ATE131477T1 - Heterozyklische verbindungen mit hemmender wirkung auf 5-lipoxygenase - Google Patents
Heterozyklische verbindungen mit hemmender wirkung auf 5-lipoxygenaseInfo
- Publication number
- ATE131477T1 ATE131477T1 AT90301934T AT90301934T ATE131477T1 AT E131477 T1 ATE131477 T1 AT E131477T1 AT 90301934 T AT90301934 T AT 90301934T AT 90301934 T AT90301934 T AT 90301934T AT E131477 T1 ATE131477 T1 AT E131477T1
- Authority
- AT
- Austria
- Prior art keywords
- alkylene
- optionally substituted
- lipoxygenase
- sulphinyl
- sulphonyl
- Prior art date
Links
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 title abstract 2
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- -1 oxy, thio, sulphinyl Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89400560 | 1989-02-28 | ||
| EP89401493 | 1989-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE131477T1 true ATE131477T1 (de) | 1995-12-15 |
Family
ID=26122823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90301934T ATE131477T1 (de) | 1989-02-28 | 1990-02-22 | Heterozyklische verbindungen mit hemmender wirkung auf 5-lipoxygenase |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0385662B1 (de) |
| JP (1) | JP2545629B2 (de) |
| KR (1) | KR100195585B1 (de) |
| CN (1) | CN1031266C (de) |
| AT (1) | ATE131477T1 (de) |
| AU (1) | AU627275B2 (de) |
| CA (1) | CA2009902C (de) |
| DE (1) | DE69024076T2 (de) |
| DK (1) | DK0385662T3 (de) |
| ES (1) | ES2081925T3 (de) |
| FI (1) | FI96512C (de) |
| GB (1) | GB9004378D0 (de) |
| GR (1) | GR3018448T3 (de) |
| HU (1) | HU210165B (de) |
| IE (1) | IE70521B1 (de) |
| IL (1) | IL93342A (de) |
| MY (1) | MY105661A (de) |
| NO (1) | NO175591C (de) |
| NZ (1) | NZ232516A (de) |
| PT (1) | PT93287B (de) |
| YU (1) | YU38490A (de) |
| ZW (1) | ZW1390A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL93343A0 (en) * | 1989-02-28 | 1990-11-29 | Ici Plc | Heterocyclic cycloalkanes |
| GB9018134D0 (en) * | 1989-09-29 | 1990-10-03 | Ici Plc | Heterocyclic derivatives |
| IE911853A1 (en) * | 1990-06-21 | 1992-01-01 | Ici Plc | Heterocyclene derivatives |
| EP0462831B1 (de) * | 1990-06-21 | 1996-02-28 | Zeneca Limited | Bizyklische Pyran-Derivate und ihre Verwendung als 5-Lipoxygenasehemmer |
| EP0462830B1 (de) * | 1990-06-21 | 1995-10-18 | Zeneca Limited | Zyklische Ether-Derivate |
| IE911919A1 (en) * | 1990-06-21 | 1992-01-01 | Zeneca Ltd | Bicyclic heterocyclic compounds |
| GB9113137D0 (en) * | 1990-07-13 | 1991-08-07 | Ici Plc | Thioxo heterocycles |
| IE913655A1 (en) * | 1990-11-06 | 1992-05-22 | Zeneca Ltd | Synergistic agents |
| IE914005A1 (en) * | 1990-12-14 | 1992-06-17 | Zeneca Ltd | Novel intermediates |
| CA2058254A1 (en) * | 1991-01-15 | 1992-07-16 | John Francis Kingston | Benzodioxole derivatives |
| US5281720A (en) * | 1991-02-28 | 1994-01-25 | Merck Frosst Canada, Inc. | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis |
| US5227399A (en) * | 1991-02-28 | 1993-07-13 | Merck Frosst Canada, Inc. | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis |
| EP0532239B1 (de) * | 1991-09-10 | 1995-12-13 | Zeneca Limited | Benzolsulfonamidderivate als 5-Lipoxygenasehemmer |
| GB9300894D0 (en) * | 1992-02-07 | 1993-03-10 | Zeneca Ltd | Oxime derivatives |
| EP0570196B1 (de) * | 1992-05-12 | 1996-03-06 | Zeneca Limited | Oximderivate |
| US5308852A (en) * | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
| US5268379A (en) * | 1992-08-24 | 1993-12-07 | Abbott Laboratories | Ether-containing inhibitors of 5-lipoxygenase |
| US5350744A (en) * | 1992-08-27 | 1994-09-27 | Merck Frosst Canada, Inc. | Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
| US5426109A (en) * | 1992-08-27 | 1995-06-20 | Merck Frosst Canada, Inc. | Phenylnaphthalene hydroxy acids |
| US5252599A (en) * | 1992-08-27 | 1993-10-12 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis |
| US5428060A (en) * | 1992-08-27 | 1995-06-27 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
| EP0586229A1 (de) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(Subst.-Alkyl)-Pyrrolidine als 5-Lipoxygenase-Inhibitoren |
| US5354865A (en) * | 1992-09-10 | 1994-10-11 | Abbott Laboratories | Phenylmethyl derivatives having lipoxygenase inhibitory activity |
| IL109254A (en) * | 1993-04-29 | 1999-03-12 | Zeneca Ltd | Tetrahydropyran and tetrahydrofuran ether derivatives their preparation and pharmaceutical compositions comprising them |
| US5410054A (en) * | 1993-07-20 | 1995-04-25 | Merck Frosst Canada, Inc. | Heteroaryl quinolines as inhibitors of leukotriene biosynthesis |
| US5459271A (en) * | 1993-07-20 | 1995-10-17 | Merck Frosst Canada, Inc. | Arylbicyclooctanes as inhibitors of leukotriene biosynthesis |
| EP0636624A1 (de) * | 1993-07-27 | 1995-02-01 | Zeneca Limited | Thiazolederivative als Lipoxygenasehemmer |
| IL110280A0 (en) * | 1993-07-27 | 1994-10-21 | Zeneca Ltd | Thiazole derivatives |
| US5446062A (en) * | 1993-11-12 | 1995-08-29 | Abbott Laboratories | ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase |
| US5407959A (en) * | 1993-11-12 | 1995-04-18 | Abbott Laboratories | (Trans-1,4-dialkoxycyclohexyl) substituted arylalkylaryl-arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase |
| WO1995026346A1 (en) * | 1994-03-28 | 1995-10-05 | Pfizer Inc. | Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis |
| WO1995030668A1 (en) * | 1994-05-06 | 1995-11-16 | Zeneca Limited | Cyclic ether derivatives and pharmaceutical composition containing them |
| US5552437A (en) * | 1994-10-27 | 1996-09-03 | Merck Frosst Canada, Inc. | Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis |
| US5576338A (en) * | 1995-02-15 | 1996-11-19 | Merck Frosst Canada, Inc. | Bis (biaryl) compounds as inhibitors of leukotriene biosynthesis |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| US6548670B1 (en) | 2001-07-19 | 2003-04-15 | Air Products And Chemicals, Inc. | Methods for preparing 5- and 6-benzyl-functionalized quinoxalines |
| US6825221B2 (en) | 2001-10-18 | 2004-11-30 | Allergan, Inc. | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain |
| US7402684B2 (en) * | 2005-09-21 | 2008-07-22 | Decode Genectics Ehf. | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation |
| CN103804289B (zh) * | 2014-01-16 | 2016-06-22 | 苏州泰利三佳纳米科技有限公司 | 6-甲氧基喹啉的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE431085B (sv) * | 1977-09-13 | 1984-01-16 | Pfizer | 3-(2-hydroxi-4-(substituerade)fenyl)cykloalkanoner och -cykloalkanoder och vissa derivat derav till anvendning for farmakologiska och medicinska endamal |
| NZ213986A (en) * | 1984-10-30 | 1989-07-27 | Usv Pharma Corp | Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such |
| US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| IL93343A0 (en) * | 1989-02-28 | 1990-11-29 | Ici Plc | Heterocyclic cycloalkanes |
| IL93344A0 (en) * | 1989-02-28 | 1990-11-29 | Ici Plc | Heterocyclic cyclic ethers |
-
1990
- 1990-02-06 IE IE42290A patent/IE70521B1/en not_active IP Right Cessation
- 1990-02-11 IL IL9334290A patent/IL93342A/en not_active IP Right Cessation
- 1990-02-12 ZW ZW13/90A patent/ZW1390A1/xx unknown
- 1990-02-13 CA CA002009902A patent/CA2009902C/en not_active Expired - Lifetime
- 1990-02-13 NZ NZ232516A patent/NZ232516A/en unknown
- 1990-02-14 AU AU49766/90A patent/AU627275B2/en not_active Expired
- 1990-02-16 HU HU90826A patent/HU210165B/hu not_active IP Right Cessation
- 1990-02-22 AT AT90301934T patent/ATE131477T1/de not_active IP Right Cessation
- 1990-02-22 DK DK90301934.7T patent/DK0385662T3/da active
- 1990-02-22 DE DE69024076T patent/DE69024076T2/de not_active Expired - Lifetime
- 1990-02-22 EP EP90301934A patent/EP0385662B1/de not_active Expired - Lifetime
- 1990-02-22 ES ES90301934T patent/ES2081925T3/es not_active Expired - Lifetime
- 1990-02-23 MY MYPI90000293A patent/MY105661A/en unknown
- 1990-02-27 NO NO900916A patent/NO175591C/no not_active IP Right Cessation
- 1990-02-27 YU YU38490A patent/YU38490A/sh unknown
- 1990-02-27 GB GB909004378A patent/GB9004378D0/en active Pending
- 1990-02-28 KR KR1019900002871A patent/KR100195585B1/ko not_active Expired - Fee Related
- 1990-02-28 CN CN90101081A patent/CN1031266C/zh not_active Expired - Lifetime
- 1990-02-28 PT PT93287A patent/PT93287B/pt not_active IP Right Cessation
- 1990-02-28 FI FI901008A patent/FI96512C/fi active IP Right Grant
- 1990-02-28 JP JP2046011A patent/JP2545629B2/ja not_active Expired - Fee Related
-
1995
- 1995-12-19 GR GR950403578T patent/GR3018448T3/el unknown
Also Published As
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| DE69024076D1 (de) | Heterozyklische Verbindungen mit hemmender Wirkung auf 5-Lipoxygenase | |
| AU6118290A (en) | Nitrogen heterocycles having 5-lipoxygenase inhibitory activity | |
| DE69023940D1 (de) | Heterozyklische Zykloalkane mit hemmender Wirkung auf 5-Lipoxygenase. | |
| DE69026639D1 (de) | Heterozyklische zyklische Ether mit hemmender Wirkung auf 5-Lipoxygenase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EELA | Cancelled due to lapse of time |