ATE138195T1 - Menschliches immunsystem in maus - Google Patents

Menschliches immunsystem in maus

Info

Publication number
ATE138195T1
ATE138195T1 AT89907883T AT89907883T ATE138195T1 AT E138195 T1 ATE138195 T1 AT E138195T1 AT 89907883 T AT89907883 T AT 89907883T AT 89907883 T AT89907883 T AT 89907883T AT E138195 T1 ATE138195 T1 AT E138195T1
Authority
AT
Austria
Prior art keywords
donor
immune system
mouse
human immune
recipient
Prior art date
Application number
AT89907883T
Other languages
English (en)
Inventor
Donald E Mosier
Darcy B Wilson
Original Assignee
Medical Biology Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Biology Inst filed Critical Medical Biology Inst
Application granted granted Critical
Publication of ATE138195T1 publication Critical patent/ATE138195T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eye Examination Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
AT89907883T 1988-06-14 1989-06-14 Menschliches immunsystem in maus ATE138195T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20727388A 1988-06-14 1988-06-14
US24159088A 1988-09-08 1988-09-08

Publications (1)

Publication Number Publication Date
ATE138195T1 true ATE138195T1 (de) 1996-06-15

Family

ID=26902105

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89907883T ATE138195T1 (de) 1988-06-14 1989-06-14 Menschliches immunsystem in maus

Country Status (9)

Country Link
EP (1) EP0379554B1 (de)
JP (2) JP2981486B2 (de)
KR (1) KR900702367A (de)
AT (1) ATE138195T1 (de)
AU (1) AU626560B2 (de)
DE (1) DE68926497T2 (de)
DK (1) DK37290A (de)
FI (1) FI900708A0 (de)
WO (1) WO1989012823A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849288A (en) * 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US5652373A (en) * 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US5147784A (en) * 1990-04-12 1992-09-15 Systemix, Inc. T-lymphocyte progenitor cell assay
AU637914B2 (en) * 1990-05-03 1993-06-10 Systemix, Inc. Human lymphoid tissue in an immunocompromised host
JPH05500617A (ja) * 1990-05-25 1993-02-12 システミックス，インコーポレイティド 免疫処理された宿主におけるヒト末梢血液細胞
DK9091D0 (da) * 1991-01-18 1991-01-18 Novo Nordisk As Fremgangsmaade til fremstilling af antistoffer
US5849987A (en) * 1992-06-02 1998-12-15 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5804160A (en) * 1991-06-04 1998-09-08 Yeda Research And Development Co. Ltd Animal model for hepatitis virus infection
US5858328A (en) * 1991-06-04 1999-01-12 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
GB9119338D0 (en) * 1991-09-10 1991-10-23 Inst Of Animal Physiology And Control of gene expression
US5866757A (en) * 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US5663481A (en) * 1993-08-06 1997-09-02 Mount Sinai Hospital Corporation Animal model of the human immune system
US7361332B2 (en) 1995-03-17 2008-04-22 The Regents Of The University Of California Treating tumors using implants comprising combinations of allogeneic cells
JP4312265B2 (ja) * 1997-04-09 2009-08-12 ラング−ジ チャン ワクチン評価のための動物モデル
ATE359080T1 (de) 1997-10-10 2007-05-15 Univ California Allogene zellkombination enthaltende implantate zur krebsbehandlung
AU9589398A (en) 1997-10-10 1999-05-03 Applied Immunotherapeutics, Inc. Cancer immunotherapy using allostimulated cells in a multiple sequential implantation strategy
US7651855B2 (en) 2003-04-17 2010-01-26 The Trustees Of The University Of Pennsylvania Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses
CA2545714C (en) * 2003-11-14 2012-10-16 Avanir Pharmaceuticals Neutralizing human antibodies to anthrax toxin generated by recall technology
EP2098536A1 (de) 2008-03-05 2009-09-09 4-Antibody AG Isolation und Identifikation antigen- oder ligandenspezifischer Bindungsproteine
CA3040377C (en) 2009-10-06 2025-12-30 Yale University Genetically modified mice and engraftment comprising the knock-in of a human thrombopoietin (tpo) gene
ES3040596T3 (en) 2011-02-15 2025-11-03 Regeneron Pharma Humanized m-csf mice and uses thereof
KR102287541B1 (ko) 2012-09-07 2021-08-10 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
EP4389764B1 (de) 2012-11-05 2026-03-18 Regeneron Pharmaceuticals, Inc. Genetisch modifizierte nagetiere und verfahren zur verwendung davon
KR20250096864A (ko) 2014-05-19 2025-06-27 리제너론 파마슈티칼스 인코포레이티드 인간 epo를 발현하는 유전자 변형된 비-인간 동물
JP6752221B2 (ja) 2015-04-13 2020-09-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｓｉｒｐａ−ｉｌ１５ノックインマウス及びその使用方法
CN111149767B (zh) * 2020-02-24 2021-07-20 中南大学湘雅二医院 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用
CN113588934B (zh) * 2021-06-18 2024-11-15 创模生物科技(北京)有限公司 Pbmc的免疫系统重建能力的检测方法及应用
WO2025042915A1 (en) 2023-08-21 2025-02-27 Slate Bio, Inc. Cell therapy methods using regulatory cells stimulated with interleukin-33 and interleukin-2

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5823973A (ja) * 1981-08-05 1983-02-12 三菱レイヨン株式会社 耐汚染性、耐黄変性壁紙
JPS6030656B2 (ja) * 1982-01-26 1985-07-17 株式会社林原生物化学研究所 ヒトｔ細胞増殖因子の製造方法
AU7873187A (en) * 1986-08-08 1988-02-24 University Of Minnesota Method of culturing leukocytes
ES2071620T3 (es) * 1987-12-23 1995-07-01 Univ Leland Stanford Junior Mamiferos inmunodeficientes quimericos y su utilizacion.
GR1001034B (el) * 1989-07-21 1993-03-31 Ortho Pharma Corp Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος.

Also Published As

Publication number Publication date
FI900708A7 (fi) 1990-02-13
DE68926497T2 (de) 1996-09-19
EP0379554A1 (de) 1990-08-01
KR900702367A (ko) 1990-12-06
AU3852689A (en) 1990-01-12
AU626560B2 (en) 1992-08-06
DE68926497D1 (de) 1996-06-20
DK37290D0 (da) 1990-02-13
DK37290A (da) 1990-02-13
WO1989012823A1 (en) 1989-12-28
EP0379554B1 (de) 1996-05-15
JP2981486B2 (ja) 1999-11-22
JP2960452B2 (ja) 1999-10-06
JPH0213336A (ja) 1990-01-17
EP0379554A4 (en) 1992-05-27
FI900708A0 (fi) 1990-02-13
JPH02502697A (ja) 1990-08-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time