ATE11289T1 - Verfahren zur herstellung von ergolinderivaten. - Google Patents
Verfahren zur herstellung von ergolinderivaten.Info
- Publication number
- ATE11289T1 ATE11289T1 AT82730112T AT82730112T ATE11289T1 AT E11289 T1 ATE11289 T1 AT E11289T1 AT 82730112 T AT82730112 T AT 82730112T AT 82730112 T AT82730112 T AT 82730112T AT E11289 T1 ATE11289 T1 AT E11289T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- carbon atoms
- production
- treating
- ergoline
- Prior art date
Links
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000005265 dialkylamine group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- ACKFDYCQCBEDNU-UHFFFAOYSA-J lead(2+);tetraacetate Chemical compound [Pb+2].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O ACKFDYCQCBEDNU-UHFFFAOYSA-J 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3135305A DE3135305C2 (de) | 1981-09-03 | 1981-09-03 | Verfahren zur Herstellung von 8-Ergolinyl-harnstoffen |
| EP82730112A EP0074921B1 (en) | 1981-09-03 | 1982-08-23 | Process for the preparation of ergoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE11289T1 true ATE11289T1 (de) | 1985-02-15 |
Family
ID=6141023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82730112T ATE11289T1 (de) | 1981-09-03 | 1982-08-23 | Verfahren zur herstellung von ergolinderivaten. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4748248A (enExample) |
| EP (1) | EP0074921B1 (enExample) |
| JP (1) | JPS5855483A (enExample) |
| AT (1) | ATE11289T1 (enExample) |
| AU (1) | AU555576B2 (enExample) |
| CA (1) | CA1175813A (enExample) |
| CS (1) | CS241122B2 (enExample) |
| DD (1) | DD203544A5 (enExample) |
| DE (2) | DE3135305C2 (enExample) |
| DK (1) | DK161646C (enExample) |
| ES (1) | ES8305361A1 (enExample) |
| GR (1) | GR76897B (enExample) |
| HU (1) | HU186969B (enExample) |
| IE (1) | IE53437B1 (enExample) |
| IL (1) | IL66679A (enExample) |
| SU (1) | SU1272988A3 (enExample) |
| YU (1) | YU199282A (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3151912A1 (de) * | 1981-12-23 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
| DE3309493A1 (de) * | 1983-03-14 | 1984-09-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel |
| CH666035A5 (de) * | 1984-12-24 | 1988-06-30 | Sandoz Ag | 8-alpha-acylaminoergolene. |
| DE3915950A1 (de) * | 1989-05-12 | 1990-11-15 | Schering Ag | 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel |
| US20060171795A1 (en) * | 2005-01-28 | 2006-08-03 | Cromwell Stephen D | Substantial embedment of metallic debris |
| JP2010119349A (ja) * | 2008-11-20 | 2010-06-03 | Shinichi Okamoto | 即席のパンなどの穀物粉加工食品の製造方法 |
| CA2974113A1 (en) | 2015-01-20 | 2016-07-28 | Xoc Pharmaceuticals, Inc. | Isoergoline compounds and uses thereof |
| BR112017015487A2 (pt) | 2015-01-20 | 2018-01-30 | Xoc Pharmaceuticals Inc | Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo |
| CA3064274A1 (en) | 2017-06-01 | 2018-12-06 | Xoc Pharmaceuticals, Inc. | Ergoline derivatives for use in medicine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0021206B1 (de) * | 1979-06-13 | 1983-06-22 | Schering Aktiengesellschaft | Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel |
-
1981
- 1981-09-03 DE DE3135305A patent/DE3135305C2/de not_active Expired
-
1982
- 1982-08-03 SU SU823470940A patent/SU1272988A3/ru active
- 1982-08-17 DK DK368382A patent/DK161646C/da not_active IP Right Cessation
- 1982-08-23 DE DE8282730112T patent/DE3261963D1/de not_active Expired
- 1982-08-23 EP EP82730112A patent/EP0074921B1/en not_active Expired
- 1982-08-23 AT AT82730112T patent/ATE11289T1/de not_active IP Right Cessation
- 1982-08-30 IL IL66679A patent/IL66679A/xx unknown
- 1982-08-31 AU AU87863/82A patent/AU555576B2/en not_active Ceased
- 1982-08-31 DD DD82242909A patent/DD203544A5/de unknown
- 1982-09-01 GR GR69181A patent/GR76897B/el unknown
- 1982-09-01 ES ES515428A patent/ES8305361A1/es not_active Expired
- 1982-09-02 CA CA000410636A patent/CA1175813A/en not_active Expired
- 1982-09-02 HU HU822824A patent/HU186969B/hu not_active IP Right Cessation
- 1982-09-03 IE IE2156/82A patent/IE53437B1/en not_active IP Right Cessation
- 1982-09-03 CS CS826422A patent/CS241122B2/cs unknown
- 1982-09-03 JP JP57152871A patent/JPS5855483A/ja active Granted
- 1982-09-03 YU YU01992/82A patent/YU199282A/xx unknown
-
1985
- 1985-12-13 US US06/808,804 patent/US4748248A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3135305C2 (de) | 1983-07-21 |
| ES515428A0 (es) | 1983-05-01 |
| JPH0239511B2 (enExample) | 1990-09-05 |
| DK161646B (da) | 1991-07-29 |
| DK368382A (da) | 1983-03-04 |
| YU199282A (en) | 1985-03-20 |
| IE53437B1 (en) | 1988-11-09 |
| AU8786382A (en) | 1983-03-10 |
| EP0074921A1 (en) | 1983-03-23 |
| EP0074921B1 (en) | 1985-01-16 |
| DK161646C (da) | 1992-01-06 |
| AU555576B2 (en) | 1986-10-02 |
| HU186969B (en) | 1985-10-28 |
| IE822156L (en) | 1983-03-03 |
| IL66679A0 (en) | 1982-12-31 |
| CA1175813A (en) | 1984-10-09 |
| US4748248A (en) | 1988-05-31 |
| JPS5855483A (ja) | 1983-04-01 |
| GR76897B (enExample) | 1984-09-04 |
| DE3135305A1 (de) | 1983-03-10 |
| DE3261963D1 (en) | 1985-02-28 |
| CS642282A2 (en) | 1985-07-16 |
| IL66679A (en) | 1986-04-29 |
| SU1272988A3 (ru) | 1986-11-23 |
| ES8305361A1 (es) | 1983-05-01 |
| CS241122B2 (en) | 1986-03-13 |
| DD203544A5 (de) | 1983-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |