ATE135585T1 - Anticoagulatorische zusammensetzung aus laci und sulfatierten polysacchariden - Google Patents

Anticoagulatorische zusammensetzung aus laci und sulfatierten polysacchariden

Info

Publication number
ATE135585T1
ATE135585T1 AT91870132T AT91870132T ATE135585T1 AT E135585 T1 ATE135585 T1 AT E135585T1 AT 91870132 T AT91870132 T AT 91870132T AT 91870132 T AT91870132 T AT 91870132T AT E135585 T1 ATE135585 T1 AT E135585T1
Authority
AT
Austria
Prior art keywords
laci
anticoagulatory
composition
sulfated polysaccharides
sulfated
Prior art date
Application number
AT91870132T
Other languages
English (en)
Inventor
Tze-Chein Wun
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ATE135585T1 publication Critical patent/ATE135585T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
AT91870132T 1990-08-27 1991-08-26 Anticoagulatorische zusammensetzung aus laci und sulfatierten polysacchariden ATE135585T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57308390A 1990-08-27 1990-08-27

Publications (1)

Publication Number Publication Date
ATE135585T1 true ATE135585T1 (de) 1996-04-15

Family

ID=24290576

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91870132T ATE135585T1 (de) 1990-08-27 1991-08-26 Anticoagulatorische zusammensetzung aus laci und sulfatierten polysacchariden

Country Status (10)

Country Link
EP (1) EP0473564B1 (de)
JP (1) JPH0733336B2 (de)
AT (1) ATE135585T1 (de)
CA (1) CA2049873C (de)
DE (1) DE69118056T2 (de)
DK (1) DK0473564T3 (de)
ES (1) ES2085462T3 (de)
GR (1) GR3020312T3 (de)
IE (1) IE913004A1 (de)
PT (1) PT98779B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
ITPD940054A1 (it) 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
DE69530084T2 (de) * 1994-07-07 2004-02-05 Washington University Methode zur verminderung arterieller stenose
AU707762B2 (en) * 1994-08-05 1999-07-22 Novartis Vaccines And Diagnostics, Inc. Production of tissue factor pathway inhibitor
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
DK1602667T3 (da) 1995-06-07 2007-07-23 Novartis Vaccines & Diagnostic Vandig formulering omfattende TFPI og solubiliseringsmidler
AU759412B2 (en) * 1995-06-07 2003-04-17 G.D. Searle & Co. Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
AU2003200506B2 (en) * 1995-06-07 2007-01-18 G.D. Searle Llc Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
AU1042597A (en) * 1995-12-18 1997-07-14 Stichting Sanquin Bloedvoorziening Potentiation of complement and coagulation inhibitory properties of c1-inhibitor.
PL372138A1 (en) 2001-10-15 2005-07-11 Chiron Corporation Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi)
EP1654283B1 (de) 2003-08-13 2011-07-13 Novartis Vaccines and Diagnostics, Inc. Verbessertes verfahren zur reinigung von tfpi und tfpi-analogen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington A method of inhibiting the isolation of a purer tissue factor
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co ANDC of human tissue factor inhibitor
EP0439442B1 (de) * 1990-01-25 1996-03-06 Washington University Faktor X-LACI-Hybridprotein

Also Published As

Publication number Publication date
PT98779B (pt) 1999-06-30
CA2049873A1 (en) 1992-02-28
JPH0733336B2 (ja) 1995-04-12
EP0473564B1 (de) 1996-03-20
DE69118056D1 (de) 1996-04-25
JPH04257524A (ja) 1992-09-11
DK0473564T3 (da) 1996-04-15
CA2049873C (en) 2001-12-04
DE69118056T2 (de) 1996-10-24
PT98779A (pt) 1992-07-31
ES2085462T3 (es) 1996-06-01
EP0473564A1 (de) 1992-03-04
IE913004A1 (en) 1992-03-11
GR3020312T3 (en) 1996-09-30

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee