ATE154594T1 - Substituierte phenylsulfonamine als selektive b3- agonisten zur behandlung von diabetes und fettleibigkeit - Google Patents

Substituierte phenylsulfonamine als selektive b3- agonisten zur behandlung von diabetes und fettleibigkeit

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Publication number
ATE154594T1
ATE154594T1 AT94200303T AT94200303T ATE154594T1 AT E154594 T1 ATE154594 T1 AT E154594T1 AT 94200303 T AT94200303 T AT 94200303T AT 94200303 T AT94200303 T AT 94200303T AT E154594 T1 ATE154594 T1 AT E154594T1
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Austria
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compounds
levels
obesity
diabetes
treatment
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AT94200303T
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English (en)
Inventor
Michael H Fisher
Emma R Parmee
Robert J Mathvink
Ann E Weber
Hyun O Ok
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Merck & Co Inc
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Publication of ATE154594T1 publication Critical patent/ATE154594T1/de

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
AT94200303T 1993-02-09 1994-02-03 Substituierte phenylsulfonamine als selektive b3- agonisten zur behandlung von diabetes und fettleibigkeit ATE154594T1 (de)

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US1568993A 1993-02-09 1993-02-09
US08/168,105 US5451677A (en) 1993-02-09 1993-12-15 Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity

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ATE154594T1 true ATE154594T1 (de) 1997-07-15

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EP (1) EP0611003B1 (de)
JP (1) JP2690006B2 (de)
AT (1) ATE154594T1 (de)
AU (1) AU670477B2 (de)
CA (1) CA2114712A1 (de)
DE (1) DE69403823T2 (de)
DK (1) DK0611003T3 (de)
ES (1) ES2104259T3 (de)
GR (1) GR3024672T3 (de)
IL (1) IL108507A (de)
WO (1) WO1994018161A1 (de)
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US5451677A (en) 1995-09-19
ZA94846B (en) 1994-09-05
DE69403823T2 (de) 1998-01-29
GR3024672T3 (en) 1997-12-31
AU5498694A (en) 1995-06-29
EP0611003A1 (de) 1994-08-17
IL108507A0 (en) 1994-05-30
DE69403823D1 (de) 1997-07-24
EP0611003B1 (de) 1997-06-18
WO1994018161A1 (en) 1994-08-18
CA2114712A1 (en) 1994-08-10
DK0611003T3 (da) 1997-08-25
AU670477B2 (en) 1996-07-18
JPH0710827A (ja) 1995-01-13
JP2690006B2 (ja) 1997-12-10
ES2104259T3 (es) 1997-10-01
IL108507A (en) 1998-09-24

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