ATE164588T1 - Triterpenderivat - Google Patents

Triterpenderivat

Info

Publication number
ATE164588T1
ATE164588T1 AT92900597T AT92900597T ATE164588T1 AT E164588 T1 ATE164588 T1 AT E164588T1 AT 92900597 T AT92900597 T AT 92900597T AT 92900597 T AT92900597 T AT 92900597T AT E164588 T1 ATE164588 T1 AT E164588T1
Authority
AT
Austria
Prior art keywords
hydrogen
triterpene derivative
formula
antiendotheline
chem
Prior art date
Application number
AT92900597T
Other languages
German (de)
English (en)
Inventor
Masafumi Fujimoto
Kensuke Sakurai
Shinichi Mihara
Miharu Nakamura
Toshiro Konoike
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE164588T1 publication Critical patent/ATE164588T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
AT92900597T 1991-01-29 1991-12-13 Triterpenderivat ATE164588T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2937291 1991-01-29

Publications (1)

Publication Number Publication Date
ATE164588T1 true ATE164588T1 (de) 1998-04-15

Family

ID=12274319

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92900597T ATE164588T1 (de) 1991-01-29 1991-12-13 Triterpenderivat

Country Status (8)

Country Link
US (1) US5248807A (cg-RX-API-DMAC7.html)
EP (1) EP0526642B1 (cg-RX-API-DMAC7.html)
JP (1) JP2950616B2 (cg-RX-API-DMAC7.html)
AT (1) ATE164588T1 (cg-RX-API-DMAC7.html)
DE (1) DE69129193T2 (cg-RX-API-DMAC7.html)
DK (1) DK0526642T3 (cg-RX-API-DMAC7.html)
ES (1) ES2115665T3 (cg-RX-API-DMAC7.html)
WO (1) WO1992012991A1 (cg-RX-API-DMAC7.html)

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US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5736509A (en) * 1990-12-14 1998-04-07 Texas Biotechnology Corporation Cyclic peptide surface feature mimics of endothelin
AU4376893A (en) * 1992-05-19 1993-12-13 Immunopharmaceutics, Inc. Compounds that modulate endothelin activity
US5352800A (en) * 1993-03-11 1994-10-04 Merck & Co., Inc. Process for the production of a novel endothelin antagonist
US5401745A (en) * 1993-03-19 1995-03-28 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5334598A (en) * 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5527890A (en) * 1993-04-16 1996-06-18 Glycomed Incorporated Derivatives of triterpenoid acids and uses thereof
FI941826A7 (fi) * 1993-04-21 1994-10-22 Takeda Chemical Industries Ltd Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
DE69410081T2 (de) * 1993-06-11 1998-10-08 Shionogi & Co Zwischenprodukte für die Herstellung von Endothelinrezeptor-Antagonist-Triterpen-Derivaten
JP3373591B2 (ja) 1993-06-11 2003-02-04 塩野義製薬株式会社 硫酸化トリテルペン誘導体およびそれを含有するエンドセリンレセプター拮抗剤
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
CN1034334C (zh) * 1993-08-14 1997-03-26 贵州省中医研究所 齐酞酸钠及其药物组合物
US5492917A (en) * 1993-09-29 1996-02-20 Merck & Co., Inc. Endothelin antagonists incorporating a cyclobutane
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
PT838223E (pt) * 1995-06-02 2003-12-31 Shionogi & Co Inibidor do edema cerebral
US5977117A (en) 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
JP3455233B2 (ja) 1997-04-28 2003-10-14 テキサス・バイオテクノロジー・コーポレイシヨン エンドテリン介在障害治療用のスルホンアミド類
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
EP1244657B1 (en) 1999-12-31 2004-12-29 Encysive Pharmaceuticals Inc. Sulfonamides and derivatives thereof that modulate the activity of endothelin
AU2003221074A1 (en) * 2002-03-22 2003-10-08 Shionogi And Co., Ltd. Process for producing triterpene derivative
US20050175667A1 (en) * 2004-02-10 2005-08-11 Wenda Carlyle Use of endothelin antagonists to prevent restenosis
US8017793B2 (en) * 2004-05-14 2011-09-13 Shionogi & Co., Ltd. Oxidation of alcohol with use of hydrogen peroxide and tungsten catalyst
MX2007007517A (es) * 2004-12-21 2007-09-04 Dow Global Technologies Inc Composiciones de adhesivo con base en polipropileno.
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US7795306B2 (en) * 2006-03-03 2010-09-14 Inderjit Kumar Dev Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of NF-κB
AU2007225139A1 (en) * 2006-03-13 2007-09-20 Encysive Pharmaceuticals, Inc. Methods and compositions for treatment of diastolic heart failure
JP2009530280A (ja) * 2006-03-13 2009-08-27 エンサイシブ・ファーマシューティカルズ・インコーポレイテッド シタクスセンタンナトリウムの配合物
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases
ME03529B (me) 2008-01-11 2020-04-20 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
BRPI0911208B1 (pt) 2008-04-18 2021-05-25 Reata Pharmaceuticals, Inc Compostos moduladores inflamatórios antioxidantes, seu uso, e composição farmacêutica
CN103342729B (zh) * 2013-03-26 2016-09-14 中国科学院上海药物研究所 咖啡酰基取代的五环三萜类衍生物及其用途
CN110198718B (zh) 2016-11-08 2023-01-10 里亚塔医药控股有限责任公司 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法
WO2019134982A1 (en) 2018-01-04 2019-07-11 Amryt Research Limited Betulin-containing birch bark extracts and their formulation

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Publication number Priority date Publication date Assignee Title
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
JPS63222119A (ja) * 1987-03-10 1988-09-16 Rooman Kogyo:Kk 肝臓疾患用剤
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Also Published As

Publication number Publication date
JP2950616B2 (ja) 1999-09-20
ES2115665T3 (es) 1998-07-01
DE69129193D1 (en) 1998-05-07
EP0526642A1 (en) 1993-02-10
DK0526642T3 (da) 1998-10-19
EP0526642B1 (en) 1998-04-01
US5248807A (en) 1993-09-28
EP0526642A4 (cg-RX-API-DMAC7.html) 1994-02-09
DE69129193T2 (de) 1998-07-30
WO1992012991A1 (fr) 1992-08-06

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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time