MD1224C2 - Utilizare a analogilor nucleozidici cu 1,3-oxatiolan în tratamentul hepatitei B - Google Patents

Utilizare a analogilor nucleozidici cu 1,3-oxatiolan în tratamentul hepatitei B Download PDF

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Publication number
MD1224C2
MD1224C2 MD95-0086A MD950086A MD1224C2 MD 1224 C2 MD1224 C2 MD 1224C2 MD 950086 A MD950086 A MD 950086A MD 1224 C2 MD1224 C2 MD 1224C2
Authority
MD
Moldova
Prior art keywords
treatment
application
hepatitis
oxathiolan
nucleoside analogues
Prior art date
Application number
MD95-0086A
Other languages
English (en)
Russian (ru)
Other versions
MD950086A (ro
MD1224B2 (ro
Inventor
Bernard Belleau
Nghe Nguyen-Ba
Original Assignee
Biochem Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26298202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD1224(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919100039A external-priority patent/GB9100039D0/en
Priority claimed from GB919109913A external-priority patent/GB9109913D0/en
Application filed by Biochem Pharma Inc. filed Critical Biochem Pharma Inc.
Publication of MD950086A publication Critical patent/MD950086A/ro
Publication of MD1224B2 publication Critical patent/MD1224B2/ro
Publication of MD1224C2 publication Critical patent/MD1224C2/ro

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

Invenţia se referă la medicină şi poate fi aplicată în tratamentul infecţiilor virotice, în particular al hepatitei, în special al hepatitei B.Esenþa invenþiei constã în utilizarea enantiomerilor izomerului cis al 2´-deoxi-3´-tiacitidinei cu formula (I):sau a derivaþilor sãi farmaceutic acceptabili pentru tratamentul hepatitei virotice B.
MD95-0086A 1991-01-03 1992-01-03 Utilizare a analogilor nucleozidici cu 1,3-oxatiolan în tratamentul hepatitei B MD1224C2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919100039A GB9100039D0 (en) 1991-01-03 1991-01-03 Medicaments
GB919109913A GB9109913D0 (en) 1991-05-07 1991-05-07 Medicaments
PCT/CA1992/000001 WO1992011852A1 (en) 1991-01-03 1992-01-03 Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis b

Publications (3)

Publication Number Publication Date
MD950086A MD950086A (ro) 1997-01-31
MD1224B2 MD1224B2 (ro) 1999-05-31
MD1224C2 true MD1224C2 (ro) 1999-11-30

Family

ID=26298202

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0086A MD1224C2 (ro) 1991-01-03 1992-01-03 Utilizare a analogilor nucleozidici cu 1,3-oxatiolan în tratamentul hepatitei B

Country Status (23)

Country Link
US (2) US5532246A (ro)
EP (2) EP0565549B1 (ro)
JP (1) JP2659863B2 (ro)
KR (1) KR0156747B1 (ro)
AT (1) ATE120644T1 (ro)
AU (1) AU660650B2 (ro)
CA (2) CA2254613A1 (ro)
CY (1) CY2047B1 (ro)
DE (1) DE69201948T2 (ro)
DK (1) DK0565549T3 (ro)
EE (1) EE02995B1 (ro)
ES (1) ES2070628T3 (ro)
GE (1) GEP19981482B (ro)
GR (1) GR3015694T3 (ro)
HK (1) HK159395A (ro)
IE (1) IE73642B1 (ro)
IL (1) IL100502A (ro)
MD (1) MD1224C2 (ro)
NO (1) NO180407C (ro)
PH (1) PH31397A (ro)
TJ (1) TJ249B (ro)
TW (1) TW202385B (ro)
WO (1) WO1992011852A1 (ro)

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US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US6812233B1 (en) 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
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US20050192299A1 (en) * 1992-04-16 2005-09-01 Yung-Chi Cheng Method of treating or preventing hepatitis B virus
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US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
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JP2000515852A (ja) 1996-06-25 2000-11-28 グラクソ、グループ、リミテッド Ｈｉｖの治療に使用するためのｖｘ４７８、ジドブジン、ｆｔｃおよび／または３ｔｃを含んでなる組合わせ
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
US6113920A (en) * 1996-10-31 2000-09-05 Glaxo Wellcome Inc. Pharmaceutical compositions
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
JP2001518899A (ja) 1997-04-07 2001-10-16 トライアングル ファーマシューティカルズ，インコーポレイティド 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
ATE313550T1 (de) 1998-08-10 2006-01-15 Idenix Cayman Ltd Beta-l-2'-deoxynukleoside für die behandlung von hepatitis b virus
ES2237189T3 (es) 1998-11-02 2005-07-16 Gilead Sciences, Inc. Terapia de combinacion para tratar virus de la hepatitis b.
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US6432966B2 (en) 1999-10-29 2002-08-13 Smithkline Beecham Corporation Antiviral combinations
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja) 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
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US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
CN1503796B (zh) 2001-03-01 2012-07-04 三角药品公司 顺-ftc的多晶型物及其它晶型
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
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TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
DK1572095T3 (en) 2002-09-13 2015-09-14 Novartis Ag BETA-L-2'-DEOXYNUCLEOTIDES FOR TREATMENT OF RESISTANT HBV STANDS AND COMBINATION THERAPIES
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
MXPA05006230A (es) 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
ES2422290T3 (es) 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
EP2435052B1 (en) 2009-05-27 2015-07-15 Hetero Research Foundation Solid oral dosage forms of lamivudine with isomalt

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206497A2 (en) * 1985-05-15 1986-12-30 The Wellcome Foundation Limited Therapeutic nucleosides and their preparation
EP0302760A2 (en) * 1987-08-07 1989-02-08 The Governors of the University of Alberta Antiviral therapy for hepatitis B using 2',3'-dideoxynucleosides
EP0382526A2 (en) * 1989-02-08 1990-08-16 Biochem Pharma Inc Substituted -1,3-oxathiolanes with antiviral properties
WO1990014091A1 (en) * 1989-05-15 1990-11-29 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method of treatment of hepatitis
WO1990014079A1 (en) * 1989-05-15 1990-11-29 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method of treatment of hepatitis
WO1991017159A1 (en) * 1990-05-02 1991-11-14 Iaf Biochem International Inc. 1,3-oxathiolane nucleoside analogues

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EP0206497A2 (en) * 1985-05-15 1986-12-30 The Wellcome Foundation Limited Therapeutic nucleosides and their preparation
EP0302760A2 (en) * 1987-08-07 1989-02-08 The Governors of the University of Alberta Antiviral therapy for hepatitis B using 2',3'-dideoxynucleosides
EP0382526A2 (en) * 1989-02-08 1990-08-16 Biochem Pharma Inc Substituted -1,3-oxathiolanes with antiviral properties
WO1990014091A1 (en) * 1989-05-15 1990-11-29 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method of treatment of hepatitis
WO1990014079A1 (en) * 1989-05-15 1990-11-29 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method of treatment of hepatitis
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Also Published As

Publication number Publication date
KR0156747B1 (en) 1998-11-16
TW202385B (ro) 1993-03-21
EE02995B1 (et) 1997-06-16
MD950086A (ro) 1997-01-31
CY2047B1 (en) 1998-04-30
ATE120644T1 (de) 1995-04-15
HK159395A (en) 1995-10-20
JPH06507150A (ja) 1994-08-11
GEP19981482B (en) 1998-12-25
AU1153492A (en) 1992-08-17
DK0565549T3 (da) 1995-07-03
IL100502A0 (en) 1992-09-06
NO180407B (no) 1997-01-06
EP0494119A1 (en) 1992-07-08
IE73642B1 (en) 1997-06-18
WO1992011852A1 (en) 1992-07-23
CA2100269C (en) 1999-02-23
EP0565549B1 (en) 1995-04-05
EP0565549A1 (en) 1993-10-20
DE69201948T2 (de) 1995-08-03
AU660650B2 (en) 1995-07-06
TJ249B (en) 1999-12-23
USRE39155E1 (en) 2006-07-04
NO932442L (no) 1993-08-26
IE920004A1 (en) 1992-07-15
JP2659863B2 (ja) 1997-09-30
PH31397A (en) 1998-10-29
US5532246A (en) 1996-07-02
IL100502A (en) 1995-12-08
MD1224B2 (ro) 1999-05-31
GR3015694T3 (en) 1995-07-31
CA2254613A1 (en) 1992-07-04
ES2070628T3 (es) 1995-06-01
NO180407C (no) 1997-04-16
NO932442D0 (no) 1993-07-05
CA2100269A1 (en) 1992-07-04
DE69201948D1 (de) 1995-05-11

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Legal Events

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PD99 Pending application
TC4A Change of name of proprietor (patent for invention)

Owner name: SHIRE BIOCHEM INC., CA; 2250, BOUL. ALFRED-NOBEL B

Free format text: PREVIOUS NAME OF PROPRIETOR: BIOCHEM PHARMA INC., CA; 275 ARMAND FRAPPIER BOULEVARD, LAVAL, QUEBAC H7V 4A7, CANADA

TC4A Change of name of proprietor (patent for invention)

Owner name: SHIRE CANADA INC, CA; 2250, BOUL. ALFRED-NOBEL BUR

Free format text: PREVIOUS NAME OF PROPRIETOR: SHIRE BIOCHEM INC., CA; 2250, BOUL. ALFRED-NOBEL BUR. 500 VILLE SAINT-LAURENT QUEBEC H4S 2C9

MK4A Patent for invention expired