ATE167662T1 - Verfahren zur herstellung eines lignan-derivats - Google Patents
Verfahren zur herstellung eines lignan-derivatsInfo
- Publication number
- ATE167662T1 ATE167662T1 AT94912092T AT94912092T ATE167662T1 AT E167662 T1 ATE167662 T1 AT E167662T1 AT 94912092 T AT94912092 T AT 94912092T AT 94912092 T AT94912092 T AT 94912092T AT E167662 T1 ATE167662 T1 AT E167662T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- general formula
- producing
- lower alkyl
- cycloalkyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 lignan compound Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000007259 addition reaction Methods 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229930013686 lignan Natural products 0.000 abstract 1
- 235000009408 lignans Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8994493 | 1993-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE167662T1 true ATE167662T1 (de) | 1998-07-15 |
Family
ID=13984820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94912092T ATE167662T1 (de) | 1993-04-16 | 1994-04-12 | Verfahren zur herstellung eines lignan-derivats |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5488134A (enFirst) |
| EP (1) | EP0646570B1 (enFirst) |
| JP (1) | JP3411036B2 (enFirst) |
| KR (1) | KR100277242B1 (enFirst) |
| CN (1) | CN1046937C (enFirst) |
| AT (1) | ATE167662T1 (enFirst) |
| AU (1) | AU666819B2 (enFirst) |
| CA (1) | CA2138264C (enFirst) |
| DE (1) | DE69411243T2 (enFirst) |
| DK (1) | DK0646570T3 (enFirst) |
| ES (1) | ES2119190T3 (enFirst) |
| TW (1) | TW255886B (enFirst) |
| WO (1) | WO1994024087A1 (enFirst) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2121060C (en) * | 1993-04-16 | 2004-04-06 | Sachio Mori | Preparation of lignan analogues |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| KR100376281B1 (ko) * | 1995-12-26 | 2003-09-26 | 에스케이케미칼주식회사 | 리그난의 제조방법 |
| RU2198885C2 (ru) | 1997-09-29 | 2003-02-20 | Мейдзи Сейка Кайся Лтд. | Производные трициклического триазолобензазепина, способы их получения, фармацевтическая композиция и способ лечения аллергических заболеваний, промежуточные соединения и способы их получения |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| EP1140190B1 (en) | 1998-12-23 | 2002-11-20 | G.D. Searle LLC. | Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications |
| ATE240120T1 (de) | 1998-12-23 | 2003-05-15 | Searle Llc | Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| IL143949A0 (en) | 1998-12-23 | 2002-04-21 | Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
| DK1140185T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer |
| WO2000038726A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
| WO2000038721A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| US20020061888A1 (en) * | 2000-03-10 | 2002-05-23 | Keller Bradley T. | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| HK1052183A1 (zh) | 2000-03-10 | 2003-09-05 | Pharmacia Corporation | 制造tetrahydrobenzothiepines的方法 |
| JP2005518347A (ja) | 2001-11-02 | 2005-06-23 | ジー．ディー． サール エルエルシー | 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物 |
| BR0306643A (pt) | 2002-01-17 | 2004-10-19 | Pharmacia Corp | Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| EP4137137A1 (en) | 2010-05-26 | 2023-02-22 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US20140323412A1 (en) | 2011-10-28 | 2014-10-30 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| SG10201909122QA (en) | 2011-10-28 | 2019-11-28 | Lumena Pharmaceuticals Inc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| CA2907214A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| JP7562546B2 (ja) | 2019-02-12 | 2024-10-07 | ミルム ファーマシューティカルズ インコーポレイテッド | 胆汁うっ滞性肝疾患を有する小児対象の成長を増加させる方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0372422A (ja) * | 1989-05-16 | 1991-03-27 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
| JPH03157351A (ja) * | 1989-11-13 | 1991-07-05 | Tanabe Seiyaku Co Ltd | ナフタレン誘導体及びその製法 |
| DK0701991T3 (da) * | 1991-10-17 | 1999-09-13 | Shionogi & Co | Fremgangsmåde til fremstilling af lignananaloger og udgangsmaterialer dertil |
-
1994
- 1994-04-12 AT AT94912092T patent/ATE167662T1/de not_active IP Right Cessation
- 1994-04-12 AU AU64379/94A patent/AU666819B2/en not_active Ceased
- 1994-04-12 KR KR1019940704565A patent/KR100277242B1/ko not_active Expired - Fee Related
- 1994-04-12 ES ES94912092T patent/ES2119190T3/es not_active Expired - Lifetime
- 1994-04-12 WO PCT/JP1994/000612 patent/WO1994024087A1/ja not_active Ceased
- 1994-04-12 DK DK94912092T patent/DK0646570T3/da active
- 1994-04-12 JP JP52298294A patent/JP3411036B2/ja not_active Expired - Fee Related
- 1994-04-12 EP EP94912092A patent/EP0646570B1/en not_active Expired - Lifetime
- 1994-04-12 DE DE69411243T patent/DE69411243T2/de not_active Expired - Fee Related
- 1994-04-12 CN CN94190286A patent/CN1046937C/zh not_active Expired - Fee Related
- 1994-04-12 CA CA002138264A patent/CA2138264C/en not_active Expired - Fee Related
- 1994-04-12 US US08/356,199 patent/US5488134A/en not_active Expired - Fee Related
- 1994-04-18 TW TW083103432A patent/TW255886B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2119190T3 (es) | 1998-10-01 |
| JP3411036B2 (ja) | 2003-05-26 |
| AU6437994A (en) | 1994-11-08 |
| KR950701902A (ko) | 1995-05-17 |
| KR100277242B1 (ko) | 2001-02-01 |
| DE69411243T2 (de) | 1998-11-19 |
| CA2138264A1 (en) | 1994-10-27 |
| DE69411243D1 (de) | 1998-07-30 |
| EP0646570A1 (en) | 1995-04-05 |
| US5488134A (en) | 1996-01-30 |
| AU666819B2 (en) | 1996-02-22 |
| CN1046937C (zh) | 1999-12-01 |
| CN1109685A (zh) | 1995-10-04 |
| EP0646570A4 (en) | 1995-08-09 |
| WO1994024087A1 (fr) | 1994-10-27 |
| CA2138264C (en) | 2004-04-06 |
| TW255886B (enFirst) | 1995-09-01 |
| EP0646570B1 (en) | 1998-06-24 |
| DK0646570T3 (da) | 1998-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |