WO1999024421A8 - Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom - Google Patents

Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom

Info

Publication number
WO1999024421A8
WO1999024421A8 PCT/US1998/023224 US9823224W WO9924421A8 WO 1999024421 A8 WO1999024421 A8 WO 1999024421A8 US 9823224 W US9823224 W US 9823224W WO 9924421 A8 WO9924421 A8 WO 9924421A8
Authority
WO
WIPO (PCT)
Prior art keywords
formula
disclosed
compound
administering
nitrogen atom
Prior art date
Application number
PCT/US1998/023224
Other languages
French (fr)
Other versions
WO1999024421A1 (en
Inventor
Wayne D Vaccaro
Ronald L Wolin
Daniel M Solomon
Robert G Aslanian
John J Piwinski
Stuart B Rosenblum
Original Assignee
Schering Corp
Wayne D Vaccaro
Ronald L Wolin
Daniel M Solomon
Robert G Aslanian
John J Piwinski
Stuart B Rosenblum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Wayne D Vaccaro, Ronald L Wolin, Daniel M Solomon, Robert G Aslanian, John J Piwinski, Stuart B Rosenblum filed Critical Schering Corp
Priority to JP2000520435A priority Critical patent/JP2001522845A/en
Priority to AU12967/99A priority patent/AU1296799A/en
Priority to EP98956443A priority patent/EP1028956A1/en
Priority to HU0102662A priority patent/HUP0102662A3/en
Priority to IL13572798A priority patent/IL135727A0/en
Priority to KR1020007004911A priority patent/KR20010031839A/en
Priority to CA002309609A priority patent/CA2309609A1/en
Publication of WO1999024421A1 publication Critical patent/WO1999024421A1/en
Publication of WO1999024421A8 publication Critical patent/WO1999024421A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula (I). Further disclosed is a method of treating allergy (for example asthma), inflammation, hypotension, raised intraocular pressure (such as glaucoma) i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyperactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimer's, Schizophrenia, obesity and migraine) comprising administering an effective amount of a compound of Formula (I) to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of Formula (I) in combination or admixture with a histamine H1 receptor antagonist.
PCT/US1998/023224 1997-11-07 1998-11-05 Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom WO1999024421A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2000520435A JP2001522845A (en) 1997-11-07 1998-11-05 Imidazoylalkyl substituted with 5, 6 or 7 membered heterocyclic rings containing one nitrogen atom
AU12967/99A AU1296799A (en) 1997-11-07 1998-11-05 Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
EP98956443A EP1028956A1 (en) 1997-11-07 1998-11-05 Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
HU0102662A HUP0102662A3 (en) 1997-11-07 1998-11-05 Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
IL13572798A IL135727A0 (en) 1997-11-07 1998-11-05 Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
KR1020007004911A KR20010031839A (en) 1997-11-07 1998-11-05 Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
CA002309609A CA2309609A1 (en) 1997-11-07 1998-11-05 Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96575497A 1997-11-07 1997-11-07
US08/965,754 1997-11-07

Publications (2)

Publication Number Publication Date
WO1999024421A1 WO1999024421A1 (en) 1999-05-20
WO1999024421A8 true WO1999024421A8 (en) 1999-08-26

Family

ID=25510440

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023224 WO1999024421A1 (en) 1997-11-07 1998-11-05 Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom

Country Status (12)

Country Link
EP (1) EP1028956A1 (en)
JP (1) JP2001522845A (en)
KR (1) KR20010031839A (en)
CN (1) CN1285828A (en)
AR (1) AR016671A1 (en)
AU (1) AU1296799A (en)
CA (1) CA2309609A1 (en)
HU (1) HUP0102662A3 (en)
IL (1) IL135727A0 (en)
PE (1) PE130699A1 (en)
WO (1) WO1999024421A1 (en)
ZA (1) ZA9810186B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140337A (en) * 1997-12-23 2000-10-31 Schering Corporation Methods for the treatment of mental disorders
FR2827863A1 (en) * 2001-07-27 2003-01-31 Sanofi Synthelabo New dihydropyrrolyl alkyl imidazole derivatives having histamine receptor antagonist activity for treatment of obesity, diabetes, and central nervous system disorders
US7880017B2 (en) 2003-11-11 2011-02-01 Allergan, Inc. Process for the synthesis of imidazoles
US7183305B2 (en) 2003-11-11 2007-02-27 Allergan, Inc. Process for the synthesis of imidazoles
JP4769082B2 (en) * 2003-12-17 2011-09-07 武田薬品工業株式会社 Urea derivatives, their production and use
MX2007008134A (en) * 2004-12-30 2008-01-16 Johnson & Johnson Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase.
UA108233C2 (en) 2010-05-03 2015-04-10 Fatty acid amide hydrolysis activity modulators
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
WO2022175384A1 (en) * 2021-02-17 2022-08-25 Fundación Universidad Católica De Valencia San Vicente Mártir Small-molecule agents with antiviral activity against rna viruses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5463074A (en) * 1991-12-18 1995-10-31 Schering Corporation Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring
JPH07121938B2 (en) * 1991-12-18 1995-12-25 シェリング・コーポレーション Imidazoyl alkyl compound substituted with nitrogen-containing 6-membered heterocycle
AU7823894A (en) * 1993-08-27 1995-03-21 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
WO1998006394A1 (en) * 1996-08-16 1998-02-19 Schering Corporation Treatment of upper airway allergic responses with a combination of histamine receptor antagonists

Also Published As

Publication number Publication date
CA2309609A1 (en) 1999-05-20
HUP0102662A2 (en) 2001-12-28
AR016671A1 (en) 2001-07-25
ZA9810186B (en) 1999-05-06
PE130699A1 (en) 1999-12-16
KR20010031839A (en) 2001-04-16
CN1285828A (en) 2001-02-28
JP2001522845A (en) 2001-11-20
AU1296799A (en) 1999-05-31
EP1028956A1 (en) 2000-08-23
HUP0102662A3 (en) 2003-01-28
IL135727A0 (en) 2001-05-20
WO1999024421A1 (en) 1999-05-20

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