ATE183998T1 - Iodierte röntgenkontrastmittel - Google Patents

Iodierte röntgenkontrastmittel

Info

Publication number
ATE183998T1
ATE183998T1 AT95932109T AT95932109T ATE183998T1 AT E183998 T1 ATE183998 T1 AT E183998T1 AT 95932109 T AT95932109 T AT 95932109T AT 95932109 T AT95932109 T AT 95932109T AT E183998 T1 ATE183998 T1 AT E183998T1
Authority
AT
Austria
Prior art keywords
group
moiety
present
contrast agents
ray contrast
Prior art date
Application number
AT95932109T
Other languages
English (en)
Inventor
Torsten Almen
Sven Andersson
Lars-Goeran Wistrand
Klaes Golman
Oyvind Antonsen
Rune Fossheim
Unni Nordby Wiggen
Haekan Wikstroem
Tomas Klingstedt
Arne Berg
Harald Dugstad
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Application granted granted Critical
Publication of ATE183998T1 publication Critical patent/ATE183998T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Exposure And Positioning Against Photoresist Photosensitive Materials (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Liquid Crystal (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
AT95932109T 1994-09-23 1995-09-22 Iodierte röntgenkontrastmittel ATE183998T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9419203A GB9419203D0 (en) 1994-09-23 1994-09-23 Contrast media

Publications (1)

Publication Number Publication Date
ATE183998T1 true ATE183998T1 (de) 1999-09-15

Family

ID=10761798

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95932109T ATE183998T1 (de) 1994-09-23 1995-09-22 Iodierte röntgenkontrastmittel

Country Status (24)

Country Link
US (2) US5882628A (de)
EP (1) EP0782564B1 (de)
JP (1) JP3591840B2 (de)
CN (1) CN1069633C (de)
AT (1) ATE183998T1 (de)
AU (1) AU710330B2 (de)
CA (1) CA2200753A1 (de)
CZ (1) CZ89597A3 (de)
DE (1) DE69511883T2 (de)
DK (1) DK0782564T3 (de)
EE (1) EE03350B1 (de)
ES (1) ES2137541T3 (de)
FI (1) FI971201A (de)
GB (1) GB9419203D0 (de)
GR (1) GR3031712T3 (de)
HK (1) HK1002359A1 (de)
HU (1) HUT76894A (de)
MX (1) MX9702082A (de)
NO (1) NO971319L (de)
NZ (1) NZ292975A (de)
PL (1) PL180863B1 (de)
RU (1) RU2145955C1 (de)
SK (1) SK35697A3 (de)
WO (1) WO1996009282A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB9828103D0 (en) * 1998-12-18 1999-02-17 Nycomed Imaging As Process
US6448442B1 (en) * 1999-04-30 2002-09-10 Amersham Health As Contrast media
US6685733B1 (en) * 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
DE10332552B3 (de) * 2003-07-14 2005-03-24 Schering Ag Verfahren zur Herstellung von Triiodtrimesinsäure
US7083516B2 (en) 2003-07-14 2006-08-01 Schering Ag Process for the production of triiodotrimesic acid
US7166740B2 (en) 2003-07-14 2007-01-23 Schering Ag Process for the production of triiodotrimesic acid
DE10332574B3 (de) * 2003-07-14 2005-04-14 Schering Ag Verfahren zur Herstellung von Triiodtrimesinsäure
US20060115437A1 (en) * 2004-11-26 2006-06-01 Robert Hayman Dental whitening compositions
US20080050408A1 (en) * 2004-11-26 2008-02-28 Discus Dental, Llc Dental Whitening Compositions
WO2007133088A1 (en) * 2006-05-11 2007-11-22 Ge Healthcare As Contrast agents
JP5340281B2 (ja) 2007-07-12 2013-11-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
EP2245004A2 (de) * 2008-02-27 2010-11-03 GE Healthcare AS Kontrastmittel
WO2009106552A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents
CN102067024B (zh) * 2008-06-17 2013-08-07 日产化学工业株式会社 液晶取向处理剂及使用了该处理剂的液晶显示元件、以及新的二胺
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
RU2544113C2 (ru) * 2009-10-29 2015-03-10 ДжиИ Хелткер АС Диагностическая композиция, содержащая катионы плазмы крови, обладающая превосходным профилем безопасности
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN104114190A (zh) * 2012-01-11 2014-10-22 通用电气医疗集团股份有限公司 具有低碘浓度的x-射线成像造影介质和x-射线成像方法
KR102172700B1 (ko) * 2012-11-12 2020-11-03 지이 헬스케어 에이에스 X-선 조영제의 중간체의 제조 방법
CN103274910B (zh) * 2013-05-27 2015-03-18 陕西师范大学 一种合成均苯三甲醛类化合物的方法
CN106366015B (zh) * 2015-07-22 2019-01-25 正大天晴药业集团股份有限公司 一种碘普罗胺的制备方法及其中间体
CN106366016B (zh) * 2015-07-22 2019-03-05 连云港润众制药有限公司 一种碘普罗胺的制备方法及其中间体
CN108191695B (zh) * 2017-12-08 2019-03-08 牡丹江医学院 一种用于ct的新型造影剂

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
CH576255A5 (de) * 1972-11-17 1976-06-15 Bracco Ind Chimica Spa
US4314055A (en) * 1975-09-29 1982-02-02 Mallinckrodt, Inc. 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3001292A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
ATE79368T1 (de) * 1987-05-22 1992-08-15 Bracco Spa Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
FR2673180B1 (fr) * 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
WO1993010078A1 (es) * 1991-11-18 1993-05-27 Centro Investigacion Justesa Imagen S.A. Nuevos agentes yodados no ionicos de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
FR2695125B1 (fr) * 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
NZ250063A (en) * 1992-12-14 1996-03-26 Eastman Kodak Co Iodinated aromatic acid ester derivatives; x-ray contrast compositions
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
US5308607A (en) * 1993-02-04 1994-05-03 Sterling Winthrop Inc. Compositions of alkylbenzenes for visualization of the gastrointestinal tract using X-ray contrast
JPH09505813A (ja) * 1993-12-03 1997-06-10 ブラッコ エッセ．ピ．ア． ビフェニル沃素化誘導体及びその診断用途
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
IT1271134B (it) * 1994-12-01 1997-05-26 Bracco Spa Derivati iodurati del bifenile e loro impiego diagnostico

Also Published As

Publication number Publication date
US5993780A (en) 1999-11-30
EP0782564B1 (de) 1999-09-01
DE69511883T2 (de) 2000-02-24
NO971319L (no) 1997-08-11
HUT76894A (en) 1997-12-29
JP3591840B2 (ja) 2004-11-24
FI971201A0 (fi) 1997-03-21
DE69511883D1 (de) 1999-10-07
CA2200753A1 (en) 1996-03-28
NZ292975A (en) 1999-02-25
CN1166826A (zh) 1997-12-03
US5882628A (en) 1999-03-16
DK0782564T3 (da) 1999-12-13
AU710330B2 (en) 1999-09-16
JPH10505857A (ja) 1998-06-09
GR3031712T3 (en) 2000-02-29
CZ89597A3 (en) 1997-10-15
PL180863B1 (pl) 2001-04-30
CN1069633C (zh) 2001-08-15
NO971319D0 (no) 1997-03-20
EP0782564A1 (de) 1997-07-09
RU2145955C1 (ru) 2000-02-27
WO1996009282A1 (en) 1996-03-28
HK1002359A1 (en) 1998-08-21
MX9702082A (es) 1997-06-28
SK35697A3 (en) 1997-11-05
GB9419203D0 (en) 1994-11-09
PL319341A1 (en) 1997-08-04
EE03350B1 (et) 2001-02-15
ES2137541T3 (es) 1999-12-16
FI971201A (fi) 1997-03-21
AU3529495A (en) 1996-04-09

Similar Documents

Publication Publication Date Title
DE69511883D1 (de) Iodierte röntgenkontrastmittel
KR880008986A (ko) D 계열 프로스타글란딘, 및 그를 함유하는 정신안정제와 최면제
KR900009935A (ko) 액정 조성물
KR920021506A (ko) 19-노르 비타민 d 화합물 합성용 중간체
DE69022675D1 (de) Flüssigkristallzusammensetzung.
KR940021059A (ko) 지질 대사 개선제
NO924980L (no) Endeavsluttede polyalkyenglykoler
EP0781667A3 (de) Reversibele thermochromische Zusammensetzung
ATE298320T1 (de) Kontrastmittel
FR2391492A1 (fr) Matieres photopolymerisables ameliorees pour la fabrication de cliches et de formes en relief
KR960001088A (ko) 액정 조성물 및 액정 표시 장치
NO971318L (no) Jodiserte röntgenkontrastmidler
DK606286A (da) Anthracyclin-derivater og laegemidler indeholdende disse forbindelser
KR940014279A (ko) 아이오드화 습윤제
WO2004071376A3 (en) Oral care composition comprising an antimicrobial agent

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee