TW263503B - - Google Patents
Info
- Publication number
- TW263503B TW263503B TW081110145A TW81110145A TW263503B TW 263503 B TW263503 B TW 263503B TW 081110145 A TW081110145 A TW 081110145A TW 81110145 A TW81110145 A TW 81110145A TW 263503 B TW263503 B TW 263503B
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- formula
- disclosed
- pharmaceutically acceptable
- effective amount
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Materials For Medical Uses (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81065191A | 1991-12-18 | 1991-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW263503B true TW263503B (zh) | 1995-11-21 |
Family
ID=25204344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW081110145A TW263503B (zh) | 1991-12-18 | 1992-12-17 |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0619818B1 (zh) |
JP (1) | JPH07121938B2 (zh) |
KR (1) | KR0142801B1 (zh) |
AT (1) | ATE140223T1 (zh) |
AU (1) | AU665604B2 (zh) |
CA (1) | CA2126086C (zh) |
DE (1) | DE69212164T2 (zh) |
DK (1) | DK0619818T3 (zh) |
ES (1) | ES2089782T3 (zh) |
GR (1) | GR3021195T3 (zh) |
HK (1) | HK31097A (zh) |
IL (1) | IL104124A (zh) |
MX (1) | MX9207392A (zh) |
MY (1) | MY108904A (zh) |
NZ (1) | NZ246434A (zh) |
SG (1) | SG44565A1 (zh) |
TW (1) | TW263503B (zh) |
WO (1) | WO1993012107A1 (zh) |
ZA (1) | ZA929785B (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7823894A (en) * | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
NL9302045A (nl) * | 1993-08-27 | 1995-03-16 | Vrije Universiteit | Nieuwe imidazoolafgeleide met agonistische of antagonistische activiteit op de histamine H3-receptor. |
FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
CA2238081A1 (en) * | 1995-11-22 | 1997-05-29 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
CA2250353A1 (en) * | 1996-04-03 | 1997-10-09 | Christopher J. Dinsmore | Inhibitors of farnesyl-protein transferase |
US6072057A (en) * | 1996-06-06 | 2000-06-06 | Gliatech Inc. | 1H-4(5)-cyclo-substituted imidazole derivatives as histamine H3 receptor agents |
US6407132B1 (en) | 1997-07-25 | 2002-06-18 | James Black Foundation Limited | Substituted imidazole derivatives and their use as histamine H3 receptor ligands |
JP2001522845A (ja) * | 1997-11-07 | 2001-11-20 | シェーリング コーポレイション | 1個の窒素原子を含有する5、6、または7員複素環式環で置換されたイミダゾイルアルキル |
US6034251A (en) * | 1997-11-07 | 2000-03-07 | Schering Corporation | Phenyl-alkyl-imidazoles |
US5990147A (en) * | 1997-11-07 | 1999-11-23 | Schering Corporation | H3 receptor ligands of the phenyl-alkyl-imidazoles type |
EP1413576A3 (en) * | 1997-12-04 | 2004-09-01 | Allergan, Inc. | Substituted imidazole derivatives having agonist-like activity at alpha 2B or 2B/2C adrenergic receptors |
US6133291A (en) * | 1998-10-16 | 2000-10-17 | Schering Corporation | N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists |
US6100279A (en) * | 1998-11-05 | 2000-08-08 | Schering Corporation | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom |
JP2002534511A (ja) | 1999-01-18 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 置換型イミダゾール、それらの調製及び使用 |
US6211182B1 (en) * | 1999-03-08 | 2001-04-03 | Schering Corporation | Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
US6794405B2 (en) | 2000-08-17 | 2004-09-21 | Merck & Co., Inc. | Alicyclic imidazoles as H3 agents |
US6951944B2 (en) | 2002-02-21 | 2005-10-04 | Azwell Inc. | Production of imidazole derivatives and novel intermediates of the derivatives |
EP1707203A1 (en) | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
EP1717235A3 (en) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
EP1717233A1 (en) | 2005-04-29 | 2006-11-02 | Bioprojet | Histamine H3-receptor ligands and their therapeutic application |
DE602007011793D1 (de) | 2006-10-18 | 2011-02-17 | Pfizer Prod Inc | Biaryl-ether-harnstoffverbindungen |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
FR2586562B1 (fr) * | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
EP0372125A1 (en) * | 1988-11-08 | 1990-06-13 | Akzo N.V. | Oxazole and thiazole derivatives |
US4925851A (en) * | 1989-05-23 | 1990-05-15 | Sandoz Pharmaceuticals Corp. | 2- or 4-substituted-[2-(1H-imidazol-1-yl)ethyl]piperidines |
-
1992
- 1992-12-16 ES ES93901399T patent/ES2089782T3/es not_active Expired - Lifetime
- 1992-12-16 SG SG1996002412A patent/SG44565A1/en unknown
- 1992-12-16 CA CA002126086A patent/CA2126086C/en not_active Expired - Fee Related
- 1992-12-16 JP JP5511084A patent/JPH07121938B2/ja not_active Expired - Lifetime
- 1992-12-16 KR KR94702080A patent/KR0142801B1/ko not_active IP Right Cessation
- 1992-12-16 AU AU32758/93A patent/AU665604B2/en not_active Ceased
- 1992-12-16 DK DK93901399.1T patent/DK0619818T3/da active
- 1992-12-16 NZ NZ246434A patent/NZ246434A/en unknown
- 1992-12-16 WO PCT/US1992/010698 patent/WO1993012107A1/en active IP Right Grant
- 1992-12-16 EP EP93901399A patent/EP0619818B1/en not_active Expired - Lifetime
- 1992-12-16 DE DE69212164T patent/DE69212164T2/de not_active Expired - Fee Related
- 1992-12-16 AT AT93901399T patent/ATE140223T1/de not_active IP Right Cessation
- 1992-12-17 MY MYPI92002333A patent/MY108904A/en unknown
- 1992-12-17 TW TW081110145A patent/TW263503B/zh active
- 1992-12-17 IL IL10412492A patent/IL104124A/en not_active IP Right Cessation
- 1992-12-17 MX MX9207392A patent/MX9207392A/es not_active IP Right Cessation
- 1992-12-17 ZA ZA929785A patent/ZA929785B/xx unknown
-
1996
- 1996-09-30 GR GR960402550T patent/GR3021195T3/el unknown
-
1997
- 1997-03-13 HK HK31097A patent/HK31097A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2126086A1 (en) | 1993-06-24 |
ZA929785B (en) | 1993-06-21 |
KR0142801B1 (en) | 1998-07-15 |
KR940703827A (zh) | 1994-12-12 |
EP0619818A1 (en) | 1994-10-19 |
DE69212164D1 (de) | 1996-08-14 |
SG44565A1 (en) | 1997-12-19 |
JPH06511252A (ja) | 1994-12-15 |
AU3275893A (en) | 1993-07-19 |
MY108904A (en) | 1996-11-30 |
DK0619818T3 (da) | 1996-11-25 |
DE69212164T2 (de) | 1996-12-05 |
IL104124A0 (en) | 1993-05-13 |
MX9207392A (es) | 1993-06-01 |
NZ246434A (en) | 1996-02-27 |
AU665604B2 (en) | 1996-01-11 |
GR3021195T3 (en) | 1996-12-31 |
CA2126086C (en) | 2000-03-28 |
ATE140223T1 (de) | 1996-07-15 |
EP0619818B1 (en) | 1996-07-10 |
JPH07121938B2 (ja) | 1995-12-25 |
IL104124A (en) | 1998-12-06 |
WO1993012107A1 (en) | 1993-06-24 |
HK31097A (en) | 1997-03-21 |
ES2089782T3 (es) | 1996-10-01 |
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