DE3887566D1 - Pyridoxamin-Chelat Verbindungen, Mangan II chelate und ihre Verwendung als NMRI Kontrastmittel. - Google Patents

Pyridoxamin-Chelat Verbindungen, Mangan II chelate und ihre Verwendung als NMRI Kontrastmittel.

Info

Publication number
DE3887566D1
DE3887566D1 DE88107335T DE3887566T DE3887566D1 DE 3887566 D1 DE3887566 D1 DE 3887566D1 DE 88107335 T DE88107335 T DE 88107335T DE 3887566 T DE3887566 T DE 3887566T DE 3887566 D1 DE3887566 D1 DE 3887566D1
Authority
DE
Germany
Prior art keywords
pyridoxamine
chelates
manganese
contrast agents
chelate compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88107335T
Other languages
English (en)
Other versions
DE3887566T2 (de
Inventor
Scott M Rocklage
Steven C Quay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of DE3887566D1 publication Critical patent/DE3887566D1/de
Publication of DE3887566T2 publication Critical patent/DE3887566T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE88107335T 1987-05-08 1988-05-06 Pyridoxamin-Chelat Verbindungen, Mangan II chelate und ihre Verwendung als NMRI Kontrastmittel. Expired - Fee Related DE3887566T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/047,584 US4935518A (en) 1987-05-08 1987-05-08 Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof

Publications (2)

Publication Number Publication Date
DE3887566D1 true DE3887566D1 (de) 1994-03-17
DE3887566T2 DE3887566T2 (de) 1994-05-11

Family

ID=21949817

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88107335T Expired - Fee Related DE3887566T2 (de) 1987-05-08 1988-05-06 Pyridoxamin-Chelat Verbindungen, Mangan II chelate und ihre Verwendung als NMRI Kontrastmittel.

Country Status (14)

Country Link
US (1) US4935518A (de)
EP (1) EP0292761B1 (de)
JP (1) JP2773870B2 (de)
AR (1) AR244208A1 (de)
AT (1) ATE101158T1 (de)
CA (1) CA1312867C (de)
DE (1) DE3887566T2 (de)
DK (1) DK251588A (de)
ES (1) ES2061546T3 (de)
FI (1) FI88032C (de)
IE (1) IE63425B1 (de)
IL (1) IL86299A (de)
NO (1) NO174710C (de)
NZ (1) NZ224531A (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
AR246956A1 (es) 1987-05-08 1994-10-31 Salutar Inc Compuesto quelante, un intermediario para preparar el mismo, y un procedimiento para preparar una composicion de medio de contraste.
US5130437A (en) * 1987-05-08 1992-07-14 Salutar, Inc. N,N'-bis-(pyridoxal)ethylenediamine-N,N'-diacetic acid derivatives
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
DE3855239T2 (de) * 1987-07-16 1996-10-31 Nycomed Imaging As Aminocarbonsäure und Derivate
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
US5155224A (en) * 1988-09-27 1992-10-13 Salutar, Inc. Manganese (II) chelates
WO1992013841A1 (de) * 1991-02-08 1992-08-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Komplexbildner
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
US5463030A (en) * 1991-05-03 1995-10-31 Research Foundation Of The State Of New York Metal chelating agents for medical application
EP0594640A4 (en) * 1991-05-23 1998-06-03 Evan C Unger Liposoluble compounds for magnetic resonance imaging
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
EP0648209A1 (de) * 1992-07-01 1995-04-19 Byk Gulden Lomberg Chemische Fabrik GmbH Kontrastmittel für die mr diagnostik
US5364953A (en) * 1992-11-05 1994-11-15 Mallinckrodt Medical, Inc. High relaxivity, paramagnetic, metal clusters for magnetic resonance imaging
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
GB9613182D0 (en) * 1996-06-24 1996-08-28 Nycomed Imaging As Method
GB9727224D0 (en) * 1997-12-23 1998-02-25 Nycomed Imaging As Method
EP1060174B1 (de) * 1997-12-23 2004-09-22 Amersham Health AS Stickstoffoxid freisetzende chelatbildner und ihre therapeutische verwendung
GB2333704A (en) * 1998-01-31 1999-08-04 Procter & Gamble Contrasting compositions for magnetic resonance imaging comprising a complex of ethylene diamine disuccinic acid and one or more paramagnetic metal ions
WO2010133907A1 (en) * 2009-05-18 2010-11-25 Carlo Ghisalberti Hexadentate chelators in inflammatory bowel disease
KR20150080616A (ko) * 2012-11-02 2015-07-09 플레드파르마 에이비 암 치료 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322361A (en) * 1980-03-03 1982-03-30 The Dow Chemical Company Method of preparing a manganese chelate having improved properties
GB8413849D0 (en) * 1984-05-31 1984-07-04 Amersham Int Plc Nmr contrast agents

Also Published As

Publication number Publication date
IE63425B1 (en) 1995-04-19
FI88032B (fi) 1992-12-15
AU612647B2 (en) 1991-07-18
FI88032C (fi) 1993-03-25
US4935518A (en) 1990-06-19
IE881367L (en) 1988-11-08
ES2061546T3 (es) 1994-12-16
ATE101158T1 (de) 1994-02-15
DK251588A (da) 1988-11-09
NO174710B (no) 1994-03-14
DE3887566T2 (de) 1994-05-11
CA1312867C (en) 1993-01-19
EP0292761A2 (de) 1988-11-30
NO174710C (no) 1994-06-22
FI882126A0 (fi) 1988-05-06
EP0292761B1 (de) 1994-02-02
AR244208A1 (es) 1993-10-29
JP2773870B2 (ja) 1998-07-09
NO882003D0 (no) 1988-05-06
JPS63287791A (ja) 1988-11-24
IL86299A0 (en) 1988-11-15
EP0292761A3 (de) 1991-01-30
NO882003L (no) 1988-11-09
FI882126A (fi) 1988-11-09
NZ224531A (en) 1993-05-26
IL86299A (en) 1993-01-14
AU1568188A (en) 1989-11-09
DK251588D0 (da) 1988-05-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee