes for their preparation and pharmaceutical compositions containing them; intermediates, useful in their preparation and a process for the preparation thereof
AU1589695A (en) Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
DE69204480D1 (de) Anilinderivate und Verfahren zu ihrer Herstellung.
DE3770913D1 (de) Cinnamylamine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE139767T1 (de) Verfahren zur herstellung 5-pyrazolomerkaptan- derivate und dessen zwischenprodukte
DE68911095D1 (de) Antitumor-Substanz, Verfahren zu deren Herstellung und diese enthaltende Antikrebsmittel.
DK0627419T3 (da) Optisk aktive derivater af 1-phenylpyrrolidon og fremgangsmåde til fremstilling deraf
PT71432A (en) Clavulanic acid derivatives a process for their preparation and their use
DE69129605D1 (de) Verfahren zur Herstellung von N-Alkylpyrazolen
GR3001003T3 (en) Novel pregnane derivatives, processes for their preparaton and pharmaceutical compositions containing same
MY104164A (en) Heterocyclic compounds.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification