ATE194835T1 - Pyridazinonderivat - Google Patents
PyridazinonderivatInfo
- Publication number
- ATE194835T1 ATE194835T1 AT91907712T AT91907712T ATE194835T1 AT E194835 T1 ATE194835 T1 AT E194835T1 AT 91907712 T AT91907712 T AT 91907712T AT 91907712 T AT91907712 T AT 91907712T AT E194835 T1 ATE194835 T1 AT E194835T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridazinone derivative
- salt
- vasodilatory
- cardiotonic
- srs
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10991490 | 1990-04-25 | ||
| PCT/JP1991/000517 WO1991016314A1 (fr) | 1990-04-25 | 1991-04-19 | Derive de pyridazinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE194835T1 true ATE194835T1 (de) | 2000-08-15 |
Family
ID=14522343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91907712T ATE194835T1 (de) | 1990-04-25 | 1991-04-19 | Pyridazinonderivat |
Country Status (17)
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202323A (en) * | 1990-04-25 | 1993-04-13 | Nissan Chemical Industries Ltd. | 5-arylmethylamino-6-oxy-substituted 3(2h)-pyridazinones |
| US5403590A (en) * | 1992-12-21 | 1995-04-04 | New England Deaconess Hospital Corporation | Method of pulsatile drug infusion |
| JP3080131B2 (ja) | 1993-06-29 | 2000-08-21 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| IL110040A (en) * | 1993-06-29 | 2000-07-16 | Nissan Chemical Ind Ltd | Pyridazinone derivatives their preparation and pharmaceutical compositions comprising them |
| CN1056369C (zh) * | 1993-09-06 | 2000-09-13 | 石原产业株式会社 | 哒嗪酮衍生物或其盐和制备方法 |
| NZ270130A (en) * | 1993-12-16 | 1995-12-21 | Nihon Nohyaku Co Ltd | Pyridazinone derivatives, preparation and pharmaceutical compositions thereof |
| AU1466395A (en) * | 1994-01-25 | 1995-08-08 | Nissan Chemical Industries Ltd. | Pyridazinone derivative |
| IL112695A (en) * | 1994-02-22 | 1999-04-11 | Green Cross Corp | Pharmaceutical compositions containing pyridazinone derivatives |
| GB9514160D0 (en) * | 1994-07-25 | 1995-09-13 | Zeneca Ltd | Aromatic compounds |
| US5670504A (en) * | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
| TW434240B (en) * | 1995-06-20 | 2001-05-16 | Zeneca Ltd | Aromatic compounds, preparation thereof and pharmaceutical composition comprising same |
| WO1997049704A1 (en) | 1996-06-27 | 1997-12-31 | Janssen Pharmaceutica N.V. | N-[4-(heteroarylmethyl)phenyl]-heteroarylamines |
| TW482675B (en) * | 1997-01-31 | 2002-04-11 | Green Cross Corp | Compositions for oral administration containing pyridazinone compounds technical field of the invention |
| CN1142779C (zh) | 1997-08-28 | 2004-03-24 | 日产化学工业株式会社 | 血管生成促进剂和血管生成增效剂 |
| RU2211217C2 (ru) * | 1998-06-05 | 2003-08-27 | Эгиш Дьёдьсердьяр Рт. | Способ получения 5-хлор-4-аминозамещенного производного 3(2н)-пиридазинона |
| KR100573376B1 (ko) | 1998-09-01 | 2006-04-25 | 닛산 가가쿠 고교 가부시키 가이샤 | 척추관 협착증 치료제 |
| CN1163230C (zh) * | 1998-12-07 | 2004-08-25 | 日产化学工业株式会社 | 勃起功能障碍治疗剂 |
| DE20009841U1 (de) * | 2000-05-31 | 2001-10-25 | Phyt-Immun GmbH, 66424 Homburg | Nasensalbe auf Basis von Vaselin |
| CA2439593C (en) * | 2001-04-05 | 2010-02-09 | Torrent Pharmaceuticals Ltd. | Heterocyclic compounds for aging-related and diabetic vascular complications |
| US20050101631A1 (en) * | 2002-08-01 | 2005-05-12 | Otsuka Pharmaceuticals Company | Process for producing carbostyril derivatives |
| US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
| KR20040007596A (ko) | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | 골절 치료 촉진용 조성물 |
| CA2447618A1 (en) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | A composition for regenerative treatment of cartilage disease |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20070027076A1 (en) * | 2003-09-09 | 2007-02-01 | Fumapham Ag | Use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
| CA2549672C (en) * | 2003-12-26 | 2010-06-22 | Nissan Chemical Industries, Ltd. | Antineutrophilia agent using 3(2h)-pyridazinone compounds |
| KR20070029133A (ko) * | 2004-02-09 | 2007-03-13 | 닛산 가가쿠 고교 가부시키 가이샤 | 혈관 내막 비후 억제약 |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CN103601792B (zh) | 2007-06-04 | 2016-06-29 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2374805A4 (en) * | 2008-12-25 | 2012-06-27 | Nissan Chemical Ind Ltd | PYRIDAZINE-3 (2H) -ONE HYDROCHLORIDE COMPOUND CRYSTALS AND METHOD FOR THE PRODUCTION THEREOF |
| ME01838B (me) | 2009-06-29 | 2014-12-20 | Lncyte Holdings Corp | Pirimidinoni kao inhibitori pi3k |
| WO2011075630A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors |
| US8759359B2 (en) * | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| EP2535048A4 (en) | 2010-02-12 | 2013-08-14 | Taisho Pharmaceutical Co Ltd | PREPARATION WITH DELAYED RELEASE |
| WO2011130342A1 (en) | 2010-04-14 | 2011-10-20 | Incyte Corporation | FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS |
| WO2011163195A1 (en) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Fused pyrrole derivatives as pi3k inhibitors |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| ES2764848T3 (es) | 2010-12-20 | 2020-06-04 | Incyte Holdings Corp | N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K |
| EP2681236B1 (en) | 2011-03-01 | 2018-01-03 | Synergy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| LT2751109T (lt) | 2011-09-02 | 2017-02-27 | Incyte Holdings Corporation | Heterociklilaminai kaip pi3k inhibitoriai |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| RS65632B1 (sr) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Ltd | Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe |
| KR20220147691A (ko) | 2013-08-09 | 2022-11-03 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
| WO2015038660A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| CN117800973A (zh) | 2015-02-27 | 2024-04-02 | 因赛特控股公司 | Pi3k抑制剂的盐及其制备方法 |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| CN107793362B (zh) * | 2016-08-30 | 2022-04-22 | 江苏恩华药业股份有限公司 | 一种苯基哒嗪酮类衍生物的合成及其应用 |
| PE20211208A1 (es) | 2018-06-01 | 2021-07-05 | Incyte Corp | Regimen de dosificacion para el tratamiento de trastornos relacionados con pi3k |
| CN114340631A (zh) | 2019-05-21 | 2022-04-12 | 阿德利克斯股份有限公司 | 用于降低患者的血清磷酸盐的组合 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2534893A1 (de) * | 1975-08-05 | 1977-02-17 | Bayer Ag | (thiono)(thiol)pyridazinonalkanphosphonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als insektizide und akarizide |
| EP0186817B1 (en) * | 1984-12-10 | 1989-08-02 | Nissan Chemical Industries Ltd. | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
| PT83530B (pt) * | 1985-10-17 | 1989-05-31 | Smith Kline French Lab | Processo de preparacao de derivados da piridona, em especial derivados fenilicos |
| HU198696B (en) * | 1987-01-20 | 1989-11-28 | Nissan Chemical Ind Ltd | Process for producing 3/2h/-pyridazinon derivatives and pharmaceutical compositions containing them as active components |
| JP2550631B2 (ja) * | 1987-01-20 | 1996-11-06 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| IE62890B1 (en) * | 1988-12-06 | 1995-03-08 | Hafslund Nycomed Pharma | New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure |
| JPH02256668A (ja) * | 1988-12-20 | 1990-10-17 | Nissan Chem Ind Ltd | ピリダジノン誘導体 |
| US5202323A (en) * | 1990-04-25 | 1993-04-13 | Nissan Chemical Industries Ltd. | 5-arylmethylamino-6-oxy-substituted 3(2h)-pyridazinones |
-
1991
- 1991-04-19 US US07/768,182 patent/US5202323A/en not_active Expired - Fee Related
- 1991-04-19 KR KR1019910701537A patent/KR970002876B1/ko not_active Expired - Lifetime
- 1991-04-19 UA UA5010505A patent/UA27031A1/uk unknown
- 1991-04-19 RU SU915010505A patent/RU2054004C1/ru active
- 1991-04-19 AU AU76511/91A patent/AU634655B2/en not_active Expired
- 1991-04-19 AT AT91907712T patent/ATE194835T1/de not_active IP Right Cessation
- 1991-04-19 EP EP91907712A patent/EP0482208B1/en not_active Expired - Lifetime
- 1991-04-19 WO PCT/JP1991/000517 patent/WO1991016314A1/ja active IP Right Grant
- 1991-04-19 ES ES91907712T patent/ES2149761T3/es not_active Expired - Lifetime
- 1991-04-19 CA CA002053863A patent/CA2053863C/en not_active Expired - Lifetime
- 1991-04-19 HU HU913497A patent/HU208124B/hu unknown
- 1991-04-19 DK DK91907712T patent/DK0482208T3/da active
- 1991-04-19 JP JP3507543A patent/JPH07107055B1/ja not_active Expired - Lifetime
- 1991-04-19 DE DE69132329T patent/DE69132329T2/de not_active Expired - Lifetime
- 1991-04-23 TW TW080103191A patent/TW204348B/zh not_active IP Right Cessation
- 1991-04-25 ZA ZA913134A patent/ZA913134B/xx unknown
-
1992
- 1992-12-21 US US07/994,413 patent/US5318968A/en not_active Expired - Fee Related
- 1992-12-21 US US07/994,404 patent/US5314883A/en not_active Expired - Lifetime
-
2000
- 2000-09-05 GR GR20000402019T patent/GR3034331T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69132329T2 (de) | 2000-11-30 |
| ES2149761T3 (es) | 2000-11-16 |
| TW204348B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-04-21 |
| HU208124B (en) | 1993-08-30 |
| EP0482208A1 (en) | 1992-04-29 |
| AU7651191A (en) | 1991-11-11 |
| DE69132329D1 (de) | 2000-08-24 |
| EP0482208A4 (en) | 1992-10-07 |
| US5314883A (en) | 1994-05-24 |
| GR3034331T3 (en) | 2000-12-29 |
| WO1991016314A1 (fr) | 1991-10-31 |
| HUT60253A (en) | 1992-08-28 |
| DK0482208T3 (da) | 2000-09-18 |
| EP0482208B1 (en) | 2000-07-19 |
| US5318968A (en) | 1994-06-07 |
| HU913497D0 (en) | 1992-01-28 |
| ZA913134B (en) | 1992-04-29 |
| US5202323A (en) | 1993-04-13 |
| KR970002876B1 (ko) | 1997-03-12 |
| CA2053863C (en) | 1996-10-29 |
| CA2053863A1 (en) | 1991-10-26 |
| UA27031A1 (uk) | 2000-02-28 |
| RU2054004C1 (ru) | 1996-02-10 |
| AU634655B2 (en) | 1993-02-25 |
| JPH07107055B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-11-15 |
| KR920701169A (ko) | 1992-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |