ATE140223T1 - Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring - Google Patents

Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring

Info

Publication number
ATE140223T1
ATE140223T1 AT93901399T AT93901399T ATE140223T1 AT E140223 T1 ATE140223 T1 AT E140223T1 AT 93901399 T AT93901399 T AT 93901399T AT 93901399 T AT93901399 T AT 93901399T AT E140223 T1 ATE140223 T1 AT E140223T1
Authority
AT
Austria
Prior art keywords
compound
formula
disclosed
imidolylalkyl
membed
Prior art date
Application number
AT93901399T
Other languages
English (en)
Inventor
Neng-Yang Shih
Michael J Green
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE140223T1 publication Critical patent/ATE140223T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT93901399T 1991-12-18 1992-12-16 Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring ATE140223T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81065191A 1991-12-18 1991-12-18

Publications (1)

Publication Number Publication Date
ATE140223T1 true ATE140223T1 (de) 1996-07-15

Family

ID=25204344

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93901399T ATE140223T1 (de) 1991-12-18 1992-12-16 Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring

Country Status (19)

Country Link
EP (1) EP0619818B1 (de)
JP (1) JPH07121938B2 (de)
KR (1) KR0142801B1 (de)
AT (1) ATE140223T1 (de)
AU (1) AU665604B2 (de)
CA (1) CA2126086C (de)
DE (1) DE69212164T2 (de)
DK (1) DK0619818T3 (de)
ES (1) ES2089782T3 (de)
GR (1) GR3021195T3 (de)
HK (1) HK31097A (de)
IL (1) IL104124A (de)
MX (1) MX9207392A (de)
MY (1) MY108904A (de)
NZ (1) NZ246434A (de)
SG (1) SG44565A1 (de)
TW (1) TW263503B (de)
WO (1) WO1993012107A1 (de)
ZA (1) ZA929785B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9302045A (nl) * 1993-08-27 1995-03-16 Vrije Universiteit Nieuwe imidazoolafgeleide met agonistische of antagonistische activiteit op de histamine H3-receptor.
AU7823894A (en) * 1993-08-27 1995-03-21 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
FR2732017B1 (fr) * 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
EP0862435A4 (de) * 1995-11-22 1999-02-03 Merck & Co Inc Inhibitoren der farnesyl-protein-transferase
AU715603B2 (en) * 1996-04-03 2000-02-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6072057A (en) * 1996-06-06 2000-06-06 Gliatech Inc. 1H-4(5)-cyclo-substituted imidazole derivatives as histamine H3 receptor agents
US6407132B1 (en) 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
WO1999024421A1 (en) * 1997-11-07 1999-05-20 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
US5990147A (en) * 1997-11-07 1999-11-23 Schering Corporation H3 receptor ligands of the phenyl-alkyl-imidazoles type
US6034251A (en) * 1997-11-07 2000-03-07 Schering Corporation Phenyl-alkyl-imidazoles
AU744798B2 (en) * 1997-12-04 2002-03-07 Allergan, Inc. Substituted imidazole derivatives having agonist-like activity at alpha 2B or 2B/2C adrenergic receptors
US6133291A (en) * 1998-10-16 2000-10-17 Schering Corporation N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists
US6100279A (en) * 1998-11-05 2000-08-08 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
AU3033100A (en) 1999-01-18 2000-08-01 Boehringer Ingelheim International Gmbh Substituted imidazoles, their preparation and use
US6211182B1 (en) * 1999-03-08 2001-04-03 Schering Corporation Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6437147B1 (en) 2000-03-17 2002-08-20 Novo Nordisk Imidazole compounds
US6610721B2 (en) 2000-03-17 2003-08-26 Novo Nordisk A/S Imidazo heterocyclic compounds
US20020042400A1 (en) 2000-08-17 2002-04-11 Yajing Rong Novel alicyclic imidazoles as H3 agents
WO2003070722A1 (fr) 2002-02-21 2003-08-28 Azwell Inc. Amelioration apportee a la production de derives d'imidazole et de nouveaux intermediaires de ces derives
EP1707203A1 (de) 2005-04-01 2006-10-04 Bioprojet Verwendung von Alkylaminen, die kein Imidazole enthalten, als Histamin H3 Rezeptor Liganden, zur Behandlung von Morbus Parkinson, obstruktiver Schlafapnoe, vaskularer Demenz, Demenz mit Lewy Korpen
EP1717235A3 (de) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
EP1717233A1 (de) 2005-04-29 2006-11-02 Bioprojet Liganden für den Histamin H3-Rezeptor und ihre therapeutische Anwendung
EP2076508B1 (de) 2006-10-18 2011-01-05 Pfizer Products Inc. Biaryl-ether-harnstoffverbindungen
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
FR2586562B1 (fr) * 1985-09-02 1989-03-10 Inst Nat Sante Rech Med Composition pharmaceutique contenant de l'a-methylhistamine
EP0372125A1 (de) * 1988-11-08 1990-06-13 Akzo N.V. Oxazol und Thiazol-Derivate
US4925851A (en) * 1989-05-23 1990-05-15 Sandoz Pharmaceuticals Corp. 2- or 4-substituted-[2-(1H-imidazol-1-yl)ethyl]piperidines

Also Published As

Publication number Publication date
SG44565A1 (en) 1997-12-19
DE69212164D1 (de) 1996-08-14
JPH07121938B2 (ja) 1995-12-25
AU665604B2 (en) 1996-01-11
MX9207392A (es) 1993-06-01
CA2126086C (en) 2000-03-28
WO1993012107A1 (en) 1993-06-24
ES2089782T3 (es) 1996-10-01
DE69212164T2 (de) 1996-12-05
CA2126086A1 (en) 1993-06-24
MY108904A (en) 1996-11-30
GR3021195T3 (en) 1996-12-31
DK0619818T3 (da) 1996-11-25
IL104124A (en) 1998-12-06
KR0142801B1 (en) 1998-07-15
EP0619818A1 (de) 1994-10-19
ZA929785B (en) 1993-06-21
HK31097A (en) 1997-03-21
KR940703827A (de) 1994-12-12
AU3275893A (en) 1993-07-19
NZ246434A (en) 1996-02-27
TW263503B (de) 1995-11-21
EP0619818B1 (de) 1996-07-10
IL104124A0 (en) 1993-05-13
JPH06511252A (ja) 1994-12-15

Similar Documents

Publication Publication Date Title
ATE140223T1 (de) Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring
IL104126A0 (en) Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
ATE141269T1 (de) Imidazolyl oder imidazolylalkyl substituiert mit einem 4- oder 5-gliedrigen stickstoff enthaltenden heterozyklischen ring
NO912410D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive heterocyklen-derivater.
WO1999024421A8 (en) Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
NO165195C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive nye derivater av 4,5-dihydro-oksazolyl-2-((2-pyridyl)-metyl-tio- eller metylsulfinyl)-benz- eller tienoimidazoler.
ATE186215T1 (de) Verwendung von n-(pyridinyl)-1h-indol-1-aminen zur herstellung eines medikamentes zur behandlung von zwangsneurotischen erkrankungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee