PT787726E - Novo composto, processo para a sua producao e agente tumoral - Google Patents

Novo composto, processo para a sua producao e agente tumoral

Info

Publication number
PT787726E
PT787726E PT95920265T PT95920265T PT787726E PT 787726 E PT787726 E PT 787726E PT 95920265 T PT95920265 T PT 95920265T PT 95920265 T PT95920265 T PT 95920265T PT 787726 E PT787726 E PT 787726E
Authority
PT
Portugal
Prior art keywords
hydrogen atom
group
lower alkyl
production
alkyl group
Prior art date
Application number
PT95920265T
Other languages
English (en)
Portuguese (pt)
Inventor
Kyoji Tomita
Katsumi Chiba
Shigeki Kashimoto
Koh-Ichiro Shibamori
Yasunori Tsuzuki
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Publication of PT787726E publication Critical patent/PT787726E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT95920265T 1994-06-14 1995-06-06 Novo composto, processo para a sua producao e agente tumoral PT787726E (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP19792194 1994-07-28
JP30691494 1994-11-15
JP33995694 1994-12-28
JP8170595 1995-03-13

Publications (1)

Publication Number Publication Date
PT787726E true PT787726E (pt) 2002-04-29

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95920265T PT787726E (pt) 1994-06-14 1995-06-06 Novo composto, processo para a sua producao e agente tumoral

Country Status (26)

Country Link
US (1) US5817669A (cg-RX-API-DMAC10.html)
EP (1) EP0787726B1 (cg-RX-API-DMAC10.html)
JP (1) JP3391796B2 (cg-RX-API-DMAC10.html)
KR (1) KR100350921B1 (cg-RX-API-DMAC10.html)
CN (1) CN1053668C (cg-RX-API-DMAC10.html)
AT (1) ATE209645T1 (cg-RX-API-DMAC10.html)
AU (1) AU679859B2 (cg-RX-API-DMAC10.html)
BR (1) BR9508037A (cg-RX-API-DMAC10.html)
CA (1) CA2192824C (cg-RX-API-DMAC10.html)
CZ (1) CZ292631B6 (cg-RX-API-DMAC10.html)
DE (1) DE69524251T2 (cg-RX-API-DMAC10.html)
DK (1) DK0787726T3 (cg-RX-API-DMAC10.html)
ES (1) ES2163512T3 (cg-RX-API-DMAC10.html)
FI (1) FI112485B (cg-RX-API-DMAC10.html)
HU (1) HU220072B (cg-RX-API-DMAC10.html)
MX (1) MX9606331A (cg-RX-API-DMAC10.html)
NO (1) NO307255B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ287139A (cg-RX-API-DMAC10.html)
PL (1) PL181867B1 (cg-RX-API-DMAC10.html)
PT (1) PT787726E (cg-RX-API-DMAC10.html)
RO (1) RO117793B1 (cg-RX-API-DMAC10.html)
RU (1) RU2151770C1 (cg-RX-API-DMAC10.html)
SI (1) SI0787726T1 (cg-RX-API-DMAC10.html)
SK (1) SK281341B6 (cg-RX-API-DMAC10.html)
TW (1) TW319769B (cg-RX-API-DMAC10.html)
WO (1) WO1995034559A1 (cg-RX-API-DMAC10.html)

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US7163948B2 (en) * 2003-04-07 2007-01-16 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
PL1666477T3 (pl) * 2003-09-10 2013-11-29 Kyorin Seiyaku Kk Pochodna kwasu 7-(4-podstawionego-3-cyklopropyloaminometylo-1- pirolidynylo)chinolonokarboksylowego
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
CN103083316B (zh) * 2004-03-15 2015-09-30 逊尼希思制药公司 Sns-595及其使用方法
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
BRPI0518164A (pt) * 2004-10-14 2008-11-04 Hoffmann La Roche quinazolinilmetilenotiazolinonas como inibidores de cdk1
RU2405781C2 (ru) * 2004-10-14 2010-12-10 Ф.Хоффманн-Ля Рош Аг 1, 5-нафтиридиназолидиноны, обладающие cdk1 антипролиферативной активностью
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
CA2619663A1 (en) * 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. Human ribosomal dna(rdna) and ribosomal rna (rrna) nucleic acids and uses thereof
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
KR20080041298A (ko) * 2005-09-02 2008-05-09 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한(＋)-1,4-디히드로-7-[(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
KR20140057409A (ko) * 2005-09-02 2014-05-12 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한 (＋)-1,4-디히드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
WO2007033232A1 (en) * 2005-09-14 2007-03-22 Janssen Pharmaceutica, N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase
JP2009539994A (ja) 2006-06-12 2009-11-19 サネシス ファーマシューティカルズ， インコーポレイテッド 癌の治療のための化合物及び組成物
US20100048609A1 (en) * 2006-08-01 2010-02-25 Jacobs Jeffrey W Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
DK2049109T3 (en) * 2006-08-02 2016-01-11 Sunesis Pharmaceuticals Inc Combined use of (+) - 1,4-dihydro-7 - [(3S, 4S) -3-methoxy-4- (methylamino) -1-pyrrolidinyl] -4-oxo-1- (2-thiazolyl) -1,8-naphthyridine-3-carboxylic acid and cytarabine (Ara-C) for the treatment of leukemia
JP6029808B2 (ja) * 2007-10-22 2016-11-24 サネシス ファーマシューティカルズ， インコーポレイテッド 併用療法における（＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の使用方法
US20110008371A1 (en) * 2007-12-10 2011-01-13 Sunesis Pharmaceuticals, Inc Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
CA2748066C (en) 2008-12-31 2017-06-27 Anantha Sudhakar Method of preparing (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
EP3287126A1 (en) 2009-02-27 2018-02-28 Sunesis Pharmaceuticals, Inc. Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity
UA110465C2 (en) 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
TW201120037A (en) * 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer
SMT201700035T1 (it) * 2011-05-13 2017-03-08 Array Biopharma Inc Composti di pirrolidinil urea, pirrolidinil tiourea e pirrolidinil guanidina come inibitori di chinasi trka
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
WO2018174266A1 (ja) 2017-03-24 2018-09-27 湧永製薬株式会社 新規ピリドンカルボン酸誘導体又はその塩

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US4384001A (en) * 1978-12-21 1983-05-17 Gosalvez Mario Treatment of tumors with thiazolidine-4-carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
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NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
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IE60420B1 (en) * 1985-06-13 1994-07-13 Schering Corp Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
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JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

Also Published As

Publication number Publication date
ES2163512T3 (es) 2002-02-01
BR9508037A (pt) 1997-09-16
RU2151770C1 (ru) 2000-06-27
CZ364396A3 (en) 1997-06-11
EP0787726B1 (en) 2001-11-28
HU220072B (hu) 2001-10-28
NZ287139A (en) 1997-07-27
FI112485B (fi) 2003-12-15
PL317726A1 (en) 1997-04-28
TW319769B (cg-RX-API-DMAC10.html) 1997-11-11
AU2576795A (en) 1996-01-05
PL181867B1 (pl) 2001-09-28
DE69524251D1 (de) 2002-01-10
SK281341B6 (sk) 2001-02-12
US5817669A (en) 1998-10-06
SK157496A3 (en) 1997-08-06
HUT75777A (en) 1997-05-28
FI965020A7 (fi) 1996-12-16
SI0787726T1 (en) 2002-04-30
KR100350921B1 (ko) 2002-11-18
HK1000495A1 (en) 2002-07-19
JP3391796B2 (ja) 2003-03-31
WO1995034559A1 (en) 1995-12-21
DE69524251T2 (de) 2002-07-11
HU9603455D0 (en) 1997-02-28
NO965305L (no) 1997-02-04
EP0787726A1 (en) 1997-08-06
NO965305D0 (no) 1996-12-11
CN1158614A (zh) 1997-09-03
ATE209645T1 (de) 2001-12-15
CN1053668C (zh) 2000-06-21
CZ292631B6 (cs) 2003-11-12
FI965020A0 (fi) 1996-12-13
NO307255B1 (no) 2000-03-06
MX9606331A (es) 1997-03-29
CA2192824C (en) 2006-11-07
AU679859B2 (en) 1997-07-10
RO117793B1 (ro) 2002-07-30
EP0787726A4 (cg-RX-API-DMAC10.html) 1997-08-06
CA2192824A1 (en) 1995-12-21
DK0787726T3 (da) 2002-02-11

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