ATE200077T1 - Substituierte phenylimidazolidine, ihre anwendung als medikamente und die sie enthaltende pharmazeutische präparate - Google Patents
Substituierte phenylimidazolidine, ihre anwendung als medikamente und die sie enthaltende pharmazeutische präparateInfo
- Publication number
- ATE200077T1 ATE200077T1 AT93401361T AT93401361T ATE200077T1 AT E200077 T1 ATE200077 T1 AT E200077T1 AT 93401361 T AT93401361 T AT 93401361T AT 93401361 T AT93401361 T AT 93401361T AT E200077 T1 ATE200077 T1 AT E200077T1
- Authority
- AT
- Austria
- Prior art keywords
- halogen
- medications
- pharmaceutical preparations
- image
- preparations containing
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Chemical group 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 239000001301 oxygen Substances 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000002280 anti-androgenic effect Effects 0.000 abstract 1
- 239000000051 antiandrogen Substances 0.000 abstract 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR929208431A FR2693461B1 (fr) | 1992-07-08 | 1992-07-08 | Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE200077T1 true ATE200077T1 (de) | 2001-04-15 |
Family
ID=9431679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93401361T ATE200077T1 (de) | 1992-07-08 | 1993-05-28 | Substituierte phenylimidazolidine, ihre anwendung als medikamente und die sie enthaltende pharmazeutische präparate |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0580459B1 (de) |
| JP (1) | JP3845455B2 (de) |
| KR (1) | KR100294383B1 (de) |
| CN (1) | CN1044234C (de) |
| AT (1) | ATE200077T1 (de) |
| AU (1) | AU670942B2 (de) |
| CA (1) | CA2097248A1 (de) |
| DE (1) | DE69330058T2 (de) |
| DK (1) | DK0580459T3 (de) |
| ES (1) | ES2155067T3 (de) |
| FR (1) | FR2693461B1 (de) |
| GR (1) | GR3035768T3 (de) |
| HU (1) | HUT64527A (de) |
| PT (1) | PT580459E (de) |
| RU (1) | RU2116298C1 (de) |
| UA (1) | UA34428C2 (de) |
| ZA (1) | ZA933786B (de) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2715402B1 (fr) * | 1994-01-05 | 1996-10-04 | Roussel Uclaf | Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
| FR2724169B1 (fr) * | 1994-09-06 | 1997-01-03 | Roussel Uclaf | Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| TW521073B (en) * | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
| FR2716110B1 (fr) * | 1994-02-16 | 1996-04-05 | Roussel Uclaf | Compositions cosmétiques ou pharmaceutiques comprenant des liposomes. |
| AU726572B2 (en) * | 1994-02-16 | 2000-11-09 | Aventis Pharma S.A. | Cosmetics or pharmaceutical compositions consisting of liposomes |
| US5656651A (en) * | 1995-06-16 | 1997-08-12 | Biophysica Inc. | Androgenic directed compositions |
| FR2741342B1 (fr) * | 1995-11-22 | 1998-02-06 | Roussel Uclaf | Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques |
| FR2742749B1 (fr) * | 1995-12-22 | 1998-02-06 | Roussel Uclaf | Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques |
| JP5162064B2 (ja) * | 1998-10-23 | 2013-03-13 | アベンティス・ファーマ・ソシエテ・アノニム | 抗アンドロゲン作用を有する物質を局所適用するための処方物 |
| FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
| JP4621335B2 (ja) | 2000-06-28 | 2011-01-26 | セイコーエプソン株式会社 | 情報端末用プリンタユニット |
| US6861432B2 (en) | 2001-11-23 | 2005-03-01 | Schering Aktiengesellschaft | Piperazine derivatives that destabilize androgen receptors |
| AU2002360932A1 (en) * | 2001-11-23 | 2003-06-10 | Schering Aktiengesellschaft | Piperazine derivatives destabilising androgen receptors |
| DE10218963A1 (de) * | 2002-04-27 | 2003-11-20 | Aventis Pharma Gmbh | Zubereitungen zur topischen Applikation von antiandrogen wirksamen Substanzen |
| FR2845383B1 (fr) * | 2002-10-04 | 2004-12-31 | Fournier Lab Sa | Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique |
| US20060025589A1 (en) * | 2002-10-01 | 2006-02-02 | Jean Binet | 2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes |
| DE10322108B4 (de) * | 2003-05-09 | 2008-12-11 | Bayer Schering Pharma Aktiengesellschaft | Antiandrogene Pyrrolidine mit tumorhemmender Wirksamkeit |
| WO2004111012A1 (ja) * | 2003-06-12 | 2004-12-23 | Chugai Seiyaku Kabushiki Kaisha | イミダゾリジン誘導体 |
| JP2007514442A (ja) | 2003-12-19 | 2007-06-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 前立腺癌治療を評価するための方法および物質 |
| US7718684B2 (en) | 2004-02-24 | 2010-05-18 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
| EP1621535A1 (de) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Cyclische Substituirte Harnstoffderivate, Verfahren zu ihrer Herstellung, und ihre pharmazeutische Verwendung als Kinase Inhibitoren |
| JP4912148B2 (ja) * | 2004-08-03 | 2012-04-11 | 中外製薬株式会社 | 新規イミダゾリジン誘導体 |
| WO2006028226A1 (ja) * | 2004-09-09 | 2006-03-16 | Chugai Seiyaku Kabushiki Kaisha | 新規イミダゾリジン誘導体およびその用途 |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| BRPI0610183A2 (pt) * | 2005-05-13 | 2012-12-04 | Lilly Co Eli | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto ou de um sal farmaceuticamente aceitável do mesmo |
| AU2013203255C1 (en) * | 2005-05-13 | 2017-01-19 | The Regents Of The University Of California | Diarylthiohydantoin compounds |
| RU2448096C3 (ru) | 2005-05-13 | 2017-12-11 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Диарилгидантоины |
| US7709516B2 (en) * | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
| CN101032483B (zh) * | 2006-03-09 | 2011-05-04 | 陈德桂 | 调节雄激素受体活性的乙内酰脲衍生物及其应用 |
| DK2656842T3 (en) | 2006-03-27 | 2016-11-07 | Univ California | Androgen receptor MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND androgen receptor-ASSOCIATED DISEASES |
| KR101519705B1 (ko) | 2006-03-29 | 2015-05-12 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴티오히단토인 화합물 |
| US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
| CL2008003158A1 (es) | 2007-10-26 | 2009-05-29 | Univ California | Compuestos derivados de diariltiohidantoina con actividad antagonista fuerte y con actividad agonista minima sobre el receptor de androgeno (ar); procedimiento de preparacion; composicion farmaceutica que los comprende; uso en el tratamiento de un desorden proliferativo tal como cancer de prostata. |
| EP2242747A1 (de) * | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| WO2009097996A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Verwendung von substituierten phenylimidazolidinen zur herstellung von arzneimitteln zur behandlung des metabolischen syndroms |
| EP2260028B1 (de) | 2008-02-22 | 2014-05-07 | Radius Health, Inc. | Selektive androgenrezeptormodulatoren |
| US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
| WO2009145286A1 (ja) | 2008-05-30 | 2009-12-03 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2010069519A1 (en) | 2008-12-18 | 2010-06-24 | Merz Pharma Gmbh & Co. Kgaa | Topical compositions comprising at least one active ingredient poorly soluble in water and biopolymers such as hyaluronic acid with a pka-value between 5-7 |
| KR20110113755A (ko) | 2009-02-10 | 2011-10-18 | 아스트라제네카 아베 | 트리아졸로 〔4,3-ｂ〕 피리다진 유도체 및 전립샘암에 대한 이의 용도 |
| FR2944524B1 (fr) * | 2009-04-17 | 2012-11-30 | Ipsen Pharma Sas | Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament |
| TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
| FR2954317B1 (fr) | 2009-12-23 | 2012-01-27 | Galderma Res & Dev | Nouveaux derives phenoliques, et leur utilisation pharmaceutique ou cosmetique |
| FR2954315B1 (fr) | 2009-12-23 | 2012-02-24 | Galderma Res & Dev | Nouveaux derives phenoliques, et leur utilisation pharmaceutique ou cosmetique |
| FR2954316B1 (fr) | 2009-12-23 | 2014-01-03 | Galderma Res & Dev | Nouveaux derives phenoliques, et leur utilisation pharmaceutique ou cosmetique |
| CA2788907A1 (en) | 2010-02-04 | 2011-08-11 | Radius Health, Inc. | Selective androgen receptor modulators |
| CA2787083C (en) | 2010-02-16 | 2018-05-22 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| RU2554081C2 (ru) * | 2010-02-24 | 2015-06-27 | Медивэйшн Простейт Терапьютикс, Инк. | Способ синтеза соединений диарилтиогидантоина и диарилгидантоина |
| PL2568806T3 (pl) | 2010-05-12 | 2017-03-31 | Radius Health, Inc. | Schematy lecznicze |
| US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
| EP2621901B1 (de) | 2010-09-28 | 2015-07-29 | Radius Health, Inc | Selektive androgen rezeptor modulatoren |
| UA117663C2 (uk) | 2012-09-26 | 2018-09-10 | Арагон Фармасьютікалз, Інк. | Антиандроген для лікування неметастатичного кастраційно-резистентного раку передміхурової залози |
| JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
| US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| SI3122426T1 (sl) | 2014-03-28 | 2023-04-28 | Duke University | Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev |
| CN103965112A (zh) * | 2014-05-13 | 2014-08-06 | 上海孚一生物科技有限公司 | 一种具有抗雄激素活性的化合物、制备方法及其应用 |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| PT3474841T (pt) | 2016-06-22 | 2022-06-20 | Radius Health Inc | Métodos de tratamento do cancro de mama ar+ |
| EP3565542B1 (de) | 2017-01-05 | 2024-04-10 | Radius Pharmaceuticals, Inc. | Polymorphe formen von rad1901-2hcl |
| BR112020007439A2 (pt) | 2017-10-16 | 2020-10-27 | Aragon Pharmaceuticals, Inc. | antiandrogênios para o tratamento de câncer de próstata resistente à castração não metastática |
| WO2025103470A1 (zh) * | 2023-11-17 | 2025-05-22 | 中国药科大学 | 作为雄激素受体(ar)拮抗剂的化合物及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4916937B1 (de) * | 1970-01-21 | 1974-04-25 | ||
| US3823240A (en) * | 1970-10-06 | 1974-07-09 | Rhone Poulenc Sa | Fungicidal hydantoin derivatives |
| US3923994A (en) * | 1973-07-13 | 1975-12-02 | Smithkline Corp | Anti-arthritic compositions comprising a 3-aryl 2-thiohydantoin and methods of producing anti-arthritic acitvity |
| FR2329276A1 (fr) * | 1975-10-29 | 1977-05-27 | Roussel Uclaf | Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant |
| MC1220A1 (fr) * | 1977-10-28 | 1979-07-20 | Hoffmann La Roche | Nouveaux derives d'imidazolidine |
| DE2933917A1 (de) * | 1979-08-22 | 1981-03-26 | Basf Ag, 67063 Ludwigshafen | 5-imino-imidazolidin-2-one und diese enthaltende herbizide. |
| US4753957A (en) * | 1981-09-28 | 1988-06-28 | Rohm And Haas Company | Substituted 2,4-imidazolidinediones and fungicidal compositions |
| EP0091596B1 (de) * | 1982-04-08 | 1991-09-11 | Shell Internationale Researchmaatschappij B.V. | Neue Hydantoine, ihre Herstellung und Verwendung |
| US4473393A (en) * | 1982-08-06 | 1984-09-25 | Buffalo Color Corporation | Pesticidal thiohydantoin compositions |
| FR2656302B1 (fr) * | 1989-12-22 | 1992-05-07 | Roussel Uclaf | Nouveau procede de preparation de l'anandron et derives de l'anandron. |
| FR2671348B1 (fr) * | 1991-01-09 | 1993-03-26 | Roussel Uclaf | Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
-
1992
- 1992-07-08 FR FR929208431A patent/FR2693461B1/fr not_active Expired - Fee Related
-
1993
- 1993-05-28 HU HU9301585A patent/HUT64527A/hu unknown
- 1993-05-28 ZA ZA933786A patent/ZA933786B/xx unknown
- 1993-05-28 JP JP14837193A patent/JP3845455B2/ja not_active Expired - Fee Related
- 1993-05-28 DE DE69330058T patent/DE69330058T2/de not_active Expired - Fee Related
- 1993-05-28 CA CA002097248A patent/CA2097248A1/fr not_active Abandoned
- 1993-05-28 DK DK93401361T patent/DK0580459T3/da active
- 1993-05-28 AT AT93401361T patent/ATE200077T1/de not_active IP Right Cessation
- 1993-05-28 RU RU93005350A patent/RU2116298C1/ru not_active IP Right Cessation
- 1993-05-28 CN CN93106567A patent/CN1044234C/zh not_active Expired - Fee Related
- 1993-05-28 EP EP93401361A patent/EP0580459B1/de not_active Expired - Lifetime
- 1993-05-28 PT PT93401361T patent/PT580459E/pt unknown
- 1993-05-28 ES ES93401361T patent/ES2155067T3/es not_active Expired - Lifetime
- 1993-05-29 KR KR1019930009431A patent/KR100294383B1/ko not_active Expired - Fee Related
- 1993-05-31 AU AU39876/93A patent/AU670942B2/en not_active Ceased
- 1993-06-18 UA UA93003085A patent/UA34428C2/uk unknown
-
2001
- 2001-04-20 GR GR20010400616T patent/GR3035768T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU670942B2 (en) | 1996-08-08 |
| UA34428C2 (uk) | 2001-03-15 |
| ES2155067T3 (es) | 2001-05-01 |
| ZA933786B (en) | 1994-05-30 |
| PT580459E (pt) | 2001-07-31 |
| DE69330058D1 (de) | 2001-05-03 |
| FR2693461A1 (fr) | 1994-01-14 |
| RU2116298C1 (ru) | 1998-07-27 |
| DE69330058T2 (de) | 2001-09-06 |
| JP3845455B2 (ja) | 2006-11-15 |
| GR3035768T3 (en) | 2001-07-31 |
| EP0580459A1 (de) | 1994-01-26 |
| KR940005582A (ko) | 1994-03-21 |
| KR100294383B1 (ko) | 2001-09-17 |
| FR2693461B1 (fr) | 1994-09-02 |
| DK0580459T3 (da) | 2001-06-11 |
| HU9301585D0 (en) | 1993-09-28 |
| CA2097248A1 (fr) | 1994-01-09 |
| JPH0673017A (ja) | 1994-03-15 |
| EP0580459B1 (de) | 2001-03-28 |
| CN1044234C (zh) | 1999-07-21 |
| CN1081182A (zh) | 1994-01-26 |
| HUT64527A (en) | 1994-01-28 |
| AU3987693A (en) | 1994-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |