DK0425109T3 - 3-substitueret-2-oxindolderivater som inhibitorer for interleukin-1-biosyntese - Google Patents

3-substitueret-2-oxindolderivater som inhibitorer for interleukin-1-biosyntese

Info

Publication number
DK0425109T3
DK0425109T3 DK90310806.6T DK90310806T DK0425109T3 DK 0425109 T3 DK0425109 T3 DK 0425109T3 DK 90310806 T DK90310806 T DK 90310806T DK 0425109 T3 DK0425109 T3 DK 0425109T3
Authority
DK
Denmark
Prior art keywords
interleukin
biosynthesis
substituted
inhibitors
oxindole derivatives
Prior art date
Application number
DK90310806.6T
Other languages
English (en)
Inventor
Gary Richard Schulte
Carl Joseph Goddard
Douglas Charles Hanson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0425109T3 publication Critical patent/DK0425109T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
DK90310806.6T 1989-10-13 1990-10-03 3-substitueret-2-oxindolderivater som inhibitorer for interleukin-1-biosyntese DK0425109T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42144589A 1989-10-13 1989-10-13
US52905090A 1990-05-25 1990-05-25

Publications (1)

Publication Number Publication Date
DK0425109T3 true DK0425109T3 (da) 1994-11-21

Family

ID=27025248

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90310806.6T DK0425109T3 (da) 1989-10-13 1990-10-03 3-substitueret-2-oxindolderivater som inhibitorer for interleukin-1-biosyntese

Country Status (14)

Country Link
US (1) US5192790A (da)
EP (1) EP0425109B1 (da)
JP (1) JPH0684300B2 (da)
KR (1) KR910007526A (da)
AT (1) ATE109349T1 (da)
AU (1) AU624739B2 (da)
CA (1) CA2027394C (da)
DE (1) DE69011272T2 (da)
DK (1) DK0425109T3 (da)
HU (2) HUT59004A (da)
IE (1) IE63140B1 (da)
IL (1) IL95880A (da)
MY (1) MY106834A (da)
PT (1) PT95566B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6266485B1 (en) 1998-02-19 2001-07-24 Emerson Electric Co. One-piece plastic tank and temperature control system for a hot water dispenser
WO2000018747A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
IN162090B (da) * 1984-03-19 1988-03-26 Pfizer
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
IN161509B (da) * 1984-05-04 1987-12-19 Pfizer
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8517958D0 (en) * 1985-07-16 1985-08-21 Cellena Cell Eng Ag Compositions containing melatonin/homologues
AU6898287A (en) * 1986-01-30 1987-08-25 University Of Utah, The Treatment of bone loss
US4677132A (en) * 1986-03-12 1987-06-30 American Home Products Corporation Inhibition of bone resorption by etodolac
US4861794A (en) * 1988-04-13 1989-08-29 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives

Also Published As

Publication number Publication date
HUT59004A (en) 1992-04-28
EP0425109B1 (en) 1994-08-03
DE69011272T2 (de) 1994-11-24
EP0425109A2 (en) 1991-05-02
JPH03133929A (ja) 1991-06-07
CA2027394C (en) 1995-01-03
HU210902A9 (en) 1995-09-28
DE69011272D1 (de) 1994-09-08
AU6458290A (en) 1991-04-18
PT95566B (pt) 1997-11-28
AU624739B2 (en) 1992-06-18
MY106834A (en) 1995-07-31
PT95566A (pt) 1991-08-14
IE903648A1 (en) 1991-04-24
IL95880A (en) 1995-12-31
US5192790A (en) 1993-03-09
CA2027394A1 (en) 1991-04-14
EP0425109A3 (en) 1992-01-15
HU906436D0 (en) 1991-04-29
ATE109349T1 (de) 1994-08-15
JPH0684300B2 (ja) 1994-10-26
IE63140B1 (en) 1995-03-22
KR910007526A (ko) 1991-05-30

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