ATE204576T1 - Methotrexat-derivate - Google Patents
Methotrexat-derivateInfo
- Publication number
- ATE204576T1 ATE204576T1 AT93902536T AT93902536T ATE204576T1 AT E204576 T1 ATE204576 T1 AT E204576T1 AT 93902536 T AT93902536 T AT 93902536T AT 93902536 T AT93902536 T AT 93902536T AT E204576 T1 ATE204576 T1 AT E204576T1
- Authority
- AT
- Austria
- Prior art keywords
- methotrexate derivatives
- antirheumatic
- chem
- iii
- image
- Prior art date
Links
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical class C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5305192 | 1992-01-27 | ||
| JP7510692 | 1992-02-13 | ||
| JP10832092 | 1992-03-16 | ||
| JP11512692 | 1992-03-24 | ||
| PCT/JP1993/000096 WO1993015077A1 (en) | 1992-01-27 | 1993-01-27 | Methotrexate derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204576T1 true ATE204576T1 (de) | 2001-09-15 |
Family
ID=27462860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93902536T ATE204576T1 (de) | 1992-01-27 | 1993-01-27 | Methotrexat-derivate |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6559149B1 (en, 2012) |
| EP (1) | EP0632038B1 (en, 2012) |
| KR (1) | KR100248324B1 (en, 2012) |
| AT (1) | ATE204576T1 (en, 2012) |
| AU (1) | AU3367693A (en, 2012) |
| CA (1) | CA2128205C (en, 2012) |
| DE (1) | DE69330639T2 (en, 2012) |
| ES (1) | ES2161713T3 (en, 2012) |
| TW (1) | TW223637B (en, 2012) |
| WO (1) | WO1993015077A1 (en, 2012) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6559149B1 (en) * | 1992-01-27 | 2003-05-06 | Chugai Seiyaku Kabushiki Kaisha | Methotrexate derivatives |
| ES2140524T3 (es) * | 1992-12-25 | 2000-03-01 | Chugai Pharmaceutical Co Ltd | Derivados de metotrexato. |
| WO1996030019A1 (fr) * | 1995-03-27 | 1996-10-03 | Chugai Seiyaku Kabushiki Kaisha | Medicament contenant un derive de methotrexate |
| US7276506B2 (en) * | 1998-12-28 | 2007-10-02 | 4 Aza Bioscience Nv | Immunosuppressive effects of pteridine derivatives |
| EP1283199A4 (en) * | 2000-05-16 | 2003-12-17 | Takeda Chemical Industries Ltd | MELANINE CONCENTRATING HORMONE ANTAGONISTS |
| US20070032477A1 (en) * | 2003-10-17 | 2007-02-08 | Waer Mark J A | Pteridine derivatives useful for making pharmaceutical compositions |
| US20060039985A1 (en) * | 2004-04-27 | 2006-02-23 | Bennett David B | Methotrexate compositions |
| US7601834B2 (en) * | 2005-02-22 | 2009-10-13 | Savvipharm Inc | Compositions and methods of reducing side effects and toxicity of methotrexate when given as orotate derivatives |
| CN101355952B (zh) | 2005-11-28 | 2012-03-21 | 韦罗制药有限公司 | 用于减少肾毒性的组合物及其使用方法 |
| WO2007098089A2 (en) * | 2006-02-17 | 2007-08-30 | Novacea, Inc. | Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US10144736B2 (en) * | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| DK2150514T3 (en) | 2007-04-11 | 2019-02-18 | Merck & Cie | 18F-LABELED FOLATES |
| EP2356979B1 (en) | 2008-11-19 | 2017-10-25 | Pola Chemical Industries Inc. | Anti-wrinkle agents |
| MX377388B (es) | 2015-03-04 | 2025-03-10 | Gilead Sciences Inc | Compuestos de 4,6-diamino-pirido[3,2-d]pirimidina moduladores del receptor tipo toll. |
| EP3507288B1 (en) | 2016-09-02 | 2020-08-26 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| SI3507276T1 (sl) | 2016-09-02 | 2022-01-31 | Gilead Sciences, Inc. | Spojine modulatorja toličnih receptorjev |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI812775A7 (fi) | 1980-09-12 | 1982-03-13 | Farmos Oy | Menetelmä N-/4-/(2,4-diamino-6- pteridinyyli)-metyyli/- metyyliamino/bentsoyyli/glutamiinihapon ja senjohdannaisten valmistamiseksi. |
| US4490529A (en) | 1983-09-06 | 1984-12-25 | Dana-Farber Cancer Institute, Inc. | Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin |
| JP3124592B2 (ja) * | 1990-08-14 | 2001-01-15 | 中外製薬株式会社 | 新規メトトレキセート誘導体 |
| EP0543997B1 (en) * | 1990-08-14 | 1999-12-08 | Chugai Seiyaku Kabushiki Kaisha | Derivatives of methotrexate with antirheumatic activity |
| US6559149B1 (en) * | 1992-01-27 | 2003-05-06 | Chugai Seiyaku Kabushiki Kaisha | Methotrexate derivatives |
| JP3207285B2 (ja) * | 1992-01-27 | 2001-09-10 | 中外製薬株式会社 | 新規メトトレキセート誘導体 |
| JP3274532B2 (ja) * | 1992-03-24 | 2002-04-15 | 中外製薬株式会社 | 抗リウマチ剤 |
-
1993
- 1993-01-27 US US08/256,441 patent/US6559149B1/en not_active Expired - Fee Related
- 1993-01-27 TW TW082100448A patent/TW223637B/zh active
- 1993-01-27 CA CA002128205A patent/CA2128205C/en not_active Expired - Fee Related
- 1993-01-27 DE DE69330639T patent/DE69330639T2/de not_active Expired - Fee Related
- 1993-01-27 AT AT93902536T patent/ATE204576T1/de active
- 1993-01-27 AU AU33676/93A patent/AU3367693A/en not_active Abandoned
- 1993-01-27 KR KR1019940702559A patent/KR100248324B1/ko not_active Expired - Fee Related
- 1993-01-27 EP EP93902536A patent/EP0632038B1/en not_active Expired - Lifetime
- 1993-01-27 WO PCT/JP1993/000096 patent/WO1993015077A1/ja active IP Right Grant
- 1993-01-27 ES ES93902536T patent/ES2161713T3/es not_active Expired - Lifetime
-
2003
- 2003-03-03 US US10/376,711 patent/US20030171376A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR100248324B1 (ko) | 2000-04-01 |
| WO1993015077A1 (en) | 1993-08-05 |
| ES2161713T3 (es) | 2001-12-16 |
| US6559149B1 (en) | 2003-05-06 |
| EP0632038A4 (en) | 1995-02-22 |
| CA2128205C (en) | 2004-03-30 |
| AU3367693A (en) | 1993-09-01 |
| EP0632038A1 (en) | 1995-01-04 |
| DE69330639T2 (de) | 2002-07-04 |
| DE69330639D1 (de) | 2001-09-27 |
| EP0632038B1 (en) | 2001-08-22 |
| US20030171376A1 (en) | 2003-09-11 |
| CA2128205A1 (en) | 1993-08-05 |
| TW223637B (en, 2012) | 1994-05-11 |
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