BR112019001179A2 - anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii - Google Patents

anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii

Info

Publication number
BR112019001179A2
BR112019001179A2 BR112019001179-0A BR112019001179A BR112019001179A2 BR 112019001179 A2 BR112019001179 A2 BR 112019001179A2 BR 112019001179 A BR112019001179 A BR 112019001179A BR 112019001179 A2 BR112019001179 A2 BR 112019001179A2
Authority
BR
Brazil
Prior art keywords
fviii
cofactor
bispecific antibody
activity
exhibiting increased
Prior art date
Application number
BR112019001179-0A
Other languages
English (en)
Inventor
Igawa Tomoyuki
Teranishi Yuri
Kato Kazuki
Koga Hikaru
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of BR112019001179A2 publication Critical patent/BR112019001179A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii". a presente invenção refere-se a substituições de aminoácidos de cadeia leve que aumentam a atividade de substituição de função de cofator fviii do ace910 (emicizumabe), novas cadeias leves que exibem atividade de substituição de função de cofator fviii e substituições de aminoácidos de cadeia pesada que aumentam a atividade de substituição de função de cofator fviii de novos anticorpos biespecíficos que contêm as cadeias leves.
BR112019001179-0A 2016-07-29 2017-07-27 anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii BR112019001179A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016150769 2016-07-29
JP2016-150769 2016-07-29
PCT/JP2017/027152 WO2018021450A1 (ja) 2016-07-29 2017-07-27 増強されたｆｖｉｉｉ補因子機能代替活性を有する二重特異性抗体

Publications (1)

Publication Number Publication Date
BR112019001179A2 true BR112019001179A2 (pt) 2019-04-30

Family

ID=61016987

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019001179-0A BR112019001179A2 (pt) 2016-07-29 2017-07-27 anticorpo biespecífico que exibe atividade alternativa aumentada de função de cofator fviii

Country Status (11)

Country Link
US (2) US20190185578A1 (pt)
EP (1) EP3492496A4 (pt)
JP (1) JP7050677B2 (pt)
KR (1) KR102591955B1 (pt)
CN (2) CN117986372A (pt)
AU (1) AU2017303205A1 (pt)
BR (1) BR112019001179A2 (pt)
CA (1) CA3027018A1 (pt)
MX (1) MX2018015721A (pt)
RU (1) RU2019104730A (pt)
WO (1) WO2018021450A1 (pt)

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US10759870B2 (en) * 2017-09-29 2020-09-01 Chugai Seiyaku Kabushiki Kaisha Multispecific antigen-binding molecules having blood coagulation factor VIII (FVIII) cofactor function-substituting activity and pharmaceutical formulations containing such a molecule as an active ingredient
WO2019096874A1 (en) 2017-11-15 2019-05-23 Novo Nordisk A/S Factor x binders enhancing fx activation
US11220554B2 (en) 2018-09-07 2022-01-11 Novo Nordisk A/S Procoagulant antibodies
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CN113874361A (zh) 2019-03-29 2021-12-31 医药生命融合研究团 具有抗癌活性的新型化合物及其制备方法
KR20230130561A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체를 2주마다 1회 투여하는 방법
KR20230130560A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체의 주 1회 투여 방법
KR20230130558A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체의 월 1회 투여 방법

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Also Published As

Publication number Publication date
CN117986372A (zh) 2024-05-07
RU2019104730A (ru) 2020-08-28
AU2017303205A1 (en) 2019-01-17
KR102591955B1 (ko) 2023-10-19
RU2019104730A3 (pt) 2020-11-30
CA3027018A1 (en) 2018-02-01
CN109415444B (zh) 2024-03-01
KR20190037271A (ko) 2019-04-05
WO2018021450A1 (ja) 2018-02-01
CN109415444A (zh) 2019-03-01
MX2018015721A (es) 2019-05-27
JP7050677B2 (ja) 2022-04-08
EP3492496A4 (en) 2020-07-29
US20220073644A1 (en) 2022-03-10
JPWO2018021450A1 (ja) 2019-05-23
US20190185578A1 (en) 2019-06-20
EP3492496A1 (en) 2019-06-05

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