ATE206133T1 - Substituierte propargylethoxyamido-nukleoside - Google Patents

Substituierte propargylethoxyamido-nukleoside

Info

Publication number
ATE206133T1
ATE206133T1 AT98914275T AT98914275T ATE206133T1 AT E206133 T1 ATE206133 T1 AT E206133T1 AT 98914275 T AT98914275 T AT 98914275T AT 98914275 T AT98914275 T AT 98914275T AT E206133 T1 ATE206133 T1 AT E206133T1
Authority
AT
Austria
Prior art keywords
group
deazapurine
purine
pyrimidine
attached
Prior art date
Application number
AT98914275T
Other languages
English (en)
Inventor
Shaheer H Khan
Steven M Menchen
Barnett B Rosenblum
Original Assignee
Pe Corp Ny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pe Corp Ny filed Critical Pe Corp Ny
Application granted granted Critical
Publication of ATE206133T1 publication Critical patent/ATE206133T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AT98914275T 1997-04-10 1998-03-23 Substituierte propargylethoxyamido-nukleoside ATE206133T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/833,855 US5770716A (en) 1997-04-10 1997-04-10 Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same
PCT/US1998/005616 WO1998045310A1 (en) 1997-04-10 1998-03-23 Substituted propargylethoxyamido nucleosides

Publications (1)

Publication Number Publication Date
ATE206133T1 true ATE206133T1 (de) 2001-10-15

Family

ID=25265453

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98914275T ATE206133T1 (de) 1997-04-10 1998-03-23 Substituierte propargylethoxyamido-nukleoside

Country Status (8)

Country Link
US (1) US5770716A (de)
EP (1) EP0923597B1 (de)
JP (3) JP2000513016A (de)
AT (1) ATE206133T1 (de)
AU (1) AU725288B2 (de)
CA (1) CA2257227C (de)
DE (1) DE69801802T2 (de)
WO (1) WO1998045310A1 (de)

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US5948648A (en) * 1998-05-29 1999-09-07 Khan; Shaheer H. Nucleotide compounds including a rigid linker
US6653462B2 (en) 1998-05-29 2003-11-25 Applera Corporation Nucleotide compounds including a rigid linker
US6096875A (en) * 1998-05-29 2000-08-01 The Perlein-Elmer Corporation Nucleotide compounds including a rigid linker
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
US6214807B1 (en) 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6221600B1 (en) 1999-10-08 2001-04-24 Board Of Regents, The University Of Texas System Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
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US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
EP1317464B1 (de) * 2000-10-11 2009-05-13 Applera Corporation Fluoreszierende nukleobasekonjugate mit anionische linker
US20030082547A1 (en) * 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
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US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
EP1524984A1 (de) * 2002-07-29 2005-04-27 Cv Therapeutics, Inc. Bildgebende verfahren zur myorcardperfusion unter verwendung von a2a-rezeptor-agonisten
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
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US20040175704A1 (en) 2003-03-06 2004-09-09 Stratagene Compositions and methods for polynucleotide sequence detection
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
JP2008501694A (ja) * 2004-06-03 2008-01-24 アイシス ファーマシューティカルズ、インク． 遺伝子調節の使用のために個別に修飾された鎖を有する二本鎖組成物
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
KR20070083714A (ko) * 2004-10-20 2007-08-24 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ 아데노신 수용체 작용제의 용도
PL1989214T3 (pl) 2006-02-03 2017-07-31 Gilead Sciences, Inc. Proces otrzymywania agonisty receptora adenozynowego a2a i jego polimorfów
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JP2012504147A (ja) * 2008-09-29 2012-02-16 ギリアード サイエンシーズ， インコーポレイテッド 多検出器型コンピュータ断層撮影法において使用するための心拍数コントロール薬およびＡ−２−α受容体作動薬の組み合わせ
WO2012044992A2 (en) 2010-09-30 2012-04-05 Agency For Science, Technology And Research (A*Star) Methods and reagents for detection and treatment of esophageal metaplasia
MY173826A (en) 2012-11-15 2020-02-24 Roche Innovation Ct Copenhagen As Oligonucleotide conjugates
BR112015018161A2 (pt) 2013-01-30 2017-08-22 Hoffmann La Roche Conjugado de oligômeros antisense de lna, composição farmacêutica e uso de um conjugado de oligômeros antisense de lna
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
CN112263682A (zh) 2013-06-27 2021-01-26 罗氏创新中心哥本哈根有限公司 靶向pcsk9的反义寡聚体和缀合物
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US10913944B2 (en) 2015-01-12 2021-02-09 Life Technologies Corporation Methods, systems and compositions thereof for nucleic acid library quality control and quantification
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KR20210043584A (ko) 2018-08-10 2021-04-21 라이프 테크놀로지스 코포레이션 규소로 치환된 로다민 염료 및 염료 접합체
EP4355757A1 (de) * 2021-06-17 2024-04-24 F. Hoffmann-La Roche AG Nukleosid-5-oligophosphate mit kationisch modifizierter nukleobase

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US5821356A (en) * 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides

Also Published As

Publication number Publication date
AU6867298A (en) 1998-10-30
WO1998045310A1 (en) 1998-10-15
AU725288B2 (en) 2000-10-12
EP0923597B1 (de) 2001-09-26
CA2257227A1 (en) 1998-10-15
JP2013166769A (ja) 2013-08-29
DE69801802D1 (de) 2001-10-31
EP0923597A1 (de) 1999-06-23
JP5280879B2 (ja) 2013-09-04
CA2257227C (en) 2005-02-22
JP2009143946A (ja) 2009-07-02
DE69801802T2 (de) 2002-04-04
JP2000513016A (ja) 2000-10-03
US5770716A (en) 1998-06-23

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