ATE119787T1 - Implantaten für grosse mengen von zellen auf polymerische matrizen. - Google Patents

Implantaten für grosse mengen von zellen auf polymerische matrizen.

Info

Publication number
ATE119787T1
ATE119787T1 AT90907948T AT90907948T ATE119787T1 AT E119787 T1 ATE119787 T1 AT E119787T1 AT 90907948 T AT90907948 T AT 90907948T AT 90907948 T AT90907948 T AT 90907948T AT E119787 T1 ATE119787 T1 AT E119787T1
Authority
AT
Austria
Prior art keywords
degradable
cells
matrix
function
growth
Prior art date
Application number
AT90907948T
Other languages
English (en)
Inventor
Joseph P Vacanti
Robert S Langer
Lynt Johnson
Linda Griffith-Cima
Original Assignee
Childrens Medical Center
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, Massachusetts Inst Technology filed Critical Childrens Medical Center
Application granted granted Critical
Publication of ATE119787T1 publication Critical patent/ATE119787T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/18—Liver cell growth factor (LCGF, Gly-His-Lys)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials For Medical Uses (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT90907948T 1989-04-25 1990-04-25 Implantaten für grosse mengen von zellen auf polymerische matrizen. ATE119787T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34315889A 1989-04-25 1989-04-25

Publications (1)

Publication Number Publication Date
ATE119787T1 true ATE119787T1 (de) 1995-04-15

Family

ID=23344941

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90907948T ATE119787T1 (de) 1989-04-25 1990-04-25 Implantaten für grosse mengen von zellen auf polymerische matrizen.

Country Status (8)

Country Link
EP (1) EP0422209B1 (de)
JP (3) JP3073766B2 (de)
AT (1) ATE119787T1 (de)
AU (1) AU636346B2 (de)
CA (1) CA2031532C (de)
DE (1) DE69017820T2 (de)
ES (1) ES2072434T3 (de)
WO (1) WO1990012604A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5376118A (en) * 1989-05-10 1994-12-27 United States Surgical Corporation Support material for cell impregnation
JPH05502178A (ja) * 1989-12-07 1993-04-22 バイオシンセシス，インコーポレーテッド 中空内臓人工器官及び移植方法
EP0554352B1 (de) * 1990-10-19 2003-03-05 New York University Eine methode zur transplantation von zellen in das gehirn und ihre therapeutische verwendung
US5618531A (en) 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
AU2900792A (en) * 1991-10-24 1993-05-21 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
ATE152631T1 (de) * 1991-10-30 1997-05-15 Massachusetts Inst Technology Vorvaskularisierte polymerimplantate für organtransplantation
US5610753A (en) 1991-12-12 1997-03-11 Eastman Kodak Company Optical design of laser scanner to reduce thermal sensitivity
DE4206585C2 (de) * 1992-03-03 1994-11-24 Augustinus Dr Med Bader Vorrichtung zur Massenkultur von Zellen
DE69331108T2 (de) * 1992-04-01 2002-07-04 Baxter Int Systeme zum einpflanzen von gefässbildendem gewebe
GB9210574D0 (en) * 1992-05-18 1992-07-01 Ca Nat Research Council Biotherapeutic cell-coated microspheres for wound/burn and prothesis implant applications
EP0655910A4 (de) * 1992-07-29 1996-02-28 Univ Washington Verwendung eines beutels zur implantation von lebenden zellen.
JP3973050B2 (ja) 1992-09-16 2007-09-05 キュリス，インコーポレイテッド モルフォゲン誘発性肝再生
US6689608B1 (en) 1993-02-01 2004-02-10 Massachusetts Institute Of Technology Porous biodegradable polymeric materials for cell transplantation
WO1994025079A1 (en) * 1993-04-23 1994-11-10 Massachusetts Institute Of Technology Porous biodegradable polymeric materials for cell transplantation
ATE183078T1 (de) 1993-08-10 1999-08-15 Gore & Ass Zelleinkapselungsvorrichtung
US5549675A (en) * 1994-01-11 1996-08-27 Baxter International, Inc. Method for implanting tissue in a host
US20020055786A1 (en) 1994-08-16 2002-05-09 Anthony Atala Reconstruction of urological structures with polymeric matrices
US5648088A (en) 1995-03-06 1997-07-15 Ethicon, Inc. Blends of absorbable polyoxaesters containing amines and/or amide groups
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
AU6854696A (en) * 1995-09-22 1997-04-09 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
DE69631402T2 (de) 1995-11-06 2004-12-09 Ethicon, Inc. Polymermischungen die Polyoxaestern und Lactonpolymeren enthalten
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US6316522B1 (en) 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
WO1999022781A2 (en) * 1997-10-31 1999-05-14 Children's Medical Center Corporation Bladder reconstruction
JP2002513036A (ja) * 1998-04-24 2002-05-08 トランスカリョティック セラピーズ インコーポレーテッド 遺伝子修飾した細胞の網内移植による治療的タンパク質の送達
US6129757A (en) 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
US6245345B1 (en) * 1998-07-07 2001-06-12 Atrix Laboratories, Inc. Filamentous porous films and methods for producing the same
WO2002030481A1 (en) * 2000-10-10 2002-04-18 Massachusetts Institute Of Technology Cell delivery using controllably degradable mesh-gel constructs
KR20010044624A (ko) * 2001-03-12 2001-06-05 정재호 연골조직공학을 위한 연골지지체의 제조방법 및 이연골지지체를 사용하여 제조한 인공연골
US7034037B2 (en) 2001-06-29 2006-04-25 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US7030127B2 (en) 2001-06-29 2006-04-18 Ethicon, Inc. Composition and medical devices utilizing bioabsorbable polymeric waxes
US6967234B2 (en) 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US7005136B2 (en) 2002-03-29 2006-02-28 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
US7326426B2 (en) 2002-03-29 2008-02-05 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable liquid polymers
US7368125B2 (en) 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7026374B2 (en) 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7101566B2 (en) 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
US6872799B2 (en) 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
US6866860B2 (en) 2002-12-19 2005-03-15 Ethicon, Inc. Cationic alkyd polyesters for medical applications
ES2628031T3 (es) 2005-10-26 2017-08-01 Genesis Technologies Limited Matrices de regeneración tisular acelulares bioabsorbibles producidas mediante incubación de productos sanguíneos acelulares
US9580688B2 (en) 2007-06-08 2017-02-28 Wake Forest University Health Sciences Kidney structures and methods of forming the same
KR101632372B1 (ko) 2007-06-08 2016-07-01 웨이크 포리스트 유니버시티 헬스 사이언시즈 신부전 치료를 위한 선택적 세포 치료법
EP2358375B1 (de) 2008-11-12 2013-07-24 Tengion, Inc. Isolierte nierenzellen und verwendungen dafür
WO2010057013A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
NZ603482A (en) 2010-05-12 2014-11-28 Tengion Inc Bioactive renal cells
US9386863B1 (en) 2010-06-18 2016-07-12 Boba Inc. Child carrier and methods of use
KR102056324B1 (ko) 2010-11-10 2019-12-16 인리젠 장기 확대를 위한 주사가능 제제
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
CH670760A5 (de) * 1986-06-02 1989-07-14 Sulzer Ag
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices

Also Published As

Publication number Publication date
ES2072434T3 (es) 1995-07-16
JPH04501080A (ja) 1992-02-27
AU636346B2 (en) 1993-04-29
JPH10263070A (ja) 1998-10-06
DE69017820T2 (de) 1995-10-05
EP0422209A1 (de) 1991-04-17
CA2031532A1 (en) 1990-10-26
JP2001314498A (ja) 2001-11-13
CA2031532C (en) 2003-02-25
WO1990012604A1 (en) 1990-11-01
DE69017820D1 (de) 1995-04-20
EP0422209B1 (de) 1995-03-15
JP3073766B2 (ja) 2000-08-07
AU5569190A (en) 1990-11-16

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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time