YU38490A - Heterocikli - Google Patents

Heterocikli

Info

Publication number
YU38490A
YU38490A YU38490A YU38490A YU38490A YU 38490 A YU38490 A YU 38490A YU 38490 A YU38490 A YU 38490A YU 38490 A YU38490 A YU 38490A YU 38490 A YU38490 A YU 38490A
Authority
YU
Yugoslavia
Prior art keywords
alkylene
optionally substituted
sulphinyl
sulphonyl
imino
Prior art date
Application number
YU38490A
Other languages
English (en)
Inventor
G.C. Crawley
P.N. Edwards
J.M.M.M. Girodeau
Original Assignee
Ici Pharma
Imperial Chemical Industries Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Pharma, Imperial Chemical Industries Plc. filed Critical Ici Pharma
Publication of YU38490A publication Critical patent/YU38490A/sh
Priority to HR930093A priority Critical patent/HRP930093A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

HETEROCIKLI s formulo I v kateri je Q v danem primeru substituiran 6-členski monicikličen ali 10-členski bicikličen heterocikličen del, ki vsebuje enega ali dva atoma dušika; A je (1-6C)alkilen, (3-6C)alkenilen, (3-6C)alkinilen ali ciklo (3-6C)alkilen; X je oksi, tio, sulfinil, sulfonil ali imino; Ar je fenilen, ki lahko v danem primeru nosi enega ali dva substituena, ali je Ar v danem primeru substituiran 6-členski heterociklenski del, ki vsebuje do 3 atome dušika; R1 je vodik, (1-6C)-alkil, (3-6C)alkenil, (3-6C)alkinil, ciano-(1-4C) alkil ali (2-4C) alkanoil ali v danem primeru substituiran benzoil; in R2 in R3 skupaj tvorita skupino s formulo -A2-X2-A3-, ki skupaj z atomom ogljika, na katerega sta vezana A2 in A3, definira obroč s 4 do 7 obročnimi atomi, v katerem sta A2 in A3, ki sta lahko enaka ali različna, vsak (1-4C)alkilen, in je X2 oksi, tio, sulfinil, sulfonil ali imino; ali na njegovo farmacevtsko sprejemljivo sol. Spojine v smislu izuma so inhibitorji encima 5-lipoksigenaze.
YU38490A 1989-02-28 1990-02-27 Heterocikli YU38490A (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HR930093A HRP930093A2 (en) 1989-02-28 1993-02-01 Heterocyclic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP89400560 1989-02-28
EP89401493 1989-05-31

Publications (1)

Publication Number Publication Date
YU38490A true YU38490A (sh) 1992-09-07

Family

ID=26122823

Family Applications (1)

Application Number Title Priority Date Filing Date
YU38490A YU38490A (sh) 1989-02-28 1990-02-27 Heterocikli

Country Status (22)

Country Link
EP (1) EP0385662B1 (sh)
JP (1) JP2545629B2 (sh)
KR (1) KR100195585B1 (sh)
CN (1) CN1031266C (sh)
AT (1) ATE131477T1 (sh)
AU (1) AU627275B2 (sh)
CA (1) CA2009902C (sh)
DE (1) DE69024076T2 (sh)
DK (1) DK0385662T3 (sh)
ES (1) ES2081925T3 (sh)
FI (1) FI96512C (sh)
GB (1) GB9004378D0 (sh)
GR (1) GR3018448T3 (sh)
HU (1) HU210165B (sh)
IE (1) IE70521B1 (sh)
IL (1) IL93342A (sh)
MY (1) MY105661A (sh)
NO (1) NO175591C (sh)
NZ (1) NZ232516A (sh)
PT (1) PT93287B (sh)
YU (1) YU38490A (sh)
ZW (1) ZW1390A1 (sh)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93343A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cycloalkanes
GB9018134D0 (en) * 1989-09-29 1990-10-03 Ici Plc Heterocyclic derivatives
EP0462831B1 (en) * 1990-06-21 1996-02-28 Zeneca Limited Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE911919A1 (en) * 1990-06-21 1992-01-01 Zeneca Ltd Bicyclic heterocyclic compounds
IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
EP0462830B1 (en) * 1990-06-21 1995-10-18 Zeneca Limited Cyclic ether derivatives
GB9113137D0 (en) * 1990-07-13 1991-08-07 Ici Plc Thioxo heterocycles
IE913655A1 (en) * 1990-11-06 1992-05-22 Zeneca Ltd Synergistic agents
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
CA2058254A1 (en) * 1991-01-15 1992-07-16 John Francis Kingston Benzodioxole derivatives
US5227399A (en) * 1991-02-28 1993-07-13 Merck Frosst Canada, Inc. Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis
US5281720A (en) * 1991-02-28 1994-01-25 Merck Frosst Canada, Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0532239B1 (en) * 1991-09-10 1995-12-13 Zeneca Limited Benzenesulphonamide derivatives as 5-lipoxygenase inhibitors
GB9300894D0 (en) * 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
EP0570196B1 (en) * 1992-05-12 1996-03-06 Zeneca Limited Oxime derivatives
US5308852A (en) * 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5268379A (en) * 1992-08-24 1993-12-07 Abbott Laboratories Ether-containing inhibitors of 5-lipoxygenase
US5350744A (en) * 1992-08-27 1994-09-27 Merck Frosst Canada, Inc. Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5428060A (en) * 1992-08-27 1995-06-27 Merck Frosst Canada, Inc. Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5252599A (en) * 1992-08-27 1993-10-12 Merck Frosst Canada, Inc. Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis
US5426109A (en) * 1992-08-27 1995-06-20 Merck Frosst Canada, Inc. Phenylnaphthalene hydroxy acids
EP0586229A1 (en) * 1992-09-01 1994-03-09 Zeneca Limited 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors
US5354865A (en) * 1992-09-10 1994-10-11 Abbott Laboratories Phenylmethyl derivatives having lipoxygenase inhibitory activity
IL109254A (en) * 1993-04-29 1999-03-12 Zeneca Ltd History of the tetrahydropyran and tetrahydropuran site preparation and pharmaceutical preparations containing them
US5410054A (en) * 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
US5459271A (en) * 1993-07-20 1995-10-17 Merck Frosst Canada, Inc. Arylbicyclooctanes as inhibitors of leukotriene biosynthesis
IL110280A0 (en) * 1993-07-27 1994-10-21 Zeneca Ltd Thiazole derivatives
EP0636624A1 (en) * 1993-07-27 1995-02-01 Zeneca Limited Thiazole derivatives as lipoxygenase inhibitors
US5446062A (en) * 1993-11-12 1995-08-29 Abbott Laboratories ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase
US5407959A (en) * 1993-11-12 1995-04-18 Abbott Laboratories (Trans-1,4-dialkoxycyclohexyl) substituted arylalkylaryl-arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase
EP0752990B1 (en) * 1994-03-28 1998-08-05 Pfizer Inc. Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis
WO1995030668A1 (en) * 1994-05-06 1995-11-16 Zeneca Limited Cyclic ether derivatives and pharmaceutical composition containing them
US5552437A (en) * 1994-10-27 1996-09-03 Merck Frosst Canada, Inc. Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis
US5576338A (en) * 1995-02-15 1996-11-19 Merck Frosst Canada, Inc. Bis (biaryl) compounds as inhibitors of leukotriene biosynthesis
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6548670B1 (en) * 2001-07-19 2003-04-15 Air Products And Chemicals, Inc. Methods for preparing 5- and 6-benzyl-functionalized quinoxalines
US6825221B2 (en) 2001-10-18 2004-11-30 Allergan, Inc. Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
WO2007040682A1 (en) * 2005-09-21 2007-04-12 Decode Genetics Ehf. Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation
CN103804289B (zh) * 2014-01-16 2016-06-22 苏州泰利三佳纳米科技有限公司 6-甲氧基喹啉的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE431085B (sv) * 1977-09-13 1984-01-16 Pfizer 3-(2-hydroxi-4-(substituerade)fenyl)cykloalkanoner och -cykloalkanoder och vissa derivat derav till anvendning for farmakologiska och medicinska endamal
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
IL93344A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cyclic ethers
IL93343A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cycloalkanes

Also Published As

Publication number Publication date
NO175591C (no) 1994-11-02
NO900916D0 (no) 1990-02-27
DK0385662T3 (da) 1996-04-15
HU210165B (en) 1995-02-28
EP0385662B1 (en) 1995-12-13
EP0385662A2 (en) 1990-09-05
NO175591B (no) 1994-07-25
FI96512C (fi) 1996-07-10
ZW1390A1 (en) 1990-10-24
AU4976690A (en) 1990-09-06
GB9004378D0 (en) 1990-04-25
IE900422L (en) 1990-08-28
EP0385662A3 (en) 1991-11-21
DE69024076T2 (de) 1996-10-17
KR910015538A (ko) 1991-09-30
CN1031266C (zh) 1996-03-13
JPH02268157A (ja) 1990-11-01
IL93342A0 (en) 1990-11-29
CA2009902A1 (en) 1990-08-31
IE70521B1 (en) 1996-12-11
AU627275B2 (en) 1992-08-20
FI901008A0 (fi) 1990-02-28
CA2009902C (en) 1999-10-05
JP2545629B2 (ja) 1996-10-23
KR100195585B1 (ko) 1999-09-01
NO900916L (no) 1990-08-29
HU900826D0 (en) 1990-04-28
ATE131477T1 (de) 1995-12-15
DE69024076D1 (de) 1996-01-25
CN1046903A (zh) 1990-11-14
NZ232516A (en) 1992-04-28
IL93342A (en) 1994-05-30
PT93287B (pt) 1996-03-29
PT93287A (pt) 1990-08-31
GR3018448T3 (en) 1996-03-31
HUT58083A (en) 1992-01-28
ES2081925T3 (es) 1996-03-16
FI96512B (fi) 1996-03-29
MY105661A (en) 1994-11-30

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