ATE111604T1 - Avidin-biotin assistiertes immunassayverfahren. - Google Patents

Avidin-biotin assistiertes immunassayverfahren.

Info

Publication number
ATE111604T1
ATE111604T1 AT90903466T AT90903466T ATE111604T1 AT E111604 T1 ATE111604 T1 AT E111604T1 AT 90903466 T AT90903466 T AT 90903466T AT 90903466 T AT90903466 T AT 90903466T AT E111604 T1 ATE111604 T1 AT E111604T1
Authority
AT
Austria
Prior art keywords
antibody
immobilized
avidin
contacted
protein
Prior art date
Application number
AT90903466T
Other languages
English (en)
Inventor
Thomas Thieme
Adolph Ferro
Jack H Fellman
Stefan Gavojdea
Original Assignee
Epitope Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epitope Inc filed Critical Epitope Inc
Application granted granted Critical
Publication of ATE111604T1 publication Critical patent/ATE111604T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6897Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
    • A61K47/6898Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548Carbohydrates, e.g. dextran
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT90903466T 1989-01-30 1990-01-25 Avidin-biotin assistiertes immunassayverfahren. ATE111604T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30287789A 1989-01-30 1989-01-30

Publications (1)

Publication Number Publication Date
ATE111604T1 true ATE111604T1 (de) 1994-09-15

Family

ID=23169594

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90903466T ATE111604T1 (de) 1989-01-30 1990-01-25 Avidin-biotin assistiertes immunassayverfahren.

Country Status (10)

Country Link
EP (1) EP0455735B1 (de)
JP (1) JPH04503109A (de)
AT (1) ATE111604T1 (de)
AU (1) AU640635B2 (de)
CA (1) CA2045673A1 (de)
DE (1) DE69012552T2 (de)
DK (1) DK0455735T3 (de)
FI (1) FI913615A0 (de)
NO (1) NO912951L (de)
WO (1) WO1990008957A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525338A (en) * 1992-08-21 1996-06-11 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin conjugates
US5198340A (en) * 1991-01-17 1993-03-30 Genentech, Inc. Assay for free igf-i, igf-ii, and gh levels in body fluids
US6087188A (en) * 1992-11-13 2000-07-11 Alk A/S Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand
IL104384A (en) * 1993-01-13 1996-11-14 Yeda Res & Dev Method for screening catalytic non-enzyme polypeptides and proteins
US5504091A (en) * 1993-04-23 1996-04-02 American Home Products Corporation Biotin esters of rapamycin
DE69435044T2 (de) 1993-04-23 2008-09-18 Wyeth Rapamycin - Konjugate und Antikörper
US7279561B1 (en) 1993-04-23 2007-10-09 Wyeth Anti-rapamycin monoclonal antibodies
DE69635753T2 (de) * 1995-06-07 2006-09-14 Abbott Laboratories, Abbott Park Verbesserte hapten-peptidkonjugaten zum nachweis von anti-hiv-1 oder anti-hiv-2 antikörpern
DE19649390A1 (de) * 1996-11-29 1998-06-04 Boehringer Mannheim Gmbh Antigenspezifischer IgG-Nachweis
DE69825653T2 (de) * 1997-04-04 2005-08-25 Seikagaku Corp. Quantitatives Bestimmungsverfahren für Heparansulfat und Diagnoseverfahren mit dessen Verwendung
US6379909B1 (en) 1998-06-24 2002-04-30 Alk-Abello A/S Method of detecting an antibody in a liquid sample
HU228049B1 (en) * 1998-06-24 2012-09-28 Alk Abello As Method of detecting an antibody in a liquid sample
CA2384693A1 (en) * 1999-09-13 2001-03-22 Nissui Pharmaceutical Co., Ltd. Kit for detecting or assaying subject substance and detection or assay method
EP1373868B1 (de) 2001-02-01 2015-05-20 Sigma-Aldrich Co. LLC Verbesserte affinitätsmatrizen mit grösserer sichtbarkeit für molekulare absenkung und immunoniederschlag anwendungen
EP1390729A4 (de) * 2001-05-03 2007-07-04 Immunetics Inc Systeme und verfahren zum nachweis von analyten in biologischen flüssigkeiten
DE10153963A1 (de) * 2001-11-06 2003-05-22 Aventis Behring Gmbh Intellect Testsystem zur Untersuchung einer biologischen Flüssigkeit
CN111208290A (zh) * 2020-02-27 2020-05-29 江苏泽成生物技术有限公司 一种磁微粒化学发光法醛固酮测定试剂盒及使用方法
CN114236131B (zh) * 2021-11-05 2022-12-06 江苏省人民医院(南京医科大学第一附属医院) 一种检测甲状腺过氧化物酶抗体及其亚型的试剂盒

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228237A (en) * 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
US4301139A (en) * 1979-06-21 1981-11-17 Ames-Yissum Ltd. Multilayer column chromatography specific binding assay method, test device and test kit
US4425438A (en) * 1981-03-13 1984-01-10 Bauman David S Assay method and device
AU8594382A (en) * 1981-08-05 1983-02-10 F. Hoffmann-La Roche Ag Immunoassay using biotin-avidin-enzyme complex
JPS5856696A (ja) * 1981-09-30 1983-04-04 Amano Pharmaceut Co Ltd カラムを用いる酵素免疫測定法
US4535057A (en) * 1982-07-26 1985-08-13 Amf Incorporated Immunoassay employing monoclonal herpes simplex antibody and biotin-avidin detection system
SE458643B (sv) * 1984-12-07 1989-04-17 Pharmacia Ab Anordning med kolonnelement uppdelat i provparti och referenspatri

Also Published As

Publication number Publication date
FI913615A0 (fi) 1991-07-29
AU5098690A (en) 1990-08-24
DE69012552D1 (de) 1994-10-20
JPH04503109A (ja) 1992-06-04
NO912951D0 (no) 1991-07-29
EP0455735B1 (de) 1994-09-14
AU640635B2 (en) 1993-09-02
CA2045673A1 (en) 1990-07-31
NO912951L (no) 1991-09-13
EP0455735A1 (de) 1991-11-13
DK0455735T3 (da) 1994-12-12
DE69012552T2 (de) 1995-04-20
WO1990008957A1 (en) 1990-08-09

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee