HU210902A9 - 3-substituted-2-oxindole derivatives as inhibitors of interleukin-1 biosynthesis - Google Patents
3-substituted-2-oxindole derivatives as inhibitors of interleukin-1 biosynthesisInfo
- Publication number
- HU210902A9 HU210902A9 HU95P/P00128P HU9500128P HU210902A9 HU 210902 A9 HU210902 A9 HU 210902A9 HU 9500128 P HU9500128 P HU 9500128P HU 210902 A9 HU210902 A9 HU 210902A9
- Authority
- HU
- Hungary
- Prior art keywords
- interleukin
- biosynthesis
- substituted
- inhibitors
- oxindole derivatives
- Prior art date
Links
- 102000000589 Interleukin-1 Human genes 0.000 title abstract 3
- 108010002352 Interleukin-1 Proteins 0.000 title abstract 3
- -1 3-substituted-2-oxindole Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42144589A | 1989-10-13 | 1989-10-13 | |
| US52905090A | 1990-05-25 | 1990-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU210902A9 true HU210902A9 (en) | 1995-09-28 |
Family
ID=27025248
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU906436A HUT59004A (en) | 1989-10-13 | 1990-10-12 | Process for applying the interleukine-1 biosynthesis of 3-substituted-2-oxyndole-derivatives carried out as inhibitor |
| HU95P/P00128P HU210902A9 (en) | 1989-10-13 | 1995-05-11 | 3-substituted-2-oxindole derivatives as inhibitors of interleukin-1 biosynthesis |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU906436A HUT59004A (en) | 1989-10-13 | 1990-10-12 | Process for applying the interleukine-1 biosynthesis of 3-substituted-2-oxyndole-derivatives carried out as inhibitor |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5192790A (hu) |
| EP (1) | EP0425109B1 (hu) |
| JP (1) | JPH0684300B2 (hu) |
| KR (1) | KR910007526A (hu) |
| AT (1) | ATE109349T1 (hu) |
| AU (1) | AU624739B2 (hu) |
| CA (1) | CA2027394C (hu) |
| DE (1) | DE69011272T2 (hu) |
| DK (1) | DK0425109T3 (hu) |
| HU (2) | HUT59004A (hu) |
| IE (1) | IE63140B1 (hu) |
| IL (1) | IL95880A (hu) |
| MY (1) | MY106834A (hu) |
| PT (1) | PT95566B (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6266485B1 (en) | 1998-02-19 | 2001-07-24 | Emerson Electric Co. | One-piece plastic tank and temperature control system for a hot water dispenser |
| JP2002525362A (ja) * | 1998-09-30 | 2002-08-13 | エスヴァイン、アンゲリカ | 代謝性骨障害の治療および予防のためのロダニンカルボン酸誘導体 |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| IN162090B (hu) * | 1984-03-19 | 1988-03-26 | Pfizer | |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| IN161509B (hu) * | 1984-05-04 | 1987-12-19 | Pfizer | |
| US4678802A (en) * | 1985-07-09 | 1987-07-07 | Pfizer Inc. | 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents |
| GB8517958D0 (en) * | 1985-07-16 | 1985-08-21 | Cellena Cell Eng Ag | Compositions containing melatonin/homologues |
| AU6898287A (en) * | 1986-01-30 | 1987-08-25 | University Of Utah, The | Treatment of bone loss |
| US4677132A (en) * | 1986-03-12 | 1987-06-30 | American Home Products Corporation | Inhibition of bone resorption by etodolac |
| US4861794A (en) * | 1988-04-13 | 1989-08-29 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
-
1990
- 1990-10-02 IL IL9588090A patent/IL95880A/en not_active IP Right Cessation
- 1990-10-03 EP EP90310806A patent/EP0425109B1/en not_active Expired - Lifetime
- 1990-10-03 AT AT90310806T patent/ATE109349T1/de not_active IP Right Cessation
- 1990-10-03 DE DE69011272T patent/DE69011272T2/de not_active Expired - Fee Related
- 1990-10-03 DK DK90310806.6T patent/DK0425109T3/da active
- 1990-10-11 MY MYPI90001771A patent/MY106834A/en unknown
- 1990-10-11 PT PT95566A patent/PT95566B/pt not_active IP Right Cessation
- 1990-10-11 JP JP2273150A patent/JPH0684300B2/ja not_active Expired - Lifetime
- 1990-10-11 CA CA002027394A patent/CA2027394C/en not_active Expired - Fee Related
- 1990-10-12 HU HU906436A patent/HUT59004A/hu unknown
- 1990-10-12 AU AU64582/90A patent/AU624739B2/en not_active Ceased
- 1990-10-12 IE IE364890A patent/IE63140B1/en not_active IP Right Cessation
- 1990-10-12 KR KR1019900016153A patent/KR910007526A/ko not_active Application Discontinuation
-
1991
- 1991-12-17 US US07/808,491 patent/US5192790A/en not_active Expired - Fee Related
-
1995
- 1995-05-11 HU HU95P/P00128P patent/HU210902A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0425109B1 (en) | 1994-08-03 |
| IE903648A1 (en) | 1991-04-24 |
| PT95566B (pt) | 1997-11-28 |
| AU624739B2 (en) | 1992-06-18 |
| CA2027394A1 (en) | 1991-04-14 |
| DE69011272D1 (de) | 1994-09-08 |
| AU6458290A (en) | 1991-04-18 |
| DK0425109T3 (da) | 1994-11-21 |
| EP0425109A3 (en) | 1992-01-15 |
| ATE109349T1 (de) | 1994-08-15 |
| HU906436D0 (en) | 1991-04-29 |
| MY106834A (en) | 1995-07-31 |
| KR910007526A (ko) | 1991-05-30 |
| CA2027394C (en) | 1995-01-03 |
| JPH03133929A (ja) | 1991-06-07 |
| EP0425109A2 (en) | 1991-05-02 |
| HUT59004A (en) | 1992-04-28 |
| IE63140B1 (en) | 1995-03-22 |
| PT95566A (pt) | 1991-08-14 |
| US5192790A (en) | 1993-03-09 |
| JPH0684300B2 (ja) | 1994-10-26 |
| DE69011272T2 (de) | 1994-11-24 |
| IL95880A (en) | 1995-12-31 |
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