ATE141285T1 - Bispezifische monoklonale antikörper, ihre produktion und verwendung - Google Patents
Bispezifische monoklonale antikörper, ihre produktion und verwendungInfo
- Publication number
- ATE141285T1 ATE141285T1 AT91104844T AT91104844T ATE141285T1 AT E141285 T1 ATE141285 T1 AT E141285T1 AT 91104844 T AT91104844 T AT 91104844T AT 91104844 T AT91104844 T AT 91104844T AT E141285 T1 ATE141285 T1 AT E141285T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- monoclonal antibodies
- bispecific monoclonal
- bispecific
- substance
- Prior art date
Links
- 230000002537 thrombolytic effect Effects 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- 239000003527 fibrinolytic agent Substances 0.000 abstract 1
- 229960000103 thrombolytic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6877—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the antibody being an immunoglobulin containing regions, domains or residues from different species
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8898590 | 1990-04-02 | ||
| JP17712190 | 1990-07-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE141285T1 true ATE141285T1 (de) | 1996-08-15 |
Family
ID=26430304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91104844T ATE141285T1 (de) | 1990-04-02 | 1991-03-27 | Bispezifische monoklonale antikörper, ihre produktion und verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5496549A (member.php) |
| EP (1) | EP0450479B1 (member.php) |
| KR (1) | KR910018039A (member.php) |
| AT (1) | ATE141285T1 (member.php) |
| CA (1) | CA2039259A1 (member.php) |
| DE (1) | DE69121272T2 (member.php) |
| HU (1) | HUT63203A (member.php) |
| IE (1) | IE76288B1 (member.php) |
| TW (1) | TW212184B (member.php) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001355A (en) * | 1982-12-14 | 1999-12-14 | Dowdle; Eugene Bernard Davey | Pro-tPA for the treatment of thrombosis, embolism and related conditions |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| DE69519929T2 (de) * | 1994-07-11 | 2001-05-23 | Board Of Regents, The University Of Texas System | Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen |
| US5869274A (en) * | 1995-08-09 | 1999-02-09 | Zymed Laboratories, Inc. | Immuno-histochemical method that reduces background staining |
| US6524553B2 (en) | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
| US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
| US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
| CA2349333A1 (en) | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
| EP1140204A2 (en) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
| US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| US7660415B2 (en) * | 2000-08-03 | 2010-02-09 | Selinfreund Richard H | Method and apparatus for controlling access to storage media |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| US6902734B2 (en) | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| BRPI0214168B8 (pt) | 2001-11-14 | 2021-05-25 | Centocor Inc | anticorpos anti-il-6, moléculas de ácido nucleico codificando os mesmos, vetores compreendendo as referidas moléculas, composições e formulações compreendendo os referidos anticorpos, bem como métodos de produção dos mesmos |
| US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
| AU2003271174A1 (en) * | 2003-10-10 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
| EP1693448A4 (en) * | 2003-10-14 | 2008-03-05 | Chugai Pharmaceutical Co Ltd | DOUBLE SPECIFIC ANTIBODIES AS REPLACEMENT FOR FUNCTIONAL PROTEIN |
| AU2003300896A1 (en) | 2003-12-10 | 2005-07-14 | Millennium Pharmaceuticals, Inc. | Humanized anti-ccr2 antibodies and methods of use |
| TWI671403B (zh) | 2005-03-31 | 2019-09-11 | 中外製藥股份有限公司 | 控制組裝之多肽的製造方法 |
| TW200714313A (en) * | 2005-04-08 | 2007-04-16 | Chugai Pharmaceutical Co Ltd | Antibodies that substitute for coagulation factor VIII |
| JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| EP1899376A2 (en) | 2005-06-16 | 2008-03-19 | The Feinstein Institute for Medical Research | Antibodies against hmgb1 and fragments thereof |
| TR201902033T4 (tr) | 2005-06-30 | 2019-03-21 | Janssen Biotech Inc | Anti-IL-23 antikorları, bileşimleri, yöntemleri ve kullanımları. |
| US7935344B2 (en) | 2005-12-29 | 2011-05-03 | Centocor Ortho Biotech Inc. | Human anti-IL-23 antibodies, compositions, methods and uses |
| DK3056568T3 (da) | 2006-03-31 | 2021-11-01 | Chugai Pharmaceutical Co Ltd | Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik |
| DK2009101T3 (en) | 2006-03-31 | 2018-01-15 | Chugai Pharmaceutical Co Ltd | Antibody modification method for purification of a bispecific antibody |
| EP3689912A1 (en) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| MX341687B (es) | 2010-02-10 | 2016-08-30 | Immunogen Inc | "anticuerpos cd20 y su utilización". |
| AU2011235232B2 (en) | 2010-03-30 | 2015-05-21 | Janssen Biotech Inc. | Humanized IL-25 antibodies |
| US9315585B2 (en) | 2010-06-19 | 2016-04-19 | Memorial Sloan Kettering Cancer Center | Anti-GD2 antibodies |
| CA2817964C (en) | 2010-11-17 | 2018-06-12 | Chugai Seiyaku Kabushiki Kaisha | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii |
| RU2680267C2 (ru) | 2013-03-15 | 2019-02-19 | Мемориал Слоан Кеттеринг Кэнсер Сентер | Высокоаффинные антитела к gd2 |
| JP2016527225A (ja) | 2013-07-15 | 2016-09-08 | ノヴォ ノルディスク アー／エス | ウロキナーゼ型プラスミノーゲン活性化因子に結合する抗体 |
| EP3050896B1 (en) | 2013-09-27 | 2021-07-07 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
| AU2014372309C1 (en) | 2013-12-24 | 2017-12-14 | Janssen Pharmaceutica Nv | Anti-VISTA antibodies and fragments |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定ｆｖｉｉｉ的反應性之方法 |
| EP3279216A4 (en) | 2015-04-01 | 2019-06-19 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR PREPARING POLYPEPTIDE HETERO OLIGOMER |
| PT3447075T (pt) | 2015-05-15 | 2023-11-16 | Massachusetts Gen Hospital | Anticorpos antagonistas anti-superfamília de recetores do fator de necrose tumoral |
| EP3722314A1 (en) | 2015-06-24 | 2020-10-14 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
| JP6954842B2 (ja) | 2015-12-25 | 2021-10-27 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| BR112018009312A8 (pt) | 2015-12-28 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | método para promover eficiência de purificação de polipeptídeo contendo região de fc |
| US10899836B2 (en) | 2016-02-12 | 2021-01-26 | Janssen Pharmaceutica Nv | Method of identifying anti-VISTA antibodies |
| JP7468992B2 (ja) | 2016-03-29 | 2024-04-16 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｉｌ１２及び／又は－２３抗体の増加した間隔投与による乾癬の処置 |
| WO2017175058A1 (en) | 2016-04-07 | 2017-10-12 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| MX2018012648A (es) | 2016-04-28 | 2019-01-30 | Chugai Pharmaceutical Co Ltd | Preparaciones que contienen anticuerpos. |
| BR112019001179A2 (pt) | 2016-07-29 | 2019-04-30 | Chugai Seiyaku Kabushiki Kaisha | anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii |
| WO2018045379A1 (en) | 2016-09-02 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Composition and methods of treating b cell disorders |
| WO2018047813A1 (en) | 2016-09-06 | 2018-03-15 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
| WO2018064436A1 (en) | 2016-09-30 | 2018-04-05 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-il23 specific antibody |
| IL323048A (en) | 2016-11-16 | 2025-10-01 | Janssen Biotech Inc | Method for treating psoriasis with a specific anti-IL-23 antibody |
| US20180230218A1 (en) | 2017-01-04 | 2018-08-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| EP3573658A4 (en) | 2017-01-30 | 2021-07-21 | Janssen Biotech, Inc. | ANTI-TNF ANTIBODIES, COMPOSITIONS, AND METHODS FOR TREATMENT OF ACTIVE PSORIATIC ARTHRITIS |
| EP3579871A4 (en) | 2017-02-07 | 2021-07-21 | Janssen Biotech, Inc. | ANTI-TNF ANTIBODIES, COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACTIVE ANKYLOSING SPONDYLARTHRITIS |
| UA128389C2 (uk) | 2017-09-29 | 2024-07-03 | Чугаі Сейяку Кабусікі Кайся | Мультиспецифічна антигензв'язувальна молекула, яка має активність заміщувати кофакторну функцію фактора коагуляції крові viii (fviii), та фармацевтичний склад, який містить згадану молекулу як активний інгредієнт |
| MX2020003472A (es) | 2017-11-01 | 2020-08-03 | Chugai Pharmaceutical Co Ltd | Variante e isoforma de anticuerpos con actividad biologica reducida. |
| JP2021502349A (ja) | 2017-11-06 | 2021-01-28 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｉｌ２３特異的抗体で乾癬性関節炎を治療する安全かつ有効な方法 |
| CA3092551A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
| EP3790587A4 (en) | 2018-05-11 | 2022-01-26 | Janssen Biotech, Inc. | Methods of treating depression using il-23 antibodies |
| MX2020014203A (es) | 2018-06-21 | 2021-05-27 | Yumanity Therapeutics Inc | Composiciones y métodos para el tratamiento y la prevención de trastornos neurológicos. |
| WO2020014306A1 (en) | 2018-07-10 | 2020-01-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| US20200025776A1 (en) | 2018-07-18 | 2020-01-23 | Janssen Biotech, Inc. | Sustained Response Predictors After Treatment With Anti-IL23 Specific Antibody |
| CA3120237A1 (en) | 2018-11-20 | 2020-05-28 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-il-23 specific antibody |
| PE20212262A1 (es) | 2019-04-17 | 2021-11-29 | Novo Nordisk As | Anticuerpos biespecificos |
| MX2021014302A (es) | 2019-05-23 | 2022-01-04 | Janssen Biotech Inc | Metodo para tratar la enfermedad inflamatoria del intestino con una terapia de combinacion de anticuerpos contra il-23 y tnf alfa. |
| MA56026A (fr) | 2019-06-03 | 2022-04-06 | Janssen Biotech Inc | Anticorps anti-tnf, compositions et méthodes pour le traitement de la spondylarthrite ankylosante active |
| WO2020245766A1 (en) | 2019-06-04 | 2020-12-10 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
| WO2021028752A1 (en) | 2019-08-15 | 2021-02-18 | Janssen Biotech, Inc. | Anti-tfn antibodies for treating type i diabetes |
| BR112022022378A2 (pt) | 2020-05-05 | 2022-12-13 | Janssen Biotech Inc | Métodos para tratamento da doença de crohn com anticorpo específico anti-il23 |
| WO2021234634A1 (en) | 2020-05-21 | 2021-11-25 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| CA3189402A1 (en) | 2020-07-13 | 2022-01-20 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
| CA3212729A1 (en) | 2021-03-12 | 2022-09-15 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
| AU2022232007A1 (en) | 2021-03-12 | 2023-10-26 | Janssen Biotech, Inc. | Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody |
| CA3236779A1 (en) | 2021-10-29 | 2023-05-04 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
| CA3238377A1 (en) | 2021-11-15 | 2023-05-19 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
| US20230159633A1 (en) | 2021-11-23 | 2023-05-25 | Janssen Biotech, Inc. | Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody |
| US20230312703A1 (en) | 2022-03-30 | 2023-10-05 | Janssen Biotech, Inc. | Method of Treating Psoriasis with IL-23 Specific Antibody |
| WO2023215498A2 (en) | 2022-05-05 | 2023-11-09 | Modernatx, Inc. | Compositions and methods for cd28 antagonism |
| US20230374122A1 (en) | 2022-05-18 | 2023-11-23 | Janssen Biotech, Inc. | Method for Evaluating and Treating Psoriatic Arthritis with IL23 Antibody |
| WO2024097639A1 (en) | 2022-10-31 | 2024-05-10 | Modernatx, Inc. | Hsa-binding antibodies and binding proteins and uses thereof |
| WO2024110898A1 (en) | 2022-11-22 | 2024-05-30 | Janssen Biotech, Inc. | Method of treating ulcerative colitis with anti-il23 specific antibody |
| WO2024118866A1 (en) | 2022-12-01 | 2024-06-06 | Modernatx, Inc. | Gpc3-specific antibodies, binding domains, and related proteins and uses thereof |
| WO2024206126A1 (en) | 2023-03-27 | 2024-10-03 | Modernatx, Inc. | Cd16-binding antibodies and uses thereof |
| CA3249015A1 (en) | 2024-03-20 | 2025-10-31 | Janssen Biotech, Inc. | Methods of treating crohn’s disease with anti-il23 specific antibody |
| WO2025262604A1 (en) | 2024-06-17 | 2025-12-26 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4714681A (en) * | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
| US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| JP3177776B2 (ja) * | 1988-09-27 | 2001-06-18 | 武田薬品工業株式会社 | ハイブリッドモノクローナル抗体，抗体産生ポリドーマおよび抗体含有薬剤 |
| ES8504461A1 (es) * | 1982-04-12 | 1985-04-16 | Hybritech Inc | Un procedimiento para obtener un polidoma. |
| EP0179872B1 (en) * | 1984-04-23 | 1991-06-19 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
| DE3426903A1 (de) * | 1984-07-20 | 1986-01-23 | Biotest Pharma GmbH, 6000 Frankfurt | Eine immunglobulinpraeparation in kombination mit einer anderen pharmakologisch wirksamen praeparation zur verwendung bei der behandlung von krankheiten |
| EP0241907A3 (en) * | 1986-04-14 | 1989-09-13 | The General Hospital Corporation | Heterobifunctional antibodies and method of use |
| US4889922A (en) * | 1986-08-13 | 1989-12-26 | Monsanto Co. | Monoclonal antibody specific for human colon fibroblast-derived T-PA |
| DE3909708A1 (de) * | 1989-03-23 | 1990-09-27 | Boehringer Mannheim Gmbh | Verfahren zur herstellung bispezifischer antikoerper |
-
1991
- 1991-03-20 TW TW080102180A patent/TW212184B/zh active
- 1991-03-27 CA CA002039259A patent/CA2039259A1/en not_active Abandoned
- 1991-03-27 DE DE69121272T patent/DE69121272T2/de not_active Expired - Fee Related
- 1991-03-27 EP EP91104844A patent/EP0450479B1/en not_active Expired - Lifetime
- 1991-03-27 AT AT91104844T patent/ATE141285T1/de not_active IP Right Cessation
- 1991-03-28 IE IE107991A patent/IE76288B1/en not_active IP Right Cessation
- 1991-03-28 HU HU911027A patent/HUT63203A/hu unknown
- 1991-04-02 KR KR1019910005314A patent/KR910018039A/ko not_active Ceased
-
1994
- 1994-12-06 US US08/350,497 patent/US5496549A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0450479B1 (en) | 1996-08-14 |
| DE69121272D1 (de) | 1996-09-19 |
| IE76288B1 (en) | 1997-10-08 |
| IE911079A1 (en) | 1991-10-09 |
| CA2039259A1 (en) | 1991-10-03 |
| HUT63203A (en) | 1993-07-28 |
| DE69121272T2 (de) | 1997-01-09 |
| EP0450479A1 (en) | 1991-10-09 |
| HU911027D0 (en) | 1991-10-28 |
| KR910018039A (ko) | 1991-11-30 |
| TW212184B (member.php) | 1993-09-01 |
| US5496549A (en) | 1996-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69121272D1 (de) | Bispezifische monoklonale Antikörper, ihre Produktion und Verwendung | |
| FI101937B1 (fi) | Menetelmä monoklonaalisen vasta-aineen tuottamiseksi, joka reagoi ihmisen cachectiinin kanssa | |
| FI900212A7 (fi) | Polydoomia, jotka tuottavat monoklonaalista hybridivasta-ainetta, joll a on kahdenlainen spesifisyys | |
| ES2106195T3 (es) | Anticuerpo igg aglicosilado anti cd3. | |
| DE59102939D1 (de) | Hybridantrieb für Fahrzeuge. | |
| EP0663140A4 (en) | PRODUCTION OF SEALED PARALLEL LOETHOECKER CONNECTIONS. | |
| GR1002306B (el) | Αναλυση και διαταξη συγκολλησεως στηλης. | |
| EP0101039A3 (en) | Monoclonal antibody, method of producing the same and use thereof | |
| DK0676414T3 (da) | Lipaser immobiliseret i sol-gel-bearbejdede, hydrofobe materialer | |
| EP0141079A3 (en) | Monoclonal antibodies specific for membrane-associated antigens | |
| DE3854502D1 (de) | Gegen hiv-antigene spezifischer monoklonaler antikörper. | |
| DE3887566D1 (de) | Pyridoxamin-Chelat Verbindungen, Mangan II chelate und ihre Verwendung als NMRI Kontrastmittel. | |
| DE3177276D1 (de) | Monoklonale antikoerper. | |
| TR25161A (tr) | DÖNüS TITRESIMI ABSORBE EDICISI. | |
| DE3850993D1 (de) | Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2. | |
| NO883963D0 (no) | Modifiserte plasminogen-aktivatorer. | |
| ATE140930T1 (de) | Hybride monoklonale antikörper, ihre herstellung und verwendung | |
| FR2726870B1 (fr) | Plateau durci pour un ensemble formant disque amortisseur, et son procede de fabrication | |
| EP0581108A3 (en) | Bispecific antibody that reacts with sialyl-lea antigen and CD3. | |
| DK176986A (da) | Monoklonalt anti-urokinase-antistof og produktion og anvendelse deraf | |
| NO168969C (no) | Fremgangsmaate for affinitetsrensing av et hybrid monoklonalt antistoff, fremgangsmaate for dets fremstilling og anvendelse av antistoffet | |
| EP0922761A4 (en) | MONOCLONAL ANTIBODY, SPECIFIC FOR ANTI-HUMAN FIBRINE MONOMER, METHOD FOR PRODUCING THE SAME, HYBRYDOM CELLS AND AN IMMUNOASSAY METHOD | |
| EP0453419A3 (en) | Use of the sp-2 monoclonal antibody for diagnostics and for monitoring of the hiv infection progress | |
| NL187176C (nl) | Werkwijze voor het vervaardigen van een tractieschijf, een riemschijf of dergelijk onderdeel. | |
| NO881780D0 (no) | Monoklonale antistoffer til fibrin. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |