ATE168674T1 - Neue perhydroisoindolderivate und ihre herstellung - Google Patents

Neue perhydroisoindolderivate und ihre herstellung

Info

Publication number
ATE168674T1
ATE168674T1 AT93909004T AT93909004T ATE168674T1 AT E168674 T1 ATE168674 T1 AT E168674T1 AT 93909004 T AT93909004 T AT 93909004T AT 93909004 T AT93909004 T AT 93909004T AT E168674 T1 ATE168674 T1 AT E168674T1
Authority
AT
Austria
Prior art keywords
radical
pct
date oct
derivatives
sec
Prior art date
Application number
AT93909004T
Other languages
English (en)
Inventor
Daniel Achard
Serge Grisoni
Jean-Luc Malleron
Jean-Francois Peyronel
Michel Tabart
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE168674T1 publication Critical patent/ATE168674T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93909004T 1992-04-10 1993-04-08 Neue perhydroisoindolderivate und ihre herstellung ATE168674T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR929204391A FR2689889B1 (fr) 1992-04-10 1992-04-10 Nouveaux derives de perhydroisoindole, et leur preparation.

Publications (1)

Publication Number Publication Date
ATE168674T1 true ATE168674T1 (de) 1998-08-15

Family

ID=9428708

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93909004T ATE168674T1 (de) 1992-04-10 1993-04-08 Neue perhydroisoindolderivate und ihre herstellung

Country Status (23)

Country Link
US (1) US5463077A (de)
EP (1) EP0635002B1 (de)
JP (1) JPH07505409A (de)
KR (1) KR950700879A (de)
AT (1) ATE168674T1 (de)
AU (1) AU667365B2 (de)
CA (1) CA2133841A1 (de)
CZ (1) CZ284596B6 (de)
DE (1) DE69319902T2 (de)
DK (1) DK0635002T3 (de)
ES (1) ES2118954T3 (de)
FI (1) FI105022B (de)
FR (1) FR2689889B1 (de)
HU (1) HUT71330A (de)
IL (2) IL105256A (de)
MX (1) MX9301985A (de)
NO (1) NO300418B1 (de)
PL (1) PL172753B1 (de)
RU (1) RU2120438C1 (de)
SK (1) SK122194A3 (de)
TW (1) TW224969B (de)
WO (1) WO1993021154A1 (de)
ZA (1) ZA932528B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689888B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
CN100391945C (zh) * 2005-05-31 2008-06-04 浙江大学 一种s-(-)-吲哚啉-2-羧酸的合成方法
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
AU2019223237A1 (en) 2018-02-26 2020-09-03 Ospedale San Raffaele S.R.L. NK-1 antagonists for use in the treatment of ocular pain
WO2021180885A1 (en) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
DE3617183A1 (de) * 1985-11-16 1987-05-27 Bayer Ag Substituierte benzylether
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2654726B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone et leur preparation.
FR2676443B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole et leur preparation.

Also Published As

Publication number Publication date
HUT71330A (en) 1995-11-28
US5463077A (en) 1995-10-31
HU9402912D0 (en) 1995-01-30
KR950700879A (ko) 1995-02-20
NO943738D0 (no) 1994-10-05
IL105256A0 (en) 1993-08-18
DE69319902T2 (de) 1999-03-18
ZA932528B (en) 1993-10-28
CA2133841A1 (fr) 1993-10-28
EP0635002B1 (de) 1998-07-22
NO300418B1 (no) 1997-05-26
FI944728A (fi) 1994-10-07
DK0635002T3 (da) 1999-02-22
JPH07505409A (ja) 1995-06-15
RU2120438C1 (ru) 1998-10-20
FI105022B (fi) 2000-05-31
IL105256A (en) 1997-08-14
PL172753B1 (en) 1997-11-28
AU667365B2 (en) 1996-03-21
RU94045867A (ru) 1996-09-10
EP0635002A1 (de) 1995-01-25
TW224969B (de) 1994-06-11
NO943738L (no) 1994-10-05
CZ284596B6 (cs) 1999-01-13
ES2118954T3 (es) 1998-10-01
AU3956493A (en) 1993-11-18
DE69319902D1 (de) 1998-08-27
WO1993021154A1 (fr) 1993-10-28
FR2689889B1 (fr) 1994-06-10
MX9301985A (es) 1994-05-31
SK122194A3 (en) 1995-05-10
FI944728A0 (fi) 1994-10-07
FR2689889A1 (fr) 1993-10-15
CZ248394A3 (en) 1995-11-15

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