DE69212164D1 - Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring - Google Patents
Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ringInfo
- Publication number
- DE69212164D1 DE69212164D1 DE69212164T DE69212164T DE69212164D1 DE 69212164 D1 DE69212164 D1 DE 69212164D1 DE 69212164 T DE69212164 T DE 69212164T DE 69212164 T DE69212164 T DE 69212164T DE 69212164 D1 DE69212164 D1 DE 69212164D1
- Authority
- DE
- Germany
- Prior art keywords
- compound
- formula
- disclosed
- imidolylalkyl
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81065191A | 1991-12-18 | 1991-12-18 | |
PCT/US1992/010698 WO1993012107A1 (en) | 1991-12-18 | 1992-12-16 | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69212164D1 true DE69212164D1 (de) | 1996-08-14 |
DE69212164T2 DE69212164T2 (de) | 1996-12-05 |
Family
ID=25204344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69212164T Expired - Fee Related DE69212164T2 (de) | 1991-12-18 | 1992-12-16 | Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0619818B1 (de) |
JP (1) | JPH07121938B2 (de) |
KR (1) | KR0142801B1 (de) |
AT (1) | ATE140223T1 (de) |
AU (1) | AU665604B2 (de) |
CA (1) | CA2126086C (de) |
DE (1) | DE69212164T2 (de) |
DK (1) | DK0619818T3 (de) |
ES (1) | ES2089782T3 (de) |
GR (1) | GR3021195T3 (de) |
HK (1) | HK31097A (de) |
IL (1) | IL104124A (de) |
MX (1) | MX9207392A (de) |
MY (1) | MY108904A (de) |
NZ (1) | NZ246434A (de) |
SG (1) | SG44565A1 (de) |
TW (1) | TW263503B (de) |
WO (1) | WO1993012107A1 (de) |
ZA (1) | ZA929785B (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7823894A (en) * | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
NL9302045A (nl) * | 1993-08-27 | 1995-03-16 | Vrije Universiteit | Nieuwe imidazoolafgeleide met agonistische of antagonistische activiteit op de histamine H3-receptor. |
FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
CA2238081A1 (en) * | 1995-11-22 | 1997-05-29 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
JP2000507585A (ja) * | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシルタンパク質トランスフェラーゼの阻害剤 |
US6072057A (en) * | 1996-06-06 | 2000-06-06 | Gliatech Inc. | 1H-4(5)-cyclo-substituted imidazole derivatives as histamine H3 receptor agents |
US6407132B1 (en) | 1997-07-25 | 2002-06-18 | James Black Foundation Limited | Substituted imidazole derivatives and their use as histamine H3 receptor ligands |
US5990147A (en) * | 1997-11-07 | 1999-11-23 | Schering Corporation | H3 receptor ligands of the phenyl-alkyl-imidazoles type |
US6034251A (en) * | 1997-11-07 | 2000-03-07 | Schering Corporation | Phenyl-alkyl-imidazoles |
CA2309609A1 (en) * | 1997-11-07 | 1999-05-20 | Schering Corporation | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom |
CN1284066A (zh) * | 1997-12-04 | 2001-02-14 | 阿勒根销售公司 | 对α2B或2B/2C肾上腺素能受体具有激动剂样活性的取代咪唑衍生物 |
US6133291A (en) * | 1998-10-16 | 2000-10-17 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
US6100279A (en) * | 1998-11-05 | 2000-08-08 | Schering Corporation | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom |
JP2002534511A (ja) | 1999-01-18 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 置換型イミダゾール、それらの調製及び使用 |
US6211182B1 (en) * | 1999-03-08 | 2001-04-03 | Schering Corporation | Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
US20020042400A1 (en) | 2000-08-17 | 2002-04-11 | Yajing Rong | Novel alicyclic imidazoles as H3 agents |
EP1477487A4 (de) * | 2002-02-21 | 2006-05-03 | Azwell Inc | Verbesserte herstellung von imidazolderivaten und neue zwischenprodukte der derivate |
EP1707203A1 (de) | 2005-04-01 | 2006-10-04 | Bioprojet | Verwendung von Alkylaminen, die kein Imidazole enthalten, als Histamin H3 Rezeptor Liganden, zur Behandlung von Morbus Parkinson, obstruktiver Schlafapnoe, vaskularer Demenz, Demenz mit Lewy Korpen |
EP1717233A1 (de) | 2005-04-29 | 2006-11-02 | Bioprojet | Liganden für den Histamin H3-Rezeptor und ihre therapeutische Anwendung |
EP1717235A3 (de) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor |
CA2663984C (en) | 2006-10-18 | 2012-02-21 | Pfizer Products Inc. | Biaryl ether urea compounds |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
FR2586562B1 (fr) * | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
EP0372125A1 (de) * | 1988-11-08 | 1990-06-13 | Akzo N.V. | Oxazol und Thiazol-Derivate |
US4925851A (en) * | 1989-05-23 | 1990-05-15 | Sandoz Pharmaceuticals Corp. | 2- or 4-substituted-[2-(1H-imidazol-1-yl)ethyl]piperidines |
-
1992
- 1992-12-16 DK DK93901399.1T patent/DK0619818T3/da active
- 1992-12-16 WO PCT/US1992/010698 patent/WO1993012107A1/en active IP Right Grant
- 1992-12-16 KR KR94702080A patent/KR0142801B1/ko not_active IP Right Cessation
- 1992-12-16 EP EP93901399A patent/EP0619818B1/de not_active Expired - Lifetime
- 1992-12-16 AT AT93901399T patent/ATE140223T1/de not_active IP Right Cessation
- 1992-12-16 AU AU32758/93A patent/AU665604B2/en not_active Ceased
- 1992-12-16 CA CA002126086A patent/CA2126086C/en not_active Expired - Fee Related
- 1992-12-16 ES ES93901399T patent/ES2089782T3/es not_active Expired - Lifetime
- 1992-12-16 JP JP5511084A patent/JPH07121938B2/ja not_active Expired - Lifetime
- 1992-12-16 SG SG1996002412A patent/SG44565A1/en unknown
- 1992-12-16 DE DE69212164T patent/DE69212164T2/de not_active Expired - Fee Related
- 1992-12-16 NZ NZ246434A patent/NZ246434A/en unknown
- 1992-12-17 TW TW081110145A patent/TW263503B/zh active
- 1992-12-17 MX MX9207392A patent/MX9207392A/es not_active IP Right Cessation
- 1992-12-17 IL IL10412492A patent/IL104124A/en not_active IP Right Cessation
- 1992-12-17 ZA ZA929785A patent/ZA929785B/xx unknown
- 1992-12-17 MY MYPI92002333A patent/MY108904A/en unknown
-
1996
- 1996-09-30 GR GR960402550T patent/GR3021195T3/el unknown
-
1997
- 1997-03-13 HK HK31097A patent/HK31097A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0619818T3 (da) | 1996-11-25 |
WO1993012107A1 (en) | 1993-06-24 |
HK31097A (en) | 1997-03-21 |
KR0142801B1 (en) | 1998-07-15 |
SG44565A1 (en) | 1997-12-19 |
IL104124A0 (en) | 1993-05-13 |
AU3275893A (en) | 1993-07-19 |
GR3021195T3 (en) | 1996-12-31 |
KR940703827A (de) | 1994-12-12 |
JPH07121938B2 (ja) | 1995-12-25 |
CA2126086A1 (en) | 1993-06-24 |
EP0619818B1 (de) | 1996-07-10 |
DE69212164T2 (de) | 1996-12-05 |
IL104124A (en) | 1998-12-06 |
EP0619818A1 (de) | 1994-10-19 |
ES2089782T3 (es) | 1996-10-01 |
AU665604B2 (en) | 1996-01-11 |
CA2126086C (en) | 2000-03-28 |
JPH06511252A (ja) | 1994-12-15 |
ATE140223T1 (de) | 1996-07-15 |
NZ246434A (en) | 1996-02-27 |
ZA929785B (en) | 1993-06-21 |
MX9207392A (es) | 1993-06-01 |
MY108904A (en) | 1996-11-30 |
TW263503B (de) | 1995-11-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69212164D1 (de) | Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring | |
KR0136207B1 (en) | Imidazolyl-alkyl-piperazine and diazepine derivatives as histamine h3 agonists/antagonists | |
ATE141269T1 (de) | Imidazolyl oder imidazolylalkyl substituiert mit einem 4- oder 5-gliedrigen stickstoff enthaltenden heterozyklischen ring | |
DE3177092D1 (en) | Medicinal composition for treatment of allergic diseases | |
WO1999024421A8 (en) | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom | |
NO172640C (no) | Analogifremgangsmaate ved fremstilling av terapeutisk aktive piperazinderivater | |
ATE186215T1 (de) | Verwendung von n-(pyridinyl)-1h-indol-1-aminen zur herstellung eines medikamentes zur behandlung von zwangsneurotischen erkrankungen | |
CO5011065A1 (es) | Ligandos del receptor h3, del tipo fenil-alquil-imidazoles | |
NO930083L (no) | Sammensetning for behandling av alzheimers sykdom og fremgangsmaate for fremstilling av samme | |
EP0358116A3 (de) | Thieno(3',4'-4,5)imidazo(2,1-b)-thiazol-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung in Medikamenten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |