ATE141921T1 - Methode zur herstellung von alpha, beta ungesättigten ketolactonen - Google Patents
Methode zur herstellung von alpha, beta ungesättigten ketolactonenInfo
- Publication number
- ATE141921T1 ATE141921T1 AT92302992T AT92302992T ATE141921T1 AT E141921 T1 ATE141921 T1 AT E141921T1 AT 92302992 T AT92302992 T AT 92302992T AT 92302992 T AT92302992 T AT 92302992T AT E141921 T1 ATE141921 T1 AT E141921T1
- Authority
- AT
- Austria
- Prior art keywords
- beta unsaturated
- producing alpha
- ketolactones
- unsaturated ketolactones
- beta
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229910000102 alkali metal hydride Inorganic materials 0.000 abstract 1
- 150000008046 alkali metal hydrides Chemical class 0.000 abstract 1
- -1 bicyclolactone aldehyde Chemical class 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 150000003752 zinc compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7148391 | 1991-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE141921T1 true ATE141921T1 (de) | 1996-09-15 |
Family
ID=13461939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92302992T ATE141921T1 (de) | 1991-04-04 | 1992-04-03 | Methode zur herstellung von alpha, beta ungesättigten ketolactonen |
Country Status (11)
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0643051T3 (da) * | 1992-09-30 | 2000-04-17 | R Tech Ueno Ltd | Fremgangsmåde til fremstilling af alfa,beta-umættede ketoner |
CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
JP4358940B2 (ja) * | 1999-08-26 | 2009-11-04 | 丸善石油化学株式会社 | シクロヘキサンラクトン構造を有する重合性化合物及び重合体 |
CA2307393A1 (en) | 2000-05-01 | 2001-11-01 | The University Of British Columbia | Ginsenoside chemotherapy |
US20030157170A1 (en) * | 2001-03-13 | 2003-08-21 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
US20030054036A1 (en) * | 2001-03-13 | 2003-03-20 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
JP2004532847A (ja) * | 2001-04-20 | 2004-10-28 | ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア | 疎水性薬物のためのミセル薬物送達システム |
US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
DE10220729A1 (de) * | 2002-05-08 | 2003-11-20 | Martin Foerster | Verfahren zum Bestimmen einer von Tieren gesoffenen Menge an flüssigen Nahrungsmitteln |
US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
DE60331367D1 (de) | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
US20070172446A1 (en) | 2003-05-16 | 2007-07-26 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
US7407973B2 (en) * | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
US7846940B2 (en) * | 2004-03-31 | 2010-12-07 | Cordis Corporation | Solution formulations of sirolimus and its analogs for CAD treatment |
US8003122B2 (en) * | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
US7989490B2 (en) | 2004-06-02 | 2011-08-02 | Cordis Corporation | Injectable formulations of taxanes for cad treatment |
AU2005273968A1 (en) * | 2004-08-09 | 2006-02-23 | Alios Biopharma Inc. | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
WO2006089209A2 (en) * | 2005-02-17 | 2006-08-24 | The Board Of Trustees Of The Leland Stanford Junior University | Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby |
US20070073385A1 (en) * | 2005-09-20 | 2007-03-29 | Cook Incorporated | Eluting, implantable medical device |
CA2637797C (en) * | 2006-02-07 | 2015-03-17 | R-Tech Ueno, Ltd. | Method for preparing prostaglandin derivative |
MX2008011978A (es) | 2006-03-22 | 2009-04-22 | Medigene Ag | Tratamiento del cancer de seno negativo al triple receptor. |
WO2008005284A2 (en) | 2006-06-30 | 2008-01-10 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
US20080241215A1 (en) * | 2007-03-28 | 2008-10-02 | Robert Falotico | Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke |
US8409601B2 (en) * | 2008-03-31 | 2013-04-02 | Cordis Corporation | Rapamycin coated expandable devices |
US8420110B2 (en) | 2008-03-31 | 2013-04-16 | Cordis Corporation | Drug coated expandable devices |
US8273404B2 (en) * | 2008-05-19 | 2012-09-25 | Cordis Corporation | Extraction of solvents from drug containing polymer reservoirs |
WO2009143454A2 (en) | 2008-05-22 | 2009-11-26 | Kereos, Inc. | Combination antitumor therapy |
EP2310507A4 (en) | 2008-07-08 | 2013-03-20 | David Gladstone Inst | METHOD AND COMPOSITIONS FOR ANGIOGENIC MODULATION |
US8642063B2 (en) | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
US8513441B2 (en) * | 2008-08-29 | 2013-08-20 | Alphora Research Inc. | Prostaglandin synthesis and intermediates for use therein |
ES2477552T3 (es) | 2008-09-08 | 2014-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos |
US9198968B2 (en) | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8389522B2 (en) | 2008-10-28 | 2013-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase and methods of use thereof |
CA2750487A1 (en) | 2009-01-22 | 2010-07-29 | Apotex Pharmachem Inc. | Methods of making lubiprostone and intermediates thereof |
US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
US20120303115A1 (en) | 2011-05-25 | 2012-11-29 | Dadino Ronald C | Expandable devices coated with a rapamycin composition |
US20120302954A1 (en) | 2011-05-25 | 2012-11-29 | Zhao Jonathon Z | Expandable devices coated with a paclitaxel composition |
US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
CN104582717B (zh) | 2012-07-19 | 2018-03-13 | 雷德伍德生物科技股份有限公司 | 对cd22有特异性的抗体及其使用方法 |
JP2016500058A (ja) | 2012-11-12 | 2016-01-07 | レッドウッド バイオサイエンス, インコーポレイテッド | 化合物および抱合体を生成するための方法 |
LT2956175T (lt) | 2013-02-15 | 2017-12-11 | The Regents Of The University Of California | Chimerinis antigeno receptorius ir jo panaudojimo būdai |
EP2970124B1 (en) | 2013-03-14 | 2019-05-22 | The Board of Trustees of the Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
WO2015081282A1 (en) | 2013-11-27 | 2015-06-04 | Redwood Bioscience, Inc. | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate |
PL3107899T3 (pl) | 2014-02-19 | 2021-01-25 | Aviv Therapeutics, Inc. | Policykliczne amidy wiążące mitochondrialną dehydrogenazę aldehydową-2 (aldh2) i ich zastosowanie w leczeniu nowotworów |
CN108135917B (zh) | 2015-09-25 | 2021-07-09 | Zy医疗 | 基于包含多糖-维生素缀合物的颗粒的药物制剂 |
US10654875B2 (en) | 2015-11-12 | 2020-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery |
TWI760319B (zh) | 2015-12-30 | 2022-04-11 | 杏國新藥股份有限公司 | 乳癌治療 |
KR20180135458A (ko) | 2016-04-26 | 2018-12-20 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 항체 컨쥬게이트 및 이의 제조 및 이용 방법 |
DK3463308T3 (da) | 2016-06-01 | 2022-01-31 | Servier Ip Uk Ltd | Formuleringer af polyalkylenoxid-asparaginase og fremgangsmåder til fremstilling og anvendelse deraf |
TWI852903B (zh) | 2017-01-05 | 2024-08-21 | 杏國新藥股份有限公司 | 胰臟癌治療 |
KR20190130559A (ko) | 2017-01-18 | 2019-11-22 | 에프1 온콜로지, 인코포레이티드 | Axl 또는 ror2에 대한 키메라 항원 수용체 및 이의 사용 방법 |
EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
CN111065623B9 (zh) | 2017-05-24 | 2024-10-25 | 德克萨斯州大学系统董事会 | 用于抗体药物缀合物的接头 |
EA202091832A1 (ru) | 2018-01-31 | 2021-01-11 | ГАЛЕРА ЛЭБЗ, ЭлЭлСи | Комбинированная терапия злокачественных новообразований макроциклическим кольцевым комплексом пентаазы и противоопухолевым агентом на основе платины |
WO2019195596A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating glioblastomas |
AU2019249215A1 (en) | 2018-04-06 | 2020-10-22 | The Regents Of The University Of California | Methods of treating EGFRvIII expressing glioblastomas |
WO2019200181A1 (en) | 2018-04-11 | 2019-10-17 | Ohio State Innovation Foundation | Methods and compositions for sustained release microparticles for ocular drug delivery |
CA3105879A1 (en) | 2018-07-18 | 2020-01-23 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
TW202038994A (zh) | 2019-01-14 | 2020-11-01 | 美商醫格耐免疫治療公司 | 重組痘瘡病毒及其使用方法 |
WO2020165730A1 (en) | 2019-02-14 | 2020-08-20 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
KR20220004653A (ko) | 2019-04-02 | 2022-01-11 | 켄조케티 바이오테크놀러지 인코포레이티드 | 유출 펌프-암 항원 다중특이적 항체 및 그것과 관련된 조성물, 시약, 키트 및 방법 |
BR112022011158A2 (pt) | 2019-12-12 | 2022-08-30 | Ignite Immunotherapy Inc | Vírus vaccinia oncolítico variante e métodos de uso do mesmo |
CN115023443A (zh) | 2020-01-29 | 2022-09-06 | 肯乔克蒂生物技术股份有限公司 | 抗mdr1抗体及其用途 |
AU2021284240A1 (en) | 2020-06-04 | 2022-12-08 | William Robert ARATHOON | Anti-ABCG2 antibodies and uses thereof |
CA3182969A1 (en) | 2020-06-04 | 2021-12-09 | Kenjockety Biotechnology, Inc. | Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
BR112023000650A2 (pt) | 2020-07-14 | 2023-01-31 | Pfizer | Vírus vaccinia recombinante |
JP2023539883A (ja) | 2020-09-02 | 2023-09-20 | ケンジョッケティ バイオテクノロジー,インク. | 抗abcc1抗体及びその使用 |
US20240010747A1 (en) | 2020-11-13 | 2024-01-11 | Kenjockety Biotechnology, Inc. | Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof |
EP4247829A1 (en) | 2020-11-20 | 2023-09-27 | R.P. Scherer Technologies, LLC | Glycoside dual-cleavage linkers for antibody-drug conjugates |
AU2022413942A1 (en) | 2021-12-13 | 2024-05-30 | William Robert Arathoon Living Trust Dated August 29, 2016 | Anti-abcb1 antibodies |
WO2023159220A1 (en) | 2022-02-18 | 2023-08-24 | Kenjockety Biotechnology, Inc. | Anti-cd47 antibodies |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4032576A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1976-01-08 | 1977-06-28 | ||
DE2655004C3 (de) * | 1976-12-02 | 1980-06-19 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von bicyclischen Laktonen |
EP0219580B1 (en) * | 1985-09-18 | 1989-11-29 | The Upjohn Company | Stereo-selective reduction |
JPS62153259A (ja) * | 1985-12-26 | 1987-07-08 | Sagami Chem Res Center | (2−クロロ−3−オキソ−1−アルケニル)−ビシクロ〔3.3.0〕オクテン誘導体及びその製法 |
DE3620442A1 (de) * | 1986-06-18 | 1987-12-23 | Merck Patent Gmbh | Ketolactone |
EP0394263B1 (en) * | 1987-09-04 | 1994-03-16 | The Upjohn Company | Process for production of prostaglandin intermediates |
-
1992
- 1992-03-28 TW TW081102387A patent/TW197439B/zh active
- 1992-03-30 JP JP4073782A patent/JPH089608B2/ja not_active Expired - Lifetime
- 1992-03-31 CA CA002064481A patent/CA2064481C/en not_active Expired - Fee Related
- 1992-04-01 US US07/861,518 patent/US5229529A/en not_active Expired - Lifetime
- 1992-04-03 DK DK92302992.0T patent/DK0507625T3/da active
- 1992-04-03 DE DE69213067T patent/DE69213067T2/de not_active Expired - Fee Related
- 1992-04-03 AT AT92302992T patent/ATE141921T1/de not_active IP Right Cessation
- 1992-04-03 EP EP92302992A patent/EP0507625B1/en not_active Expired - Lifetime
- 1992-04-03 ES ES92302992T patent/ES2093776T3/es not_active Expired - Lifetime
- 1992-04-04 KR KR1019920005662A patent/KR970003125B1/ko not_active Expired - Fee Related
-
1996
- 1996-08-29 GR GR960402124T patent/GR3020903T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR920019771A (ko) | 1992-11-20 |
KR970003125B1 (ko) | 1997-03-14 |
DK0507625T3 (da) | 1996-09-16 |
DE69213067T2 (de) | 1997-01-16 |
EP0507625B1 (en) | 1996-08-28 |
CA2064481C (en) | 1996-12-24 |
DE69213067D1 (de) | 1996-10-02 |
JPH0592965A (ja) | 1993-04-16 |
CA2064481A1 (en) | 1992-10-05 |
US5229529A (en) | 1993-07-20 |
JPH089608B2 (ja) | 1996-01-31 |
TW197439B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-01-01 |
ES2093776T3 (es) | 1997-01-01 |
GR3020903T3 (en) | 1996-11-30 |
EP0507625A1 (en) | 1992-10-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE141921T1 (de) | Methode zur herstellung von alpha, beta ungesättigten ketolactonen | |
NO944644D0 (no) | Fremstilling av 3,4,4-trisubstituert-piperidinyl-N-alkylkarboksylater og mellomprodukter | |
ATE74592T1 (de) | Verfahren zur herstellung fungizid aktiver 4phenyl-pyrrol-derivate. | |
ATE176236T1 (de) | Verfahren zur herstellung von diorganodialkoxysilanen | |
IL80391A (en) | Process for the preparation of decabromodiphenyl ether with improved thermal stability | |
NO922321D0 (no) | Bis(fluormetyl)eter, fremgangsmaate for fremstilling, samtfremgangsmaate for fremstilling av difluormetan av bis(fluormetyl)eter | |
ES2045215T3 (es) | (+)-o (+)-1-(2-n-aminoetil sustituido) -1-metil-7-metoxi-1,2,3,4-tetrahidronaftaleno, y procedimiento para su produccion. | |
ES2057289T3 (es) | Procedimiento para la obtencion de octadienoles. | |
ATE49185T1 (de) | Verfahren zur herstellung von halogen-magnesium- alanat und dessen verwendung. | |
DE50200980D1 (de) | Verfahren zur Herstellung von 2,7-Dimethyl-2,4,6-octatrienal-monoacetalen | |
DE69914493D1 (de) | Verfahren zur herstellung von 2-hydroxy-6-trifluormethylpyridin | |
ES2145060T3 (es) | Procedimiento para producir una cetona alfa, beta insaturada. | |
DE59405089D1 (de) | Verfahren zur Herstellung von 4,5-Difluorbenzaldehyden | |
ATE104959T1 (de) | Verfahren zur herstellung von vitamin a aldehyd. | |
ATE57520T1 (de) | Verfahren zur herstellung von bromierten bisphenolen. | |
ATE106858T1 (de) | Verfahren zur herstellung von halogenacetalen aus enaminen. | |
DE59209468D1 (de) | Verfahren zur herstellung von 2,5-dihydroxyphenylessigsäure | |
ATE168110T1 (de) | Verfahren und zwischenprodukte zur herstellung von 5-oxaspiro (2.4> heptan-6-on | |
ATE41141T1 (de) | Verfahren zur herstellung von trichlorphenol. | |
ES535991A0 (es) | Un procedimiento para preparar un 10-ftalil-1, 5-diprotegido-1, 5, 10-triazadecano | |
ATE10936T1 (de) | Verfahren zur herstellung von 2-alkoxy-4aminopyrimidinen. | |
DE3766989D1 (de) | Verfahren zur herstellung von polyenaldehyden. | |
ES2070517T3 (es) | Productos intermedios en la preparacion del acido 4,5-difluoroantranilico. | |
GB2097792B (en) | 1,3-dihydro-2h-imidazol-2-ones | |
GR3017087T3 (en) | Process for the purification of pseudo-ionone. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |