GB982207A - Process for the production of quinazolone derivatives - Google Patents

Process for the production of quinazolone derivatives

Info

Publication number
GB982207A
GB982207A GB4630862A GB4630862A GB982207A GB 982207 A GB982207 A GB 982207A GB 4630862 A GB4630862 A GB 4630862A GB 4630862 A GB4630862 A GB 4630862A GB 982207 A GB982207 A GB 982207A
Authority
GB
United Kingdom
Prior art keywords
prepared
group
formula
reacting
cephalosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4630862A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orgamol AG
Original Assignee
Orgamol AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1494761A external-priority patent/CH419143A/en
Application filed by Orgamol AG filed Critical Orgamol AG
Publication of GB982207A publication Critical patent/GB982207A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Compounds of the general formula <FORM:0982207/C2/1> (wherein R1 represents a methyl or ethyl group, R2 represents a substituted phenyl group or an unsubstituted or substituted heterocyclic group, and R3 represents a hydrogen or halogen atom or an alkyl, nitro or amino group) are prepared by subjecting the acid sodium salt of the appropriate N-acetyl- or N-propionyl-anthranilic acid to ring-closing condensation with R2NH2, the product being isolated as the free base or an acid addition salt thereof. The acid sodium salt starting materials are prepared by reacting the neutral sodium salt of the appropriate anthranilic acid in aqueous solution with acetic or propionic anhydride. Specifications 843,073 and 936,902 are referred to.ALSO:N-formyl cephalosporin hydantoins of formula <FORM:0982207/C2/1> may be prepared by reacting an N-carbamyl derivative of cephalosporin C of the formula <FORM:0982207/C2/2> with a mixed formic anhydride in the presence of a tertiary amine. Heterocyclic base derivatives of hydantoin of cephalosporin C of formula <FORM:0982207/C2/3> may be prepared by reacting the above N-formyl compounds with a heterocyclic base. In the above formulae B represents a heterocyclic base such as pyridine or N-methylimidazole, R1 is oxygen or sulphur and R2 a hydrocarbon or substituted-hydrocarbon group, particularly an alkyl or aryl group.
GB4630862A 1961-12-22 1962-12-07 Process for the production of quinazolone derivatives Expired GB982207A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1494761A CH419143A (en) 1961-12-22 1961-12-22 Process for the production of quinazolone derivatives
CH731862 1962-06-16

Publications (1)

Publication Number Publication Date
GB982207A true GB982207A (en) 1965-02-03

Family

ID=25701116

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4630862A Expired GB982207A (en) 1961-12-22 1962-12-07 Process for the production of quinazolone derivatives

Country Status (1)

Country Link
GB (1) GB982207A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010221A1 (en) * 1995-09-15 1997-03-20 Torrey Pines Institute For Molecular Studies Synthesis of quinazolinone libraries

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010221A1 (en) * 1995-09-15 1997-03-20 Torrey Pines Institute For Molecular Studies Synthesis of quinazolinone libraries

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