PT98779A - Processo para a preparacao de uma composicao anticoagulante contendo inibidor sulfatados e metodos para a sua utilizacao - Google Patents

Processo para a preparacao de uma composicao anticoagulante contendo inibidor sulfatados e metodos para a sua utilizacao

Info

Publication number
PT98779A
PT98779A PT98779A PT9877991A PT98779A PT 98779 A PT98779 A PT 98779A PT 98779 A PT98779 A PT 98779A PT 9877991 A PT9877991 A PT 9877991A PT 98779 A PT98779 A PT 98779A
Authority
PT
Portugal
Prior art keywords
preparation
methods
composition containing
containing sulfate
anticoagulant composition
Prior art date
Application number
PT98779A
Other languages
English (en)
Other versions
PT98779B (pt
Inventor
Tze-Chein Wun
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of PT98779A publication Critical patent/PT98779A/pt
Publication of PT98779B publication Critical patent/PT98779B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT98779A 1990-08-27 1991-08-26 Processo para a preparacao de uma composicao anticoagulante contendo inibidor sulfatados e metodos para a sua utilizacao PT98779B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57308390A 1990-08-27 1990-08-27

Publications (2)

Publication Number Publication Date
PT98779A true PT98779A (pt) 1992-07-31
PT98779B PT98779B (pt) 1999-06-30

Family

ID=24290576

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98779A PT98779B (pt) 1990-08-27 1991-08-26 Processo para a preparacao de uma composicao anticoagulante contendo inibidor sulfatados e metodos para a sua utilizacao

Country Status (10)

Country Link
EP (1) EP0473564B1 (pt)
JP (1) JPH0733336B2 (pt)
AT (1) ATE135585T1 (pt)
CA (1) CA2049873C (pt)
DE (1) DE69118056T2 (pt)
DK (1) DK0473564T3 (pt)
ES (1) ES2085462T3 (pt)
GR (1) GR3020312T3 (pt)
IE (1) IE913004A1 (pt)
PT (1) PT98779B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
ITPD940054A1 (it) 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
WO1996001649A1 (en) * 1994-07-07 1996-01-25 Washington University Method of attenuating arterial stenosis
EP0774001B1 (en) * 1994-08-05 2002-10-16 Chiron Corporation Production of tissue factor pathway inhibitor
US5589359A (en) 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
AU759412B2 (en) * 1995-06-07 2003-04-17 G.D. Searle & Co. Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
AU2003200506B2 (en) * 1995-06-07 2007-01-18 G.D. Searle Llc Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
DK0837883T3 (da) 1995-06-07 2005-12-19 Chiron Corp Fremgangsmåde til oplösning, oprensning og genfoldning af protein
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
JP2000507204A (ja) * 1995-12-18 2000-06-13 ステイヒテイング・サンキン・ブロードボールジーニング Ｃ１―インヒビターの補体及び血液凝固阻害特性の強化
BR0213292A (pt) 2001-10-15 2006-05-23 Chiron Corp tratamento de pneumonia severa por administração de inibidor da via de fator tecidual (tfpi)
US7851433B2 (en) 2003-08-13 2010-12-14 Novartis Vaccines And Diagnostics, Inc. Method of purifying TFPI and TFPI analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington A method of inhibiting the isolation of a purer tissue factor
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co ANDC of human tissue factor inhibitor
DE69117545T2 (de) * 1990-01-25 1996-10-31 Univ Washington Faktor X-LACI-Hybridprotein

Also Published As

Publication number Publication date
CA2049873A1 (en) 1992-02-28
EP0473564A1 (en) 1992-03-04
EP0473564B1 (en) 1996-03-20
ES2085462T3 (es) 1996-06-01
DE69118056D1 (de) 1996-04-25
IE913004A1 (en) 1992-03-11
GR3020312T3 (en) 1996-09-30
JPH04257524A (ja) 1992-09-11
DE69118056T2 (de) 1996-10-24
DK0473564T3 (da) 1996-04-15
ATE135585T1 (de) 1996-04-15
PT98779B (pt) 1999-06-30
CA2049873C (en) 2001-12-04
JPH0733336B2 (ja) 1995-04-12

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920313

FG3A Patent granted, date of granting

Effective date: 19990317

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20100917